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1988 …2021

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PROFESSOR | Cell, Developmental and Regenerative Biology

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Research Topics http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Gene+Discovery&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Gene Discovery http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Genomics&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Genomics http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Hematopoiesis&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Hematopoiesis http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Molecular+Biology&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Molecular Biology http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Stem+Cells&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Stem Cells Training Areas http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&ta=Developmental+and+Stem+Cell+Biology+[DSCB]&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Developmental and Stem Cell Biology [DSCB] Education B.S., Kansas State University D.V.M., Kansas State University Post-Doctoral Research, Baylor College of Medicine Biography My laboratory is studying both the basic biology and molecular mechanisms that make a hematopoietic stem cell a self-renewing stem cell that sustains our blood system throughout life. We do this by investigating these properties in model systems and by trying to convert other cell types into hematopoietic stem cells for eventual therapeutic uses. http://drb.mssm.edu/labs/lm.html http://drb.mssm.edu/labs/lm.html Research Hematopoietic Stem Cells Normal and Reprogrammed Specific Clinical/Research Interest: Stem Cells/Microenvironment/Stem Cell Niche, Molecular regulation of hematopoietic stem cell self renewal and differentiation, molecular interaction of stem cells and microenvironmental elements. Direct differentiation of somatic cells into hematopoietic stem cells. Current Students: Jeffrey Bernitz Postdoctoral Fellows: Carlos Filipe Pereira Research Personnel: Xiaohong Niu Summary of Research Studies: Primary research interest is in defining the cellular and molecular nature of the hematopoietic stem cells (HSCs) and in particular the molecular cross-talk between stem cells and their niche. Approach is to use mouse models to study HSC during normal homeostasis and after stress. Also using specific factors to directly induce HSCs from somatic cells to develop patient specific stem cells and differentiated blood products for cell replacement therapies.

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