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ASSISTANT PROFESSOR | Orthopedics
Dr. Holguin is Assistant Professor in the Leni and Peter W. May Department of Orthopaedics and a Biomedical Laureate at the Icahn School of Medicine at Mount Sinai in New York City. Dr. Holguin joined Mount Sinai in 2022 to promote translational spine research and serves as the Director of the MicroCT Core. Dr. Holguin was a faculty member in the Department of Mechanical and Energy Engineering at Indiana University-Purdue University Indianapolis and an adjunct in the Department of Anatomy, Cell Biology and Physiology at Indiana University. Dr. Holguin completed his post-doctoral training and was a Research Instructor in the Department of Orthopaedic Surgery at Washington University in St. Louis. He earned his M.S. and Ph.D. in Biomedical Engineering at Stony Brook University and his B.S. in Engineering at Trinity College.
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Development Regeneration and Stem Cells [DRS], Pharmacology and Therapeutics Discovery [PTD]
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Role of Mechanical Forces on Beta-Catenin of Aged Intervertebral Discs
1/07/14 → 30/06/16
Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in MiceBhadouria, N., Berman, A. G., Wallace, J. M. & Holguin, N., 11 Aug 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 924918.
Research output: Contribution to journal › Article › peer-reviewOpen Access
Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in MiceKroon, T., Bhadouria, N., Niziolek, P., Edwards, D., Choi, R., Clinkenbeard, E. L., Robling, A. & Holguin, N., Jun 2022, In: Journal of Bone and Mineral Research. 37, 6, p. 1156-1169 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Scopus citations
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesisSilva, M. J. & Holguin, N., 1 Feb 2020, In: FASEB Journal. 34, 2, p. 1970-1982 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access18 Scopus citations
Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading durationSun, D., Brodt, M. D., Zannit, H. M., Holguin, N. & Silva, M. J., Feb 2018, In: Journal of Orthopaedic Research. 36, 2, p. 682-691 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access30 Scopus citations
In-Vivo Nucleus Pulposus-Specific Regulation of Adult Murine Intervertebral Disc Degeneration via Wnt/Beta-Catenin SignalingHolguin, N. & Silva, M. J., 1 Dec 2018, In: Scientific Reports. 8, 1, 11191.
Research output: Contribution to journal › Article › peer-reviewOpen Access28 Scopus citations
Icahn School of Medicine at Mount Sinai Announces New Biomedical Laureates as Part of Drive to Diversify Research
Eric Nestler, Lynne Richardson, Sidney Hankerson , James Iatridis,, Emma Benn & Nilsson Holguin
13/12/21 → 14/12/21
3 items of Media coverage