Sacha Gnjatic

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Research activity per year

Headline

PROFESSOR Medicine, Hematology and Medical Oncology
PROFESSOR Oncological Sciences
PROFESSOR Pathology, Molecular and Cell Based Medicine

Biography

Sacha Gnjatic is a professor and the co-director of the Human Immune Monitoring Center at Mount Sinai. After obtaining his PhD evaluating p53 as a tumor antigen in Paris, he trained with Dr. Lloyd Old at the Ludwig Institute in New York where he studied T cell and antibody responses specific to NY-ESO-1, in particular for antigen presentation and tolerance mechanisms. As a tumor immunologist, he specializes in studying immune correlates, both circulating and tissue-based, to define biomarkers of immunotherapies from human clinical trials. His work has recently also extended to other inflammatory diseases, including COVID-19 and Crohn's disease. Dr. Gnjatic’s work has established the immunological basis for testing human cancer immunotherapies in over 50 clinical trials. His work has resulted in over 215 publications in high-impact peer-reviewed journals and more than 10 patents.

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210 Article
16 Review article
13 Comment/debate
3 Chapter
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An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
LaMarche, N. M., Hegde, S., Park, M. D., Maier, B. B., Troncoso, L., Le Berichel, J., Hamon, P., Belabed, M., Mattiuz, R., Hennequin, C., Chin, T., Reid, A. M., Reyes-Torres, I., Nemeth, E., Zhang, R., Olson, O. C., Doroshow, D. B., Rohs, N. C., Gomez, J. E. & Veluswamy, R. & 18 others, Hall, N., Venturini, N., Ginhoux, F., Liu, Z., Buckup, M., Figueiredo, I., Roudko, V., Miyake, K., Karasuyama, H., Gonzalez-Kozlova, E., Gnjatic, S., Passegué, E., Kim-Schulze, S., Brown, B. D., Hirsch, F. R., Kim, B. S., Marron, T. U. & Merad, M., 4 Jan 2024, In: Nature. 625, 7993, p. 166-174 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
39 Scopus citations
Author Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial(Nature Medicine, 10.1038/s41591-023-02568-1)
Galsky, M. D., Daneshmand, S., Izadmehr, S., Gonzalez-Kozlova, E., Chan, K. G., Lewis, S., Achkar, B. E., Dorff, T. B., Cetnar, J. P., Neil, B. O., D’Souza, A., Mamtani, R., Kyriakopoulos, C., Jun, T., Gogerly-Moragoda, M., Brody, R., Xie, H., Nie, K., Kelly, G. & Horowitz, A. & 20 others, Kinoshita, Y., Ellis, E., Nose, Y., Ioannou, G., Cabal, R., Del Valle, D. M., Haines, G. K., Wang, L., Mouw, K. W., Samstein, R. M., Mehrazin, R., Bhardwaj, N., Yu, M., Zhao, Q., Kim-Schulze, S., Sebra, R., Zhu, J., Gnjatic, S., Sfakianos, J. & Pal, S. K., Apr 2024, In: Nature Medicine. 30, 4, p. 1211 1 p.
Research output: Contribution to journal › Comment/debate

Open Access
1 Scopus citations
Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection
Cossarini, F., Shang, J., Krek, A., Al-Taie, Z., Hou, R., Canales-Herrerias, P., Tokuyama, M., Tankelevich, M., Tillowitz, A., Jha, D., Livanos, A. E., Leyre, L., Uzzan, M., Martinez-Delgado, G., Taylor, M. D., Sharma, K., Bourgonje, A. R., Cruz, M., Ioannou, G. & Dawson, T. & 15 others, D'Souza, D., Kim-Schulze, S., Akm, A., Aberg, J. A., Chen, B. K., Kwon, D. S., Gnjatic, S., Polydorides, A. D., Cerutti, A., Argmann, C., Vujkovic-Cvijin, I., Suarez-Fariñas, M., Petralia, F., Faith, J. J. & Mehandru, S., 25 Oct 2024, In: Science immunology. 9, 100, p. eado0090
Research output: Contribution to journal › Article › peer-review

Open Access
Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer
Jahangir, C. A., Page, D. B., Broeckx, G., Gonzalez, C. A., Burke, C., Murphy, C., Reis-Filho, J. S., Ly, A., Harms, P. W., Gupta, R. R., Vieth, M., Hida, A. I., Kahila, M., Kos, Z., van Diest, P. J., Verbandt, S., Thagaard, J., Khiroya, R., Abduljabbar, K. & Acosta Haab, G. & 117 others, Acs, B., Adams, S., Almeida, J. S., Alvarado-Cabrero, I., Azmoudeh-Ardalan, F., Badve, S., Baharun, N. B., Bellolio, E. R., Bheemaraju, V., Blenman, K. R. M., Botinelly Mendonça Fujimoto, L., Burgues, O., Chardas, A., Cheang, M. C. U., Ciompi, F., Cooper, L. A. D., Coosemans, A., Corredor, G., Dantas Portela, F. L., Deman, F., Demaria, S., Dudgeon, S. N., Elghazawy, M., Fernandez-Martín, C., Fineberg, S., Fox, S. B., Giltnane, J. M., Gnjatic, S., Gonzalez-Ericsson, P. I., Grigoriadis, A., Halama, N., Hanna, M. G., Harbhajanka, A., Hart, S. N., Hartman, J., Hewitt, S., Horlings, H. M., Husain, Z., Irshad, S., Janssen, E. A. M., Kataoka, T. R., Kawaguchi, K., Khramtsov, A. I., Kiraz, U., Kirtani, P., Kodach, L. L., Korski, K., Akturk, G., Scott, E., Kovács, A., Lænkholm, A. V., Lang-Schwarz, C., Larsimont, D., Lennerz, J. K., Lerousseau, M., Li, X., Madabhushi, A., Maley, S. K., Manur Narasimhamurthy, V., Marks, D. K., McDonald, E. S., Mehrotra, R., Michiels, S., Kharidehal, D., Minhas, F. U. A. A., Mittal, S., Moore, D. A., Mushtaq, S., Nighat, H., Papathomas, T., Penault-Llorca, F., Perera, R. D., Pinard, C. J., Pinto-Cardenas, J. C., Pruneri, G., Pusztai, L., Rajpoot, N. M., Rapoport, B. L., Rau, T. T., Ribeiro, J. M., Rimm, D., Vincent-Salomon, A., Saltz, J., Sayed, S., Hytopoulos, E., Mahon, S., Siziopikou, K. P., Sotiriou, C., Stenzinger, A., Sughayer, M. A., Sur, D., Symmans, F., Tanaka, S., Taxter, T., Tejpar, S., Teuwen, J., Thompson, E. A., Tramm, T., Tran, W. T., van der Laak, J., Verghese, G. E., Viale, G., Wahab, N., Walter, T., Waumans, Y., Wen, H. Y., Yang, W., Yuan, Y., Bartlett, J., Loibl, S., Denkert, C., Savas, P., Loi, S., Specht Stovgaard, E., Salgado, R., Gallagher, W. M. & Rahman, A., Mar 2024, In: Journal of Pathology. 262, 3, p. 271-288 18 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
2 Scopus citations
Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond
Pandey, S., Cholak, M. E., Yadali, R., Sosman, J. A., Tetreault, M. P., Fang, D., Pollack, S. M., Gnjatic, S., Obeng, R. C., Lyerly, H. K., Sonabend, A. M., Guevara-Patiño, J. A., Butterfield, L. H., Zhang, B., Maecker, H. T. & Le Poole, I. C., Feb 2024, In: Cancers. 16, 3, 475.
Research output: Contribution to journal › Article › peer-review

Open Access

Findings from Icahn School of Medicine at Mount Sinai Yields New Findings on Cancer (An Il-4 Signalling Axis In Bone Marrow Drives Pro-tumorigenic Myelopoiesis)
Hegde, S., Hirsch, F., Merad, M., Kim-Schulze, S., Hamon, P., Hirsch, F., Veluswamy, R., Brown, B., Gomez, J., Gnjatic, S. & Kim, B.
9/09/24
1 item of Media coverage
Press/Media
New Breast Cancer Study Findings Recently Were Reported by Researchers at University College Dublin (Image-based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-oncology Biomarker ...)
Gnjatic, S.
4/03/24
1 item of Media coverage
Press/Media
A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests
Hegde, S., Hirsch, F., Merad, M., Kim-Schulze, S., Hamon, P., Hirsch, F., Veluswamy, R., Brown, B., Gomez, J., Marron, T., Gnjatic, S. & Kim, B.
1/01/24
1 item of Media coverage
Press/Media
Mount Sinai Lung Cancer Breakthrough: Allergy Medicine’s Unexpected Role in Treatment
Hegde, S., Hirsch, F., Merad, M., Kim-Schulze, S., Hamon, P., Hirsch, F., Veluswamy, R., Brown, B., Gomez, J., Marron, T., Gnjatic, S. & Kim, B.
8/12/23
1 item of Media coverage
Press/Media
A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests
Hegde, S., Hirsch, F., Merad, M., Kim-Schulze, S., Hamon, P., Hirsch, F., Veluswamy, R., Brown, B., Gomez, J., Marron, T., Gnjatic, S. & Kim, B.
6/12/23 → 7/12/23
75 items of Media coverage
Press/Media

Sacha Gnjatic

Personal profile

Headline

Biography

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis

Author Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial(Nature Medicine, 10.1038/s41591-023-02568-1)

Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection

Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer

Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond

Findings from Icahn School of Medicine at Mount Sinai Yields New Findings on Cancer (An Il-4 Signalling Axis In Bone Marrow Drives Pro-tumorigenic Myelopoiesis)

New Breast Cancer Study Findings Recently Were Reported by Researchers at University College Dublin (Image-based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-oncology Biomarker ...)

A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests

Mount Sinai Lung Cancer Breakthrough: Allergy Medicine’s Unexpected Role in Treatment

A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests

Sacha Gnjatic

Personal profile

Headline

Biography

Fingerprint

Collaborations and top research areas from the last five years

Research output

Press/Media