If you made any changes in Pure these will be visible here soon.

Personal profile

Headline

ASSOCIATE PROFESSOR | Neuroscience, ASSOCIATE PROFESSOR | Psychiatry

Biography

Research Topics http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Brain+Imaging&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Brain Imaging http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Cognitive+Neuroscience&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Cognitive Neuroscience http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Depression&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Depression http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&rt=Memory&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Memory Training Areas http://icahn.mssm.edu/vgn-ext-templating/FapServlet?tab=far&ta=Neuroscience+[NEU]&kw=&loc=&ips=&hrs=&g=&ln=&fn=&vgnextoid=24fc8af68fc17210VgnVCM1000003242020aRCRD&sitename=MSSM&fpa=true&inst= Neuroscience [NEU] Biography Website: http://transmitter.neuro.mssm.edu/schiller http://transmitter.neuro.mssm.edu/schiller The Neural mechanisms of emotional control and flexibility Dr. Schiller's line of research focuses on the neural mechanisms underlying emotional control. Because the environment we live in is constantly changing, our learned emotional responses need to be continuously updated to appropriately reflect current circumstances. Understanding the neural mechanisms that make such emotional flexibility may shed light on the impairments leading to anxiety disorders and may also promote new forms of treatment. In her doctoral research she studied one such aspect of emotional learning, namely, the ability to acquire emotional responses to previously ignored stimuli, which is impaired in patients suffering from chronic schizophrenia. Under the mentorship of Ina Weiner, she developed an animal model of this symptom (persistent latent inhibition) and examined the underlying neural circuitry, as well as the efficacy of antipsychotic drugs in ameliorating it. For post-doctoral training, Dr. Schiller chose to extend her knowledge to human emotional systems under the mentorship of Elizabeth Phelps and Joseph LeDoux. Together, they came up with a translational research program aimed at extending fundamental findings in rats to humans. This research project includes parallel findings in rats and humans on the recovery of extinguished fear, elucidation of the neural circuitry of flexible fear reversal, and how fear motivates instrumental responding. In addition, to extend these findings to more complex situations unique to humans, she's investigating how emotional systems are recruited to rapidly evaluate others during initial social encounters. Finally, in extreme situations, when emotional memories become traumatic, it might be beneficial to erase fear memories altogether preventing them from resurfacing. New evidence in rats and other non-human species suggests this might be possible using pharmacological manipulations. However, these finding have yet to be demonstrated convincingly in humans. Dr. Schiller is currently testing this possibility, by examining whether emotional memories induced in the laboratory can be erased using beta-adrenergic receptor blockade as well as drug-free behavioral manipulations. These studies are essential in providing a critical link between animal models and the clinical population. Visit Dr. Daniela Schiller's http://transmitter.neuro.mssm.edu/schiller/index.html Laboratory of Affective Neuroscience for more information.

Fingerprint

Dive into the research topics where Daniela Schiller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • The Human Affectome

    Schiller, D., Yu, A. N. C., Alia-Klein, N., Becker, S., Cromwell, H. C., Dolcos, F., Eslinger, P. J., Frewen, P., Kemp, A. H., Pace-Schott, E. F., Raber, J., Silton, R. L., Stefanova, E., Williams, J. H. G., Abe, N., Aghajani, M., Albrecht, F., Alexander, R., Anders, S., Aragón, O. R., & 153 othersArias, J. A., Arzy, S., Aue, T., Baez, S., Balconi, M., Ballarini, T., Bannister, S., Banta, M. C., Barrett, K. C., Belzung, C., Bensafi, M., Booij, L., Bookwala, J., Boulanger-Bertolus, J., Boutros, S. W., Bräscher, A. K., Bruno, A., Busatto, G., Bylsma, L. M., Caldwell-Harris, C., Chan, R. C. K., Cherbuin, N., Chiarella, J., Cipresso, P., Critchley, H., Croote, D. E., Demaree, H. A., Denson, T. F., Depue, B., Derntl, B., Dickson, J. M., Dolcos, S., Drach-Zahavy, A., Dubljević, O., Eerola, T., Ellingsen, D. M., Fairfield, B., Ferdenzi, C., Friedman, B. H., Fu, C. H. Y., Gatt, J. M., de Gelder, B., Gendolla, G. H. E., Gilam, G., Goldblatt, H., Gooding, A. E. K., Gosseries, O., Hamm, A. O., Hanson, J. L., Hendler, T., Herbert, C., Hofmann, S. G., Ibanez, A., Joffily, M., Jovanovic, T., Kahrilas, I. J., Kangas, M., Katsumi, Y., Kensinger, E., Kirby, L. A. J., Koncz, R., Koster, E. H. W., Kozlowska, K., Krach, S., Kret, M. E., Krippl, M., Kusi-Mensah, K., Ladouceur, C. D., Laureys, S., Lawrence, A., Li, C. S. R., Liddell, B. J., Lidhar, N. K., Lowry, C. A., Magee, K., Marin, M. F., Mariotti, V., Martin, L. J., Marusak, H. A., Mayer, A. V., Merner, A. R., Minnier, J., Moll, J., Morrison, R. G., Moore, M., Mouly, A. M., Mueller, S. C., Mühlberger, A., Murphy, N. A., Muscatello, M. R. A., Musser, E. D., Newton, T. L., Noll-Hussong, M., Norrholm, S. D., Northoff, G., Nusslock, R., Okon-Singer, H., Olino, T. M., Ortner, C., Owolabi, M., Padulo, C., Palermo, R., Palumbo, R., Palumbo, S., Papadelis, C., Pegna, A. J., Pellegrini, S., Peltonen, K., Penninx, B. W. J. H., Pietrini, P., Pinna, G., Lobo, R. P., Polnaszek, K. L., Polyakova, M., Rabinak, C., Helene Richter, S., Richter, T., Riva, G., Rizzo, A., Robinson, J. L., Rosa, P., Sachdev, P. S., Sato, W., Schroeter, M. L., Schweizer, S., Shiban, Y., Siddharthan, A., Siedlecka, E., Smith, R. C., Soreq, H., Spangler, D. P., Stern, E. R., Styliadis, C., Sullivan, G. B., Swain, J. E., Urben, S., Van den Stock, J., vander Kooij, M. A., van Overveld, M., Van Rheenen, T. E., VanElzakker, M. B., Ventura-Bort, C., Verona, E., Volk, T., Wang, Y., Weingast, L. T., Weymar, M., Williams, C., Willis, M. L., Yamashita, P., Zahn, R., Zupan, B. & Lowe, L., Mar 2024, In: Neuroscience and Biobehavioral Reviews. 158, 105450.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    1 Scopus citations
  • An Interpretable and Predictive Connectivity-Based Neural Signature for Chronic Cannabis Use

    Kulkarni, K. R., Schafer, M., Berner, L. A., Fiore, V. G., Heflin, M., Hutchison, K., Calhoun, V., Filbey, F., Pandey, G., Schiller, D. & Gu, X., Mar 2023, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 8, 3, p. 320-330 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Scopus citations
  • Consensus design of a calibration experiment for human fear conditioning

    Bach, D. R., Sporrer, J., Abend, R., Beckers, T., Dunsmoor, J. E., Fullana, M. A., Gamer, M., Gee, D. G., Hamm, A., Hartley, C. A., Herringa, R. J., Jovanovic, T., Kalisch, R., Knight, D. C., Lissek, S., Lonsdorf, T. B., Merz, C. J., Milad, M., Morriss, J., Phelps, E. A., & 4 othersPine, D. S., Olsson, A., van Reekum, C. M. & Schiller, D., May 2023, In: Neuroscience and Biobehavioral Reviews. 148, 105146.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    5 Scopus citations
  • Exploring the Frontiers of Neuroscience: Highlights from the 11th IBRO World Congress

    Schiller, D. & Lerma, J., 10 Aug 2023, In: Neuroscience. 525, p. 1-2 2 p.

    Research output: Contribution to journalEditorial

  • Neural patterns differentiate traumatic from sad autobiographical memories in PTSD

    Perl, O., Duek, O., Kulkarni, K. R., Gordon, C., Krystal, J. H., Levy, I., Harpaz-Rotem, I. & Schiller, D., Dec 2023, In: Nature Neuroscience. 26, 12, p. 2226-2236 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations