Eric J. Nestler

Phone212-659-5656
Emaileric.nestlermssmedu

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Research activity per year

Headline

DEAN FOR ACADEMIC AND SCIENTIFIC AFFAIRS DIRECTOR FRIEDMAN BRAIN INSTITUTE PROFESSOR | Neuroscience PROFESSOR | PharmacologicalSciences PROFESSOR | Psychiatry

Biography

Biography Dr. Nestler is the Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models. Visit Eric Nestler's http://neuroscience.mssm.edu/nestler/ Laboratory of Molecular Psychiatry, http://neuroscience.mssm.edu/nestler/contecenter/index.html Conte Center on Depressionand http://transmitter.neuro.mssm.edu/nestler/nidappg/index.html NIDA Program Project Grant for more information.

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1 Similar Profiles

595 Article
100 Review article
35 Chapter
32 Comment/debate
More

Cellular and molecular mechanisms of astrocyte plasticity in learning and memory
Holt, L. M., Nestler, E. J. & Olsen, M. L., 2026, (Accepted/In press) In: Trends in Neurosciences.
Research output: Contribution to journal › Review article › peer-review

Open Access
Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB
McNeme, S., Yim, Y. Y., Kumar, A., Li, Y., Hughes, B., St Romain, C. P., Aglyamova, G., Chen, J., Nguyen, N. D., Fan, S., Stephens, G. S., Zhao, W. N., Kruzshak, S., Estill, M., Brener, C., Tofani, S., Kumar, A., Chen, E. P., Takatka, N. & Robison, A. J. & 9 others, Chen, H., Powell, R. T., Haggarty, S. J., Stephan, C., Nestler, E. J., Chin, J., Machius, M., Zhou, J. & Rudenko, G., Feb 2026, In: Journal of Biological Chemistry. 302, 2, 111080.
Research output: Contribution to journal › Article › peer-review

Open Access
Efficient In Vivo Pharmacological Inhibition of ΔFOSB, an AP-1 Transcription Factor, in the Brain
McNeme, S., Kumar, A., Yim, Y. Y., Hughes, B. W., St Romain, C., Li, Y., Kumar, A., Bao, Q., Estill, M., Fan, S., Takatka, N., Chen, E. P., Rivera, M., Chen, H., Robison, A. J., Machius, M., Haggarty, S. J., Chin, J., Nestler, E. J. & Zhou, J. & 1 others, Rudenko, G., 1 Apr 2026, In: ACS Chemical Neuroscience. 17, 7, p. 1316-1331 16 p.
Research output: Contribution to journal › Article › peer-review
Establishing the relationship between brain cellular senescence and brain structure
Lund, A. N., Kopell, B. H., Golestani, N., Vornholt, E., Thompson, R. C., Liharska, L. E., Luo, Y., Cheng, E., Park, Y. J., Fennessy, B., Wilkins, L., Kaji, D. A., Silk, H., Ziafat, K., Hashemi, A., Moya, E., Feng, C., Linares, L. M., Grice, A. B. & Xie, S. & 19 others, Rieder, M. K., Scarpa, J., Kota, P., Cohen, V., Sullivan, B., Shah, P., Ma, W., Johnson, J. S., Miller, G. M., Searfoss, R., Chand, N. M., Wang, P., Nadkarni, G. N., Narain, N. R., Nestler, E. J., Kiebish, M. A., Schadt, E. E., Charney, A. W. & Beckmann, N. D., 22 Jan 2026, In: Cell. 189, 2, p. 511-527.e17
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Genome-wide methylation patterns associated with chronic stress
O’Toole, N., Zhang, T. Y., Fitzgerald, E., Wen, X., Diorio, J., Silveira, P. P., Labonté, B., Nestler, E. J. & Meaney, M. J., 2026, In: Epigenomics. 18, 1, p. 73-88 16 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations

Mount Sinai Launches Adams Valve Institute, Specializing in Complex Valve Surgery and Valvular Heart Disease
Flatow, E., Nestler, E. J., El-Hamamsy, I. & Adams, D.
7/04/26 → 8/04/26
4 items of Media coverage
Press/Media
Mount Sinai Establishes Adams Valve Institute to Advance Complex Valve Surgery and Valvular Heart Disease Treatment
Flatow, E., Nestler, E. J., El-Hamamsy, I. & Adams, D.
7/04/26
2 items of Media coverage
Press/Media
Mount Sinai’s Roxana Mehran, MD, Named President of the American College of Cardiology
Nestler, E. J., Fuster, V., Mehran,, R. & Bhatt, D. L.
4/04/26
1 item of Media coverage
Press/Media
Mount Sinai’s Roxana Mehran, MD, Named President of the American College of Cardiology
Nestler, E. J., Fuster, V., Mehran,, R. & Bhatt, D. L.
30/03/26
2 items of Media coverage
Press/Media
The Mount Sinai Hospital Ranked Among World's Best In Newsweek/Statista Rankings
Nestler, E. J., Reich, D., Carr, B. & Breen, T.
10/03/26 → 11/03/26
8 items of Media coverage
Press/Media

Eric J. Nestler

Personal profile

Headline

Biography

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Cellular and molecular mechanisms of astrocyte plasticity in learning and memory

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

Efficient In Vivo Pharmacological Inhibition of ΔFOSB, an AP-1 Transcription Factor, in the Brain

Establishing the relationship between brain cellular senescence and brain structure

Genome-wide methylation patterns associated with chronic stress

Mount Sinai Launches Adams Valve Institute, Specializing in Complex Valve Surgery and Valvular Heart Disease

Mount Sinai Establishes Adams Valve Institute to Advance Complex Valve Surgery and Valvular Heart Disease Treatment

Mount Sinai’s Roxana Mehran, MD, Named President of the American College of Cardiology

Mount Sinai’s Roxana Mehran, MD, Named President of the American College of Cardiology

The Mount Sinai Hospital Ranked Among World's Best In Newsweek/Statista Rankings

Eric J. Nestler

Personal profile

Headline

Biography

Fingerprint

Collaborations and top research areas from the last five years

Research output

Press/Media