Research output per year
Research output per year
Personal profile
Headline
PROFESSOR Medicine, Hematology and Medical Oncology
PROFESSOR Oncological Sciences
PROFESSOR Pathology, Molecular and Cell Based Medicine
Biography
Sacha Gnjatic is a professor and the co-director of the Human Immune Monitoring Center at Mount Sinai. After obtaining his PhD evaluating p53 as a tumor antigen in Paris, he trained with Dr. Lloyd Old at the Ludwig Institute in New York where he studied T cell and antibody responses specific to NY-ESO-1, in particular for antigen presentation and tolerance mechanisms. As a tumor immunologist, he specializes in studying immune correlates, both circulating and tissue-based, to define biomarkers of immunotherapies from human clinical trials. His work has recently also extended to other inflammatory diseases, including COVID-19 and Crohn's disease. Dr. Gnjatic’s work has established the immunological basis for testing human cancer immunotherapies in over 50 clinical trials. His work has resulted in over 215 publications in high-impact peer-reviewed journals and more than 10 patents.
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Collaborations and top research areas from the last five years
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A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation
Biobank Team, 2023, (Accepted/In press) In: Molecular Systems Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis
CCC-GEM Project Research Consortium & OSCCAR Consortium, Apr 2023, In: Gastroenterology. 164, 4, p. 619-629 11 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells
Malle, L., Patel, R. S., Martin-Fernandez, M., Stewart, O. J., Philippot, Q., Buta, S., Richardson, A., Barcessat, V., Taft, J., Bastard, P., Samuels, J., Mircher, C., Rebillat, A. S., Maillebouis, L., Vilaire-Meunier, M., Tuballes, K., Rosenberg, B. R., Trachtman, R., Casanova, J. L., Notarangelo, L. D., & 3 others, 9 Mar 2023, In: Nature. 615, 7951, p. 305-314 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Circulating proteins to predict COVID-19 severity
Dec 2023, In: Scientific Reports. 13, 1, 6236.Research output: Contribution to journal › Article › peer-review
Open Access -
Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma
Pilcher, W., Thomas, B. E., Bhasin, S. S., Jayasinghe, R. G., Yao, L., Gonzalez-Kozlova, E., Dasari, S., Kim-Schulze, S., Rahman, A., Patton, J., Fiala, M., Cheloni, G., Kourelis, T., Dhodapkar, M. V., Vij, R., Mehr, S., Hamilton, M., Cho, H. J., Auclair, D., Avigan, D. E., & 4 others, Dec 2023, In: npj Genomic Medicine. 8, 1, 3.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Press/Media
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Reports from Icahn School of Medicine at Mount Sinai Describe Recent Advances in Multiple Myeloma (High Dimensional Immune Profiling of Smoldering Multiple Myeloma Distinguishes Distinct Tumor Microenvironments)
Seunghee Kim-Schulze, Adeeb Rahman, Samir Parekh, Hearn Cho & Sacha Gnjatic
11/09/23
1 item of Media coverage
Press/Media
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Investigators at Icahn School of Medicine at Mount Sinai Discuss Findings in Liver Cancer [Intratumoral Dendritic Cell-cd4(+) T Helper Cell Niches Enable Cd8(+) T Cell Differentiation Following Pd-1 Blockade In Hepatocellular Carcinoma]
Samarth Hegde, Yonit Lavin, Bruno Giotti, Nausicaa Malissen, Miriam Merad, Seunghee Kim-Schulze, Darwin D'Souza, Pauline Hamon, Yi Wei, Travis Dawson, Alexander Tsankov, Adeeb Rahman, Myron Schwartz, Sacha Gnjatic, Stephen Ward, Alice O. Kamphorst & Ephraim Kenigsberg
29/08/23
1 item of Media coverage
Press/Media
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Findings from Icahn School of Medicine at Mount Sinai Broaden Understanding of Liver Cancer [Abstract 2178: Circulating tumor DNA (ctDNA) correlates closely with tumor necrosis and relapse-free survival (RFS) in hepatocellular carcinoma (HCC) ...]
Miriam Merad, Elizabeth Miller, Edward Kim, Myron Schwartz, Maria Fiel, Sacha Gnjatic, Stephen Ward, Alice O. Kamphorst, Nina Bhardwaj, Pauline Hamon & Israel Lowy,
26/06/23
1 item of Media coverage
Press/Media
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Reports Summarize COVID-19 Study Results from Icahn School of Medicine at Mount Sinai (Evaluation of Immunological Responses To Third Covid-19 Vaccine Among People Treated With Sphingosine Receptor-1 Modulators and Anti-cd20 Therapy)
Miriam Merad, Erin Beck, Aaron Miller, Fred Lublin, Sylvia Klineova, Sacha Gnjatic, Michelle Fabian, Florian Krammer, Stephen C. Krieger, Sam Horng, Stephanie Tankou, Neha Safi & Neha Safi
21/06/23
1 item of Media coverage
Press/Media
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Mount Sinai Hospital: Study Reveals a Trio of Immune Cells Vital in Response to Liver Cancer Immunotherapy
Samarth Hegde, Miriam Merad, Seunghee Kim-Schulze, Darwin D'Souza, Travis Dawson, Adeeb Rahman, Myron Schwartz, Thomas Marron, Sacha Gnjatic, Alice O. Kamphorst, Ephraim Kenigsberg, Yonit Lavin, Bruno Giotti, Nausicaa Malissen, Yi Wei, Stephen Ward & Pauline Hamon
16/06/23
1 item of Media coverage
Press/Media