Alison Goate

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Alison Goate

DPhil

 https://orcid.org/0000-0002-0576-2472
Calculated based on number of publications stored in Pure and citations from Scopus
1987 …2023

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  • 2015

    Age and amyloid effects on human central nervous system amyloid-beta kinetics

    Patterson, B. W., Elbert, D. L., Mawuenyega, K. G., Kasten, T., Ovod, V., Ma, S., Xiong, C., Chott, R., Yarasheski, K., Sigurdson, W., Zhang, L., Goate, A., Benzinger, T., Morris, J. C., Holtzman, D. & Bateman, R. J., 1 Sep 2015, In: Annals of Neurology. 78, 3, p. 439-453 15 p.

    Research output: Contribution to journal › Article › peer-review

    108 Scopus citations

  • A genetic variant (COMT) coding dopaminergic activity predicts personality traits in healthy elderly

    Kotyuk, E., Duchek, J., Head, D., Szekely, A., Goate, A. M. & Balota, D. A., 1 Aug 2015, In: Personality and Individual Differences. 82, p. 61-66 6 p.

    Research output: Contribution to journal › Article › peer-review

    9 Scopus citations

  • A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence

    Hancock, D. B., Wang, J. C., Gaddis, N. C., Levy, J. L., Saccone, N. L., Stitzel, J. A., Goate, A., Bierut, L. J. & Johnson, E. O., 5 Jun 2015, In: Human Molecular Genetics. 24, 20, p. 5940-5954 15 p.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes

    Cady, J., Allred, P., Bali, T., Pestronk, A., Goate, A., Miller, T. M., Mitra, R. D., Ravits, J., Harms, M. B. & Baloh, R. H., 1 Jan 2015, In: Annals of Neurology. 77, 1, p. 100-113 14 p.

    Research output: Contribution to journal › Article › peer-review

    147 Scopus citations

  • APOE ε4 genotype predicts memory for everyday activities

    Bailey, H. R., Sargent, J. Q., Flores, S., Nowotny, P., Goate, A. & Zacks, J. M., 2 Nov 2015, In: Aging, Neuropsychology, and Cognition. 22, 6, p. 639-666 28 p.

    Research output: Contribution to journal › Article › peer-review

    8 Scopus citations

  • Association of long runs of homozygosity with Alzheimer disease among African American individuals

    Ghani, M., Reitz, C., Cheng, R., Vardarajan, B. N., Jun, G., Sato, C., Naj, A., Rajbhandary, R., Wang, L. S., Valladares, O., Lin, C. F., Larson, E. B., Graff-Radford, N. R., Evans, D., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Murrell, J. R., Raj, T., Ertekin-Taner, N., & 153 othersLogue, M., Baldwin, C. T., Green, R. C., Barnes, L. L., Cantwell, L. B., Fallin, M. D., Go, R. C. P., Griffith, P. A., Obisesan, T. O., Manly, J. J., Lunetta, K. L., Kamboh, M. I., Lopez, O. L., Bennett, D. A., Hendrie, H., Hall, K. S., Goate, A. M., Byrd, G. S., Kukull, W. A., Foroud, T. M., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Lee, J. H., Schellenberg, G. D., St. George-Hyslop, P., Mayeux, R., Rogaeva, E., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barmada, M. M., Beach, T. G., Beecham, G. W., Beekly, D., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cai, G., Cairns, N. J., Cao, C., Carlson, C. S., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Cruchaga, C., DeCarli, C., DeKosky, S. T., Demirci, F. Y., Dick, M., Faber, K. M., Fallon, K. B., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Gilman, S., Glass, J. D., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Hamilton-Nelson, K. L., Haroutunian, V., Harrell, L. E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kauwe, J. S. K., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., Kramer, P., LaFerla, F. M., Lah, J. J., Lang-Walker, R., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Olichney, J. M., Parisi, J. E., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Ringman, J. M., Roberson, E. D., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. E. & Yu, L., Nov 2015, In: JAMA Neurology. 72, 11, p. 1313-1323 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    30 Scopus citations

  • Association of substance dependence phenotypes in the COGA sample

    Wetherill, L., Agrawal, A., Kapoor, M., Bertelsen, S., Bierut, L. J., Brooks, A., Dick, D., Hesselbrock, M., Hesselbrock, V., Koller, D. L., Le, N., Nurnberger, J. I., Salvatore, J. E., Schuckit, M., Tischfield, J. A., Wang, J. C., Xuei, X., Edenberg, H. J., Porjesz, B., Bucholz, K., & 2 othersGoate, A. M. & Foroud, T., 1 May 2015, In: Addiction Biology. 20, 3, p. 617-627 11 p.

    Research output: Contribution to journal › Article › peer-review

    34 Scopus citations

  • Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

    Alzheimer’s Disease Genetics Consortium, The GERAD1 Consortium & EPIC-InterAct Consortium, 1 Jun 2015, In: PLoS Medicine. 12, 6, e1001841.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    132 Scopus citations

  • Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

    Wang, F., Gordon, B. A., Ryman, D. C., Ma, S., Xiong, C., Hassenstab, J., Goate, A., Fagan, A. M., Cairns, N. J., Marcus, D. S., McDade, E., Ringman, J. M., Graff-Radford, N. R., Ghetti, B., Farlow, M. R., Sperling, R., Salloway, S., Schofield, P. R., Masters, C. L., Martins, R. N., & 8 othersRossor, M. N., Jucker, M., Danek, A., Förster, S., Lane, C. A. S., Morris, J. C., Benzinger, T. L. S. & Bateman, R. J., 1 Sep 2015, In: Neurology. 85, 9, p. 790-798 9 p.

    Research output: Contribution to journal › Article › peer-review

    21 Scopus citations

  • Common polygenic variation enhances risk prediction for Alzheimer's disease

    Escott-Price, V., Sims, R., Bannister, C., Harold, D., Vronskaya, M., Majounie, E., Badarinarayan, N., Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Goate, A., Cruchaga, C., Lambert, J. C., Van Duijn, C., Maier, W., Ramirez, A., & 7 othersHolmans, P., Jones, L., Hardy, J., Seshadri, S., Schellenberg, G. D., Amouyel, P. & Williams, J., 1 Dec 2015, In: Brain. 138, 12, p. 3673-3684 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    241 Scopus citations

  • Convergent genetic and expression data implicate immunity in Alzheimer's disease

    International Genomics of Alzheimer's Disease Consortium (IGAP), 1 Jun 2015, In: Alzheimer's and Dementia. 11, 6, p. 658-671 14 p.

    Research output: Contribution to journal › Article › peer-review

    142 Scopus citations

  • Cruchaga & Goate reply

    Cruchaga, C. & Goate, A. M., 2 Apr 2015, In: Nature. 520, 7545, p. E5-E6

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Cruchaga & Goate reply

    Cruchaga, C. & Goate, A. M., 2 Apr 2015, In: Nature. 520, 7545, p. E10

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

    Ringman, J. M., Liang, L. J., Zhou, Y., Vangala, S., Teng, E., Kremen, S., Wharton, D., Goate, A., Marcus, D. S., Farlow, M., Ghetti, B., McDade, E., Masters, C. L., Mayeux, R. P., Rossor, M., Salloway, S., Schofield, P. R., Cummings, J. L., Buckles, V., Bateman, R., & 1 othersMorris, J. C., 1 Apr 2015, In: Brain. 138, 4, p. 1036-1045 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    55 Scopus citations

  • Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample

    COGA Investigators, 1 Jan 2015, In: Journal of Studies on Alcohol and Drugs. 76, 1, p. 38-46 9 p.

    Research output: Contribution to journal › Article › peer-review

    11 Scopus citations

  • Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses

    Adult Changes in Thought Study Investigators, Religious Orders Study/Memory and Aging Project Investigators & Alzheimer's Disease Genetics Consortium, 1 Dec 2015, In: Alzheimer's and Dementia. 11, 12, p. 1439-1451 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families

    NIA-LOAD/NCRAD Family Study Group, Nov 2015, In: Neurobiology of Aging. 36, 11, p. 3116.e9-3116.e16

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Integrating mRNA and miRNA weighted gene co-expression networks with eQTLs in the nucleus accumbens of subjects with alcohol dependence

    Mamdani, M., Williamson, V., McMichael, G. O., Blevins, T., Aliev, F., Adkins, A., Hack, L., Bigdeli, T., Van Der Vaart, A. D., Web, B. T., Bacanu, S. A., Kalsi, G., Kendler, K. S., Miles, M. F., Dick, D., Riley, B. P., Dumur, C., Vladimirov, V. I., Hesselbrock, V., Edenberg, H. J., & 29 othersNurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Porjesz, B., Bierut, L., Goate, A., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Almasy, L., Taylor, R., Dick, D., Bauer, L., Koller, D., O'Connor, S., Wetherill, L., Xuei, X., Chan, G., Kang, S., Manz, N., Rangaswamy, M., Rohrbaugh, J., Wang, J. C., Brooks, A., Aliev, F., Parsian, A. & Reilly, M., 18 Sep 2015, In: PLoS ONE. 10, 9, e0137671.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    61 Scopus citations

  • Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory

    Kim, A., Fagan, A. M., Goate, A. M., Benzinger, T. L. S., Morris, J. C. & Head, D., 8 Sep 2015, In: Cognitive, Affective and Behavioral Neuroscience. 15, 3, p. 625-643 19 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    34 Scopus citations

  • Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease

    Barral, S., Cheng, R., Reitz, C., Vardarajan, B., Lee, J., Kunkle, B., Beecham, G., Cantwell, L. S., Pericak-Vance, M. A., Farrer, L. A., Haines, J. L., Goate, A. M., Foroud, T., Boerwinkle, E., Schellenberg, G. D. & Mayeux, R., 1 Dec 2015, In: Alzheimer's and Dementia. 11, 12, p. 1397-1406 10 p.

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations

  • Peroxisome Proliferator-Activated Receptors α and γ are Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

    Blednov, Y. A., Benavidez, J. M., Black, M., Ferguson, L. B., Schoenhard, G. L., Goate, A. M., Edenberg, H. J., Wetherill, L., Hesselbrock, V., Foroud, T. & Adron Harris, R., 1 Jan 2015, In: Alcoholism: Clinical and Experimental Research. 39, 1, p. 136-145 10 p.

    Research output: Contribution to journal › Article › peer-review

    69 Scopus citations

  • Positive selection on loci associated with drug and alcohol dependence

    Sadler, B., Haller, G., Edenberg, H., Tischfield, J., Brooks, A., Kramer, J., Schuckit, M., Nurnberger, J. & Goate, A., 13 Aug 2015, In: PLoS ONE. 10, 8, e0134393.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

    the Genetic and Environmental Risk for Alzheimer’s Disease (GERAD1) Consortium, 19 May 2015, In: Cell Reports. 11, 7, p. 1134-1146 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    71 Scopus citations

  • Rarity of the alzheimer disease-protective APP A673T variant in the United States

    National Institute on Aging-Late-Onset Alzheimer's Disease (NIA-LOAD) Family Study & Alzheimer's Disease Genetics Consortium, 1 Feb 2015, In: JAMA Neurology. 72, 2, p. 209-216 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    30 Scopus citations

  • TREM2 is associated with increased risk for Alzheimer's disease in African Americans

    Jin, S. C., Carrasquillo, M. M., Benitez, B. A., Skorupa, T., Carrell, D., Patel, D., Lincoln, S., Krishnan, S., Kachadoorian, M., Reitz, C., Mayeux, R., Wingo, T. S., Lah, J. J., Levey, A. I., Murrell, J., Hendrie, H., Foroud, T., Graff-Radford, N. R., Goate, A. M., Cruchaga, C., & 1 othersErtekin-Taner, N., 10 Apr 2015, In: Molecular Neurodegeneration. 10, 1, 19.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    105 Scopus citations
  • 2014

    Age-specific incidence rates for dementia and alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for late-onset Alzheimer disease/National Cell Repository for Alzheimer disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)

    Vardarajan, B. N., Faber, K. M., Bird, T. D., Bennett, D. A., Rosenberg, R., Boeve, B. F., Graff-Radford, N. R., Goate, A. M., Farlow, M., Sweet, R. A., Lantigua, R., Medrano, M. Z., Ottman, R., Schaid, D. J., Foroud, T. M. & Mayeux, R., Mar 2014, In: JAMA Neurology. 71, 3, p. 315-323 9 p.

    Research output: Contribution to journal › Article › peer-review

    42 Scopus citations

  • Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

    Izzo, N. J., Xu, J., Zeng, C., Kirk, M. J., Mozzoni, K., Silky, C., Rehak, C., Yurko, R., Look, G., Rishton, G., Safferstein, H., Cruchaga, C., Goate, A., Cahill, M. A., Arancio, O., Mach, R. H., Craven, R., Head, E., LeVine, H., Spires-Jones, T. L., & 1 othersCatalano, S. M., 12 Nov 2014, In: PLoS ONE. 9, 11, e111899.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    148 Scopus citations

  • An ADH1B variant and peer drinking in progression to adolescent drinking milestones: Evidence of a gene-by-environment interaction

    Olfson, E., Edenberg, H. J., Nurnberger, J., Agrawal, A., Bucholz, K. K., Almasy, L. A., Chorlian, D., Dick, D. M., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Porjesz, B., Schuckit, M. A., Tischfield, J. A., Wang, J. C., Wetherill, L., Foroud, T. M., Rice, J., Goate, A. & Bierut, L. J., 1 Oct 2014, In: Alcoholism: Clinical and Experimental Research. 38, 10, p. 2541-2549 9 p.

    Research output: Contribution to journal › Article › peer-review

    29 Scopus citations

  • A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman

    Ting, S. K. S., Benzinger, T., Kepe, V., Fagan, A., Coppola, G., Porter, V., Hecimovic, S., Chakraverty, S., Alvarez-Retuerto, A. I., Goate, A. & Ringman, J. M., 2014, In: Journal of Alzheimer's Disease. 40, 2, p. 271-275 5 p.

    Research output: Contribution to journal › Article › peer-review

    11 Scopus citations

  • A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

    Wetzel-Smith, M. K., Hunkapiller, J., Bhangale, T. R., Srinivasan, K., Maloney, J. A., Atwal, J. K., Sa, S. M., Yaylaoglu, M. B., Foreman, O., Ortmann, W., Rathore, N., Hansen, D. V., Tessier-Lavigne, M., Mayeux, R., Pericak-Vance, M., Haines, J., Farrer, L. A., Schellenberg, G. D., Goate, A., Behrens, T. W., & 3 othersCruchaga, C., Watts, R. J. & Graham, R. R., 1 Dec 2014, In: Nature Medicine. 20, 12, p. 1452-1457 6 p.

    Research output: Contribution to journal › Article › peer-review

    97 Scopus citations

  • Beyond cigarettes per day: A genome-wide association study of the biomarker carbon monoxide

    Bloom, A. J., Hartz, S. M., Baker, T. B., Chen, L. S., Piper, M. E., Fox, L., Martinez, M., Hatsukami, D., Johnson, E. O., Laurie, C. C., Saccone, N. L., Goate, A. & Bierut, L. J., 1 Sep 2014, In: Annals of the American Thoracic Society. 11, 7, p. 1003-1010 8 p.

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Coding variants in TREM2 increase risk for Alzheimer's disease

    Jin, S. C., Benitez, B. A., Karch, C. M., Cooper, B., Skorupa, T., Carrell, D., Norton, J. B., Hsu, S., Harari, O., Cai, Y., Bertelsen, S., Goate, A. M. & Cruchaga, C., 1 Nov 2014, In: Human Molecular Genetics. 23, 21, p. 5838-5846 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    194 Scopus citations

  • DSM-5 cannabis use disorder: A phenotypic and genomic perspective

    Agrawal, A., Lynskey, M. T., Bucholz, K. K., Kapoor, M., Almasy, L., Dick, D. M., Edenberg, H. J., Foroud, T., Goate, A., Hancock, D. B., Hartz, S., Johnson, E. O., Hesselbrock, V., Kramer, J. R., Kuperman, S., Nurnberger, J. I., Schuckit, M. & Bierut, L. J., 1 Jan 2014, In: Drug and Alcohol Dependence. 134, 1, p. 362-369 8 p.

    Research output: Contribution to journal › Article › peer-review

    33 Scopus citations

  • Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study

    Alzheimer Disease Genetics Consortium, 1 Nov 2014, In: JAMA Neurology. 71, 11, p. 1394-1404 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    138 Scopus citations

  • Family-Based Association Analysis of Alcohol Dependence Criteria and Severity

    Wetherill, L., Kapoor, M., Agrawal, A., Bucholz, K., Koller, D., Bertelsen, S. E., Le, N., Wang, J. C., Almasy, L., Hesselbrock, V., Kramer, J., Nurnberger, J. I., Schuckit, M., Tischfield, J. A., Xuei, X., Porjesz, B., Edenberg, H. J., Goate, A. M. & Foroud, T., Feb 2014, In: Alcoholism: Clinical and Experimental Research. 38, 2, p. 354-366 13 p.

    Research output: Contribution to journal › Article › peer-review

    18 Scopus citations

  • Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior

    Haller, G., Li, P., Esch, C., Hsu, S., Goate, A. M. & Steinbach, J. H., 7 May 2014, In: PLoS ONE. 9, 5, e96753.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Functional connectivity in autosomal dominant and late-onset Alzheimer disease

    Thomas, J. B., Brier, M. R., Bateman, R. J., Snyder, A. Z., Benzinger, T. L., Xiong, C., Raichle, M., Holtzman, D. M., Sperling, R. A., Mayeux, R., Ghetti, B., Ringman, J. M., Salloway, S., McDade, E., Rossor, M. N., Ourselin, S., Schofield, P. R., Masters, C. L., Martins, R. N., Weiner, M. W., & 18 othersThompson, P. M., Fox, N. C., Koeppe, R. A., Jack, C. R., Mathis, C. A., Oliver, A., Blazey, T. M., Moulder, K., Buckles, V., Hornbeck, R., Chhatwal, J., Schultz, A. P., Goate, A. M., Fagan, A. M., Cairns, N. J., Marcus, D. S., Morris, J. C. & Ances, B. M., 1 Sep 2014, In: JAMA Neurology. 71, 9, p. 1111-1122 12 p.

    Research output: Contribution to journal › Article › peer-review

    74 Scopus citations

  • Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood

    Dick, D. M., Cho, S. B., Latendresse, S. J., Aliev, F., Nurnberger, J. I., Edenberg, H. J., Schuckit, M., Hesselbrock, V. M., Porjesz, B., Bucholz, K., Wang, J. C., Goate, A., Kramer, J. R. & Kuperman, S., 1 Nov 2014, In: Addiction Biology. 19, 6, p. 1055-1064 10 p.

    Research output: Contribution to journal › Article › peer-review

    30 Scopus citations

  • Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

    Proitsi, P., Lupton, M. K., Velayudhan, L., Newhouse, S., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Williams, J., Harold, D., Sims, R., Gerrish, A., Chapman, J., Escott-Price, V., Abraham, R., Hollingworth, P., & 74 othersHamshere, M., Singh Pahwa, J., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A., Williams, K., Lovestone, S., Powell, J. F., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K., Passmore, P., Craig, D., Mcguinness, B., Johnston, J. A., Todd, S., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Guerreiro, R., Singleton, A., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Heun, R., Schürmann, B., Ramirez, A., Becker, T., Herold, C., Lacour, A., Drichel, D., Van Den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., Mcquillin, A., Gwilliam, R., Deloukas, P., Nöthen, M. M., Holmans, P., O'donovan, M., Owen, M. J., Williams, J., Stewart, R. & Sham, P., 1 Sep 2014, In: PLoS Medicine. 11, 9

    Research output: Contribution to journal › Article › peer-review

    Open Access
    62 Scopus citations

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

    Escott-Price, V., Bellenguez, C., Wang, L. S., Choi, S. H., Harold, D., Jones, L., Holmans, P., Gerrish, A., Vedernikov, A., Richards, A., DeStefano, A. L., Lambert, J. C., Ibrahim-Verbaas, C. A., Naj, A. C., Sims, R., Jun, G., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., & 167 othersThornton-Wells, T. A., Denning, N., Smith, A. V., Chouraki, V., Thomas, C., Arfan Ikram, M., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Schmidt, H., Kunkle, B., Dunstan, M. L., Vronskaya, M., Johnson, A. D., Ruiz, A., Bihoreau, M. T., Reitz, C., Pasquier, F., Hollingworth, P., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Becker, C. B. T., Gudnason, V., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Hernández, I., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiévet, N., Huentelman, M. J., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuinness, B., Larson, E. B., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. D., Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Scarpini, E., Bonuccelli, U., Mancuso, M., Siciliano, G., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Frank-García, A., Panza, F., Solfrizzi, V., Caffarra, P., Nacmias, B., Perry, W., Mayhaus, M., Lannfelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., De Bruijn, R. F. A. G., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S. K., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltunen, M., Martin, E. R., Schmidt, R., Rujescu, D., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Psaty, B. M., Haines, J. L., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Van Broeckhoven, C., Farrer, L. A., Van Duijn, C. M., Ramirez, A., Seshadri, S., Schellenberg, G. D., Amouyel, P. & Williams, J., 12 Jun 2014, In: PLoS ONE. 9, 6, e94661.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    89 Scopus citations

  • Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

    Kauwe, J. S. K., Bailey, M. H., Ridge, P. G., Perry, R., Wadsworth, M. E., Hoyt, K. L., Staley, L. A., Karch, C. M., Harari, O., Cruchaga, C., Ainscough, B. J., Bales, K., Pickering, E. H., Bertelsen, S., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., 1 Oct 2014, In: PLoS Genetics. 10, 10

    Research output: Contribution to journal › Article › peer-review

    Open Access
    88 Scopus citations

  • Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families

    Kapoor, M., Wang, J. C., Wetherill, L., Le, N., Bertelsen, S., Hinrichs, A. L., Budde, J., Agrawal, A., Almasy, L., Bucholz, K., Dick, D. M., Harari, O., Xiaoling, X., Hesselbrock, V., Kramer, J., Nurnberger, J. I., Rice, J., Schuckit, M., Tischfield, J., Porjesz, B., & 4 othersEdenberg, H. J., Bierut, L., Foroud, T. & Goate, A., 1 Sep 2014, In: Drug and Alcohol Dependence. 142, p. 56-62 7 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    The Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson’s Disease Consortium, Alzheimer Genetic Analysis Group, International Parkinson’s Disease Genomics Consortium (IPDGC), Parkinson’s Study Group (PSG) Parkinson’s Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC) & Hussman Institute of Human Genomics (HIHG), 2014, In: Nature Genetics. 46, 9, p. 989-993 5 p.

    Research output: Contribution to journal › Article › peer-review

    1191 Scopus citations

  • Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease

    Fagan, A. M., Xiong, C., Jasielec, M. S., Bateman, R. J., Goate, A. M., Benzinger, T. L. S., Ghetti, B., Martins, R. N., Masters, C. L., Mayeux, R., Ringman, J. M., Rossor, M. N., Salloway, S., Schofield, P. R., Sperling, R. A., Marcus, D., Cairns, N. J., Buckles, V. D., Ladenson, J. H., Morris, J. C., & 1 othersHoltzman, D. M., 5 Mar 2014, In: Science Translational Medicine. 6, 226, 226ra30.

    Research output: Contribution to journal › Article › peer-review

    271 Scopus citations

  • Missense variant in TREML2 protects against Alzheimer's disease

    Benitez, B. A., Jin, S. C., Guerreiro, R., Graham, R., Lord, J., Harold, D., Sims, R., Lambert, J. C., Gibbs, J. R., Bras, J., Sassi, C., Harari, O., Bertelsen, S., Lupton, M. K., Powell, J., Bellenguez, C., Brown, K., Medway, C., Haddick, P. C. G., Van der Brug, M. P., & 22 othersBhangale, T., Ortmann, W., Behrens, T., Mayeux, R., Pericak-Vance, M. A., Farrer, L. A., Schellenberg, G. D., Haines, J. L., Turton, J., Braae, A., Barber, I., Fagan, A. M., Holtzman, D. M., Morris, J. C., Williams, J., Kauwe, J. S. K., Amouyel, P., Morgan, K., Singleton, A., Hardy, J., Goate, A. M. & Cruchaga, C., Jun 2014, In: Neurobiology of Aging. 35, 6, p. 1510.e19-1510.e26

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    Open Access
    93 Scopus citations

  • Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans

    Culverhouse, R. C., Johnson, E. O., Breslau, N., Hatsukami, D. K., Sadler, B., Brooks, A. I., Hesselbrock, V. M., Schuckit, M. A., Tischfield, J. A., Goate, A. M., Saccone, N. L. & Bierut, L. J., May 2014, In: Addiction. 109, 5, p. 814-822 9 p.

    Research output: Contribution to journal › Article › peer-review

    27 Scopus citations

  • Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)

    Chen, L. S., Bloom, A. J., Baker, T. B., Smith, S. S., Piper, M. E., Martinez, M., Saccone, N., Hatsukami, D., Goate, A. & Bierut, L., Jan 2014, In: Addiction. 109, 1, p. 128-137 10 p.

    Research output: Contribution to journal › Article › peer-review

    70 Scopus citations

  • Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid

    Harari, O., Cruchaga, C., Kauwe, J. S. K., Ainscough, B. J., Bales, K., Pickering, E. H., Bertelsen, S., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., 1 May 2014, In: Biological Psychiatry. 75, 9, p. 723-731 9 p.

    Research output: Contribution to journal › Article › peer-review

    63 Scopus citations

  • Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

    Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A. T., Cooper, B., Skorupa, T., Carrell, D., Levitch, D., Hsu, S., Choi, J., Ryten, M., Hardy, J., Trabzuni, D., & 60 othersWeale, M. E., Ramasamy, A., Smith, C., Sassi, C., Bras, J., Gibbs, J. R., Hernandez, D. G., Lupton, M. K., Powell, J., Forabosco, P., Ridge, P. G., Corcoran, C. D., Tschanz, J. T., Norton, M. C., Munger, R. G., Schmutz, C., Leary, M., Demirci, F. Y., Bamne, M. N., Wang, X., Lopez, O. L., Ganguli, M., Medway, C., Turton, J., Lord, J., Braae, A., Barber, I., Brown, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D. M., Pickering-Brown, S., Kalsheker, N., Lowe, J., Morgan, K., David Smith, A., Wilcock, G., Warden, D., Holmes, C., Pastor, P., Lorenzo-Betancor, O., Brkanac, Z., Scott, E., Topol, E., Rogaeva, E., Singleton, A. B., Kamboh, M. I., St George-Hyslop, P., Cairns, N., Morris, J. C., Kauwe, J. S. K. & Goate, A. M., 2014, In: Nature. 505, 7484, p. 550-554 5 p.

    Research output: Contribution to journal › Article › peer-review

    351 Scopus citations

  • Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence

    Haller, G., Kapoor, M., Budde, J., Xuei, X., Edenberg, H., Nurnberger, J., Kramer, J., Brooks, A., Tischfield, J., Almasy, L., Agrawal, A., Bucholz, K., Rice, J., Saccone, N., Bierut, L. & Goate, A., Feb 2014, In: Human Molecular Genetics. 23, 3, p. 810-819 10 p., ddt463.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations