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PROFESSOR | Pharmacological Sciences, PROFESSOR | Neuroscience
Biography
Ian S. Maze, Ph.D., is a neurobiologist with extensive training in the molecular biology and chromatin biochemistry of histone regulation in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease. Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU] Education BS, The Ohio State University PhD, Mount Sinai School of Medicine Postdoctoral Fellowship, The Rockefeller University
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Neurotransmission-independent Roles of Biogenic Monoamines
Howard Hughes Medical Institute
1/01/21 → …
Project: Research
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Aberrant chromatin regulatory mechanisms in Down syndrome brain
National Institute of Child Health and Human Development
15/09/19 → 30/06/23
Project: Research
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Molecular studies of neural histone monoaminylation in normal and aberrant brain plasticity
NATIONAL INSTITUTE OF MENTAL HEALTH
1/02/19 → 30/11/23
Project: Research
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Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Farrelly, L. A., Zheng, S., Schrode, N., Topol, A., Bhanu, N. V., Bastle, R. M., Ramakrishnan, A., Chan, J. C., Cetin, B., Flaherty, E., Shen, L., Gleason, K., Tamminga, C. A., Garcia, B. A., Li, H., Brennand, K. J. & Maze, I., Dec 2022, In: Nature Communications. 13, 1, 2195.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats
Fulton, S. L., Mitra, S., Lepack, A. E., Martin, J. A., Stewart, A. F., Converse, J., Hochstetler, M., Dietz, D. M. & Maze, I., Sep 2022, In: Neuropsychopharmacology. 47, 10, p. 1776-1783 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
Fulton, S. L., Wenderski, W., Lepack, A. E., Eagle, A. L., Fanutza, T., Bastle, R. M., Ramakrishnan, A., Hays, E. C., Neal, A., Bendl, J., Farrelly, L. A., Al-Kachak, A., Lyu, Y., Cetin, B., Chan, J. C., Tran, T. N., Neve, R. L., Roper, R. J., Brennand, K. J., Roussos, P., & 7 others, Dec 2022, In: Nature Communications. 13, 1, 6384.Research output: Contribution to journal › Article › peer-review
Open Access -
Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons
De Gregorio, R., Subah, G., Chan, J. C., Speranza, L., Zhang, X., Ramakrishnan, A., Shen, L., Maze, I., Stanton, P. K. & Sze, J. Y., Nov 2022, In: Development (Cambridge). 149, 21, dev200549.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
TGM2-mediated histone transglutamination is dictated by steric accessibility
Lukasak, B. J., Mitchener, M. M., Kong, L., Dul, B. E., Lazarus, C. D., Ramakrishnan, A., Ni, J., Shen, L., Maze, I. & Muir, T. W., 25 Oct 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 43, e2208672119.Research output: Contribution to journal › Article › peer-review
Open Access
Press / Media
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Icahn School of Medicine at Mount Sinai Details Findings in Down Syndrome (Rescue of Deficits By Brwd1 Copy Number Restoration In the Ts65dn Mouse Model of Down Syndrome)
Amni Al-Kachak, Lorna Farrelly, Sasha Fulton, Ryan Bastle, Jaroslav Bendl, Ashley Lepack, Kristen Brennand, Panagiotis Roussos, Li Shen, Robert Blitzer & Ian Maze
6/12/22
1 item of Media coverage
Press/Media
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Mount Sinai Hospital: Ian Maze, PhD, Named 2022 Recipient of Jacob P. Waletzky Award by Society for Neuroscience
16/11/22
1 item of Media coverage
Press/Media
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Mount Sinai Health System: Ian Maze, PhD, Named 2022 Recipient of Jacob P. Waletzky Award by Society for Neuroscience
14/11/22
1 item of Media coverage
Press/Media
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Ian Maze, PhD, Named 2022 Recipient of Jacob P. Waletzky Award by Society for Neuroscience
14/11/22
1 item of Media coverage
Press/Media
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Pregnancy and childbirth have lasting effects on the maternal brain.
13/11/22
1 item of Media coverage
Press/Media