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PROFESSOR & CHAIR | Neuroscience, DIRECTOR | Drug Discovery Institute

Biography

Biography Paul J. Kenny, PhD, is Ward-Coleman Professor and Chair of the https://icahn.mssm.edu/about/departments/neuroscience Nash Family Department of Neuroscience. Dr. Kenny also serves as the Director of the https://icahn.mssm.edu/research/ddi Drug Discovery Institute. His multidisciplinary research involves the study of behavioral paradigms, physiological analyses, and the molecular underpinnings of neurobehavioral disorders. Dr. Kenny is actively investigating the brains of rodents to uncover new signaling cascades that may play a role in addiction-like behaviors. The http://labs.icahn.mssm.edu/kennylab/ Kenny Laboratory is focused on understanding the neurobiological mechanisms of drug addiction, obesity and schizophrenia, with an emphasis on the role of nicotinic acetylcholine receptors (nAChRs) in these processes. They employ a multidisciplinary approach that includes complex behavioral paradigms, physiological analyses and molecular biological techniques. Current projects include the utilization of vector-based delivery systems to modify gene expression in the brains of rodents to identify novel signaling cascades that may play a role in addiction-like behaviors Awards 2020 - Annual Alton Ochsner Award Relating Smoking and Disease 2018- Daniel H. Efron Research Award 2015 - Tom Connor Distinguished Investigator Award 2012 - Mathilde Solowey Lecture Award in the Neurosciences Foundation for Advanced Education in the Sciences 2010 - Jacob P. Waletzky Memorial Award Society for Neuroscience Research The http://labs.icahn.mssm.edu/kennylab/ Kenny Laboratory is focused on understanding the neurobiological mechanisms of drug addiction, obesity and schizophrenia, with an emphasis on the role of nicotinic acetylcholine receptors (nAChRs) in these processes. They employ a multidisciplinary approach that includes complex behavioral paradigms, physiological analyses and molecular biological techniques. Current projects include the utilization of vector-based delivery systems to modify gene expression in the brains of rodents to identify novel signaling cascades that may play a role in addiction-like behaviors. https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Kenny+PJ&cauthor_id=12829420 Search PubMed for articles

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  • A master regulator of opioid reward in the ventral prefrontal cortex

    Smith, A. C. W., Ghoshal, S., Centanni, S. W., Heyer, M. P., Corona, A., Wills, L., Andraka, E., Lei, Y., O'Connor, R. M., Caligiuri, S. P. B., Khan, S., Beaumont, K., Sebra, R. P., Kieffer, B. L., Winder, D. G., Ishikawa, M. & Kenny, P. J., 7 Jun 2024, In: Science. 384, 6700, p. eadn0886

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • Generative artificial intelligence-enabled dynamic detection of rat nicotine-related circuits

    Gong, C., Jing, C., Liu, X. A., Wang, V. X., Tang, C. Y., Kenny, P. J., Li, Y., Chen, Z. & Wang, S., Mar 2024, In: Neural Computing and Applications. 36, 9, p. 4693-4707 15 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Hypothalamic CRF neurons facilitate brain reward function

    Xu, X., Zheng, S., Ren, J., Li, Z., Li, J., Xu, Z., Yuan, F., Yang, Q., Margetts, A. V., Pollock, T. A., Vilca, S. J., Yang, C., Chen, G., Shen, P., Li, S., Xia, J., Chen, C., Zhou, T., Zhu, Y. & Tuesta, L. M. & 4 others, Wang, L., Kenny, P. J., Liu, X. A. & Chen, Z., 22 Jan 2024, In: Current Biology. 34, 2, p. 389-402.e5

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats

    Braunscheidel, K. M., Voren, G., Fowler, C. D., Lu, Q., Kuryatov, A., Cameron, M. D., Ibañez-Tallon, I., Lindstrom, J. M., Kamenecka, T. M. & Kenny, P. J., 2024, In: Frontiers in Molecular Neuroscience. 17, 1459098.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • The single-cell opioid responses in the context of HIV (SCORCH) consortium

    Ament, S. A., Campbell, R. R., Lobo, M. K., Receveur, J. P., Agrawal, K., Borjabad, A., Byrareddy, S. N., Chang, L., Clarke, D., Emani, P., Gabuzda, D., Gaulton, K. J., Giglio, M., Giorgi, F. M., Gok, B., Guda, C., Hadas, E., Herb, B. R., Hu, W. & Huttner, A. & 57 others, Ishmam, M. R., Jacobs, M. M., Kelschenbach, J., Kim, D. W., Lee, C., Liu, S., Liu, X., Madras, B. K., Mahurkar, A. A., Mash, D. C., Mukamel, E. A., Niu, M., O’Connor, R. M., Pagan, C. M., Pang, A. P. S., Pillai, P., Repunte-Canonigo, V., Ruzicka, W. B., Stanley, J., Tickle, T., Tsai, S. Y. A., Wang, A., Wills, L., Wilson, A. M., Wright, S. N., Xu, S., Yang, J., Zand, M., Zhang, L., Zhang, J., Akbarian, S., Buch, S., Cheng, C. S., Corley, M. J., Fox, H. S., Gerstein, M., Gummuluru, S., Heiman, M., Ho, Y. C., Kellis, M., Kenny, P. J., Kluger, Y., Milner, T. A., Moore, D. J., Morgello, S., Ndhlovu, L. C., Rana, T. M., Sanna, P. P., Satterlee, J. S., Sestan, N., Spector, S. A., Spudich, S., Tilgner, H. U., Volsky, D. J., White, O. R., Williams, D. W. & Zeng, H., 2024, (Accepted/In press) In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations