PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease

Biography Donald Scott, PhD, is a Professor in the Division of Endocrinology, Diabetes and Bone Disease. Dr. Scott’s group works on the nutritional regulation of cellular phenotype. The http://labs.icahn.mssm.edu/scottlab/ Scott Laboratory works on molecular mechanisms that coordinate how nutrients, especially glucose, alter the regulation of genes to change the phenotype of cells. His work focuses on two glucose-sensing transcription factors, ChREBP and c-Myc. He found that ChREBP activity requires the presence of c-Myc and is currently working out the molecular mechanisms of this relationship. In addition, his lab, in collaboration with colleagues from the Metabolism Institute (Drs. Garcia-Ocaña, Vasavada, and Stewart) found that ChREBP is required for glucose-stimulated beta cell proliferation. This work is funded by the NIH, the American Diabetes Association, and the Juvenile Diabetes Research Foundation. Dr. Scott is member of the Graduate Faculty and is affiliated with the Systems Biology of Disease and Therapeutics Multiple Training Area. Research Topic Cancer, Cell Biology, Cell Cycle, Chromatin, Diabetes, Epigenetics, Gene Expressions, Gene Regulation, Gene Therapy, Growth Factors and Receptors, Hormones, Image Analysis, Imaging, Insulin, Insulin Receptor, Knockout Mice, Liver, Molecular Biology, Nucleus, Obesity, Oncogenes, Protein Kinases, RNA, RNA Splicing & Processing, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice Multi-Disciplinary Training Area Biophysics and Systems Pharmacology [BSP] Education AB, University of Missouri MA, University of Missouri PhD, Saint Louis University