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Assistant Professor | Psychiatry
Biography
Dr. Mina Rizk is an Assistant Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai and a physician-scientist specializing in the neurobiology of mood disorders and suicide. His research integrates neuroimaging, immune-proteomic profiling, and clinical trials to investigate the biological mechanisms underlying suicidal behavior and treatment-resistant depression, with the goal of developing novel therapeutics for these conditions.
Dr. Rizk completed medical school and residency training in neurology and psychiatry in Egypt. He later joined Columbia University as a visiting scholar and subsequently as a Paul Janssen Postdoctoral Fellow, where he contributed to translational neuroscience studies on depression and suicidal behavior and received a NARSAD Young Investigator Grant to study the potential anti-suicidal effects of buprenorphine. He then completed a psychiatry residency on the Physician-Scientist Track at Mount Sinai, where he worked on projects examining the immune mechanisms underlying depression and suicide risk.
Dr. Rizk’s current work focuses on blood-brain barrier imaging combined with high-dimensional immune proteomics to identify biomarkers of suicide risk. He has also received funding from the American Foundation for Suicide Prevention to investigate the immune mechanisms underlying the anti-suicidal effects of ketamine and electroconvulsive therapy. In addition, he serves as co-investigator on several clinical trials exploring novel therapeutics for depression.
Dr. Rizk is a licensed psychiatrist in New York State. Clinically, he provides care to individuals with mood, anxiety, and psychotic disorders, including those with treatment-resistant conditions, integrating evidence-based pharmacologic and interventional treatments.
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Collaborations and top research areas from the last five years
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Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases
He, H., Cathomas, F., Parise, L. F., David, E., Rizk, M., Hawkins, K., Karpman, E., Russo, S. J., Guttman, E. & Murrough, J. W., May 2026, In: Molecular Psychiatry. 31, 5, p. 2498-2508 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Suicidal ideation in adults with opioid use disorder treated with buprenorphine-naloxone versus extended-release naltrexone
Rizk, M. M., Stanley, B., Choo, T. H., Pavlicova, M., Scodes, J. M., Rotrosen, J. & Nunes, E. V., 2025, In: American Journal of Drug and Alcohol Abuse. 51, 5, p. 658-666 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Immune-Targeted Therapies for Depression: Current Evidence for Antidepressant Effects of Monoclonal Antibodies
Rizk, M. M., Bolton, L., Cathomas, F., He, H., Russo, S. J., Guttman-Yassky, E., Mann, J. J. & Murrough, J., Sep 2024, In: Journal of Clinical Psychiatry. 85, 3, 23nr15243.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Ketamine, Dissociation, and Depression: What Is “Special” About Ketamine? (Revisited)
Rizk, M. M. & Murrough, J. W., 1 Jun 2024, In: International Journal of Neuropsychopharmacology. 27, 6, pyae024.Research output: Contribution to journal › Comment/debate
Open Access -
Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression
Goldenthal, A. R., Lieberman, E., Rizk, M. M., Ogden, R. T., Rubin-Falcone, H., Zanderigo, F., Huang, Y. Y., Min, E., Yuan, M., Milak, M., Sullivan, G. M., Sublette, M. E., Oquendo, M. A., Mann, J. J. & Miller, J. M., 15 Dec 2024, In: Journal of Affective Disorders. 367, p. 307-317 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Press/Media
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Major Depression Shares Immune Signature With Inflammatory Skin Ailments, Suggesting Novel Therapeutic Possibilities, Study Indicates
Cathomas, F., Rizk, M., Murrough, J., Russo, S. & Guttman, E.
2/04/26
1 item of Media coverage
Press/Media
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Mapping Gene Activity in the Living Human Brain
Cathomas, F., Rizk, M., Murrough, J., Russo, S., Kopell,, B., Charney, A., Guttman, E. & Saez, I.
17/03/26
1 item of Media coverage
Press/Media
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HMN 2026: How Major depressive disorder shares immune abnormalities and potential therapies with inflammatory skin diseases
Rizk, M., Murrough, J., Guttman, E. & Charney, D.
26/02/26
1 item of Media coverage
Press/Media
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Recent Findings from Icahn School of Medicine at Mount Sinai Has Provided New Data on Atopic Dermatitis (Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases)
Cathomas, F., Rizk, M., Murrough, J., Russo, S. & Guttman, E.
25/02/26
1 item of Media coverage
Press/Media
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Major Depressive Disorder Shares Immune Abnormalities and Potential Therapeutic Targets With Inflammatory Skin Diseases, According to New Study
Rizk, M., Murrough, J., Guttman, E. & Charney, D.
11/02/26 → 13/02/26
5 items of Media coverage
Press/Media