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ASSISTANT PROFESSOR | Neuroscience, ASSISTANT PROFESSOR | Neurosurgery, ASSISTANT PROFESSOR | Neurology
Biography
Dr. Saez’s research focuses on the study of the neural basis of human cognition, particularly decision-making, through the examination of invasive brain activity in neurosurgical patients. He combines human electrophysiological and electrochemical recordings during decision-making tasks with computational models of reward and choice. This experimental combination provides access to fast, highly detailed, high signal-to-noise, multi-areal neural activity from the human brain, which is highly suited to studying the relationship of distributed neural activity to aspects of cognition and the use of neurostimulation techniques to modulate behavior and treat cognitive aspects of disease. Dr. Saez completed his postdoctoral training in the laboratories of Drs. Read Montague (Virginia Tech), Robert T. Knight and Ming Hsu (UC Berkeley), where he trained in invasive recordings (DBS, ECoG, sEEG), behavior and computational (RL) models of reward. Prior to that, he obtained his PhD in Neuroscience in Michael Friedlander’s lab (Baylor College of Medicine), where he carried out in vitro electrophysiological recordings in animal models. Before joining Sinai, Dr. Saez held a faculty position at the University of California, Davis.
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Collaborations and top research areas from the last five years
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A transcriptional program associated with neurotransmission in the living human brain
Charney, A. W., Liharska, L. E., Vornholt, E., Valentine, A., Lund, A., Hashemi, A., Thompson, R. C., Lohrenz, T., Johnson, J. S., Bussola, N., Cheng, E., Park, Y. J., Qasim, S., Aristel, A., Wilkins, L., Ziafat, K., Silk, H., Linares, L. M., Sullivan, B. & Feng, C. & 18 others, , May 2026, In: Molecular Psychiatry. 31, 5, p. 2727-2738 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Neural and computational mechanisms underlying one-shot perceptual learning in humans
Hachisuka, A., Shor, J. D., Liu, X. C., Friedman, D., Dugan, P., Saez, I., Panov, F. E., Wang, Y., Doyle, W., Devinsky, O., Oermann, E. K. & He, B. J., Dec 2026, In: Nature Communications. 17, 1, 1204.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Sustained activity of human substantia nigra neurons reflect prior rewards
Imtiaz, Z., Kato, A., Kopell, B. H., Qasim, S. E., Davis, A. N., Martinez, L. N., Heflin, M., Kulkarni, K., Morsi, A., Charney, A. W., Gu, X. & Saez, I., 17 Apr 2026, In: iScience. 29, 4, 115458.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum to ‘The thalamus: Structure, function, and neurotherapeutics’ (Neurotherapeutics (2025) 22(2), (S1878747925000285), (10.1016/j.neurot.2025.e00550))
Marcuse, L. V., Langan, M., Hof, P. R., Panov, F., Saez, I., Jimenez-Shahed, J., Figee, M., Mayberg, H., Yoo, J. Y., Ghatan, S., Balchandani, P. & Fields, M. C., Apr 2025, In: Neurotherapeutics. 22, 3, e00585.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Distributed Intracranial Activity Underlying Human Decision-making Behavior
Overton, J. A., Moxon, K. A., Stickle, M. P., Peters, L. M., Lin, J. J., Chang, E. F., Knight, R. T., Hsu, M. & Saez, I., 9 Apr 2025, In: Journal of Neuroscience. 45, 15, e0572242024.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Press/Media
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Tu cerebro puede empezar a cambiar tan solo dos minutos después de hacer este ejercicio mental
7/06/26
4 items of Media coverage
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Mount Sinai Health System: Study Identifies Gene Expression Program Linked to Neurotransmission in the Living Human Brain
Kopell,, B., Charney, A. & Saez, I.
16/03/26 → 18/03/26
7 items of Media coverage
Press/Media
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Mapping Gene Activity in the Living Human Brain
Cathomas, F., Rizk, M., Murrough, J., Russo, S., Kopell,, B., Charney, A., Guttman, E. & Saez, I.
17/03/26
1 item of Media coverage
Press/Media
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Study identifies brain region driving one-shot visual learning
Oermann, E., Panov , F. & Saez, I.
4/02/26 → 5/02/26
2 items of Media coverage
Press/Media