Samuel Gandy

Projects

Projects per year 1984 1995 2009 2010 2011 2014 2017 2024

• 10 Active
• 53 Finished

Projects per year

Search results

• Active

  MICROGLIAL-SPECIFIC INPP5D KNOCKDOWN MODULATES BEHAVIOR, AMYLOIDOSIS AND TAUOPATHY IN ALZHEIMER'S MOUSE MODELS

  Gandy, S. & Ehrlich, M.

  Cure Alzheimer's Fund

  1/01/22 → …

  Project: Research

  • amyloidosis 100%
  • animal models 73%
  • enzymes 37%
  • municipal solid waste 35%
  • Alzheimer disease 34%

• Integrated understanding of complex viral network biology in Alzheimer's Disease

  Ehrlich, M., Dudley, J. & Gandy, S.

  National Institute on Aging

  1/03/19 → 29/02/24

  Project: Research

  • Alzheimer Disease 100%
  • Neuropathology 22%
  • CYS2-HIS2 Zinc Fingers 21%
  • Molecular Pathology 15%
  • Viruses 13%

• Use of iPSC systems to define roles of microglial TREM2/DAP12 and CR3/DAP12 complexes and their genetic variants in specifying risk for late onset sporadic Alzheimer's disease

  Noggle, S. S. A., Fossati, V., Gandy, S., Noggle, S. A., Gandy, S. S. E. & Fossati, V. V.

  National Institute on Aging

  30/09/18 → 30/04/23

  Project: Research

  • Alzheimer Disease 100%
  • Microglia 83%
  • Brain 28%
  • Late Onset Disorders 20%
  • Organoids 19%

• SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)

  Gandy, S., Dudley, J. & Ehrlich, M.

  National Institute on Aging

  15/07/18 → 31/03/23

  Project: Research

  • Drug Repositioning 100%
  • Alzheimer Disease 77%
  • Drug Delivery Systems 53%
  • Animal Diseases 12%
  • Preliminary Data 10%

• INTERSECTION OF MICROGLIAL TRANSCRIPTOMES TO IDENTIFY KEY ALZHEIMER'S PATHWAYS OF BRAIN PHAGOCYTES

  Gandy, S.

  Cure Alzheimer's Fund

  1/01/16 → …

  Project: Research

  • Alzheimer Disease 100%
  • Phagocytes 79%
  • Transcriptome 79%
  • Brain 52%
  • National Institute on Aging (U.S.) 34%

• STEM CELL APPROACH TO INVESTIGATING THE PHENOMENON OF BRAIN INSULIN RESISTANCE

  Gandy, S.

  Cure Alzheimer's Fund

  1/01/15 → …

  Project: Research

  • Insulin Resistance 100%
  • Brain 59%
  • Insulin 56%
  • Stem Cells 53%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 44%

• GENERATION OF IPS CELLS AND NEURONS FROM SKIN FIBROBLASTS FROM SUBJECTS WITH FAMILIAL AND SPORADIC AD

  Gandy, S. & Noggle, S. S.

  Cure Alzheimer's Fund

  1/01/14 → …

  Project: Research

  • Induced Pluripotent Stem Cells 100%
  • Neurons 81%
  • Fibroblasts 76%
  • Skin 56%
  • Cell Line Authentication 50%

• Integrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's Disease

  Zhang, B. B., Buxbaum, J., Ehrlich, M., Schadt, E., Gandy, S., Haroutunian, V., Iijima, K., Ehrlich, M. M. E., Wang, M., Noggle, S. A., Gandy, S. S. E., Schadt, E. E., Noggle, S. S. A., Haroutunian, V. V., Zhang, B. & Zhu, J.

  National Institute on Aging

  20/09/13 → 31/08/23

  Project: Research

  • Alzheimer Disease 100%
  • Brain 31%
  • Adenosine Monophosphate 31%
  • VGF peptide 26%
  • Cell culture 24%

• STEM CELL CONSORTIUM

  Gandy, S., Ben-hur, T. T., Eggan, K. K., Kim, D. Y. D. Y., Noggle, S. S. & Tessier-lavigne, M. M.

  Cure Alzheimer's Fund

  1/01/13 → …

  Project: Research

  • Alzheimer Disease 100%
  • Stem Cells 66%
  • Induced Pluripotent Stem Cells 64%
  • Neurons 57%
  • Mutation 29%

• BRAIN STRUCTURE, ABETA METABOLISM AND BEHAVIOR IN MICE DEFICIENT IN DIABETES AND ALZHEIMER'S ASSOCIATED SORCS1

  Gandy, S.

  Cure Alzheimer's Fund

  1/01/10 → …

  Project: Research

  • Amyloid beta-Peptides 100%
  • Alzheimer Disease 69%
  • sortilin 48%
  • Brain 36%
  • Organized Financing 35%
• Finished

  Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M. & Gandy, S.

  National Institute on Aging

  15/09/20 → 31/08/21

  Project: Research

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 66%
  • Alzheimer Disease 57%
  • Amyloidosis 32%
  • Insulin 30%

• Integrated understanding of complex viral network biology in Alzheimer's Disease

  Dudley, J., Ehrlich, M. & Gandy, S.

  National Institute on Aging

  15/09/17 → 28/02/19

  Project: Research

  • Alzheimer Disease 100%
  • Neuropathology 24%
  • CYS2-HIS2 Zinc Fingers 23%
  • Molecular Pathology 16%
  • Viruses 14%

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• Imaging [18F] AV-1451 and [18F] AV-45 in acute and chronic traumatic brain injury - Add On Funding

  Gandy, S.

  ALZHEIMER'S DRUG DISCOVERY FOUNDATION

  1/01/17 → 31/12/21

  Project: Research

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

• Proneurogenic Treatment for Amyloid or Tau-Based Neurodegeneration

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/21

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Amyloid 75%
  • Exercise 73%
  • Neurogenesis 59%

• PRONEUROGENIC TREATMENT FOR AMYLOID OR TAU-BASED NEURODEGENERATION

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/01/17 → 31/12/20

  Project: Research

  • BCI-838 100%
  • Tauopathies 76%
  • Exercise 63%
  • Neurogenesis 59%
  • Amyloid 53%

• Imaging [18F]AV-1451 and [18F]AV-45 in acute and chronic traumatic brain injury

  Gandy, S.

  ALZHEIMER'S DRUG DISCOVERY FOUNDATION

  1/01/15 → 1/01/17

  Project: Research

  • Chronic Traumatic Encephalopathy 100%
  • florbetapir 71%
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole 65%
  • Chronic Brain Injury 60%
  • Tauopathies 50%

• Network Based Predictive Drug Discovery for Alzheimer's Disease

  Dudley, J. & Gandy, S.

  National Institute on Aging

  30/09/14 → 31/03/16

  Project: Research

  • Drug Discovery 100%
  • Information Dissemination 91%
  • Pharmacology 77%
  • Alzheimer Disease 75%
  • Research Personnel 54%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• REHAB THERAPY ADJUNCT WITH A NEUROGENIC, MNEMOACTIVE, A-BETA-LOWERING COMPOUND

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• Rehab Therapy Adjunct with a Neurogenic, Mnemoactive, A-Beta-Lowering Compound

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/03/14 → 28/02/18

  Project: Research

  • BCI-838 100%
  • 2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid 90%
  • Post-Traumatic Stress Disorders 41%
  • Traumatic Brain Injury 31%
  • Prodrugs 23%

• Generation and Characterization of Alzheimer Brain Cells

  Gandy, S. & Noggle, S. A.

  National Institute on Aging

  1/09/12 → 31/08/15

  Project: Research

  • Induced Pluripotent Stem Cells 100%
  • Alzheimer Disease 83%
  • Mutation 38%
  • Alzheimer disease, familial, type 3 31%
  • Presenilin-2 30%

• Model for SorCS1-mediated Diabetes with Dementia

  Gandy, S.

  National Institute of Neurological Disorders and Stroke

  15/01/12 → 31/12/16

  Project: Research

  • Dementia 100%
  • Alzheimer Disease 73%
  • Cultured Cells 30%
  • Brain 26%
  • Protein Interaction Domains and Motifs 26%

• STATISTICAL BASIS FOR DETERMINING SIGNIFICANCE OF LOCALIZATION OF MODIFICATIONS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • mass spectrometry 100%
  • infrastructure 86%
  • protein 85%
  • resource 65%
  • cost 61%

• PROTEIN QUANTITATION USING MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Mass Spectrometry 100%
  • Organized Financing 74%
  • Proteins 46%
  • Peptides 40%
  • Research Personnel 22%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Organized Financing 100%
  • Research Personnel 29%
  • Costs and Cost Analysis 26%

• IMPROVING THE SUCCESS RATE OF PROTEOME ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Proteome 100%
  • Research Design 76%
  • Organized Financing 45%
  • Mass Spectrometry 34%
  • Systems Biology 22%

• AUTOMATIC PEAK FINDING AND DATABASE SEARCH USING RAW MALDI-LTQ-ORBITRAP DATA

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Costs 100%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • principal investigators 100%
  • histone code 72%
  • Trypanosoma brucei 71%
  • funding 64%
  • Trypanosoma 64%

• ANALYSIS OF MASS-SPECTRA OF CROSS-LINKED PEPTIDES

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • Organized Financing 100%
  • Mass Spectrometry 76%
  • Peptides 54%
  • Glutaral 49%
  • Proteins 46%

• DETECTION AND CORRECTION OF INTERFERENCE IN MRM ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/11 → 31/03/12

  Project: Research

  • monitoring 100%
  • assay 73%
  • detection 66%
  • protein 61%
  • computer simulation 41%

• EVIDENCE FOR GAMMA-SECRETASE DYSFUNCTION IN SPORADIC AD

  Gandy, S.

  National Institute on Aging

  1/05/10 → 31/03/15

  Project: Research

  • Amyloid Precursor Protein Secretases 100%
  • Flavin-Adenine Dinucleotide 42%
  • Cerebral Cortex 29%
  • Dementia 26%
  • Presenilin-1 21%

• PROTEIN QUANTITATION USING MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • mass spectrometry 100%
  • peptides 53%
  • computational methodology 52%
  • proteins 45%
  • funding 44%

• IMPROVING THE SUCCESS RATE OF PROTEOME ANALYSIS

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • experimental design 100%
  • organization 35%
  • protein 34%
  • rate 27%
  • biotechnology 26%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Genes 100%
  • Transcription 40%
  • Chromosomes 40%
  • Genomics 36%

• DEVELOPED SOFTWARE FOR ANALYSIS OF MASS-SPECTRA OF CROSS-LINKED PEPTIDES

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • proteins 100%
  • peptides 86%
  • mass spectra 81%
  • computer programs 68%
  • protease 46%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Websites 100%
  • Network protocols 53%

• INFORMATICS DEVELOPMENT: CHALLENGES AND SOLUTIONS FOR MALDI MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/10 → 28/02/11

  Project: Research

  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry 100%
  • Nucleic Acid 73%
  • Mass Spectrometry 57%
  • Protein 35%
  • Chemistry 25%

• ALZHEIMER MOUSE MODEL FOR INTRANEURONAL AMYLOID-BETA OLIGOMER BIOLOGY

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • amyloid 100%
  • mice 80%
  • animal models 74%
  • Biological Sciences 56%
  • Alzheimer disease 38%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 30/09/12

  Project: Research

  • amyloid 100%
  • animal models 74%
  • dementia 66%
  • mice 60%
  • Biological Sciences 53%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • Amyloid 100%
  • amyloid 89%
  • mice 60%
  • animal models 56%
  • Biological Sciences 42%

• Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

  Gandy, S.

  U.S. Department of Veterans Affairs

  1/10/09 → 31/03/13

  Project: Research

  • amyloid 100%
  • animal models 74%
  • Biological Sciences 61%
  • dementia 53%
  • mice 49%

• INFORMATICS DEVELOPMENT: CHALLENGES AND SOLUTIONS FOR MALDI MASS SPECTROMETRY

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry 100%
  • Nucleic Acid 73%
  • Mass Spectrometry 57%
  • Protein 35%
  • Chemistry 25%

• NEW WEB SITE CONSTRUCTION

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • resources 100%
  • grant 95%
  • funding 79%

• DEVELOPED A VIEWER FOR CHIP-SEQ DATA

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Genes 100%
  • Chromosomes 60%
  • Genomics 54%

• OPTIMIZING SEARCH CONDITIONS FOR THE MASS FINGERPRINT-BASED ID OF PROTEINS

  Gandy, S.

  National Center for Research Resources

  1/03/09 → 28/02/10

  Project: Research

  • Proteins 100%
  • Peptides 16%
  • Blood 11%
  • Plasmas 11%