Research output per year
Research output per year
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ASSOCIATE PROFESSOR | Neuroscience ASSOCIATE PROFESSOR | Neurosurgery
Biography
Dr. Roland Friedel, is an expert in the fields of developmental neurobiology and brain tumor research. His research team focuses on the question of how axon guidance molecules and growth factors regulate the migration and differentiation of brain tumor cells. He is also investigating the molecular characteristics that define brain tumor stem cells. Multi-Disciplinary Training Areas Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU] Education Ph D, University of Munich Postdoctoral, Stanford University
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Collaborations and top research areas from the last five years
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3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
Lee, V. K., Tejero, R., Silvia, N., Sattiraju, A., Ramakrishnan, A., Shen, L., Wojcinski, A., Kesari, S., Friedel, R. H., Zou, H. & Dai, G., 2025, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
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Generation of Plexin-B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology
Ni, H., Kelley, K., Xie, N., Zou, H. & Friedel, R. H., Jun 2025, In: Genesis (United States). 63, 3, e70019.Research output: Contribution to journal › Article › peer-review
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Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches
Kang, S., Ughetta, M. E., Zhang, J. Y., Marallano, V. J., Sattiraju, A., Hannah, T., Wahane, S., Ramakrishnan, A., Estill, M., Tsankova, N. M., Shen, L., Tsankov, A. M., Friedel, R. H. & Zou, H., 2025, (Accepted/In press) In: Nature Cancer. 3606.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
Junqueira Alves, C., Hannah, T., Sadia, S., Kolsteeg, C., Dixon, A., Wiener, R. J., Nguyen, H., Tipping, M. J., Silva Ladeira, J., Fernandes da Costa Franklin, P., de Paula Dutra de Nigro, N., Alves Dias, R., Zabala Capriles, P. V., Rodrigues Furtado de Mendonça, J. P., Slesinger, P. A., Costa, K. D., Zou, H. & Friedel, R. H., Dec 2025, In: Nature Communications. 16, 1, 272.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines
Marallano, V. J., Ughetta, M. E., Tejero, R., Nanda, S., Ramalingam, R., Stalbow, L., Sattiraju, A., Huang, Y., Ramakrishnan, A., Shen, L., Wojcinski, A., Kesari, S., Zou, H., Tsankov, A. M. & Friedel, R. H., Dec 2024, In: Scientific Reports. 14, 1, 7246.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations
Press/Media
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Icahn School of Medicine at Mount Sinai Researchers Update Current Data on Gliomas (Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2)
Wiener, R., Costa, K., Friedel, R., Slesinger, P. & Zou, H.
17/01/25
1 item of Media coverage
Press/Media
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Investigators from Icahn School of Medicine at Mount Sinai Zero in on Alzheimer Disease (Regulation of Cell Distancing In Peri-plaque Glial Nets By Plexin-b1 Affects Glial Activation and Amyloid Compaction In Alzheimer's Disease)
Kang, S., Brennand, K., Wang, M., Li, A., Friedel, R., Ho, L., Zou, H., Buxbaum, J., Kostic, A. & Crary, J.
14/06/24
1 item of Media coverage
Press/Media
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Early-stage research suggests new way to fight Alzheimer’s disease…
3/06/24
3 items of Media coverage
Press/Media
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Is it possible for a new approach to stop or delay progression?
3/06/24
1 item of Media coverage
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Without Plexin-B1, Glial Net Closes in Around Plaques
Wang, M., Friedel, R., Zou, H. & Wang, P.
1/06/24
1 item of Media coverage
Press/Media