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20072022

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ASSISTANT PROFESSOR | Medicine, Clinical Immunology

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Specialty http://www.mountsinai.org/vgn-ext-templating/FapServlet?tab=fad&sp=Allergy+and+Immunology&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=276c2ed69fb76210VgnVCM1000003242020aRCRD&sitename=MSMC&fpa=&inst= Allergy and Immunology Certifications American Board of Allergy & Immunology American Board of Internal Medicine Clinical Focus http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/allergic-bronchopulmonary-aspergillosis-abpa Allergic Bronchopulmonary Aspergillosis (ABPA) http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/allergic-rhinitis Allergic Rhinitis http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/allergy-testing Allergy Testing http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/anaphylaxis Anaphylaxis http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/angioedema Angioedema http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/asthma Asthma http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/eosinophilia Eosinophilia http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/food-allergy Food Allergy http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/hives Hives http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/pulmonary-function-tests Pulmonary Function Tests http://www.mountsinai.org/patient-care/health-library/diseases-and-conditions/sinusitis Sinusitis Education MD/PHD, Albert Einstein College of Medicine Residency, Internal Medicine Mount Sinai Hospital Fellowship, Allergy & Immunology Mount Sinai Hospital Fellowship, Allergy & Immunology Mount Sinai Hospital Biography PJ Maglione, MD, PhD is a physician-scientist in the Division of Clinical Immunology of the Department of Medicine. His research efforts in the areas of primary antibody deficiency and B cell biology have been supported by the Thrasher Research Fund, Clinical Immunology Society, and Jeffrey Modell Foundation. Dr. Maglione is board-certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology, sees patients at the clinical immunology faculty practice, and supervises a weekly teaching clinic with the fellows in Mount Sinai's Allergy/Immunology training program. Awards 2013 - Clemens von Pirquet Award American College of Allergy, Asthma, and Immunology 2013 - 2014 Senior Fellowship Award Clinical Immunology Society 2012 - 2013 Early Career Award Thrasher Research Fund Research Non-infectious complications of primary immunodeficiency While susceptibility to infection is a hallmark of primary immunodeficiency, dysregulated immune function can occur, manifesting as autoimmunity, inflammatory disease, or malignancy. Dr. Maglione is exploring the clinical and immunological parameters that predispose certain patients to these non-infectious, but markedly deleterious, complications of primary immunodeficiency. He has a particular interest in studying interstitial lung disease and B cell lymphoproliferative complications occurring in common variable immunodeficiency, and is involved in clinical research studies exploring possible treatments. This work has the potential to elucidate the determinants of dysregulated B cell responses underlying many types of autoimmunity and maligancy. T-independent antibody responses against bacteria Current vaccines against bacteria are limited by serotype specificity and lack of long-term efficacy. With expanding resistance against antibiotics, new strategies for augmenting antibacterial immunity are clearly needed. Using a "bedside-to-bench" research approach, Dr. Maglione is studying human primary immunodeficiencies that impair the ability to produce antibodies against bacteria in order to understand the biological determinants of successful immunity against these pathogens. The goal of this work is to translate new information about how humans make antibodies against bacteria into novel strategies for immune therapies and vaccines. Particular attention is paid to "T-independent" antibody responses, as they are quite potent against bacteria but have not been extensively studied outside of animal models.

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