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PROFESSOR | Pharmacological Sciences PROFESSOR | Oncological Sciences
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Dive into the research topics where Aneel Aggarwal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Development of MS2045 for inhibition of Zika methyltransferase
National Institute of Allergy and Infectious Diseases
2/01/23 → 31/12/23
Project: Research
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Structure and mechanism of multisubunit complexes of DNA polymerase zeta
Aggarwal, A. & Prakash, L.
National Institute of General Medical Sciences
15/09/18 → 31/08/22
Project: Research
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Structure-function analysis of a molecular switch for long-range diffusion on DNA
National Institute of General Medical Sciences
15/09/14 → 31/07/18
Project: Research
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Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Dec 2022, In: Nature Communications. 13, 1, 1050.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Li, D., Yu, X., Kottur, J., Gong, W., Zhang, Z., Storey, A. J., Tsai, Y. H., Uryu, H., Shen, Y., Byrum, S. D., Edmondson, R. D., Mackintosh, S. G., Cai, L., Liu, Z., Aggarwal, A. K., Tackett, A. J., Liu, J., Jin, J. & Wang, G. G., 10 Jun 2022, In: Oncogene. 41, 24, p. 3328-3340 13 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
Kottur, J., Rechkoblit, O., Quintana-Feliciano, R., Sciaky, D. & Aggarwal, A. K., Sep 2022, In: Nature Structural and Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Yu, X., Li, D., Kottur, J., Shen, Y., Kim, H. S., Park, K. S., Tsai, Y. H., Gong, W., Wang, J., Suzuki, K., Parker, J., Herring, L., Kaniskan, H. Ü., Cai, L., Jain, R., Liu, J., Aggarwal, A. K., Wang, G. G. & Jin, J., 29 Sep 2021, In: Science Translational Medicine. 13, 613, eabj1578.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
Shah, R. B., Kernan, J. L., van Hoogstraten, A., Ando, K., Li, Y., Belcher, A. L., Mininger, I., Bussenault, A. M., Raman, R., Ramanagoudr-Bhojappa, R., Huang, T. T., D'Andrea, A. D., Chandrasekharappa, S. C., Aggarwal, A. K., Thompson, R. & Sidi, S., 9 Aug 2021, In: Developmental Cell. 56, 15, p. 2207-2222.e7Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Press / Media
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Researchers unravel the crystal structure of a key enzyme of SARS-CoV-2, paving the way for new antivirals
Jithesh Kottur & Aneel Aggarwal
8/09/22 → 14/09/22
4 items of Media coverage
Press/Media
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Mount Sinai Researchers Unravel the Crystal Structure of a Key Enzyme of SARS-CoV-2, Paving the Way for New Antivirals
Jithesh Kottur & Aneel Aggarwal
8/09/22 → 10/09/22
5 items of Media coverage
Press/Media
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Researchers produce high-resolution crystal structure of enzyme critical to SARS-CoV-2 survival
Jithesh Kottur & Aneel Aggarwal
9/09/22
1 item of Media coverage
Press/Media
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SARS-CoV-2 Enzyme’s Crystal Structure Paves Way to New Antivirals
Jithesh Kottur & Aneel Aggarwal
9/09/22
1 item of Media coverage
Press/Media