Samuel Gandy

Projects

Projects per year 1984 1995 2009 2010 2011 2014 2017 2024

• 10 Active
• 53 Finished

Projects per year

Search results

• Finished

  Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M. & Gandy, S.

  National Institute on Aging

  15/09/20 → 31/08/21

  Project: Research

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 66%
  • Alzheimer Disease 57%
  • Amyloidosis 32%
  • Insulin 30%

• Integrated understanding of complex viral network biology in Alzheimer's Disease

  Dudley, J., Ehrlich, M. & Gandy, S.

  National Institute on Aging

  15/09/17 → 28/02/19

  Project: Research

  • Alzheimer Disease 100%
  • Neuropathology 24%
  • CYS2-HIS2 Zinc Fingers 23%
  • Molecular Pathology 16%
  • Viruses 14%

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• Imaging [18F] AV-1451 and [18F] AV-45 in acute and chronic traumatic brain injury - Add On Funding

  Gandy, S.

  ALZHEIMER'S DRUG DISCOVERY FOUNDATION

  1/01/17 → 31/12/21

  Project: Research

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• Proneurogenic Treatment for Amyloid or Tau-Based Neurodegeneration

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/21

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Amyloid 75%
  • Exercise 73%
  • Neurogenesis 59%

• Imaging [18F]AV-1451 and [18F]AV-45 in acute and chronic traumatic brain injury

  Gandy, S.

  ALZHEIMER'S DRUG DISCOVERY FOUNDATION

  1/01/15 → 1/01/17

  Project: Research

  • Chronic Traumatic Encephalopathy 100%
  • florbetapir 71%
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole 65%
  • Chronic Brain Injury 60%
  • Tauopathies 50%

• Network Based Predictive Drug Discovery for Alzheimer's Disease

  Dudley, J. & Gandy, S.

  National Institute on Aging

  30/09/14 → 31/03/16

  Project: Research

  • Drug Discovery 100%
  • Information Dissemination 91%
  • Pharmacology 77%
  • Alzheimer Disease 75%
  • Research Personnel 54%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• Rehab Therapy Adjunct with a Neurogenic, Mnemoactive, A-Beta-Lowering Compound

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• Generation and Characterization of Alzheimer Brain Cells

  Gandy, S. & Noggle, S. A.

  National Institute on Aging

  1/09/12 → 31/08/15

  Project: Research

  • Induced Pluripotent Stem Cells 100%
  • Alzheimer Disease 83%
  • Mutation 38%
  • Alzheimer disease, familial, type 3 31%
  • Presenilin-2 30%

• Model for SorCS1-mediated Diabetes with Dementia

  Gandy, S.

  National Institute of Neurological Disorders and Stroke

  15/01/12 → 31/12/16

  Project: Research

  • Dementia 100%
  • Alzheimer Disease 73%
  • Cultured Cells 30%
  • Brain 26%
  • Protein Interaction Domains and Motifs 26%

• STATISTICAL BASIS FOR DETERMINING SIGNIFICANCE OF LOCALIZATION OF MODIFICATIONS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • mass spectrometry 100%
  • infrastructure 86%
  • protein 85%
  • resource 65%
  • cost 61%

• PROTEIN QUANTITATION USING MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Mass Spectrometry 100%
  • Organized Financing 74%
  • Proteins 46%
  • Peptides 40%
  • Research Personnel 22%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Organized Financing 100%
  • Research Personnel 29%
  • Costs and Cost Analysis 26%

• IMPROVING THE SUCCESS RATE OF PROTEOME ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Proteome 100%
  • Research Design 76%
  • Organized Financing 45%
  • Mass Spectrometry 34%
  • Systems Biology 22%

• AUTOMATIC PEAK FINDING AND DATABASE SEARCH USING RAW MALDI-LTQ-ORBITRAP DATA

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Costs 100%

• ANALYSIS OF MASS-SPECTRA OF CROSS-LINKED PEPTIDES

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Organized Financing 100%
  • Mass Spectrometry 76%
  • Peptides 54%
  • Glutaral 49%
  • Proteins 46%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • principal investigators 100%
  • histone code 72%
  • Trypanosoma brucei 71%
  • funding 64%
  • Trypanosoma 64%

• DETECTION AND CORRECTION OF INTERFERENCE IN MRM ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • monitoring 100%
  • assay 73%
  • detection 66%
  • protein 61%
  • computer simulation 41%

• EVIDENCE FOR GAMMA-SECRETASE DYSFUNCTION IN SPORADIC AD

  Gandy, S.

  National Institute on Aging

  1/05/10 → 31/03/15

  Project: Research

  • Amyloid Precursor Protein Secretases 100%
  • Flavin-Adenine Dinucleotide 42%
  • Cerebral Cortex 29%
  • Dementia 26%
  • Presenilin-1 21%

• PROTEIN QUANTITATION USING MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • mass spectrometry 100%
  • peptides 53%
  • computational methodology 52%
  • proteins 45%
  • funding 44%

• IMPROVING THE SUCCESS RATE OF PROTEOME ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • experimental design 100%
  • organization 35%
  • protein 34%
  • rate 27%
  • biotechnology 26%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Genes 100%
  • Transcription 40%
  • Chromosomes 40%
  • Genomics 36%

• DEVELOPED SOFTWARE FOR ANALYSIS OF MASS-SPECTRA OF CROSS-LINKED PEPTIDES

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • proteins 100%
  • peptides 86%
  • mass spectra 81%
  • computer programs 68%
  • protease 46%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Websites 100%
  • Network protocols 53%

• INFORMATICS DEVELOPMENT: CHALLENGES AND SOLUTIONS FOR MALDI MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry 100%
  • Nucleic Acid 73%
  • Mass Spectrometry 57%
  • Protein 35%
  • Chemistry 25%

• ALZHEIMER MOUSE MODEL FOR INTRANEURONAL AMYLOID-BETA OLIGOMER BIOLOGY

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • amyloid 100%
  • mice 80%
  • animal models 74%
  • Biological Sciences 56%
  • Alzheimer disease 38%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 30/09/12

  Project: Research

  • amyloid 100%
  • animal models 74%
  • dementia 66%
  • mice 60%
  • Biological Sciences 53%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • Amyloid 100%
  • amyloid 89%
  • mice 60%
  • animal models 56%
  • Biological Sciences 42%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • amyloid 100%
  • animal models 74%
  • Biological Sciences 61%
  • dementia 53%
  • mice 49%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • resources 100%
  • grant 95%
  • funding 79%

• INFORMATICS DEVELOPMENT: CHALLENGES AND SOLUTIONS FOR MALDI MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry 100%
  • Nucleic Acid 73%
  • Mass Spectrometry 57%
  • Protein 35%
  • Chemistry 25%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Genes 100%
  • Chromosomes 60%
  • Genomics 54%

• OPTIMIZING SEARCH CONDITIONS FOR THE MASS FINGERPRINT-BASED ID OF PROTEINS

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Proteins 100%
  • Peptides 16%
  • Blood 11%
  • Plasmas 11%

• DEVELOPED SOFTWARE FOR ANALYSIS OF MASS-SPECTRA OF CROSS-LINKED PEPTIDES

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • proteins 100%
  • peptides 86%
  • mass spectra 81%
  • computer programs 68%
  • protease 46%

• IMPROVING THE SUCCESS RATE OF PROTEOME ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • proteome 100%
  • experimental design 75%
  • systems biology 28%
  • funding 26%
  • computer simulation 25%

• DEVELOPMENT OF A DATABASE FOR MASS SPECTRA - MASS BANK.

  Zhang, W., Miller, D. L., Riggs, A. A. F. & Gandy, S.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Proteins 100%
  • Mass spectrometry 69%
  • World Wide Web 53%
  • Internet 37%

• DVMT OF METHODS TO ELUCIDATE POST TRANSLATIONAL MOD OF PROTEINS: GLYCOSYLATION

  Wang, R., Gandy, S., Adzuma, K. K. & Zhao, Y.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Oligosaccharide 100%
  • Proteins 98%
  • Peptides 70%
  • Ions 49%
  • Carbohydrate 44%

• PROWL AN INTERNET-BASED RESOURCE FOR PROTEIN MASS SPECTROMETRY

  MIRZA, U., Eriksson, J., Severinov, K. K. & Gandy, S.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Internet 100%
  • resources 87%
  • chemistry 42%
  • engineer 38%
  • software 32%

• DISULFIDE MAPPING

  Chait, B. T., Gandy, S., Qin, J. J. & Qin, J.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Proteins 100%
  • Radar 87%
  • Growth Factor 64%
  • Toxin 52%
  • Protein 45%

• RAPID EFFECTIVE PROTEIN IDENTIFICATION ALGORITHMS: "PEPFRAG"

  Riggs, A. F., Padovan, J. C., Wang, R. R. & Gandy, S.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Proteins 100%
  • Peptides 89%
  • Ions 62%
  • Mass spectrometers 48%
  • Enzymes 39%

• DVMT OF SOFTWARE TOOL FOR ANALYSIS OF MASS SPECT DISULFIDE MAPPING EXPERIMENTS

  Lindsey, J., Young, R., Merrifield, R. R. B. & Gandy, S.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Proteins 100%
  • Alkylation 54%
  • Chemical modification 53%
  • Experiments 51%
  • Enzymes 41%

• BIOCHEMISTRY AND FUNCTION OF THE MULTICATALYTIC PROTEINASE COMPLEX

  Chait, B. T., Gandy, S., Fenyo, D. D. & Orlowski, M.

  National Center for Research Resources

  1/10/95 → 30/09/01

  Project: Research

  • Proteasome Endopeptidase Complex 100%
  • Proteins 65%
  • Isocoumarins 60%
  • Proteolysis 60%
  • Biochemistry 57%

• DISPOSITION, METABOLISM &PROCESSING OF OPIATE AGONISTS, ANTAGONISTS &OPIOIDS

  Buxbaum, J., Burley, S. K., Gandy, S., Burley, S. S. K. & Kreek, M. J.

  National Center for Research Resources

  1/10/91 → 30/09/01

  Project: Research

  • Peptides 100%
  • peptide P3 97%
  • Amyloid beta-Protein Precursor 90%
  • Amyloid 74%
  • Protein Phosphatase 1 71%