Projects per year
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Headline
ASSISTANT PROFESSOR | Medicine, Infectious Diseases
Biography
During my doctoral and post-doctoral training, my research was focused on understanding the interplay between viral infections and the host immune response. In particular, I was interested in how Human Immunodeficiency Virus (HIV) evades human innate and adaptive immune responses. While the advent of highly active antiretroviral therapy (HAART) has turned HIV/AIDS into a lifelong, chronic infection in most of the developed world, the epidemic continues to be an ongoing and substantial threat to public health in the developing world where approximately 90% of people infected with HIV/AIDS reside. Therefore, the development of an effective HIV vaccine is widely believed to be the most effective way to control the spread of HIV infection in endemic areas. My research aims to identify and characterize the mechanisms by which the human immune system can effectively inhibit HIV replication, which will aid in the development of an effective HIV vaccine.
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Projects
- 1 Finished
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IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes
Garrido, J. L., Medina, M. A., Bravo, F., McGee, S., Fuentes-Villalobos, F., Calvo, M., Pinos, Y., Bowman, J. W., Bahl, C. D., Barria, M. I., Brachman, R. A. & Alvarez, R. A., 31 May 2022, In: Cell Reports. 39, 9, 110904.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
Hioe, C. E., Li, G., Liu, X., Tsahouridis, O., He, X., Funaki, M., Klingler, J., Tang, A. F., Feyznezhad, R., Heindel, D. W., Wang, X. H., Spencer, D. A., Hu, G., Satija, N., Prévost, J., Finzi, A., Hessell, A. J., Wang, S., Lu, S., Chen, B. K., & 4 others , Jan 2022, In: PLoS Pathogens. 18, 1, e1010183.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence
COVID-19 South Chile Group, 7 Feb 2022, In: Frontiers in Immunology. 13, 796481.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection
Salinas, T. P., Garrido, J. L., Salazar, J. R., Gonzalez, P., Zambrano, N., Fuentes-Villalobos, F., Bravo, F., Fica-Leon, V., Salas-Burgos, A., Calvo, M., Alvarez, R., Armien, B. & Barria, M. I., 19 Mar 2021, In: Frontiers in Immunology. 12, 603228.Research output: Contribution to journal › Article › peer-review
Open Access -
Endocytic motif on a biotin-tagged hiv-1 env modulates the co-transfer of env and gag during cell-to-cell transmission
Barría, M. I., Alvarez, R. A., Law, K., Wolfson, D. L., Huser, T. & Chen, B. K., Sep 2021, In: Viruses. 13, 9, 1729.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Press / Media
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Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters.(DISPATCHES)
1/10/21
1 item of Media coverage
Press/Media