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Dissecting and targeting canonical and non-canonical oncogenic functions of EZH2 in cancer
Wang, G. G. G. G. & Jin, J.
1/01/22 → 31/12/23
Project: Research
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Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias
Jin, J., Wen, H. H., Jin, J. & Wen, H.
1/04/21 → 31/03/23
Project: Research
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(PQ9) Developing EZH2 Degraders for Treating Triple-Negative Breast Cancer
Jin, J. J., Jin, J., Parsons, R. E. & Parsons, R.
10/09/18 → 31/08/23
Project: Research
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Targeting Lysine Methyltransferases EZH2 and EZH1 for Treating MLL-rearranged Leukemias
Jin, J. & Wang, G. G.
8/06/17 → 31/05/22
Project: Research
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Discovery of Selective Inhibitors for Histone Methyltransferases
National Institute of General Medical Sciences
1/04/17 → 31/01/21
Project: Research
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A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation
Wang, J., Park, K. S., Yu, X., Gong, W., Earp, H. S., Wang, G. G., Jin, J. & Cai, L., 28 Oct 2022, In: Nucleic Acids Research. 50, 19, p. 10929-10946 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An MDM2 degrader for treatment of acute leukemias
Marcellino, B. K., Yang, X., Ümit Kaniskan, H., Brady, C., Chen, H., Chen, K., Qiu, X., Clementelli, C., Herschbein, L., Li, Z., Elghaity-Beckley, S., Arandela, J., Kelly, B., Hoffman, R., Liu, J., Xiong, Y., Jin, J. & Shih, A. H., 2022, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
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A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
Xu, C., Meng, F., Park, K. S., Storey, A. J., Gong, W., Tsai, Y. H., Gibson, E., Byrum, S. D., Li, D., Edmondson, R. D., Mackintosh, S. G., Vedadi, M., Cai, L., Tackett, A. J., Kaniskan, H. Ü., Jin, J. & Wang, G. G., 17 Mar 2022, In: Cell Chemical Biology. 29, 3, p. 386-397.e9Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia
Ren, Z., Kim, A., Huang, Y. T., Pi, W. C., Gong, W., Yu, X., Qi, J., Jin, J., Cai, L., Roeder, R. G., Chen, W. Y. & Wang, G. G., 1 Mar 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, e2122940119.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets
Xiong, Y., Zhong, Y., Yim, H., Yang, X., Park, K. S., Xie, L., Poulikakos, P. I., Han, X., Xiong, Y., Chen, X., Liu, J. & Jin, J., 14 Dec 2022, In: Journal of the American Chemical Society. 144, 49, p. 22622-22632 11 p.Research output: Contribution to journal › Article › peer-review
Press / Media
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US Patent Issued to Icahn School of Medicine at Mount Sinai on Jan. 3 for "Compositions and methods for treating CDK4/6-mediated cancer" (New York, New Jersey Inventors)
Tamer Ahmed, Zoi Karoulia, XUEWEI WU , Yan Xiong , Poulikos Poulikakos, Jing Liu & Jian Jin
21/01/23
1 item of Media coverage
Press/Media
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U.S. Patents Awarded to Inventors in New Jersey (Jan. 5)
Tamer Ahmed, Zoi Karoulia, XUEWEI WU , Yan Xiong , Yang Yang, Poulikos Poulikakos, Jing Liu & Jian Jin
5/01/23
1 item of Media coverage
Press/Media
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U.S. Patents Awarded to Inventors in New York (Jan. 5)
Tamer Ahmed, Zoi Karoulia, XUEWEI WU , Yan Xiong , Arvind Kumar, Poulikos Poulikakos, Jing Liu & Jian Jin
5/01/23
1 item of Media coverage
Press/Media
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Compositions and Methods for Treating CDK4/6-mediated Cancer
Tamer Ahmed, Zoi Karoulia, XUEWEI WU , Yan Xiong , Poulikos Poulikakos, Jing Liu & Jian Jin
3/01/23
1 item of Media coverage
Press/Media
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U.S. Patents Awarded to Inventors in New York (Dec. 2)
ANQI MA , Michael Ohlmeyer, Dongming Cai, Ramon Parsons & Jian Jin
2/12/22
1 item of Media coverage
Press/Media