Personal profile
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PROFESSOR Medicine, Hematology and Medical Oncology
PROFESSOR Oncological Sciences
PROFESSOR Pathology, Molecular and Cell Based Medicine
Biography
Sacha Gnjatic is a professor and the co-director of the Human Immune Monitoring Center at Mount Sinai. After obtaining his PhD evaluating p53 as a tumor antigen in Paris, he trained with Dr. Lloyd Old at the Ludwig Institute in New York where he studied T cell and antibody responses specific to NY-ESO-1, in particular for antigen presentation and tolerance mechanisms. As a tumor immunologist, he specializes in studying immune correlates, both circulating and tissue-based, to define biomarkers of immunotherapies from human clinical trials. His work has recently also extended to other inflammatory diseases, including COVID-19 and Crohn's disease. Dr. Gnjatic’s work has established the immunological basis for testing human cancer immunotherapies in over 50 clinical trials. His work has resulted in over 215 publications in high-impact peer-reviewed journals and more than 10 patents.
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Collaborations and top research areas from the last five years
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A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma
Immune Atlas Consortium, Jan 2026, In: Nature Cancer. 7, 1, p. 224-246 23 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A Tumor-Promoting Inflammatory SPP1+ Macrophage–IL6–CRP Axis Drives Immune Dysfunction in Bladder Cancer
Tran, M. A., Cho, B. A., Izadmehr, S., Yoo, S. K., Youssef, D., Anker, J. F., Farkas, A. M., Figueiredo, I., Lee, K., Ananthanarayanan, A., Balan, S., Onkar, S., Banchereau, R., Gupta, S., Chhibber, A., Wang, L., Beaumont, K. G., Li, Z., Garcia-Barros, M. & Bicak, M. & 18 others, , Jun 2026, In: Cancer Discovery. 16, 6, p. 1126-1151 26 p.Research output: Contribution to journal › Article › peer-review
Open Access -
CD3 and PD-L1 tissue expression have synergistic value in head and neck squamous cell carcinoma prognosis
Witzleben, A. V., Remark, R., Idel, C., Ribbat-Idel, J., Krupar, R., Schröck, A., Klümper, N., Doescher, J., Sikora, A. G., Kors, T. A., Vahl, J. M., Brand, M., Sonntag, M., Brunner, C., Hoffmann, T. K., Perner, S., Gnjatic, S. & Laban, S., Jun 2026, In: Translational Oncology. 68, 102776.Research output: Contribution to journal › Article › peer-review
Open Access -
Could a COVID-19 vaccine improve the effectiveness of cancer immunotherapy?
Gnjatic, S., Feb 2026, In: Nature Reviews Clinical Oncology. 23, 2, p. 90-91 2 p.Research output: Contribution to journal › Comment/debate
1 Scopus citations -
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
Gonzalez-Kozlova, E., Sweeney, R., Figueiredo, I., Tuballes, K., Ozbey, S., Hamon, P., Park, M. D., Ioannou, G., Nose, Y., Guo, R., Restrepo, P., Buckup, M., Roudko, V., Hennequin, C., Le Berichel, J., Venturini, N., Halasz, L., Troncoso, L., Tabachnikova, A. & Chang, C. & 42 others, , Mar 2026, In: Nature Medicine. 32, 3, p. 978-991 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
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Findings on Immunotherapy Detailed by Investigators at Icahn School of Medicine at Mount Sinai (Humoral Igg1 Responses To Tumor Antigens Underpin Clinical Outcomes In Immune Checkpoint Blockade)
Sweeney, R., Merad, M., Nie, K., Kim-Schulze, S., D'Souza, D., Hamon, P., Tabrizian, P., Cohen, N., Gunasekaran, G., Schwartz, M., Marron, T., Fiel, M., Gnjatic, S., Ward, S., Curotto de Lafaille, M., Kamphorst, A. O., Chen, Z. & Brody, R.
23/02/26
1 item of Media coverage
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Mount Sinai Study Finds Antibody-Producing Immune Cells Can Help Shape Cancer Immunotherapy
Sweeney, R., Merad, M., Kim-Schulze, S., Marron, T. & Gnjatic, S.
27/01/26 → 28/01/26
8 items of Media coverage
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Recent Findings in COVID-19 Described by a Researcher from Icahn School of Medicine at Mount Sinai (Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV-2 Infection)
Beckmann, N., Vasquez Rios , G., Jayaraman, P., Liharska, L., Oh, W., Merad, M., Dellepiane, S., Kim-Schulze, S., Nadkarni, G., Suarez-Farinas, M., Rajagopal, M., Coca, S., Chan, L., Charney, A., Gnjatic, S., Sakhuja, A. & Thompson, R.
21/01/26
1 item of Media coverage
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