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Biography
Allison Bond, Ph.D. is an Assistant Professor in the Departments of Neuroscience and Cell, Developmental, and Regenerative Biology. She is also a member of the Friedman Brain Institute, the Institute for Regenerative Medicine, and the Alper Center for Neural Development and Regeneration. Dr. Bond received her undergraduate degree in Psychology and her Ph.D. in Neuroscience from Northwestern University in Chicago, where she studied signaling mechanisms regulating adult neurogenesis. She then completed her postdoc at the University of Pennsylvania in Philadelphia, where she explored the origin and development of neural stem cells in the adult brain. Dr. Bond recently established her own lab at Mount Sinai focused on uncovering endogenous programs that regulate neural stem cell capacity across the lifespan. The goal of her research program is to successfully target the brain’s innate regenerative capacity to promote neuroplasticity in vivo for therapeutic purposes. Dr. Bond is particularly interested in understanding how neural stem cell capacity is regulated by changes in the cellular environment across development and uses the hippocampus region of the mammalian brain as a model for long-lived neural stem cells. The lab employs clonal lineage tracing, single-cell omics, flow cytometry, and advanced imaging techniques to investigate neural stem cell behavior in an in vivo mouse model, and cell type-specific genetic manipulation to investigate how cell-cell interactions drive brain development. Future projects will investigate how experience, pathology, and disease-associated genetic interventions during development can have long-term impact on neural stem cell behavior and brain function.
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Collaborations and top research areas from the last five years
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Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state
Jimenez-Cyrus, D., Adusumilli, V. S., Stempel, M. H., Maday, S., Ming, G. L., Song, H. & Bond, A. M., 25 Jun 2024, In: Cell Reports. 43, 6, 114339.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Author Correction: Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum (Nature Communications, (2022), 13, 1, (7720), 10.1038/s41467-022-35384-1)
Carpenter, M. D., Fischer, D. K., Zhang, S., Bond, A. M., Czarnecki, K. S., Woolf, M. T., Song, H. & Heller, E. A., Dec 2023, In: Nature Communications. 14, 1, 987.Research output: Contribution to journal › Comment/debate
Open Access -
Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum
Carpenter, M. D., Fischer, D. K., Zhang, S., Bond, A. M., Czarnecki, K. S., Woolf, M. T., Song, H. & Heller, E. A., Dec 2022, In: Nature Communications. 13, 1, 7720.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Molecular landscapes of human hippocampal immature neurons across lifespan
Zhou, Y., Su, Y., Li, S., Kennedy, B. C., Zhang, D. Y., Bond, A. M., Sun, Y., Jacob, F., Lu, L., Hu, P., Viaene, A. N., Helbig, I., Kessler, S. K., Lucas, T., Salinas, R. D., Gu, X., Chen, H. I., Wu, H., Kleinman, J. E. & Hyde, T. M. & 4 others, , 21 Jul 2022, In: Nature. 607, 7919, p. 527-533 7 p.Research output: Contribution to journal › Article › peer-review
Open Access236 Scopus citations -
What Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?
Bond, A. M., Ming, G. L. & Song, H., 24 May 2022, In: Frontiers in Neuroscience. 16, 891713.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations