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Alleviation of Glucotoxicity in Pancreatic Beta Cells
Scott, D. & Scott, D. K.
National Institute of Diabetes and Digestive and Kidney Diseases
20/07/21 → 30/06/23
Project: Research
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Myc Physiology in the Pancreatic Beta Cell
Scott, D., García-Ocaña, A., García-Ocaña, A. & Scott, D. K.
National Institute of Diabetes and Digestive and Kidney Diseases
28/07/20 → 30/04/23
Project: Research
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Nrf2 and the adaptive expansion of beta cell mass
National Institute of Diabetes and Digestive and Kidney Diseases
1/07/18 → 30/04/19
Project: Research
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Epigenetic Control of Human Beta Cell Proliferation
Stewart, A., Argmann, C., Scott, D. & Walsh, M.
National Institute of Diabetes and Digestive and Kidney Diseases
1/04/18 → 31/03/19
Project: Research
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ChREBP Isoforms in Pancreatic Beta Cells
National Institute of Diabetes and Digestive and Kidney Diseases
18/04/17 → 31/03/21
Project: Research
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Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure (Nature Communications, (2022), 13, 1, (4423), 10.1038/s41467-022-32162-x)
Katz, L. S., Brill, G., Zhang, P., Kumar, A., Baumel-Alterzon, S., Honig, L. B., Gómez-Banoy, N., Karakose, E., Tanase, M., Doridot, L., Alvarsson, A., Davenport, B., Wang, P., Lambertini, L., Stanley, S. A., Homann, D., Stewart, A. F., Lo, J. C., Herman, M. A., Garcia-Ocaña, A., & 1 others , Dec 2022, In: Nature Communications. 13, 1, 5681.Research output: Contribution to journal › Comment/debate
Open Access -
Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells
Wang, P., Karakose, E., Argmann, C., Wang, H., Balev, M., Brody, R. I., Rivas, H. G., Liu, X., Wood, O., Liu, H., Choleva, L., Hasson, D., Bernstein, E., Paulo, J. A., Scott, D. K., Lambertini, L., DeCaprio, J. A. & Stewart, A. F., 1 Aug 2022, In: Journal of Clinical Investigation. 132, 15, e157086.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
Katz, L. S., Brill, G., Zhang, P., Kumar, A., Baumel-Alterzon, S., Honig, L. B., Gómez-Banoy, N., Karakose, E., Tanase, M., Doridot, L., Alvarsson, A., Davenport, B., Wang, P., Lambertini, L., Stanley, S. A., Homann, D., Stewart, A. F., Lo, J. C., Herman, M. A., Garcia-Ocaña, A., & 1 others , Dec 2022, In: Nature Communications. 13, 1, 4423.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nrf2 Regulates b-Cell Mass by Suppressing b-Cell Death and Promoting b-Cell Proliferation
Baumel-Alterzon, S., Katz, L. S., Brill, G., Jean-Pierre, C., Li, Y., Tse, I., Biswal, S., Garcia-Ocaña, A. & Scott, D. K., May 2022, In: Diabetes. 71, 5, p. 989-1011 23 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells
Baumel-Alterzon, S. & Scott, D. K., 15 Sep 2022, In: Frontiers in Endocrinology. 13, 1011187.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Press / Media
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Researchers at Icahn School of Medicine at Mount Sinai Have Published New Study Findings on Lentivirus [T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased b-cell proliferation]
Carmen Argmann, Luca Lambertini & Donald Scott
28/12/22
1 item of Media coverage
Press/Media
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A Potential Game Changer for Type 2 Diabetics – New Therapeutic Target Identified
Lee Honig, Dirk Homann, Esra Karakose, Luca Lambertini, Donald Scott, Alexandra Alvarsson & Peng Wang
14/10/22
1 item of Media coverage
Press/Media
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Researchers Discover New Targets that May Aid in the Development of Therapies for Type 2 Diabetes
22/08/22
1 item of Media coverage
Press/Media
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Study discovers therapeutic target for patients with type 2 diabetes
4/08/22 → 5/08/22
4 items of Media coverage
Press/Media
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Researchers Identify Potential Target for Treatment Among Patients With Type 2 Diabetes
4/08/22 → 5/08/22
11 items of Media coverage
Press/Media