Alison Goate

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Alison Goate

DPhil

 https://orcid.org/0000-0002-0576-2472
Calculated based on number of publications stored in Pure and citations from Scopus
1987 …2023

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  • 2014

    SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

    International Genomics of Alzheimer's Project (IGAP) & Alzheimer's Disease Neuroimaging Initiative (ADNI), 15 Dec 2014, In: Human Molecular Genetics. 23, 24, p. 6644-6658 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    33 Scopus citations

  • Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis

    Ryman, D. C., Acosta-Baena, N., Aisen, P. S., Bird, T., Danek, A., Fox, N. C., Goate, A., Frommelt, P., Ghetti, B., Langbaum, J. B. S., Lopera, F., Martins, R., Masters, C. L., Mayeux, R. P., McDade, E., Moreno, S., Reiman, E. M., Ringman, J. M., Salloway, S., Schofield, P. R., & 5 othersSperling, R., Tariot, P. N., Xiong, C., Morris, J. C. & Bateman, R. J., 15 Jul 2014, In: Neurology. 83, 3, p. 253-260 8 p.

    Research output: Contribution to journal › Article › peer-review

    300 Scopus citations

  • TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

    Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., Pestronk, A., Goate, A. M., Miller, T. M., Cruchaga, C. & Harms, M. B., Apr 2014, In: JAMA Neurology. 71, 4, p. 449-453 5 p.

    Research output: Contribution to journal › Article › peer-review

    203 Scopus citations

  • Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans

    Logue, M. W., Schu, M., Vardarajan, B. N., Farrell, J., Bennett, D. A., Buxbaum, J. D., Byrd, G. S., Ertekin-Taner, N., Evans, D., Foroud, T., Goate, A., Graff-Radford, N. R., Kamboh, M. I., Kukull, W. A., Manly, J. J., Hainesm, J. L., Mayeuxl, R., Pericak-Vancen, M. A., Schellenbergo, G. D., Lunettab, K. L., & 3 othersBaldwina, C. T., Daniele Fallinp, M. & Farrer, L. A., 1 Nov 2014, In: Alzheimer's and Dementia. 10, 6, p. 609-618.e11

    Research output: Contribution to journal › Article › peer-review

    78 Scopus citations

  • Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence

    Yan, J., Aliev, F., Webb, B. T., Kendler, K. S., Williamson, V. S., Edenberg, H. J., Agrawal, A., Kos, M. Z., Almasy, L., Nurnberger, J. I., Schuckit, M. A., Kramer, J. R., Rice, J. P., Kuperman, S., Goate, A. M., Tischfield, J. A., Porjesz, B. & Dick, D. M., Jul 2014, In: Addiction Biology. 19, 4, p. 708-721 14 p.

    Research output: Contribution to journal › Article › peer-review

    34 Scopus citations

  • Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study

    Peterson, D., Munger, C., Crowley, J., Corcoran, C., Cruchaga, C., Goate, A. M., Norton, M. C., Green, R. C., Munger, R. G., Breitner, J. C. S., Welsh-Bohmer, K. A., Lyketsos, C., Tschanz, J. & Kauwe, J. S. K., May 2014, In: Alzheimer's and Dementia. 10, 3, p. 366-371 6 p.

    Research output: Contribution to journal › Article › peer-review

    26 Scopus citations

  • Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms

    Bloom, A. J., Baker, T. B., Chen, L. S., Breslau, N., Hatsukami, D., Bierut, L. J. & Goate, A., Jan 2014, In: Human Molecular Genetics. 23, 2, p. 555-561 7 p.

    Research output: Contribution to journal › Article › peer-review

    29 Scopus citations

  • Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: Evidence for pleiotropy

    Sadler, B., Haller, G., Agrawal, A., Culverhouse, R., Bucholz, K., Brooks, A., Tischfield, J., Johnson, E. O., Edenberg, H., Schuckit, M., Saccone, N., Bierut, L. & Goate, A., 28 Mar 2014, In: Scientific Reports. 4, 4497.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations
  • 2013

    A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele

    Bloom, A. J., Harari, O., Martinez, M., Zhang, X., McDonald, S. A., Murphy, S. E. & Goate, A., Mar 2013, In: Pharmacogenetics and Genomics. 23, 3, p. 107-116 10 p.

    Research output: Contribution to journal › Article › peer-review

    15 Scopus citations

  • A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

    Wang, J. C., Foroud, T., Hinrichs, A. L., Le, N. X. H., Bertelsen, S., Budde, J. P., Harari, O., Koller, D. L., Wetherill, L., Agrawal, A., Almasy, L., Brooks, A. I., Bucholz, K., Dick, D., Hesselbrock, V., Johnson, E. O., Kang, S., Kapoor, M., Kramer, J., Kuperman, S., & 17 othersMadden, P. A. F., Manz, N., Martin, N. G., McClintick, J. N., Montgomery, G. W., Nurnberger, J. I., Rangaswamy, M., Rice, J., Schuckit, M., Tischfield, J. A., Whitfield, J. B., Xuei, X., Porjesz, B., Heath, A. C., Edenberg, H. J., Bierut, L. J. & Goate, A. M., Nov 2013, In: Molecular Psychiatry. 18, 11, p. 1218-1224 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    64 Scopus citations

  • A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks

    Kapoor, M., Wang, J. C., Wetherill, L., Le, N., Bertelsen, S., Hinrichs, A. L., Budde, J., Agrawal, A., Bucholz, K., Dick, D., Harari, O., Hesselbrock, V., Kramer, J., Nurnberger, J. I., Rice, J., Saccone, N., Schuckit, M., Tischfield, J., Porjesz, B., Edenberg, H. J., & 3 othersBierut, L., Foroud, T. & Goate, A., Oct 2013, In: Human Genetics. 132, 10, p. 1141-1151 11 p.

    Research output: Contribution to journal › Article › peer-review

    59 Scopus citations

  • Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders

    Morgan, E. E., Woods, S. P., Letendre, S. L., Franklin, D. R., Bloss, C., Goate, A., Heaton, R. K., Collier, A. C., Marra, C. M., Gelman, B. B., McArthur, J. C., Morgello, S., Simpson, D. M., McCutchan, J. A., Ellis, R. J., Abramson, I., Gamst, A., Fennema-Notestine, C., Smith, D. M., Grant, I., & 2 othersVaida, F. & Clifford, D. B., Apr 2013, In: Journal of NeuroVirology. 19, 2, p. 150-156 7 p.

    Research output: Contribution to journal › Article › peer-review

    49 Scopus citations

  • C9orf72 hexanucleotide repeat expansions in clinical alzheimer disease

    Harms, M., Benitez, B. A., Cairns, N., Cooper, B., Cooper, P., Mayo, K., Carrell, D., Faber, K., Williamson, J., Bird, T., Diaz-Arrastia, R., Foroud, T. M., Boeve, B. F., Graff-Radford, N. R., Mayeux, R., Chakraverty, S., Goate, A. M. & Cruchaga, C., Jun 2013, In: JAMA Neurology. 70, 6, p. 736-741 6 p.

    Research output: Contribution to journal › Article › peer-review

    80 Scopus citations

  • Calcium phosphatase calcineurin influences tau metabolism

    Karch, C. M., Jeng, A. T. & Goate, A. M., Feb 2013, In: Neurobiology of Aging. 34, 2, p. 374-386 13 p.

    Research output: Contribution to journal › Article › peer-review

    31 Scopus citations

  • Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer's Disease Neurodegeneration

    Honea, R. A., Cruchaga, C., Perea, R. D., Saykin, A. J., Burns, J. M., Weinberger, D. R. & Goate, A. M., 26 Sep 2013, In: PLoS ONE. 8, 9, e76001.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    45 Scopus citations

  • Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry

    Wang, J. C., Spiegel, N., Bertelsen, S., Le, N., McKenna, N., Budde, J. P., Harari, O., Kapoor, M., Brooks, A., Hancock, D., Tischfield, J., Foroud, T., Bierut, L. J., Steinbach, J. H., Edenberg, H. J., Traynor, B. J. & Goate, A. M., 26 Nov 2013, In: PLoS ONE. 8, 11, e80204.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Common biological networks underlie genetic risk for alcoholism in African- and European-American populations

    Kos, M. Z., Yan, J., Dick, D. M., Agrawal, A., Bucholz, K. K., Rice, J. P., Johnson, E. O., Schuckit, M., Kuperman, S., Kramer, J., Goate, A. M., Tischfield, J. A., Foroud, T., Nurnberger, J., Hesselbrock, V., Porjesz, B., Bierut, L. J., Edenberg, H. J. & Almasy, L., Jul 2013, In: Genes, Brain and Behavior. 12, 5, p. 532-542 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes

    Bloom, A. J., Martinez, M., Chen, L. S., Bierut, L. J., Murphy, S. E. & Goate, A., 15 Nov 2013, In: PLoS ONE. 8, 11, e79700.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • Dosage Transmission Disequilibrium Test (dTDT) for Linkage and Association Detection

    Zhang, Z., Wang, J. C., Howells, W., Lin, P., Agrawal, A., Edenberg, H. J., Tischfield, J. A., Schuckit, M. A., Bierut, L. J., Goate, A. & Rice, J. P., 14 May 2013, In: PLoS ONE. 8, 5, e63526.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

    Bloom, A. J., Murphy, S. E., Martinez, M., Von Weymarn, L. B., Bierut, L. J. & Goate, A., Feb 2013, In: Pharmacogenetics and Genomics. 23, 2, p. 62-68 7 p.

    Research output: Contribution to journal › Article › peer-review

    26 Scopus citations

  • Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

    Chorlian, D. B., Rangaswamy, M., Manz, N., Wang, J. C., Dick, D., Almasy, L., Bauer, L., Bucholz, K., Foroud, T., Hesselbrock, V., Kang, S. J., Kramer, J., Kuperman, S., Nurnberger, J., Rice, J., Schuckit, M., Tischfield, J., Edenberg, H. J., Goate, A., Bierut, L., & 1 othersPorjesz, B., Sep 2013, In: Behavior Genetics. 43, 5, p. 386-401 16 p.

    Research output: Contribution to journal › Article › peer-review

    21 Scopus citations

  • Genome-wide association study of irritable vs. Elated Mania suggests genetic differences between clinical subtypes of bipolar disorder

    Bipolar Genome Study (BiGS) Consortium, 17 Jan 2013, In: PLoS ONE. 8, 1, e53804.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • GWAS of cerebrospinal fluid tau levels identifies risk variants for alzheimer's disease

    Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., Bertelsen, S., Bailey, M., McKean, D., Shulman, J. M., De Jager, P. L., Chibnik, L., Bennett, D. A., Arnold, S. E., Harold, D., Sims, R., & 17 othersGerrish, A., Williams, J., Van Deerlin, V. M., Lee, V. M. Y., Shaw, L. M., Trojanowski, J. Q., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Farrer, L. A., Schellenberg, G. D., Peskind, E. R., Galasko, D., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., 24 Apr 2013, In: Neuron. 78, 2, p. 256-268 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    261 Scopus citations

  • Impaired default network functional connectivity in autosomal dominant Alzheimer disease

    Chhatwal, J. P., Schultz, A. P., Johnson, K., Benzinger, T. L. S., Jack, C., Ances, B. M., Sullivan, C. A., Salloway, S. P., Ringman, J. M., Koeppe, R. A., Marcus, D. S., Thompson, P., Saykin, A. J., Correia, S., Schofield, P. R., Rowe, C. C., Fox, N. C., Brickman, A. M., Mayeux, R., McDade, E., & 7 othersBateman, R., Fagan, A. M., Goate, A. M., Xiong, C., Buckles, V. D., Morris, J. C. & Sperling, R. A., 20 Aug 2013, In: Neurology. 81, 8, p. 736-744 9 p.

    Research output: Contribution to journal › Article › peer-review

    104 Scopus citations

  • Increased in vivo amyloid-b42 production, exchange, and loss in presenilin mutation carriers

    Potter, R., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T., Sigurdson, W., Mawuenyega, K., Blazey, T., Goate, A., Chott, R., Yarasheski, K. E., Holtzman, D. M., Morris, J. C., Benzinger, T. L. S. & Bateman, R. J., 12 Jun 2013, In: Science Translational Medicine. 5, 189, 189ra77.

    Research output: Contribution to journal › Article › peer-review

    169 Scopus citations

  • Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis

    Harms, M. B., Cady, J., Zaidman, C., Cooper, P., Bali, T., Allred, P., Cruchaga, C., Baughn, M., Libby, R. T., Pestronk, A., Goate, A., Ravits, J. & Baloh, R. H., Sep 2013, In: Neurobiology of Aging. 34, 9, p. 2234.e13-2234.e19

    Research output: Contribution to journal › Article › peer-review

    56 Scopus citations

  • Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer's Disease Pathology

    Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, 28 May 2013, In: PLoS ONE. 8, 5, e64802.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    11 Scopus citations

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., Jun, G., DeStefano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thornton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., & 162 othersKamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Fiévet, N., Amouyel, P., Pasquier, F., Deramecourt, V., De Bruijn, R. F. A. G., Amin, N., Hofman, A., Van Duijn, C. M., Dunstan, M. L., Hollingworth, P., Owen, M. J., O'Donovan, M. C., Jones, L., Holmans, P. A., Moskvina, V., Williams, J., Baldwin, C., Farrer, L. A., Choi, S. H., Lunetta, K. L., Fitzpatrick, A. L., Harris, T. B., Psaty, B. M., Gilbert, J. R., Hamilton-Nelson, K. L., Martin, E. R., Pericak-Vance, M. A., Haines, J. L., Gudnason, V., Jonsson, P. V., Eiriksdottir, G., Bihoreau, M. T., Lathrop, M., Valladares, O., Cantwell, L. B., Wang, L. S., Schellenberg, G. D., Ruiz, A., Boada, M., Reitz, C., Mayeux, R., Ramirez, A., Maier, W., Hanon, O., Kukull, W. A., Buxbaum, J. D., Campion, D., Wallon, D., Hannequin, D., Crane, P. K., Larson, E. B., Becker, T., Cruchaga, C., Goate, A. M., Craig, D., Johnston, J. A., Mc-Guinness, B., Todd, S., Passmore, P., Berr, C., Ritchie, K., Lopez, O. L., De Jager, P. L., Evans, D., Lovestone, S., Proitsi, P., Powell, J. F., Letenneur, L., Barberger-Gateau, P., Dufouil, C., Dartigues, J. F., Morón, F. J., Rubinsztein, D. C., St. George-Hyslop, P., Sleegers, K., Bettens, K., Van Broeckhoven, C., Huentelman, M. J., Gill, M., Brown, K., Morgan, K., Kamboh, M. I., Keller, L., Fratiglioni, L., Green, R., Myers, A. J., Love, S., Rogaeva, E., Gallacher, J., Bayer, A., Clarimon, J., Lleo, A., Tsuang, D. W., Yu, L., Bennett, D. A., Tsolaki, M., Bossù, P., Spalletta, G., Collinge, J., Mead, S., Sorbi, S., Nacmias, B., Sanchez-Garcia, F., Deniz Naranjo, M. C., Fox, N. C., Hardy, J., Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Mayhaus, M., Pichler, S., Gu, W., Riemenschneider, M., Lannfelt, L., Ingelsson, M., Hakonarson, H., Carrasquillo, M. M., Zou, F., Younkin, S. G., Beekly, D., Alvarez, V., Coto, E., Razquin, C., Pastor, P., Mateo, I., Combarros, O., Faber, K. M., Foroud, T. M., Soininen, H., Hiltunen, M., Blacker, D., Mosley, T. H., Graff, C., Holmes, C., Montine, T. J., Rotter, J. I., Brice, A., Nalls, M. A., Kauwe, J. S. K., Boerwinkle, E., Schmidt, R., Rujescu, D., Tzourio, C., Nöthen, M. M., Launer, L. J. & Seshadri, S., 1 Dec 2013, In: Nature Genetics. 45, 12, p. 1452-1458 7 p.

    Research output: Contribution to journal › Article › peer-review

    2796 Scopus citations

  • Novel progranulin variants do not disrupt progranulin secretion and cleavage

    Karch, C. M., Jeng, A. T., Skorupa, T., Cruchaga, C. & Goate, A. M., Nov 2013, In: Neurobiology of Aging. 34, 11, p. 2538-2540 3 p.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations

  • Parkinson disease is not associated with C9ORF72 repeat expansions

    Harms, M. B., Neumann, D., Benitez, B. A., Cooper, B., Carrell, D., Racette, B. A., Perlmutter, J. S., Goate, A. & Cruchaga, C., May 2013, In: Neurobiology of Aging. 34, 5, p. 1519.e1-1519.e2

    Research output: Contribution to journal › Article › peer-review

    36 Scopus citations

  • Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial

    Mills, S. M., Mallmann, J., Santacruz, A. M., Fuqua, A., Carril, M., Aisen, P. S., Althage, M. C., Belyew, S., Benzinger, T. L., Brooks, W. S., Buckles, V. D., Cairns, N. J., Clifford, D., Danek, A., Fagan, A. M., Farlow, M., Fox, N., Ghetti, B., Goate, A. M., Heinrichs, D., & 22 othersHornbeck, R., Jack, C., Jucker, M., Klunk, W. E., Marcus, D. S., Martins, R. N., Masters, C. M., Mayeux, R., McDade, E., Morris, J. C., Oliver, A., Ringman, J. M., Rossor, M. N., Salloway, S., Schofield, P. R., Snider, J., Snyder, P., Sperling, R. A., Stewart, C., Thomas, R. G., Xiong, C. & Bateman, R. J., Oct 2013, In: Revue Neurologique. 169, 10, p. 737-743 7 p.

    Research output: Contribution to journal › Article › peer-review

    60 Scopus citations

  • Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases

    Campbell, M. C., Markham, J., Flores, H., Hartlein, J. M., Goate, A. M., Cairns, N. J., Videen, T. O. & Perlmutter, J. S., 6 Aug 2013, In: Neurology. 81, 6, p. 520-527 8 p.

    Research output: Contribution to journal › Article › peer-review

    35 Scopus citations

  • Pupil response biomarkers distinguish Amyloid precursor protein mutation carriers from non-carriers

    Frost, S. M., Kanagasingam, Y., Sohrabi, H. R., Taddei, K., Bateman, R., Morris, J., Benzinger, T., Goate, A., Masters, C. L. & Martins, R. N., 2013, In: Current Alzheimer Research. 10, 8, p. 790-796 7 p.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

    Benzinger, T. L. S., Blazey, T., Jack, C. R., Koeppe, R. A., Su, Y., Xiong, C., Raichle, M. E., Snyder, A. Z., Ances, B. M., Bateman, R. J., Cairns, N. J., Fagan, A. M., Goate, A., Marcus, D. S., Aisen, P. S., Christensen, J. J., Ercole, L., Hornbeck, R. C., Farrar, A. M., Aldea, P., & 30 othersJasielec, M. S., Owen, C. J., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C. A., Ringman, J., Thompson, P. M., Ghetti, B., Saykin, A. J., Sperling, R. A., Johnson, K. A., Salloway, S., Correia, S., Schofield, P. R., Masters, C. L., Rowe, C., Villemagne, V. L., Martins, R., Ourselin, S., Rossor, M. N., Fox, N. C., Cash, D. M., Weiner, M. W., Holtzman, D. M., Buckles, V. D., Moulder, K. & Morris, J. C., 19 Nov 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. E4502-E4509

    Research output: Contribution to journal › Article › peer-review

    Open Access
    265 Scopus citations

  • Stress-response pathways are altered in the hippocampus of chronic alcoholics

    McClintick, J. N., Xuei, X., Tischfield, J. A., Goate, A., Foroud, T., Wetherill, L., Ehringer, M. A. & Edenberg, H. J., Nov 2013, In: Alcohol. 47, 7, p. 505-515 11 p.

    Research output: Contribution to journal › Article › peer-review

    57 Scopus citations

  • The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among european americans

    Bloom, A. J., Von Weymarn, L. B., Martinez, M., Bierut, L. J., Goate, A. & Murphy, S. E., Dec 2013, In: Pharmacogenetics and Genomics. 23, 12, p. 706-716 11 p.

    Research output: Contribution to journal › Article › peer-review

    12 Scopus citations

  • The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers

    Benitez, B. A., Karch, C. M., Cai, Y., Jin, S. C., Cooper, B., Carrell, D., Bertelsen, S., Chibnik, L., Schneider, J. A., Bennett, D. A., Fagan, A. M., Holtzman, D., Morris, J. C., Goate, A. M. & Cruchaga, C., Aug 2013, In: PLoS Genetics. 9, 8, e1003685.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Scopus citations

  • The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

    Klebe, S., Golmard, J. L., Nalls, M. A., Saad, M., Singleton, A. B., Bras, J. M., Hardy, J., Simon-Sanchez, J., Heutink, P., Kuhlenbäumer, G., Charfi, R., Klein, C., Hagenah, J., Gasser, T., Wurster, I., Lesage, S., Lorenz, D., Deuschl, G., Durif, F., Pollak, P., & 157 othersDamier, P., Tison, F., Durr, A., Amouyel, P., Lambert, J. C., Tzourio, C., Maubaret, C., Charbonnier-Beaupel, F., Tahiri, K., Vidailhet, M., Martinez, M., Brice, A., Corvol, J. C., Agid, Y., Anheim, M., Bonnet, A. M., Borg, M., Brice, A., Broussolle, E., Corvol, J. C., Damier, P., Destée, A., Durif, F., Klebe, S., Lohmann, E., Martinez, M., Penet, C., Pollak, P., Krack, P., Rascol, O., Tison, F., Tranchant, C., Vérin, M., Viallet, F., Vidailhet, M., Nalls, M. A., Plagnol, V., Bras, J. M., Hernandez, D. G., Sharma, M., Sheerin, U. M., Schulte, C., Sveinbjörnsdóttir, S., Arepalli, S., Band, G., Vukcevic, D., Barker, R. A., Bellinguez, C., Ben-Shlomo, Y., Berendse, H. W., Berg, D., Bhatia, K., De Bie, R. M. A., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Brockmann, K., Brooks, J., Burn, D. J., Charlesworth, G., Chen, H., Chinnery, P. F., Chong, S., Clarke, C. E., Cookson, M. R., Cooper, J. M., Corvol, J. C., Counsell, C., Dartigues, J. F., Deloukas, P., Dexter, D. T., Van Dijk, K. D., Dillman, A., Durif, F., Edkins, S., Evans, J. R., Foltynie, T., Freeman, C., Gao, J., Gardner, M., Gibbs, R., Goate, A., Gray, E., Guerreiro, R., Gústafsson, Ó., Harris, C., Hellenthal, G., Van Hilten, J. J., Hofman, A., Hollenbeck, A., Holton, J., Hu, M., Huang, X., Huber, H., Hudson, G., Hunt, S. E., Huttenlocher, J., Illig, T., Jónsson, P. V., Langford, C., Lees, A., Lichtner, P., Limousin, P., Lopez, G., McNeill, A., Moorby, C., Moore, M., Morris, H., Morrison, K. E., Mudanohwo, E., O'Sullivan, S. S., Pearson, J., Pearson, R., Perlmutter, J. S., Pétursson, H., Pirinen, M., Post, B., Ravina, B., Revesz, T., Riess, O., Rivadeneira, F., Rizzu, P., Ryten, M., Sawcer, S., Schapira, A., Scheffer, H., Shaw, K., Shoulson, I., Sidransky, E., De Silva, R., Smith, C., Spencer, C. C. A., Stefánsson, H., Steinberg, S., Stockton, J. D., Strange, A., Su, Z., Talbot, K., Tanner, C. M., Tashakkori-Ghanbaria, A., Trabzuni, D., Traynor, B. J., Uitterlinden, A. G., Vandrovcova, J., Velseboer, D., Marie Vidailhet, V., Walker, R., Van De Warrenburg, B., Weale, M. E., Wickremaratchi, M., Williams, N., Williams-Gray, C. H., Winder-Rhodes, S., Stefánsson, K., Wood, N. W. & Singleton, A. B., 1 Jun 2013, In: Journal of Neurology, Neurosurgery and Psychiatry. 84, 6, p. 666-673 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • TREM2 variants in Alzheimer's disease

    Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., Hazrati, L., Collinge, J., Pocock, J., Lashley, T., Williams, J., Lambert, J. C., Amouyel, P., Goate, A., Rademakers, R., Morgan, K., & 4 othersPowell, J., George-Hyslop, P. S., Singleton, A. & Hardy, J., 10 Jan 2013, In: New England Journal of Medicine. 368, 2, p. 117-127 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1956 Scopus citations

  • Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein e ε4, and the risk of late-onset Alzheimer disease in African Americans

    Reitz, C., Jun, G., Naj, A., Rajbhandary, R., Vardarajan, B. N., Wang, L. S., Valladares, O., Lin, C. F., Larson, E. B., Graff-Radford, N. R., Evans, D., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Murrell, J. R., Raj, T., Ertekin-Taner, N., Logue, M., Baldwin, C. T., Green, R. C., & 22 othersBarnes, L. L., Cantwell, L. B., Fallin, M. D., Go, R. C. P., Griffith, P., Obisesan, T. O., Manly, J. J., Lunetta, K. L., Kamboh, M. I., Lopez, O. L., Bennett, D. A., Hendrie, H., Hall, K. S., Goate, A. M., Byrd, G. S., Kukull, W. A., Foroud, T. M., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Schellenberg, G. D. & Mayeux, R., 10 Apr 2013, In: JAMA - Journal of the American Medical Association. 309, 14, p. 1483-1492 10 p.

    Research output: Contribution to journal › Article › peer-review

    284 Scopus citations
  • 2012

    ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

    Bierut, L. J., Goate, A. M., Breslau, N., Johnson, E. O., Bertelsen, S., Fox, L., Agrawal, A., Bucholz, K. K., Grucza, R., Hesselbrock, V., Kramer, J., Kuperman, S., Nurnberger, J., Porjesz, B., Saccone, N. L., Schuckit, M., Tischfield, J., Wang, J. C., Foroud, T., Rice, J. P., & 1 othersEdenberg, H. J., Apr 2012, In: Molecular Psychiatry. 17, 4, p. 445-450 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    160 Scopus citations

  • Cerebrospinal fluid APOE levels: An endophenotype for genetic studies for Alzheimer's disease

    Cruchaga, C., Kauwe, J. S. K., Nowotny, P., Bales, K., Pickering, E. H., Mayo, K., Bertelsen, S., Hinrichs, A., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., Oct 2012, In: Human Molecular Genetics. 21, 20, p. 4558-4571 14 p., dds296.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    156 Scopus citations

  • CHRNB3 is more strongly associated with Fagerström Test for Cigarette Dependence-based nicotine dependence than cigarettes per day: Phenotype definition changes genome-wide association studies results

    Rice, J. P., Hartz, S. M., Agrawal, A., Almasy, L., Bennett, S., Breslau, N., Bucholz, K. K., Doheny, K. F., Edenberg, H. J., Goate, A. M., Hesselbrock, V., Howells, W. B., Johnson, E. O., Kramer, J., Krueger, R. F., Kuperman, S., Laurie, C., Manolio, T. A., Neuman, R. J., Nurnberger, J. I., & 7 othersPorjesz, B., Pugh, E., Ramos, E. M., Saccone, N., Saccone, S., Schuckit, M. & Bierut, L. J., Nov 2012, In: Addiction. 107, 11, p. 2019-2028 10 p.

    Research output: Contribution to journal › Article › peer-review

    60 Scopus citations

  • Clinical and biomarker changes in dominantly inherited Alzheimer's disease

    Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., Holtzman, D. M., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, P. S., Ghetti, B., Klunk, W. E., McDade, E., Martins, R. N., & 8 othersMasters, C. L., Mayeux, R., Ringman, J. M., Rossor, M. N., Schofield, P. R., Sperling, R. A., Salloway, S. & Morris, J. C., 30 Aug 2012, In: New England Journal of Medicine. 367, 9, p. 795-804 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2470 Scopus citations

  • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

    Whitcomb, D. C., LaRusch, J., Krasinskas, A. M., Klei, L., Smith, J. P., Brand, R. E., Neoptolemos, J. P., Lerch, M. M., Tector, M., Sandhu, B. S., Guda, N. M., Orlichenko, L., Alkaade, S., Amann, S. T., Anderson, M. A., Baillie, J., Banks, P. A., Conwell, D., Coté, G. A., Cotton, P. B., & 178 othersDiSario, J., Farrer, L. A., Forsmark, C. E., Johnstone, M., Gardner, T. B., Gelrud, A., Greenhalf, W., Haines, J. L., Hartman, D. J., Hawes, R. A., Lawrence, C., Lewis, M., Mayerle, J., Mayeux, R., Melhem, N. M., Money, M. E., Muniraj, T., Papachristou, G. I., Pericak-Vance, M. A., Romagnuolo, J., Schellenberg, G. D., Sherman, S., Simon, P., Singh, V. P., Slivka, A., Stolz, D., Sutton, R., Weiss, F. U., Wilcox, C. M., Zarnescu, N. O., Wisniewski, S. R., O'Connell, M. R., Kienholz, M. L., Roeder, K., Barmada, M. M., Yadav, D., Devlin, B., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Baldwin, C. T., Barber, R., Barnes, L. L., Beach, T. G., Beecham, G. W., Beekly, D., Bennett, D. A., Bigio, E. H., Bird, T. D., Blacker, D., Boxer, A., Burke, J. R., Buxbaum, J. D., Cairns, N. J., Cantwell, L. B., Cao, C., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Cruchaga, C., DeCarli, C., Demirci, F. Y., Dick, M., Dickson, D. W., Duara, R., Ertekin-Taner, N., Faber, K. M., Fallon, K. B., Farlow, M. R., Ferris, S., Foroud, T. M., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Gilman, S., Glass, J. D., Goate, A. M., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hakonarson, H., Hamilton-Nelson, K. L., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jicha, G. A., Jin, L. W., Jun, G., Kamboh, M. I., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., Kramer, P., Kukul, W. A., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lin, C. F., Lieberman, A. P., Lopez, O. L., Lunetta, K. L., Lyketsos, C. G., MacK, W. J., Marson, D. C., Martin, E. R., Martiniuk, F., Mash, D. C., Masliah, E., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Murrel, J. R., Naj, A. C., Olichney, J. M., Parisi, J. E., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rosen, H. J., Rosenberg, R. N., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Valladares, O., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsatte, J. P., Wang, L. S., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. E. & Yu, L., Dec 2012, In: Nature Genetics. 44, 12, p. 1349-1354 6 p.

    Research output: Contribution to journal › Article › peer-review

    248 Scopus citations

  • Copy Number Variations in 6q14.1 and 5q13.2 are Associated with Alcohol Dependence

    Lin, P., Hartz, S. M., Wang, J. C., Agrawal, A., Zhang, T. X., McKenna, N., Bucholz, K., Brooks, A. I., Tischfield, J. A., Edenberg, H. J., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Schuckit, M. A., Goate, A. M., Bierut, L. J. & Rice, J. P., Sep 2012, In: Alcoholism: Clinical and Experimental Research. 36, 9, p. 1512-1518 7 p.

    Research output: Contribution to journal › Article › peer-review

    13 Scopus citations

  • Dissection of the phenotypic and genotypic associations with nicotinic dependence

    Chen, L. S., Baker, T. B., Grucza, R., Wang, J. C., Johnson, E. O., Breslau, N., Hatsukami, D., Smith, S. S., Saccone, N., Saccone, S., Rice, J. P., Goate, A. M. & Bierut, L. J., Nov 2012, In: Nicotine and Tobacco Research. 14, 4, p. 425-433 9 p.

    Research output: Contribution to journal › Article › peer-review

    40 Scopus citations

  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

    Alzheimer's Disease Genetics Consortium, 1 Jan 2012, In: Human Molecular Genetics. 21, 15, p. 3500-3512 13 p.

    Research output: Contribution to journal › Article › peer-review

    174 Scopus citations

  • Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition

    Head, D., Bugg, J. M., Goate, A. M., Fagan, A. M., Mintun, M. A., Benzinger, T., Holtzman, D. M. & Morris, J. C., May 2012, In: Archives of Neurology. 69, 5, p. 636-643 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    202 Scopus citations

  • Expression of Novel Alzheimer's Disease Risk Genes in Control and Alzheimer's Disease Brains

    Karch, C. M., Jeng, A. T., Nowotny, P., Cady, J., Cruchaga, C. & Goate, A. M., 30 Nov 2012, In: PLoS ONE. 7, 11, e50976.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    224 Scopus citations