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MOUNT SINAI PROFESSOR IN BIOINFORMATICS | DIRECTOR, Mount Sinai Center for Bioinformatics | PROFESSOR, Department of Pharmacological Sciences | PROFESSOR, Department of Artificial Intelligence and Human Health
Biography
Dr. Ma’ayan is a Mount Sinai Endowed Professor in Bioinformatics, Director of the Mount Sinai Center for Bioinformatics, Professor in the Department of Pharmacological Sciences, Professor in the Department of Artificial Intelligence and Human Health, and faculty member of the Icahn Genomics Institute. Dr. Ma'ayan is also a Principal Investigator of the NIH Common Fund Data Resource Center (DRC) for the Common Fund Data Ecosystem (CFDE), a NCI-funded ITCR resource center, a NIDDK-funded diabetes hypothesis platform, and the NCI-funded Mount Sinai Proteogenomic Data Analysis Center. The Ma'ayan Laboratory applies computational methods to study the inner workings of regulatory networks in mammalian cells. His research team applies machine learning and other statistical mining techniques to study how intracellular regulatory systems function as networks to control cellular processes such as differentiation, dedifferentiation, apoptosis and proliferation. The Ma'ayan Laboratory develops bioinformatics software applications to enable experimental biologists to form novel hypotheses from high-throughput omics datasets, while aiming to better understand the structure and function of regulatory networks in mammalian cellular and multi-cellular complex systems.
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Collaborations and top research areas from the last five years
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A tool based on objective data to identify patients at elevated risk of hospital-onset Staphylococcus aureus bacteremia: a nested case–control study
Silvera, R., Jeon, M., Ma’Ayan, A., Aberg, J., Camins, B. & Factor, S. H., 7 Apr 2026, In: Antimicrobial Stewardship and Healthcare Epidemiology. 6, 1, e94.Research output: Contribution to journal › Article › peer-review
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Molecular signatures and signaling interactions of the hair follicle stem cell niche
Ghuwalewala, S., Cao, J., Rezza, A., Rangl, M., Kwiatkowski, A., Brown, A., Grisanti, L., Heitman, N., Schober, M., Wang, Z., Ma’ayan, A., Almet, A. A., Plikus, M. V. & Rendl, M., 2026, (Accepted/In press) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Open Access -
The CFDE Workbench: Integrating Metadata and Processed Data from Common Fund Programs
Evangelista, J. E., Clarke, D. J. B., Byrd, A. I., Srinivasan, S., Srinivasan, S., Maurya, M. R., Jenkins, S. L., Diamant, I., Sanchez, E., Xie, Z., Olaiya, S., Kim, H., Marino, G. B., Ahmed, N., Ramachandran, S., Subramaniam, S. & Ma'ayan, A., 2026, (Accepted/In press) In: Journal of Molecular Biology. 169631.Research output: Contribution to journal › Article › peer-review
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Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets
Lachmann, A., Amadori, L., Nicoletti, P., Crane, H. M., Giannarelli, C., Ma’ayan, A. & Peter, I., 2026, In: Frontiers in Pharmacology. 16, 1743543.Research output: Contribution to journal › Article › peer-review
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Creating an Interactive Web Interface for Networks Stored in Knowledge Graph Databases
Evangelista, J. E., Lutsky, A. D., Byrd, A. I., Clarke, D. J. B., Prabhakaran, A., Jenkins, S. L. & Ma'ayan, A., Sep 2025, In: Current Protocols. 5, 9, e70200.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
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Researchers at Icahn School of Medicine at Mount Sinai Target Bioinformatics (sc2DAT: workflow for targeting tumor subpopulations of single cells)
24/10/25
1 item of Media coverage
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Reports on Transcription Factor from Icahn School of Medicine at Mount Sinai Provide New Insights (ChEA-KG: Human Transcription Factor Regulatory Network with a Knowledge Graph Interactive User Interface)
Jenkins, S. & Ma’ayan, A.
25/09/25
1 item of Media coverage
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Icahn School of Medicine at Mount Sinai Reports Findings in Personalized Medicine (L2S2: chemical perturbation and CRISPR KO LINCS L1000 signature search engine)
14/05/25
1 item of Media coverage
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Mount Sinai Highlights Cancer Research at 2025 AACR
Fisher, R., Marron, T., Jin, J., Ma’ayan, A., Chipuk, J., Bhardwaj, N., Chakraborty, G., Gaire, B. & Parsons, R.
25/04/25
1 item of Media coverage
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Mount Sinai Showcases Innovative Cancer Research at 2025 AACR Annual Meeting in Chicago
Fisher, R., Marron, T., Jin, J., Ma’ayan, A., Chipuk, J., Bhardwaj, N., Chakraborty, G., Gaire, B. & Parsons, R.
24/04/25
1 item of Media coverage
Press/Media