Research output per year
Research output per year
Personal profile
Headline
PROFESSOR | Pharmacological Sciences, PROFESSOR | Neuroscience
Biography
Ian S. Maze, Ph.D., is a neurobiologist with extensive training in the molecular biology and chromatin biochemistry of histone regulation in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease. Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU] Education BS, The Ohio State University PhD, Mount Sinai School of Medicine Postdoctoral Fellowship, The Rockefeller University
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Collaborations and top research areas from the last five years
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A Novel Role for the Histone Demethylase JMJD3 in Mediating Heroin-Induced Relapse-Like Behaviors
Mitra, S., Werner, C. T., Shwani, T., Lopez, A. G., Federico, D., Higdon, K., Li, X., Gobira, P. H., Thomas, S. A., Martin, J. A., An, C., Chandra, R., Maze, I., Neve, R., Lobo, M. K., Gancarz, A. M. & Dietz, D. M., 15 Mar 2025, In: Biological Psychiatry. 97, 6, p. 602-613 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity
Zheng, Q., Weekley, B. H., Vinson, D. A., Zhao, S., Bastle, R. M., Thompson, R. E., Stransky, S., Ramakrishnan, A., Cunningham, A. M., Dutta, S., Chan, J. C., Di Salvo, G., Chen, M., Zhang, N., Wu, J., Fulton, S. L., Kong, L., Wang, H., Zhang, B. & Vostal, L. & 9 others, , 23 Jan 2025, In: Nature. 637, 8047, p. 974-982 9 p., e2208672119.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders
Weekley, B. H., Ahmed, N. I. & Maze, I., 21 Mar 2025, In: iScience. 28, 3, 112092.Research output: Contribution to journal › Review article › peer-review
Open Access -
Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility
Fulton, S. L., Bendl, J., Di Salvo, G., Fullard, J. F., Al-Kachak, A., Lepack, A. E., Stewart, A. F., Singh, S., Poller, W. F., Bastle, R. M., Hauberg, M. E., Fakira, A. K., Patel, V., Chen, M., Durand-de Cuttoli, R., Gameiro-Ros, I., Cathomas, F., Ramakrishnan, A., Gleason, K. & Shen, L. & 9 others, , 2025, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Bioorthogonal Labeling and Enrichment of Histone Monoaminylation Reveal Its Accumulation and Regulatory Function in Cancer Cell Chromatin
Zhang, N., Wu, J., Hossain, F., Peng, H., Li, H., Gibson, C., Chen, M., Zhang, H., Gao, S., Zheng, X., Wang, Y., Zhu, J., Wang, J. J., Maze, I. & Zheng, Q., 19 Jun 2024, In: Journal of the American Chemical Society. 146, 24, p. 16714-16720 7 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations
Press/Media
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Researchers identify a new mechanism to control circadian gene expression
26/02/25
1 item of Media coverage
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New Nucleoproteins Findings from Icahn School of Medicine at Mount Sinai Described (Bidirectional Histone Monoaminylation Dynamics Regulate Neural Rhythmicity)
Bastle, R., Maze, I. & Chan, C.
3/02/25
1 item of Media coverage
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Neurotransmitters regulate the body’s clock by reorganizing DNA
16/01/25
1 item of Media coverage
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KMN 2025: How mechanism neurotransmitters are linked to circadian gene expression
12/01/25
1 item of Media coverage
Press/Media