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ASSISTANT PROFESSOR | Pharmacological Sciences
Biography
Dr. Schlessinger is an Assistant Professor in the Department of Pharmacology and Systems Therapeutics, and is a member of the Tisch Cancer Institute, at the Icahn School of Medicine at Mount Sinai in New York City. The overall goal of Dr. Schlessinger’s lab is to improve and automate the structure-based discovery process by developing and applying novel computational approaches, and to collaborate with experimental labs to characterize pharmacologically important proteins, with a long-term goal of developing cancer drugs. His lab publishes in the areas of structural biology, bioinformatics, and drug discovery, as well as in personalized medicine and pharmacogenetics. Dr. Schlessinger graduated from Tel Aviv University with a B.Sc. in Chemistry and Biology, and completed his Ph.D. from Columbia University in the Department of Biochemistry and Molecular Biophysics. Following his graduate studies, Dr. Schlessinger was an NIH NRSA postdoctoral fellow at the Department of Bioengineering and Therapeutic Sciences, University of California San Francisco (UCSF), where he developed methods for protein structure prediction and structure-based drug design. Dr. Schlessinger is an Associate Editor of PLOS Computational Biology. Dr. Schlessinger joined the faculty at the Icahn School of Medicine at Mount Sinai in January, 2013.
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A critical residue mediates proper assembly and gating of GIRK2 channels
Nguyen, H., Mount, J., Hutchinson, K., Zhao, Y., Zhao, Y., Glaaser, I. W., Yuan, P., Schlessinger, A. & Slesinger, P. A., 5 Jan 2026, In: Journal of General Physiology. 158, 1Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Development of a genetic priority score to predict drug side effects using human genetic evidence
Duffy, Á., Chen, R., Stein, D., Park, J. K., Mort, M., Verbanck, M., Schlessinger, A., Itan, Y., Cooper, D. N., Jordan, D. M., Rocheleau, G. & Do, R., Dec 2025, In: Nature Communications. 16, 1, 8713.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Expanding the utility of variant effect predictions with phenotype-specific models
Stein, D., Kars, M. E., Milisavljevic, B., Mort, M., Stenson, P. D., Casanova, J. L., Cooper, D. N., Boisson, B., Zhang, P., Schlessinger, A. & Itan, Y., Dec 2025, In: Nature Communications. 16, 1, 11113.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Maternal medication use in pregnancy and offspring ASD risk: A prescription-wide, target-informed study
Zaks, N., Kodesh, A., Zatorski, N., Wang, Y., Levine, S. Z., Sandin, S., Reichenberg, A., Schlessinger, A. & Janecka, M., 19 Aug 2025, In: European Psychiatry. 68, 1, e125.Research output: Contribution to journal › Article › peer-review
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The Charge of the Substrate Determines Sodium-Coupling Stoichiometry of the Amino Acid Transporter SLC6A14
Shi, Y., Dong, Y., Herrington, N. B., Singh, S., Wang, J., Schlessinger, A. & Grewer, C., 1 Jul 2025, In: Biochemistry. 64, 13, p. 2886-2898 13 p.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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Scientists Uncover Hidden Drug-binding Pocket in Cancer Protein, Highlighting the Power and Limitations of AI Drug Discovery
Schlessinger, A. & Lazarus, M.
3/06/26
5 items of Media coverage
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Researchers Reveal Concealed Drug-Binding Site in Cancer Protein, Showcasing Both Strengths and Challenges of AI in Drug Discovery
Schlessinger, A. & Lazarus, M.
3/06/26
2 items of Media coverage
Press/Media
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A One-Atom Shuffle Reveals Hidden Cancer-Drug Pocket That AI Couldn’t Find
Schlessinger, A. & Lazarus, M.
3/06/26
1 item of Media coverage
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HMN 2026: How New AI tool identifies not just genetic mutations, but the diseases they may cause
Stein, D., Schlessinger, A. & Itan, Y.
3/01/26
1 item of Media coverage
Press/Media