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PROFESSOR | Cell, Developmental and Regenerative Biology
Biography
Ross L. Cagan, PhD, is Professor of the Department of Developmental and Regenerative Biology and Director of the Center for Personalized Cancer Therapeutics. He is also Senior Editor of Disease Models and Mechanisms and co-founder of Medros Inc. Dr. Cagan's laboratory focuses on the use of Drosophila to address disease mechanisms and therapeutics, primarily for cancer. Their work helped validate vandetanib as a therapeutic for Medullary Thyroid Carcinoma, combined Drosophila genetics and medicinal chemistry to develop a new generation of lead compounds that emphasize "balanced polypharmacology", and identified novel mechanisms that direct transformed cells into the first steps towards metastasis. Combining these basic research approaches, Dr. Cagan has established the Center for Personalized Cancer Therapeutics, in which new tools including 'personalized Drosophila avatars' are developed and used to screen for personalized drug cocktails. Working with co-directors Marshall Posner, Krzysztof Misiukiewicz and Eric Schadt, the CPCT is designed to treat patients with drug combinations that best address the tumor's complexities. For more information, please visit the Cagan Laboratory website. For more information, please visit the http://labs.icahn.mssm.edu/caganlab/ Cagan Laboratory website. For patient information please visit the https://icahn.mssm.edu/research/personalized-cancer-therapeutics Center for Personalized Cancer Therapeutics website.
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A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.
1/03/21 → 28/02/23
Project: Research
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Embracing Genetic Complexity in Personalized Fly Models of Lung Cancer
Lung Cancer Research Foundation
1/01/14 → …
Project: Research
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Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics
1/09/15 → 1/09/15
Project: Research
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Drugging the undruggable: Ross Cagan interviews Kevan Shokat
Cagan, R. & Shokat, K., Feb 2022, In: DMM Disease Models and Mechanisms. 15, 2, dmm049468.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma
Bangi, E., Smibert, P., Uzilov, A. V., Teague, A. G., Gopinath, S., Antipin, Y., Chen, R., Hecht, C., Gruszczynski, N., Yon, W. J., Malyshev, D., Laspina, D., Selkridge, I., Wang, H., Gomez, J., Mascarenhas, J., Moe, A. S., Lau, C. Y., Taik, P., Pandya, C., & 10 others , 19 Mar 2021, In: iScience. 24, 3, 102212.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Crowdsourced identification of multi-target kinase inhibitors for RET- And TAU- based disease- And Multi-Targeting Drug DREAM Challenge
Xiong, Z., Jeon, M., Allaway, R. J., Kang, J., Park, D., Lee, J., Jeon, H., Ko, M., Jiang, H., Zheng, M., Tan, A. C., Guo, X., Dang, K. K., Tropsha, A., Hecht, C., Das, T. K., Carlson, H. A., Abagyan, R., Guinney, J., Schlessinger, A., & 1 others , Sep 2021, In: PLoS Computational Biology. 17, 9, e1009302.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy
Das, T. K., Gatto, J., Mirmira, R., Hourizadeh, E., Kaufman, D., Gelb, B. D. & Cagan, R., 23 Apr 2021, In: iScience. 24, 4, 102306.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6
Padash Barmchi, M., Thomas, M., Thatte, J. V., Vats, A., Zhang, B., Cagan, R. L. & Banks, L., Dec 2021, In: Scientific Reports. 11, 1, 1111.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Press / Media
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Could Fruit Flies Help Match Patients With Cancer Treatments?
26/02/21
1 item of Media coverage
Press/Media
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Specially created animal 'cancer avatars' could personalise treatments
23/05/19
1 item of Media coverage
Press/Media