Research output per year
Research output per year
- 27 results
Search results
-
2024
Osteoporosis treatments for intervertebral disc degeneration and back pain: A perspective
Bhadouria, N. & Holguin, N., Jun 2024, In: JBMR Plus. 8, 6, ziae048.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – an in vivo rat model
Wang, D., Lai, A., Gansau, J., Seifert, A. C., Munitz, J., Zaheer, K., Bhadouria, N., Lee, Y., Nasser, P., Laudier, D. M., Holguin, N., Hecht, A. C. & Iatridis, J. C., Sep 2023, In: Spine Journal. 23, 9, p. 1375-1388 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2022
Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice
Bhadouria, N., Berman, A. G., Wallace, J. M. & Holguin, N., 11 Aug 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 924918.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in Mice
Kroon, T., Bhadouria, N., Niziolek, P., Edwards, D., Choi, R., Clinkenbeard, E. L., Robling, A. & Holguin, N., Jun 2022, In: Journal of Bone and Mineral Research. 37, 6, p. 1156-1169 14 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2020
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis
Silva, M. J. & Holguin, N., 1 Feb 2020, In: FASEB Journal. 34, 2, p. 1970-1982 13 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2018
Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading duration
Sun, D., Brodt, M. D., Zannit, H. M., Holguin, N. & Silva, M. J., Feb 2018, In: Journal of Orthopaedic Research. 36, 2, p. 682-691 10 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
In-Vivo Nucleus Pulposus-Specific Regulation of Adult Murine Intervertebral Disc Degeneration via Wnt/Beta-Catenin Signaling
Holguin, N. & Silva, M. J., 1 Dec 2018, In: Scientific Reports. 8, 1, 11191.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
2017
Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury
Duan, X., Rai, M. F., Holguin, N., Silva, M. J., Patra, D., Liao, W. & Sandell, L. J., 1 Mar 2017, In: Journal of Orthopaedic Research. 35, 3, p. 524-536 13 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Erratum: Suppression of NF-κB activity via nanoparticlebased siRNA delivery alters early cartilage responses to injury (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E6199-E6208) DOI: 10.1073/pnas.1608245113)
Yan, H., Duan, X., Pan, H., Holguin, N., Rai, M. F., Akk, A., Springer, L. E., Wickline, S. A., Sandell, L. J. & Pham, C. T. N., 9 May 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 19, p. E3871Research output: Contribution to journal › Comment/debate
Open Access -
Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint
Rai, M. F., Duan, X., Quirk, J. D., Holguin, N., Schmidt, E. J., Chinzei, N., Silva, M. J. & Sandell, L. J., 27 Mar 2017, In: Scientific Reports. 7, 45223.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading
Duan, X., Sandell, L. J., Chinzei, N., Holguin, N., Silva, M. J., Schiavinato, A. & Rai, M. F., Apr 2017, In: PLoS ONE. 12, 4, e0175682.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2016
Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice
Holguin, N., Brodt, M. D. & Silva, M. J., 1 Dec 2016, In: Journal of Bone and Mineral Research. 31, 12, p. 2215-2226 12 p.Research output: Contribution to journal › Article › peer-review
Open Access113 Scopus citations -
CORR Insights ®: The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration
Holguin, N., 1 Aug 2016, In: Clinical Orthopaedics and Related Research. 474, 8, p. 1827-1829 3 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
CORR Insights ®: Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?
Holguin, N., 1 May 2016, In: Clinical Orthopaedics and Related Research. 474, 5, p. 1303-1306 4 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury
Yan, H., Duan, X., Pan, H., Holguin, N., Rai, M. F., Akk, A., Springer, L. E., Wickline, S. A., Sandell, L. J. & Pham, C. T. N., 11 Oct 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. E6199-E6208Research output: Contribution to journal › Article › peer-review
Open Access110 Scopus citations -
2015
mTORC2 signaling promotes skeletal growth and bone formation in mice
Chen, J., Holguin, N., Shi, Y., Silva, M. J. & Long, F., 1 Feb 2015, In: Journal of Bone and Mineral Research. 30, 2, p. 369-378 10 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2014
Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6
Holguin, N., Brodt, M. D., Sanchez, M. E. & Silva, M. J., Aug 2014, In: Bone. 65, p. 83-91 9 p.Research output: Contribution to journal › Article › peer-review
Open Access87 Scopus citations -
Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets
Wu, P., Holguin, N., Silva, M. J., Fu, M., Liao, W. & Sandell, L. J., May 2014, In: Arthritis and Rheumatology. 66, 5, p. 1256-1265 10 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
The aging mouse partially models the aging human spine: Lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice
Holguin, N., Aguilar, R., Harland, R. A., Bomar, B. A. & Silva, M. J., 15 Jun 2014, In: Journal of Applied Physiology. 116, 12, p. 1551-1560 10 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2013
Adaptation of tibial structure and strength to axial compression depends on loading history in Both C57BL/6 and BALB/c mice
Holguin, N., Brodt, M. D., Sanchez, M. E., Kotiya, A. A. & Silva, M. J., Sep 2013, In: Calcified Tissue International. 93, 3, p. 211-221 11 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Low-intensity vibrations partially maintain intervertebral disc mechanics and spinal muscle area during deconditioning
Holguin, N., Martin, J. T., Elliott, D. M. & Judex, S., Apr 2013, In: Spine Journal. 13, 4, p. 428-436 9 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2011
Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner
Holguin, N., Uzer, G., Chiang, F. P., Rubin, C. & Judex, S., Dec 2011, In: Journal of Applied Physiology. 111, 6, p. 1846-1853 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access38 Scopus citations -
2010
Rat intervertebral disc health during hindlimb unloading: Brief ambulation with or without vibration
Holguin, N. & Judex, S., Dec 2010, In: Aviation Space and Environmental Medicine. 81, 12, p. 1078-1084 7 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Reply
Holguin, N., Muir, J., Rubin, C. & Judex, S., Apr 2010, In: Spine Journal. 10, 4, p. 364-365 2 p.Research output: Contribution to journal › Letter › peer-review
1 Scopus citations -
2009
Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest
Holguin, N., Muir, J., Rubin, C. & Judex, S., Jun 2009, In: Spine Journal. 9, 6, p. 470-477 8 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
2007
Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest
Holguin, N., Muir, J., Evans, H. J., Qin, Y. X., Rubin, C., Wagshul, M. & Judex, S., 2007, 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC. Institute of Electrical and Electronics Engineers Inc., p. 25-26 2 p. 4413262. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Open Access3 Scopus citations -
Retention of bone density and postural status with a non-invasive extremely low level mechanical signal: A ground based evaluation of efficacy
Muir, J., Xia, Y., Holguin, N., Judex, S., Qin, Y. X., Jeka, J., Evans, H., Lang, T. & Rubin, C., 2007, 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC. p. 1-2 2 p. 4413250. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review