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Dr. René Kahn is the Esther and Joseph Klingenstein Professor and System Chair of Psychiatry at the Icahn School of Medicine at Mount Sinai. After completing medical school in the Netherlands (1979), he was trained as a psychiatrist and neurologist in Utrecht and Amsterdam, respectively. He then moved to New York City (1985), where he did a research fellowship in biological psychiatry at Albert Einstein College of Medicine. He subsequently completed his psychiatry residencies at Mount Sinai Hospital and then worked as Chief of the psychiatry research unit at the Bronx VA. In 1993 he moved back to Utrecht to become Chair of Psychiatry at the University hospital, going on to lead the Brain Center Rudolf Magnus, which combines research in basic neuroscience, psychiatry and neurology. He remained connected to Mount Sinai School of Medicine as an Adjunct Associate professor for several years.
One of his most important contributions to science has been to help provide the scientific foundation of the century-old postulate that schizophrenia debuts with cognitive dysfunction—preceding the onset of the first psychosis by more than a decade. Moreover, he and his group have shown that brain changes in schizophrenia are progressive over time, and that these changes are clinically relevant, related as they are to outcome and to loss of cognitive function during the course of the illness. Finally, his research has shown that brain volume is one of the most heritable characteristics of man, paving the way to link brain volumes in health and disease to genetic variation. During his time in Europe he initiated several large treatment trials in schizophrenia in order to improve the outcome of patients with schizophrenia. He is also involved in many other collaborative studies, examining both genetic and neuroimaging parameters. His work has been funded by various sources such as the European Union, the Dutch Government, NIMH and the Stanley Foundation.
Dr. Kahn has published over 900 research papers and was named Thomson Reuters’ highly cited researcher every year since 2015, representing ‘some of the world’s most influential scientific minds.’ He has served on neuroscience grant review boards in the Netherlands as well as those of the United Kingdom and Germany. He received several honors, such as a Fulbright Scholarship, membership of the Royal Netherlands Academy of Arts and Sciences, the ECNP Neuropsychopharmacology Award, an honorary doctorate at Semmelweis University in Budapest, Hungary and the lifetime achievement award of the Netherlands Psychiatric Association. He is Honorary Lifetime Professor at Jilin University in Changchun, China. He was Treasurer and Vice-Presidentof the European College of Neuropsychopharmacology and is currently past-President of The Schizophrenia International Research Society. He is a fellow of the American College of Neuropsychopharmacology. Dr. Kahn also actively served in the 42 Armored Brigade of the Royal Army of the Netherlands as a 1st Lt (he retired a Lt. Col in the Army Reserve).
Education
- School of Medicine, University Groningen, The Netherlands 1972-1979
- Psychiatry residencies, University Hospital Utrecht, The Netherlands 1981-1983
- Neurology residencies, Academic Medical Center, Amsterdam, The Netherlands 1983-1985
- Fellowship Biological Psychiatry, Montefiore Hospital and Albert Einstein College of Medicine, New York, U.S.A. 1985-1988
- Residencies Psychiatry, Mount Sinai Hospital/Bronx VA Medical Center, New York, U.S.A. 1988-1992
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Collaborations and top research areas from the last five years
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Aberrant effective connectivity during working memory performance in schizotypal personality disorder and schizophrenia: A spectrum approach
Hazlett, E. A., Fiore, V. G., Shafritz, K. M., Ng, S., Aladin, S., Kowalchyk, M. L., Dolgopolskaia, E. S., Russo, D. L., Chan, C. C., Perez-Rodriguez, M. M., Haznedar, M. M., Kahn, R. S., McClure, M. M., Goldstein, K. E. & Szeszko, P. R., Mar 2026, In: Neuropsychopharmacology. 51, 4, p. 791-798 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Accurate DNA methylation predictor for C9orf72 repeat expansion alleles in the pathogenic range
Ramesh, N., Evans, A., Wojta, K., Yang, Z., Boks, M. P., Kahn, R. S., de Boer, S. C. M., van der Lee, S. J., Pijnenburg, Y. A. L., Reus, L. M. & Ophoff, R. A., 15 Jan 2026, In: Human Genetics and Genomics Advances. 7, 1, 100522.Research output: Contribution to journal › Article › peer-review
Open Access -
Cognitive impairment preceding the onset of the first psychosis episode in schizophrenia
Reichenberg, A. & Kahn, R. S., 2026, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Review article › peer-review
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DGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts
Lifespan Brain Chart Consortium, 1 Jan 2026, In: Bioinformatics. 42, 1, btaf625.Research output: Contribution to journal › Article › peer-review
Open Access -
Ensuring generalizability and clinical utility in mental health care applications: Robust artificial intelligence-based treatment predictions in diverse psychosis populations
Coutts, F., Mena, S., Ucur, E., Fleischhacker, W. W., Kahn, R., Lieberman, J., Hasan, A., Howes, O., Correll, C., Koutsouleris, N. & Lalousis, P. A., Jan 2026, In: Psychiatry and Clinical Neurosciences. 80, 1, p. 64-75 12 p.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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New Psychosis Study Results from King's College London Described (Identifying Transdiagnostic Predictors of Depression across Psychoses: Informing Stratified Antidepressant Treatments)
Kahn, R. & Kahn, R. S.
15/04/26
1 item of Media coverage
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Studies from Icahn School of Medicine at Mount Sinai Provide New Data on Schizotypal Personality Disorders (Aberrant effective connectivity during working memory performance in schizotypal personality disorder and schizophrenia: A spectrum ...)
McNamara McClure, M., Kahn, R., Fiore, V., Hazlett, E., Chan, C., Perez-Rodriguez, M. D. L. M. & Kahn, R. S.
24/12/25
1 item of Media coverage
Press/Media
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Findings from King's College London Provide New Insights into Schizophrenia (Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study)
Kahn, R. & Kahn, R. S.
19/12/25
1 item of Media coverage
Press/Media
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Investigators at University Medical Center Utrecht Target Autism Spectrum Disorders (Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia)
Kahn, R. & Kahn, R. S.
5/12/25
1 item of Media coverage
Press/Media