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ASSOCIATE PROFESSOR | Neuroscience ASSOCIATE PROFESSOR | Neurosurgery
Biography
Dr. Roland Friedel, is an expert in the fields of developmental neurobiology and brain tumor research. His research team focuses on the question of how axon guidance molecules and growth factors regulate the migration and differentiation of brain tumor cells. He is also investigating the molecular characteristics that define brain tumor stem cells. Multi-Disciplinary Training Areas Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU] Education Ph D, University of Munich Postdoctoral, Stanford University
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Collaborations and top research areas from the last five years
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AhR inhibition promotes axon regeneration via a stress–growth switch
Halawani, D., Wang, Y., Li, J., Halperin, D., Ni, H., Estill, M., Ramakrishnan, A., Shen, L., Sefiani, A., Geoffroy, C. G., Friedel, R. H. & Zou, H., 2026, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Directional guidance to orient Schwann cell alignment in nerve regeneration requires Plexin-B1
Li, J., Ni, H., Halawani, D., Estill, M., Ramakrishnan, A., Alves, C. J., Shen, L., He, X., Friedel, R. H. & Zou, H., 24 Apr 2026, In: Science advances. 12, 17, p. eadw4136Research output: Contribution to journal › Article › peer-review
Open Access -
3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
Lee, V. K., Tejero, R., Silvia, N., Sattiraju, A., Ramakrishnan, A., Shen, L., Wojcinski, A., Kesari, S., Friedel, R. H., Zou, H. & Dai, G., 4 Sep 2025, In: Advanced Science. 12, 33, e00689.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Developing Topics
Comandante-Lou, N., Lama, T. D., Chen, K. W., Zhang, J., Hu, B., Liu, S., Heuer, S. E., Brennand, K., Schneider, J. A., Barnes, L. L., Zhang, B., Wang, M., Zou, H., Friedel, R. H., Ma, Y., Young-Pearse, T. L., Li, A., Fujita, M., Bennett, D. A. A. & Zhang, Y. & 4 others, , 1 Dec 2025, In: Alzheimer's and Dementia. 21, p. e108184Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of Plexin-B1 Conditional Knockout Mouse With CRISPR/Cas9 Technology
Ni, H., Kelley, K., Xie, N., Zou, H. & Friedel, R. H., Jun 2025, In: Genesis (United States). 63, 3, e70019.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Press/Media
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Researchers Unlock the Key to Axon Regeneration
Friedel, R., Zou, H. & Halawani, D.
1/04/26
1 item of Media coverage
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Studies from Icahn School of Medicine at Mount Sinai Yield New Data on Engineering (Generation of Plexin-b1 Conditional Knockout Mouse With Crispr/cas9 Technology)
21/07/25
1 item of Media coverage
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Study Findings from Icahn School of Medicine at Mount Sinai Provide New Insights into Glioblastomas (Glioblastoma Shift From Bulk To Infiltrative Growth Is Guided By Plexin-b2-mediated Microglia Alignment In Invasive Niches)
Kang, S., Marallano, V., Tsankov, A., Friedel, R., Tsankova, N. & Zou, H.
20/06/25
1 item of Media coverage
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Icahn School of Medicine at Mount Sinai Researchers Update Current Data on Gliomas (Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2)
Wiener, R., Costa, K., Friedel, R., Slesinger, P. & Zou, H.
17/01/25
1 item of Media coverage
Press/Media