Ghislain Rocheleau

2024

Comparison of blood-based liver fibrosis scores in the Mount Sinai Health System, MASLD Registry, and NHANES 2017-2020 study

Chen, R., Petrazzini, B. O., Nadkarni, G., Rocheleau, G., Bansal, M. B. & Do, R., Aug 2024, In: Hepatology Communications. 8, 9, e0515.

Research output: Contribution to journal › Article › peer-review

Open Access

Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications

Duffy, Á., Petrazzini, B. O., Stein, D., Park, J. K., Forrest, I. S., Gibson, K., Vy, H. M., Chen, R., Márquez-Luna, C., Mort, M., Verbanck, M., Schlessinger, A., Itan, Y., Cooper, D. N., Rocheleau, G., Jordan, D. M. & Do, R., Jan 2024, In: Nature Genetics. 56, 1, p. 51-59 9 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease

Petrazzini, B. O., Forrest, I. S., Rocheleau, G., Vy, H. M. T., Márquez-Luna, C., Duffy, Á., Chen, R., Park, J. K., Gibson, K., Goonewardena, S. N., Malick, W. A., Rosenson, R. S., Jordan, D. M. & Do, R., Jul 2024, In: Nature Genetics. 56, 7, p. 1412-1419 8 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score

Chen, R., Duffy, Á., Petrazzini, B. O., Vy, H. M., Stein, D., Mort, M., Park, J. K., Schlessinger, A., Itan, Y., Cooper, D. N., Jordan, D. M., Rocheleau, G. & Do, R., Dec 2024, In: Nature Communications. 15, 1, 8891.

Research output: Contribution to journal › Article › peer-review

Open Access

Muesli Intake May Protect Against Coronary Artery Disease: Mendelian Randomization on 13 Dietary Traits

Park, J. K., Petrazzini, B. O., Bafna, S., Duffy, Á., Forrest, I. S., Vy, H. M., Marquez-Luna, C., Verbanck, M., Narula, J., Rosenson, R. S., Jordan, D. M., Rocheleau, G. & Do, R., Apr 2024, In: JACC: Advances. 3, 4, 100888.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Rare variant contribution to the heritability of coronary artery disease

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2024, In: Nature Communications. 15, 1, 8741.

Research output: Contribution to journal › Article › peer-review

Open Access

Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record–Linked Biobanks

Tran, J. H., Kang, J., Han, E., Gupta, U., Seresirikachorn, K., Vy, H. M. T., Zhao, Y., Rocheleau, G., Luo, Y., Lee, R., Do, R., Friedman, D. S., Kang, J. H., Wiggs, J. L., Pasquale, L. R., Segrè, A. V. & Zebardast, N., Nov 2024, In: American Journal of Ophthalmology. 267, p. 204-212 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2023

A machine learning model identifies patients in need of autoimmune disease testing using electronic health records

Forrest, I. S., Petrazzini, B. O., Duffy, Á., Park, J. K., O’Neal, A. J., Jordan, D. M., Rocheleau, G., Nadkarni, G. N., Cho, J. H., Blazer, A. D. & Do, R., Dec 2023, In: Nature Communications. 14, 1, 2385.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Genetic Associations Between Smoking-and Glaucoma-Related Traits

UK Biobank Eye and Vision Consortium, and for the International Glaucoma Genetics Consortium, Feb 2023, In: Translational Vision Science and Technology. 12, 2, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts

Forrest, I. S., Petrazzini, B. O., Duffy, Á., Park, J. K., Marquez-Luna, C., Jordan, D. M., Rocheleau, G., Cho, J. H., Rosenson, R. S., Narula, J., Nadkarni, G. N. & Do, R., 21 Jan 2023, In: The Lancet. 401, 10372, p. 215-225 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

Park, J. K., Bafna, S., Forrest, I. S., Duffy, Á., Marquez-Luna, C., Petrazzini, B. O., Vy, H. M., Jordan, D. M., Verbanck, M., Narula, J., Rosenson, R. S., Rocheleau, G. & Do, R., 29 Mar 2023, In: eLife. 12

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank

Rocheleau, G., Forrest, I. S., Duffy, Á., Bafna, S., Dobbyn, A., Verbanck, M., Won, H. H., Jordan, D. M. & Do, R., Dec 2022, In: Communications Biology. 5, 1, 849.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Coronary Risk Estimation Based on Clinical Data in Electronic Health Records

Petrazzini, B. O., Chaudhary, K., Márquez-Luna, C., Forrest, I. S., Rocheleau, G., Cho, J., Narula, J., Nadkarni, G. & Do, R., 29 Mar 2022, In: Journal of the American College of Cardiology. 79, 12, p. 1155-1166 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure

Forrest, I. S., Rocheleau, G., Bafna, S., Argulian, E., Narula, J., Natarajan, P. & Do, R., Nov 2022, In: European Journal of Heart Failure. 24, 11, p. 2118-2127 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Population-Based Penetrance of Deleterious Clinical Variants

Forrest, I. S., Chaudhary, K., Vy, H. M. T., Petrazzini, B. O., Bafna, S., Jordan, D. M., Rocheleau, G., Loos, R. J. F., Nadkarni, G. N., Cho, J. H. & Do, R., 25 Jan 2022, In: JAMA - Journal of the American Medical Association. 327, 4, p. 350-359 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2021

Genetic pleiotropy of ERCC6 loss-of-function and deleterious missense variants links retinal dystrophy, arrhythmia, and immunodeficiency in diverse ancestries

Forrest, I. S., Chaudhary, K., Vy, H. M. T., Bafna, S., Kim, S., Won, H. H., Loos, R. J. F., Cho, J., Pasquale, L. R., Nadkarni, G. N., Rocheleau, G. & Do, R., Aug 2021, In: Human Mutation. 42, 8, p. 969-977 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Genome-wide polygenic risk score for retinopathy of type 2 diabetes

Forrest, I. S., Chaudhary, K., Paranjpe, I., Vy, H. M. T., Marquez-Luna, C., Rocheleau, G., Saha, A., Chan, L., Van Vleck, T., Loos, R. J. F., Cho, J., Pasquale, L. R., Nadkarni, G. N. & Do, R., 15 May 2021, In: Human Molecular Genetics. 30, 10, p. 952-960 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2020

General regression model: A “model-free” association test for quantitative traits allowing to test for the underlying genetic model

The D.E.S.I.R. Study Group, 1 May 2020, In: Annals of Human Genetics. 84, 3, p. 280-290 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Tissue-specific genetic features inform prediction of drug side effects in clinical trials

Duffy, Á., Verbanck, M., Dobbyn, A., Won, H. H., Rein, J. L., Forrest, I. S., Nadkarni, G., Rocheleau, G. & Do, R., Sep 2020, In: Science advances. 6, 37, eabb6242.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2019

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

Liu, C. T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N. & Vogelzangs, N. & 30 others, Willems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., 1 Dec 2019, In: Scientific Reports. 9, 1, 9439.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2018

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

Imatoh, T., Yengo, L., Rocheleau, G., Kamimura, S., Maeda, S., Miyazaki, M. & Froguel, P., Aug 2018, In: Lipids. 53, 8, p. 797-807 11 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Jointly modelling single nucleotide polymorphisms with longitudinal and time-to-event trait: An application to type 2 diabetes and fasting plasma glucose

Canouil, M., Balkau, B., Roussel, R., Froguel, P. & Rocheleau, G., 14 Jun 2018, In: Frontiers in Genetics. 9, JUN, 210.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

SMMB: A stochastic Markov blanket framework strategy for epistasis detection in GWAS

Niel, C., Sinoquet, C., Dina, C. & Rocheleau, G., 15 Aug 2018, In: Bioinformatics. 34, 16, p. 2773-2780 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2016

Detection of human adaptation during the past 2000 years

Field, Y., Boyle, E. A., Telis, N., Gao, Z., Gaulton, K. J., Golan, D., Yengo, L., Rocheleau, G., Froguel, P., McCarthy, M. I. & Pritchard, J. K., 11 Nov 2016, In: Science. 354, 6313, p. 760-764 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

253 Scopus citations

2014

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

The MAGIC investigators & The GIANT Consortium, 7 Aug 2014, In: PLoS Genetics. 10, 8, e1004517.

Research output: Contribution to journal › Article › peer-review

Open Access

175 Scopus citations

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

Vaxillaire, M., Yengo, L., Lobbens, S., Rocheleau, G., Eury, E., Lantieri, O., Marre, M., Balkau, B., Bonnefond, A. & Froguel, P., Aug 2014, In: Diabetologia. 57, 8, p. 1601-1610 10 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2013

Aging and diets regulate the rat anterior pituitary and hypothalamic transcriptome

Bédard, K., Bédard, J., Rocheleau, G., Ferland, G. & Gaudreau, P., 2013, In: Neuroendocrinology. 97, 2, p. 146-159 14 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2012

A genome-wide association search for type 2 diabetes genes in african americans

DIAGRAM Consortium, MAGIC Investigators, Anders Hamsten on behalf of Procardis Consortium, DIAGRAM Consortium, GIANT Consortium, Global BPgen Consortium & for the MAGIC investigators, 4 Jan 2012, In: PLoS ONE. 7, 1, e29202.

Research output: Contribution to journal › Article › peer-review

Open Access

144 Scopus citations

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J. L., Dechaume, A., Payne, F., Roussel, R., Czernichow, S., Hercberg, S., Hadjadj, S., Balkau, B., Marre, M., Lantieri, O., Langenberg, C., Bouatia-Naji, N., Charpentier, G., Vaxillaire, M. & Rocheleau, G. & 7 others, Wareham, N. J., Sladek, R., McCarthy, M. I., Dina, C., Barroso, I., Jockers, R. & Froguel, P., Mar 2012, In: Nature Genetics. 44, 3, p. 297-301 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

309 Scopus citations

2011

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., Baas, A. F., Gretarsdottir, S., Badger, S. A., Bradley, D. T., Burnand, K., Child, A. H., Clough, R. E., Cockerill, G., Hafez, H., Scott, D. J. A., Futers, S., Johnson, A., Sohrabi, S., Smith, A. & Thompson, M. M. & 461 others, van Bockxmeer, F. M., Waltham, M., Matthiasson, S. E., Thorleifsson, G., Thorsteinsdottir, U., Blankensteijn, J. D., Teijink, J. A. W., Wijmenga, C., de Graaf, J., Kiemeney, L. A., Assimes, T. L., McPherson, R., Folkersen, L., Franco-Cereceda, A., Palmen, J., Smith, A. J., Sylvius, N., Wild, J. B., Refstrup, M., Edkins, S., Gwilliam, R., Hunt, S. E., Potter, S., Lindholt, J. S., Frikke-Schmidt, R., Tybjærg-Hansen, A., Hughes, A. E., Golledge, J., Norman, P. E., van Rij, A., Powell, J. T., Eriksson, P., Stefansson, K., Thompson, J. R., Humphries, S. E., Sayers, R. D., Deloukas, P., Samani, N. J., Schunkert, H., König, I. R., Kathiresan, S., Reilly, M. P., Holm, H., Preuss, M., Stewart, A. F. R., Barbalic, M., Gieger, C., Absher, D., Aherrahrou, Z., Allayee, H., Altshuler, D., Anand, S. S., Andersen, K., Anderson, J. L., Ardissino, D., Ball, S. G., Balmforth, A. J., Barnes, T. A., Becker, D. M., Becker, L. C., Berger, K., Bis, J. C., Matthijs Boekholdt, S., Boerwinkle, E., Braund, P. S., Susan Burnett, M., Buysschaert, I., Carlquist, J. F., Chen, L., Cichon, S., Codd, V., Davies, R. W., Dedoussis, G., Dehghan, A., Demissie, S., Devaney, J. M., Diemert, P., Do, R., Doering, A., Eifert, S., El Mokhtari, N. E., Ellis, S. G., Elosua, R., Engert, J. C., Epstein, S. E., de Faire, U., Fischer, M., Folsom, A. R., Freyer, J., Gigante, B., Girelli, D., Gudnason, V., Gulcher, J. R., Halperin, E., Hammond, N., Hazen, S. L., Hofman, A., Horne, B. D., Illig, T., Iribarren, C., Wouter Jukema, J., Kaiser, M. A., Kaplan, L. M., Kastelein, J. J. P., Khaw, K. T., Knowles, J. W., Kolovou, G., Kong, A., Laaksonen, R., Lambrechts, D., Leander, K., Lettre, G., Li, M., Lieb, W., Loley, C., Lotery, A. J., Mannucci, P. M., Maouche, S., Martinelli, N., McKeown, P. P., Meisinger, C., Meitinger, T., Melander, O., Angelica Merlini, P., Mooser, V., Morgan, T., Mühleisen, T. W., Muhlestein, J. B., Münzel, T., Musunuru, K., Nahrstaedt, J., Nelson, C. P., Nöthen, M. M., Olivieri, O., Patel, R. S., Patterson, C. C., Peters, A., Peyvandi, F., Qu, L., Quyyumi, A. A., Rader, D. J., Rallidis, L. S., Rice, C., Rosendaal, F. R., Rubin, D., Salomaa, V., Lourdes Sampietro, M., Sandhu, M. S., Schadt, E., Schäfer, A., Schillert, A., Schreiber, S., Schrezenmeir, J., Schwartz, S. M., Siscovick, D. S., Sivananthan, M., Sivapalaratnam, S., Smith, T. B., Snoep, J. D., Soranzo, N., Spertus, J. A., Stark, K., Stirrups, K., Stoll, M., Wilson Tang, W. H., Tennstedt, S., Thorgeirsson, G., Tomaszewski, M., van Rij, A. M., Voight, B. F., Wareham, N. J., Wells, G. A., Wichmann, H. E., Wild, P. S., Willenborg, C., Witteman, J. C. M., Ye, S., Zeller, T., Ziegler, A., Cambien, F., Goodall, A. H., Adrienne Cupples, L., Quertermous, T., März, W., Hengstenberg, C., Blankenberg, S., Ouwehand, W. H., Hall, A. S., Roberts, R., O'Donnell, C. J., Erdmann, J., Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Hua Zhao, J., Heath, S. C., Eyheramendy, S., Papadakis, K., Scott, L. J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J. C., Nilsson, P., van der Harst, P., Polidoro, S., Grobbee, D. E., Onland-Moret, N. C., Bots, M. L., Wain, L. V., Elliott, K. S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P. R., Hadley, D., McArdle, W. L., Brown, M., Dominiczak, A., Newhouse, S. J., Webster, J., Zeggini, E., Beckmann, J. S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D. M., Yuan, X., Groop, L., Orho-Melander, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Luben, R. N., Crawford, G. J., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, L. L., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Valle, T. T., Willer, C. J., Bergman, R. N., Morken, M. A., Döring, A., Org, E., Pfeufer, A., Marrugat, J., Subirana, I., Freimer, N. B., Hartikainen, A. L., McCarthy, M. I., O'Reilly, P. F., Peltonen, L., Pouta, A., de Jong, P. E., Snieder, H., van Gilst, W. H., Clarke, R., Goel, A., Hamsten, A., Peden, J. F., Seedorf, U., Syvänen, A. C., Tognoni, G., Lakatta, E. G., Sanna, S., Scheet, P., Schlessinger, D., Scuteri, A., Dörr, M., Ernst, F., Felix, S. B., Homuth, G., Lorbeer, R., Reffelmann, T., Rettig, R., Völker, U., Galan, P., Gut, I. G., Hercberg, S., Mark Lathrop, G., Zelenika, D., Williams, F. M., Zhai, G., Laakso, M., Forouhi, N. G., Völzke, H., Uiterwaal, C. S., van der Schouw, Y. T., Numans, M. E., Matullo, G., Navis, G., Berglund, G., Bingham, S. A., Kooner, J. S., Connell, J. M., Bandinelli, S., Ferrucci, L., Watkins, H., Spector, T. D., Tuomilehto, J., Strachan, D. P., Laan, M., Meneton, P., Uda, M., Jarvelin, M. R., Loos, R. J. F., Elliott, P., Abecasis, G. R., Caulfield, M., Munroe, P. B., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Huth, C., Aulchenko, Y. S., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Hofmann, O. M., Dupuis, J., Qi, L., Segrè, A. V., van Hoek, M., Navarro, P., Ardlie, K., Balkau, B., Benediktsson, R., Bennett, A. J., Blagieva, R., Bengtsson Boström, K., Bravenboer, B., Burtt, N. P., Charpentier, G., Chines, P. S., Cornelis, M., Couper, D. J., Crawford, G., Doney, A. S. F., Elliott, A. L., Elliott, A. L., Erdos, M. R., Fox, C. S., Franklin, C. S., Ganser, M., Grarup, N., Green, T., Griffin, S., Groves, C. J., Guiducci, C., Hadjadj, S., Hassanali, N., Herder, C., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Kao, W. H. L., Klopp, N., Kraft, P., Lauritzen, T., Lieverse, A., Lindgren, C. M., Lyssenko, V., Marre, M., Midthjell, K., Narisu, N., Owen, K. R., Payne, F., Perry, J. R. B., Petersen, A. K., Platou, C., Proença, C., Prokopenko, I., Rathmann, W., William Rayner, N., Robertson, N. R., Rocheleau, G., Roden, M., Sampson, M. J., Saxena, R., Shields, B. M., Shrader, P., Sigurdsson, G., Sparsø, T., Strassburger, K., Sun, Q., Swift, A. J., Thorand, B., Tichet, J., Tuomi, T., van Dam, R. M., van Haeften, T. W., van Herpt, T., van Vliet-Ostaptchouk, J. V., Bragi Walters, G., Weedon, M. N., Cauchi, S., Gloyn, A. L., Gyllensten, U., Hansen, T., Hide, W. A., Hitman, G. A., Hunter, D. J., Hveem, K., Morris, A. D., Palmer, C. N. A., Pramstaller, P. P., Rudan, I., Sijbrands, E., Stein, L. D., Uitterlinden, A., Walker, M., Watanabe, R. M., Boehm, B. O., Campbell, H., Daly, M. J., Hattersley, A. T., Hu, F. B., Meigs, J. B., Pankow, J. S., Pedersen, O., Florez, J. C., Frayling, T. M., Sladek, R., Wilson, J. F., Froguel, P., van Duijn, C. M., Blair, R. D., Hill, A. A., Gerry Hill, B., Lewis, D. R., McNoe, L. A., Merriman, T. R., Naik, D. K., Vicky Phillips, L., Thomson, I. A., Topless, R., Vasudevan, T. M. & Yu, G., 11 Nov 2011, In: American Journal of Human Genetics. 89, 5, p. 619-627 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

161 Scopus citations

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

Global BPgen Consortium, NASH CRN, GIANT Consortium, MAGIC Investigators, GOLD Consortium, MAGIC, on behalf of Procardis Consortium, DIAGRAM Consortium & GIANT Consortium, 1 Mar 2011, In: PLoS Genetics. 7, 3, e1001324.

Research output: Contribution to journal › Article › peer-review

Open Access

809 Scopus citations

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge, R. J., Dupuis, J., Prokopenko, I., Barker, A., Ahlqvist, E., Rybin, D., Petrie, J. R., Travers, M. E., Bouatia-Naji, N., Dimas, A. S., Nica, A. C., Wheeler, E., Chen, H., Voight, B. F., Taneera, J., Kanoni, S., Peden, J. F., Turrini, F., Gustafsson, S. & Zabena, C. & 670 others, Almgren, P., Barker, D. J. P., Barnes, D., Dennison, E. M., Eriksson, J. G., Eriksson, P., Eury, E., Folkersen, L., Fox, C. S., Frayling, T. M., Goel, A., Gu, H. F., Horikoshi, M., Isomaa, B., Jackson, A. U., Jameson, K. A., Kajantie, E., Kerr-Conte, J., Kuulasmaa, T., Kuusisto, J., Loos, R. J. F., Luan, J., Makrilakis, K., Manning, A. K., Martínez-Larrad, M. T., Narisu, N., Mannila, M. N., Öhrvik, J., Osmond, C., Pascoe, L., Payne, F., Sayer, A. A., Sennblad, B., Silveira, A., Stančcáková, A., Stirrups, K., Swift, A. J., Syvänen, A. C., Tuomi, T., Van't Hooft, F. M., Walker, M., Weedon, M. N., Xie, W., Zethelius, B., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. 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M., Stefansson, K., Altshuler, D., Boehnke, M., McCarthy, M. I., Speliotes, E. K., Berndt, S. I., Monda, K. L., Allen, H. L., Magi, R., Randall, J. C., Vedantam, S., Winkler, T. W., Workalemahu, T., Heid, I. M., Wood, A. R., Weyant, R. J., Estrada, K., Liang, L., Nemesh, J., Park, J. H., Kilpelainen, T. O., Yang, J., Esko, T., Feitosa, M. F., Kutalik, Z., Mangino, M., Scherag, A., Smith, A. V., Zhao, J. H., Aben, K. K., Absher, D. M., Dixon, A. L., Fisher, E., Glazer, N. L., Goddard, M. E., Heard-Costa, N. L., Hoesel, V., Hottenga, J. J., Johansson, A., Johnson, T., Ketkar, S., Lamina, C., Li, S., Moffatt, M. F., Myers, R. H., Peters, M. J., Preuss, M., Ripatti, S., Rivadeneira, F., Sandholt, C., Timpson, N. J., Tyrer, J. P., Van Wingerden, S., White, C. C., Wiklund, F., Barlassina, C., Chasman, D. I., Cooper, M. N., Jansson, J. O., Lawrence, R. W., Pellikka, N., Shi, J., Thiering, E., Alavere, H., Alibrandi, M. T. S., Arnold, A. M., Aspelund, T., Atwood, L. D., Balmforth, A. 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297 Scopus citations

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) & Collaborators, 1 Nov 2011, In: Nature Genetics. 43, 11, p. 1131-1138 8 p.

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2010

Common variants at 10 genomic loci influence hemoglobin A_1C levels via glycemic and nonglycemic pathways

Soranzo, N., Sanna, S., Wheeler, E., Gieger, C., Radke, D., Dupuis, J., Bouatia-Naji, N., Langenberg, C., Prokopenko, I., Stolerman, E., Sandhu, M. S., Heeney, M. M., Devaney, J. M., Reilly, M. P., Ricketts, S. L., Stewart, A. F. R., Voight, B. F., Willenborg, C., Wright, B. & Altshuler, D. & 157 others, Arking, D., Balkau, B., Barnes, D., Boerwinkle, E., Böhm, B., Bonnefond, A., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Böttcher, Y., Bumpstead, S., Burnett-Miller, M. S., Campbell, H., Cao, A., Chambers, J., Clark, R., Collins, F. S., Coresh, J., De Geus, E. J. C., Dei, M., Deloukas, P., Döring, A., Egan, J. M., Elosua, R., Ferrucci, L., Forouhi, N., Fox, C. S., Franklin, C., Franzosi, M. G., Gallina, S., Goel, A., Graessler, J., Grallert, H., Greinacher, A., Hadley, D., Hall, A., Hamsten, A., Hayward, C., Heath, S., Herder, C., Homuth, G., Hottenga, J. J., Hunter-Merrill, R., Illig, T., Jackson, A. U., Jula, A., Kleber, M., Knouff, C. W., Kong, A., Kooner, J., Köttgen, A., Kovacs, P., Krohn, K., Kühnel, B., Kuusisto, J., Laakso, M., Lathrop, M., Lecoeur, C., Li, M., Li, M., Loos, R. J. F., Luan, J., Lyssenko, V., Mägi, R., Magnusson, P. K. E., Mälarstig, A., Mangino, M., Martínez-Larrad, M. T., März, W., McArdle, W. L., McPherson, R., Meisinger, C., Meitinger, T., Melander, O., Mohlke, K. L., Mooser, V. E., Morken, M. A., Narisu, N., Nathan, D. M., Nauck, M., O'Donnell, C., Oexle, K., Olla, N., Pankow, J. S., Payne, F., Peden, J. F., Pedersen, N. L., Peltonen, L., Perola, M., Polasek, O., Porcu, E., Rader, D. J., Rathmann, W., Ripatti, S., Rocheleau, G., Roden, M., Rudan, I., Salomaa, V., Saxena, R., Schlessinger, D., Schunkert, H., Schwarz, P., Seedorf, U., Selvin, E., Serrano-Ríos, M., Shrader, P., Silveira, A., Siscovick, D., Song, K., Spector, T. D., Stefansson, K., Steinthorsdottir, V., Strachan, D. P., Strawbridge, R., Stumvoll, M., Surakka, I., Swift, A. J., Tanaka, T., Teumer, A., Thorleifsson, G., Thorsteinsdottir, U., Tönjes, A., Usala, G., Vitart, V., Völzke, H., Wallaschofski, H., Waterworth, D. M., Watkins, H., Wichmann, H. E., Wild, S. H., Willemsen, G., Williams, G. H., Wilson, J. F., Winkelmann, J., Wright, A. F., Zabena, C., Zhao, J. H., Epstein, S. E., Erdmann, J., Hakonarson, H. H., Kathiresan, S., Khaw, K. T., Roberts, R., Samani, N. J., Fleming, M. D., Sladek, R., Abecasis, G., Boehnke, M., Froguel, P., Groop, L., McCarthy, M. I., Kao, W. H. L., Florez, J. C., Uda, M., Wareham, N. J., Barroso, I. & Meigs, J. B., Dec 2010, In: Diabetes. 59, 12, p. 3229-3239 11 p.

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349 Scopus citations

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V. & Henneman, P. & 283 others, Grallert, H., Dehghan, A., JanHottenga, J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Der IdaChen, Y., Chines, P., Clarke, R., McOin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., GraziaFranzosi, M., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., -LiisaHartikainen, A., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., AnteroKesaniemi, Y., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Bacquer, O. L., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., TeresaMartínez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., APalmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., -ChristineSyvänen, A., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Hoek, M. V., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., BragiWalters, G., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., MWitteman, J. C., GYarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Linda Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., -RiittaJarvelin, M., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105-116 12 p.

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1800 Scopus citations

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C. & Hofmann, O. M. & 138 others, Dupuis, J., Qi, L., Segrè, A. V., Van Hoek, M., Navarro, P., Ardlie, K., Balkau, B., Benediktsson, R., Bennett, A. J., Blagieva, R., Boerwinkle, E., Bonnycastle, L. L., Boström, K. B., Bravenboer, B., Bumpstead, S., Burtt, N. P., Charpentier, G., Chines, P. S., Cornelis, M., Couper, D. J., Crawford, G., Doney, A. S. F., Elliott, K. S., Elliott, A. L., Erdos, M. R., Fox, C. S., Franklin, C. S., Ganser, M., Gieger, C., Grarup, N., Green, T., Griffin, S., Groves, C. J., Guiducci, C., Hadjadj, S., Hassanali, N., Herder, C., Isomaa, B., Jackson, A. U., Johnson, P. R. V., Jørgensen, T., Kao, W. H. L., Klopp, N., Kong, A., Kraft, P., Kuusisto, J., Lauritzen, T., Li, M., Lieverse, A., Lindgren, C. M., Lyssenko, V., Marre, M., Meitinger, T., Midthjell, K., Morken, M. A., Narisu, N., Nilsson, P., Owen, K. R., Payne, F., Perry, J. R. B., Petersen, A. K., Platou, C., Proença, C., Prokopenko, I., Rathmann, W., Rayner, N. W., Robertson, N. R., Rocheleau, G., Roden, M., Sampson, M. J., Saxena, R., Shields, B. M., Shrader, P., Sigurdsson, G., Sparsø, T., Strassburger, K., Stringham, H. M., Sun, Q., Swift, A. J., Thorand, B., Tichet, J., Tuomi, T., Van Dam, R. M., Van Haeften, T. W., Van Herpt, T., Van Vliet-Ostaptchouk, J. V., Walters, G. B., Weedon, M. N., Wijmenga, C., Witteman, J., Bergman, R. N., Cauchi, S., Collins, F. S., Gloyn, A. L., Gyllensten, U., Hansen, T., Hide, W. A., Hitman, G. A., Hofman, A., Hunter, D. J., Hveem, K., Laakso, M., Mohlke, K. L., Morris, A. D., Palmer, C. N. A., Pramstaller, P. P., Rudan, I., Sijbrands, E., Stein, L. D., Tuomilehto, J., Uitterlinden, A., Walker, M., Wareham, N. J., Watanabe, R. M., Abecasis, G. R., Boehm, B. O., Campbell, H., Daly, M. J., Hattersley, A. T., Hu, F. B., Meigs, J. B., Pankow, J. S., Pedersen, O., Wichmann, H. E., Barroso, I., Florez, J. C., Frayling, T. M., Groop, L., Sladek, R., Thorsteinsdottir, U., Wilson, J. F., Illig, T., Froguel, P., Van Duijn, C. M., Stefansson, K., Altshuler, D., Boehnke, M. & McCarthy, M. I., Jul 2010, In: Nature Genetics. 42, 7, p. 579-589 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1508 Scopus citations

2009

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., De Graeve, F., Chèvre, J. C., Borch-Johnsen, K., Hartikainen, A. L., Ruokonen, A., Tichet, J., Marre, M., Weill, J., Heude, B. & Tauber, M. & 21 others, Lemaire, K., Schuit, F., Elliott, P., Jørgensen, T., Charpentier, G., Hadjadj, S., Cauchi, S., Vaxillaire, M., Sladek, R., Visvikis-Siest, S., Balkau, B., Lévy-Marchal, C., Pattou, F., Meyre, D., Blakemore, A. I. F., Jarvelin, M. R., Walley, A. J., Hansen, T., Dina, C., Pedersen, O. & Froguel, P., Jan 2009, In: Nature Genetics. 41, 1, p. 89-94 6 p.

Research output: Contribution to journal › Article › peer-review

509 Scopus citations

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Rung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., Charpentier, G., Dina, C., Durand, E., Elliott, P., Hadjadj, S., Järvelin, M. R., Laitinen, J., Lauritzen, T., Marre, M. & Mazur, A. & 20 others, Meyre, D., Montpetit, A., Pisinger, C., Posner, B., Poulsen, P., Pouta, A., Prentki, M., Ribel-Madsen, R., Ruokonen, A., Sandbaek, A., Serre, D., Tichet, J., Vaxillaire, M., Wojtaszewski, J. F. P., Vaag, A., Hansen, T., Polychronakos, C., Pedersen, O., Froguel, P. & Sladek, R., Oct 2009, In: Nature Genetics. 41, 10, p. 1110-1115 6 p.

Research output: Contribution to journal › Article › peer-review

373 Scopus citations

2008

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

Bouatia-Naji, N., Rocheleau, G., Van Lommel, L., Lemaire, K., Schuit, F., Cavalcanti-Proença, C., Marchand, M., Hartikainen, A. L., Sovio, U., De Graeve, F., Rung, J., Vaxillaire, M., Tichet, J., Marre, M., Balkau, B., Weill, J., Elliott, P., Jarvelin, M. R., Meyre, D. & Polychronakos, C. & 3 others, Dina, C., Sladek, R. & Froguel, P., 23 May 2008, In: Science. 320, 5879, p. 1085-1088 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

205 Scopus citations

2007

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, T. J., Montpetit, A., Pshezhetsky, A. V., Prentki, M., Posner, B. I., Balding, D. J. & Meyre, D. & 2 others, Polychronakos, C. & Froguel, P., 22 Feb 2007, In: Nature. 445, 7130, p. 881-885 5 p.

Research output: Contribution to journal › Article › peer-review

2470 Scopus citations

2004

Kin selection and coefficients of relatedness in family-structured populations with inbreeding

Lessard, S. & Rocheleau, G., Dec 2004, In: Theoretical Population Biology. 66, 4, p. 287-306 20 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2003

Change in frequency of a rare mutant allele: A general formula and applications to partial inbreeding models

Lessard, S. & Rocheleau, G., Jan 2003, In: Journal of Mathematical Biology. 46, 1, p. 71-94 24 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2000

Stability analysis of the partial selfing selection model

Rocheleau, G. & Lessard, S., Jun 2000, In: Journal of Mathematical Biology. 40, 6, p. 541-574 34 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Ghislain Rocheleau

Research output

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