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PROFESSOR | Surgery
Biography
As Section Chief of Hepatobiliary Surgery, Dr. Ganesh Gunasekaran is responsible for leading the clinical and academic efforts of the hepatobiliary section of the Division of Surgical Oncology. Dr. Gunasekaran developed and supervises the improvement of the hepatobiliary program at all sites within the Department of Surgery at Mount Sinai Health System.
Dr. Ganesh Gunasekaran graduated from Madras Medical College in India. He completed his residency in general surgery at Montefiore Medical Center in New York and subsequently completed his fellowship in multi-organ transplant and hepatobiliary surgery at the Cleveland Clinic Foundation in Ohio. Since then, Dr. Gunasekaran has devoted his career to the field of hepatobiliary/pancreatic surgery and liver transplantation. He was part of the faculty at the Westchester Medical Center and joined the faculty at Mount Sinai Hospital as an Attending in 2014.
Dr. Ganesh Gunasekaran is a national leader in hepatobiliary and pancreatic surgery. He has been an integral part of the team at the Mount Sinai Liver and Pancreatic Cancer Program. This program is at the forefront in liver and pancreatic cancer clinical care as well as clinical/translational research worldwide. Dr. Gunasekaran has served in various committees of renowned national and international organizations to improve the field of hepatobiliary and transplant surgery. He is regarded highly in the international community given his expertise on liver and pancreatic surgery, a subject which he lectures frequently on in both the United States and globally. He has also authored and co-authored multiple peer-reviewed publications on various aspects of Hepatobiliary and Transplant surgery. Both a renowned surgeon and an active researcher, Dr. Gunasekaran oversees various clinical trials investigating new treatments for liver, pancreatic, and biliary tract tumors. He has also mentored numerous surgeons across the world who now lead the field of hepatobiliary and transplant surgery.
Dr. Ganesh Gunasekaran has served as a multi organ transplant and hepatobiliary- pancreatic surgeon to address the complex demands of patients with end organ failure and malignancy. Over the years, he focused more towards the management of patients with liver, biliary tract and pancreatic tumors. Dr. Ganesh Gunasekaran has collaborated with surgeons from different parts of the world and performed surgeries in different continents to create an impact on the training process and improve the quality of health care.
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Collaborations and top research areas from the last five years
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ASO Visual Abstract: Worse Survival in Co-altered RAS-TP53 Patients with Resected Colorectal Liver Metastases
Li, J., Waller, G., Qin, Y., Yu, A. T., Li, T., Li, D., Srouji, R., Correa-Gallego, C., Hiotis, S., Gunasekaran, G., Leinwand, J., Lad, N. L., Park, J. O. & Cohen, N. A., 1 Feb 2026, In: Annals of Surgical Oncology. 33, 2, p. 1569 1 p.Research output: Contribution to journal › Article › peer-review
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Assessing Clinical Factors and Communication Barriers Impacting Postoperative Regret in Patients with Pancreatic Cancer
Li, J., Li, T. M., Geffner, A., Neugarten, S., Correa-Gallego, C., Leinwand, J., Lad, N. L., Gunasekaran, G., Hiotis, S., Schwartz, M. E., Tabrizian, P., Sarpel, U., Labow, D. M., Park, J. O. & Cohen, N. A., Apr 2026, In: Annals of Surgical Oncology. 33, 4, p. 3553-3562 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A Systematic Review of Gallbladder Anomalies
Takahashi, H., Raj, R., Hughes, A., Katz, O. & Gunasekaran, G., 2026, In: Journal of the Society of Laparoscopic and Robotic Surgeons. 30, 1, e2025.00102.Research output: Contribution to journal › Review article › peer-review
Open Access -
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
Gonzalez-Kozlova, E., Sweeney, R., Figueiredo, I., Tuballes, K., Ozbey, S., Hamon, P., Park, M. D., Ioannou, G., Nose, Y., Guo, R., Restrepo, P., Buckup, M., Roudko, V., Hennequin, C., Le Berichel, J., Venturini, N., Halasz, L., Troncoso, L., Tabachnikova, A. & Chang, C. & 42 others, , Mar 2026, In: Nature Medicine. 32, 3, p. 978-991 14 p.Research output: Contribution to journal › Article › peer-review
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Perihilar cholangiocarcinoma: microscopic positive margin and its clinical relevance
Waller, G., Takahashi, H., Bekki, Y., Raj, R., Amodeo, S., Buckstein, M., Fiel, M. I., Facciuto, M. E., Schwartz, M. & Gunasekaran, G., Apr 2026, In: HPB. 28, 4, p. 574-581 8 p.Research output: Contribution to journal › Article › peer-review
Press/Media
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Studies from Mount Sinai Hospital Yield New Data on Medical Devices and Surgical Technology (A Systematic Review of Gallbladder Anomalies)
28/04/26
1 item of Media coverage
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LI Hospital Makes Top 60 Pancreatic Cancer Facilities In The U.S.
9/03/26
1 item of Media coverage
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Findings on Immunotherapy Detailed by Investigators at Icahn School of Medicine at Mount Sinai (Humoral Igg1 Responses To Tumor Antigens Underpin Clinical Outcomes In Immune Checkpoint Blockade)
Sweeney, R., Merad, M., Nie, K., Kim-Schulze, S., D'Souza, D., Hamon, P., Tabrizian, P., Cohen, N., Gunasekaran, G., Schwartz, M., Marron, T., Fiel, M., Gnjatic, S., Ward, S., Curotto de Lafaille, M., Kamphorst, A. O., Chen, Z. & Brody, R.
23/02/26
1 item of Media coverage
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Researchers from Icahn School of Medicine at Mount Sinai Discuss Findings in Cholangiocarcinoma (Perihilar cholangiocarcinoma: microscopic positive margin and its clinical relevance)
Amodeo, S., Gunasekaran, G., Schwartz, M., Buckstein, M., Fiel, M., Facciuto, M. & Takahashi, H.
13/02/26
1 item of Media coverage
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New Pancreatic Cancer Study Findings Recently Were Reported by Researchers at University of California San Francisco (UCSF) (Assessing Clinical Factors and Communication Barriers Impacting Postoperative Regret in Patients with Pancreatic Cancer)
Tabrizian, P., Gunasekaran, G. & Schwartz, M.
31/12/25
1 item of Media coverage
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