Darwin D'Souza

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Associate Computational Scientist

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1 Similar Profiles

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Hegde, S., Giotti, B., Soong, B. Y., Halasz, L., Le Berichel, J., Schaefer, M. M., Kloeckner, B., Mattiuz, R., Park, M. D., Magen, A., Marks, A., Belabed, M., Hamon, P., Chin, T., Troncoso, L., Lee, J. J., Fan, K., Ahimovic, D., Bale, M. J. & Nie, K. & 14 others, Chung, G., D’souza, D., Angeliadis, K., Kim-Schulze, S., Flores, R. M., Kaufman, A. J., Ginhoux, F., Buenrostro, J. D., Josefowicz, S. Z., Tsankov, A. M., Marron, T. U., Ma, S., Brown, B. D. & Merad, M., 30 Oct 2025, In: Nature. 646, 8087, p. 1214-1222 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
17 Scopus citations
Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection
Cossarini, F., Shang, J., Krek, A., Al-Taie, Z., Hou, R., Canales-Herrerias, P., Tokuyama, M., Tankelevich, M., Tillowitz, A., Jha, D., Livanos, A. E., Leyre, L., Uzzan, M., Martinez-Delgado, G., Taylor, M. D., Sharma, K., Bourgonje, A. R., Cruz, M., Ioannou, G. & Dawson, T. & 15 others, D'Souza, D., Kim-Schulze, S., Akm, A., Aberg, J. A., Chen, B. K., Kwon, D. S., Gnjatic, S., Polydorides, A. D., Cerutti, A., Argmann, C., Vujkovic-Cvijin, I., Suarez-Fariñas, M., Petralia, F., Faith, J. J. & Mehandru, S., Oct 2024, In: Science immunology. 9, 100, eado0090.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Hematopoietic aging promotes cancer by fueling IL-1a–driven emergency myelopoiesis
Park, M. D., Le Berichel, J., Hamon, P., Wilk, C. M., Belabed, M., Yatim, N., Saffon, A., Boumelha, J., Falcomatà, C., Tepper, A., Hegde, S., Mattiuz, R., Soong, B. Y., LaMarche, N. M., Rentzeperis, F., Troncoso, L., Halasz, L., Hennequin, C., Chin, T. & Chen, E. P. & 19 others, Reid, A. M., Su, M., Cahn, A. R., Koekkoek, L. L., Venturini, N., Wood-Isenberg, S., D’souza, D., Chen, R., Dawson, T., Nie, K., Chen, Z., Kim-Schulze, S., Casanova-Acebes, M., Swirski, F. K., Downward, J., Vabret, N., Brown, B. D., Marron, T. U. & Merad, M., 25 Oct 2024, In: Science. 386, 6720, eadn0327.
Research output: Contribution to journal › Article › peer-review

Open Access
106 Scopus citations
Myocardial infarction augments sleep to limit cardiac inflammation and damage
Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T. & Ferreira da Silva, J. & 17 others, Ameral, N. J., Morgenroth-Rebin, J., D’Souza, D., Koekkoek, L. L., Jacob, W., Munitz, J., Lee, D., Fullard, J. F., van Leent, M. M. T., Roussos, P., Kim-Schulze, S., Shah, N., Kleinstiver, B. P., Swirski, F. K., Leistner, D., St-Onge, M. P. & McAlpine, C. S., 7 Nov 2024, In: Nature. 635, 8037, p. 168-177 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
78 Scopus citations
Intratumoral dendritic cell–CD4⁺ T helper cell niches enable CD8⁺ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Magen, A., Hamon, P., Fiaschi, N., Soong, B. Y., Park, M. D., Mattiuz, R., Humblin, E., Troncoso, L., D’souza, D., Dawson, T., Kim, J., Hamel, S., Buckup, M., Chang, C., Tabachnikova, A., Schwartz, H., Malissen, N., Lavin, Y., Soares-Schanoski, A. & Giotti, B. & 33 others, Hegde, S., Ioannou, G., Gonzalez-Kozlova, E., Hennequin, C., Le Berichel, J., Zhao, Z., Ward, S. C., Fiel, I., Kou, B., Dobosz, M., Li, L., Adler, C., Ni, M., Wei, Y., Wang, W., Atwal, G. S., Kundu, K., Cygan, K. J., Tsankov, A. M., Rahman, A., Price, C., Fernandez, N., He, J., Gupta, N. T., Kim-Schulze, S., Gnjatic, S., Kenigsberg, E., Deering, R. P., Schwartz, M., Marron, T. U., Thurston, G., Kamphorst, A. O. & Merad, M., Jun 2023, In: Nature Medicine. 29, 6, p. 1389-1399 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
282 Scopus citations

Data on Suicide Discussed by Researchers at Icahn School of Medicine at Mount Sinai (Protein expression is associated with brain white matter in Veterans with Bipolar disorder and suicide attempts)
D'Souza, D., Xie, H., Rizk, M., Yehuda, R., Fleysher, L., Russo, S., Hazlett, E., Szeszko, P. & Chan, C.
4/06/26
1 item of Media coverage
Press/Media
Findings on Immunotherapy Detailed by Investigators at Icahn School of Medicine at Mount Sinai (Humoral Igg1 Responses To Tumor Antigens Underpin Clinical Outcomes In Immune Checkpoint Blockade)
Sweeney, R., Merad, M., Nie, K., Kim-Schulze, S., D'Souza, D., Hamon, P., Tabrizian, P., Cohen, N., Gunasekaran, G., Schwartz, M., Marron, T., Fiel, M., Gnjatic, S., Ward, S., Curotto de Lafaille, M., Kamphorst, A. O., Chen, Z. & Brody, R.
23/02/26
1 item of Media coverage
Press/Media
BIDMC Researchers Help Define Risk in Multiple Myeloma Using Tumor Microenvironment Analysis
Nie, K., Kim-Schulze, S., D'Souza, D., Rahman, A., Laganà, A., Cho, H., Gnjatic, S. & Chen, Z.
9/01/26
1 item of Media coverage
Press/Media
BIDMC Researchers Help Define Risk in Multiple Myeloma Using Tumor Microenvironment Analysis
Nie, K., Kim-Schulze, S., D'Souza, D., Rahman, A., Laganà, A., Cho, H., Gnjatic, S. & Chen, Z.
9/01/26
2 items of Media coverage
Press/Media
Lung Cancer Rewires Immune Cells in the Bone Marrow to Weaken Body’s Defenses
Hegde, S., Marks, A., Giotti, B., Merad, M., Nie, K., Kim-Schulze, S., D'Souza, D., Hamon, P., Tsankov, A., Brown, B., Flores, R., Marron, T. & Ma, S.
10/09/25 → 12/09/25
4 items of Media coverage
Press/Media

Darwin D'Souza

Personal profile

Headline

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Collaborations and top research areas from the last five years

Dive into details

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection

Hematopoietic aging promotes cancer by fueling IL-1a–driven emergency myelopoiesis

Myocardial infarction augments sleep to limit cardiac inflammation and damage

Intratumoral dendritic cell–CD4⁺ T helper cell niches enable CD8⁺ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Data on Suicide Discussed by Researchers at Icahn School of Medicine at Mount Sinai (Protein expression is associated with brain white matter in Veterans with Bipolar disorder and suicide attempts)

Findings on Immunotherapy Detailed by Investigators at Icahn School of Medicine at Mount Sinai (Humoral Igg1 Responses To Tumor Antigens Underpin Clinical Outcomes In Immune Checkpoint Blockade)

BIDMC Researchers Help Define Risk in Multiple Myeloma Using Tumor Microenvironment Analysis

BIDMC Researchers Help Define Risk in Multiple Myeloma Using Tumor Microenvironment Analysis

Lung Cancer Rewires Immune Cells in the Bone Marrow to Weaken Body’s Defenses

Darwin D'Souza

Personal profile

Headline

Fingerprint

Collaborations and top research areas from the last five years

Research output

Press/Media