Research output per year
Research output per year
Personal profile
Headline
PROFESSOR | Pharmacological Sciences, PROFESSOR | Neuroscience
Biography
Ian S. Maze, Ph.D., is a neurobiologist with extensive training in the molecular biology and chromatin biochemistry of histone regulation in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease. Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU] Education BS, The Ohio State University PhD, Mount Sinai School of Medicine Postdoctoral Fellowship, The Rockefeller University
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Collaborations and top research areas from the last five years
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A Novel Role for the Histone Demethylase JMJD3 in Mediating Heroin-Induced Relapse-Like Behaviors
Mitra, S., Werner, C. T., Shwani, T., Lopez, A. G., Federico, D., Higdon, K., Li, X., Gobira, P. H., Thomas, S. A., Martin, J. A., An, C., Chandra, R., Maze, I., Neve, R., Lobo, M. K., Gancarz, A. M. & Dietz, D. M., 2024, (Accepted/In press) In: Biological Psychiatry.Research output: Contribution to journal › Article › peer-review
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Bioorthogonal Labeling and Enrichment of Histone Monoaminylation Reveal Its Accumulation and Regulatory Function in Cancer Cell Chromatin
Zhang, N., Wu, J., Hossain, F., Peng, H., Li, H., Gibson, C., Chen, M., Zhang, H., Gao, S., Zheng, X., Wang, Y., Zhu, J., Wang, J. J., Maze, I. & Zheng, Q., 19 Jun 2024, In: Journal of the American Chemical Society. 146, 24, p. 16714-16720 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior
Al-Kachak, A., Di Salvo, G., Fulton, S. L., Chan, J. C., Farrelly, L. A., Lepack, A. E., Bastle, R. M., Kong, L., Cathomas, F., Newman, E. L., Menard, C., Ramakrishnan, A., Safovich, P., Lyu, Y., Covington, H. E., Shen, L., Gleason, K., Tamminga, C. A., Russo, S. J. & Maze, I., Dec 2024, In: Nature Communications. 15, 1, 5042.Research output: Contribution to journal › Article › peer-review
Open Access -
Repurposing the dopamine transporter antagonist vanoxerine to treat colorectal cancer
Chen, W. & Maze, I., Mar 2024, In: Nature Cancer. 5, 3, p. 378-379 2 p.Research output: Contribution to journal › Comment/debate
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Serotonin Transporter-dependent Histone Serotonylation in Placenta Contributes to the Neurodevelopmental Transcriptome
Chan, J. C., Alenina, N., Cunningham, A. M., Ramakrishnan, A., Shen, L., Bader, M. & Maze, I., 1 Apr 2024, In: Journal of Molecular Biology. 436, 7, 168454.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Press/Media
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Reports on Gene Therapy Findings from Icahn School of Medicine at Mount Sinai Provide New Insights (Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior)
Al-Kachak, A., Bastle, R., Cathomas, F., Russo, S. & Maze, I.
1/07/24
1 item of Media coverage
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New York Academy of Sciences: 2023 Blavatnik National Awards for Young Scientists Announced
26/07/23
1 item of Media coverage
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2023 Blavatnik National Awards for Young Scientists announced
26/07/23
2 items of Media coverage
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Baylor College of Medicine: Astrocyte Processing of Serotonin Regulates Olfactory Perception
16/06/23
1 item of Media coverage
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Baylor College of Medicine: Astrocyte processing of serotonin regulates olfactory perception
15/06/23
1 item of Media coverage
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