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ASSISTANT PROFESSOR | Medicine, Hematology and Medical Oncology ASSISTANT PROFESSOR | Oncological Sciences
Biography
I am a medical oncologist specializing in the care of patients with breast cancer. As a physician-scientist, I also lead a research laboratory that is focused on developing targeted therapies tailored for specific breast cancer subtypes and for individual patients. I have a particular interest in better understanding triple negative breast cancers, with the goal of integrating genetic analysis to the development of improved treatments for our patients. I am co-PI of the Breast Tumor Biospecimen Repository, which is a bank of patient breast tumors; analysis of these tumors will provide insights into the genetic changes that determine sensitivity to specific targeted therapies for breast cancer. I am also co-PI of a study investigating the use of patient-derived xenograft models as a model for chemotherapy treatment sensitivity for patients with triple negative breast cancers; if successful, these models may be used in the future to help us better tailor treatments for individual patients. My research laboratory has identified several new candidate therapeutic targets for Her2+ and triple negative breast cancers resistant to current treatments, and we are working to translate our findings to clinical studies and trials. I am a member of the American Society of Clinical Oncology and the American Association for Cancer Research.
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Novel tumoral and immunoregulatory roles for ptk6 in TNBC metastasis
1/07/18 → 30/06/22
Project: Research
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Author Correction: Neoadjuvant study of niraparib in patients with HER2-negative, BRCA-mutated, resectable breast cancer (Nature Cancer, (2022), 3, 8, (927-931), 10.1038/s43018-022-00400-2)
Spring, L. M., Han, H., Liu, M. C., Hamilton, E., Irie, H., Santa-Maria, C. A., Reeves, J., Pan, P., Shan, M., Tang, Y., Graham, J. R., Hazard, S., Ellisen, L. W. & Isakoff, S. J., Sep 2022, In: Nature Cancer. 3, 9, p. 1138 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
CDK4: a master regulator of the cell cycle and its role in cancer
Baker, S. J., Poulikakos, P. I., Irie, H. Y., Parekh, S. & Reddy, E. P., 2022, In: Genes and Cancer. 13, p. 21-45 25 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Neoadjuvant study of niraparib in patients with HER2-negative, BRCA-mutated, resectable breast cancer
Spring, L. M., Han, H., Liu, M. C., Hamilton, E., Irie, H., Santa-Maria, C. A., Reeves, J., Pan, P., Shan, M., Tang, Y., Graham, J. R., Hazard, S., Ellisen, L. W. & Isakoff, S. J., Aug 2022, In: Nature Cancer. 3, 8, p. 927-931 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
Sato, K., Padgaonkar, A. A., Baker, S. J., Cosenza, S. C., Rechkoblit, O., Subbaiah, D. R. C. V., Domingo-Domenech, J., Bartkowski, A., Port, E. R., Aggarwal, A. K., Ramana Reddy, M. V., Irie, H. Y. & Premkumar Reddy, E., 1 Dec 2021, In: Nature Communications. 12, 1, 4671.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim
Byerly, J. H., Port, E. R. & Irie, H. Y., 29 Jun 2020, In: Breast Cancer Research. 22, 1, 72.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Press / Media
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A Tennis Champion Who is Also a Breast Cancer Survivor
Kenneth L. Davis & Hanna Irie
25/01/23
1 item of Media coverage
Press/Media
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Mount Sinai’s Dubin Breast Center Raises $3M for 12th Anniversary
17/12/22
1 item of Media coverage
Press/Media
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Mount Sinai's Dubin Breast Center Raises More than $3 Million for 12th Anniversary
16/12/22
1 item of Media coverage
Press/Media
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Mount Sinai's Dubin Breast Cancer Center Raises $3 Million for 12th Anniversary.
14/12/22
1 item of Media coverage
Press/Media
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Mount Sinai’s Dubin Breast Cancer Center Raises $3 Million for 12th Anniversary
14/12/22
57 items of Media coverage
Press/Media