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Alison Goate

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Alison Goate

DPhil

 https://orcid.org/0000-0002-0576-2472
1987 …2026

Research activity per year

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PROFESSOR AND CHAIR, GENETICS AND GENOMIC SCIENCES

Biography

Alison M. Goate, DPhil, is the Jean C. and James W. Crystal Professor of Genomics, Chair of the Department of Genetics and Genomic Sciences, Professor of Neuroscience and Neurology, and faculty of the Icahn Genomics Institute at the Icahn School of Medicine at Mount Sinai. She has worked on the genetics of neurodegenerative diseases including Alzheimer’s disease (AD) and Frontotemporal Dementia (FTD) since 1987, and is the founding director of the Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai.

Over the last three decades, Dr. Goate has been part of many gene finding teams that have successfully identified disease-causing variants for both AD and FTD. While working at Imperial College in London, she reported the first mutation to cause familial Alzheimer’s disease, and her early studies at Washington University in St. Louis identified a genetic mutation in Colombian families that are now part of the Alzheimer’s Prevention Initiative clinical trial. Her lab was also part of the team that first reported MAPT mutations in FTD.

Dr. Goate is also a leader in the study of late onset AD genetics using integrative genomic approaches to identify novel genetic risk factors. Her work led to the identification of Trem2 as a risk factor for AD and has highlighted the enrichment of AD risk variants in microglial enhancers, regulatory elements in DNA that control gene expression in immune cells of the brain. Dr. Goate is now building upon these insights using genome editing in induced pluripotent stem cells to understand the molecular mechanisms of disease and to develop novel therapeutics.

Dr. Goate has received the Potamkin Award from the American Academy of Neurology, the Khalid Iqbal Lifetime Achievement Award from the Alzheimer’s Association, the Rainwater Prize, and the MetLife Award for herresearch on AD. She was elected a fellow of the American Association for the Advancement of Science in 2012, and a fellow of the National Academy of Medicine in 2016.

Visit Dr. Goate's Lab Page here. 

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  • Cortical asymmetry in autosomal dominant Alzheimer’s disease progression

    Pérez-Millan, A., Falgàs, N., Bosch, B., Borrego-Écija, S., Antonell, A., Fernández-Villullas, G., Esteller-Gauxax, D., Tort-Merino, A., Bargalló, N., Balasa, M., Lladó, A., Aguillon, D., Chrem, P., Day, G. S., Devenney, E., Huey, E. D., Ikeuchi, T., Jucker, M., Kasuga, K. & Vöglein, J. & 119 others, Roh, J. H., Vitali, P., Sosa Ortiz, A. L., Llibre-Guerra, J. J., Gordon, B. A., McDade, E., Bateman, R. J., Sánchez-Valle, R., McDade, Bateman, R., Daniels, A. J., Courtney, L., Ziegemeier, A., Skrbec, K., Hellm, C., Martin, M., Ziegemeier, E., Bartzel, J., Supnet-Bell, C., Xiong, C., Xu, X., Lu, R., Wang, G., Li, Y., Nie, Y., Gremminger, E., Perrin, R. J., Franklin, E., Ibanez, L., Jerome, G., Stauber, J., Baker, B., Minton, M., Cruchaga, C., Goate, A. M., Renton, A. E., Picarello, D. M., Fulton-Howard, B., Benzinger, T. L. S., Banks, J., Hornbeck, R., Chen, A., Chen, C., Flores, S., Goyal, M., Hobbs, D., Joseph-Mathurin, N., Jackson, K., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Sabaredzovic, E., Scott, J., Simmons, A., Rizzo, J., Vlassenko, A., Wang, Y., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holtzman, D. M., Barthélemy, N. R., Xu, J., Berman, S. B., Ikonomovic, S., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Maa, C., Ishiguro, T., Ishii, K., Senda, M., Niimi, Y., Salloway, S., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Laske, C., Timofejavaite, R., Kuder-Buletta, E., Graber-Sultan, S., La Fougère, C., Reischl, G., Obermueller, U., Levin, J., Rödenbeck, Y., Lee, J. H., Allegri, R. F., Mendez, P. C., Surace, E., Vazquez, S., Leon, Y. M., Ramirez, L., Serna, L., Baena, A., Bocanegra, Y., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J., Fagan, A. M., Mori, H., Masters, C., Noble, J. M., Sanchez-Valle, R. & Lopera, F., 2026, In: Brain Communications. 8, 1, fcaf488.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

    Llibre-Guerra, J. J., Lu, R., Clarens, M. F., Liu, I., Renton, A., Ryan, N. S., Goate, A. M., Aguillón, D., Allegri, R. F., Benzinger, T. L. S., Berman, S., Chhatwal, J. P., Chrem Mendez, P., Vigo, G., Cruchaga, C., Day, G. S., Farlow, M. R., Fox, N. C., Gordon, B. A. & Hassenstab, J. & 20 others, Huey, E. D., Ibanez, L., Ikeuchi, T., Jucker, M., Lee, J. H., Levey, A. I., Levin, J., Niimi, Y., Perrin, R. J., Rosa-Neto, P., Sánchez-Valle, R., Schofield, P. R., Wang, G., Li, Y., Xiong, C., Morris, J. C., Karch, C., Daniels, A. J., McDade, E. & Bateman, R. J., 28 Apr 2026, In: Neurology. 106, 8, p. e214804

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic modifiers of APOE-ε4-associated cognitive decline

    the Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Genetics Consortium (ADGC) & The Alzheimer’s Disease Sequencing Project (ADSP), Dec 2026, In: Nature Communications. 17, 1, 2982.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder

    Warden, A. S., Salem, N. A., Brenner, E., Sutherland, G. T., Stevens, J., Kapoor, M., Goate, A. M. & Mayfield, R. D., 1 Jan 2026, In: Biological Psychiatry. 99, 1, p. 34-48 15 p.

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer’s disease

    Choo, I. H., Park, H., Gordon, B. A., Bateman, R. J., Bateman, R., Daniels, A. J., Courtney, L., Ziegemeier, A., Skrbec, K., Hellm, C., Martin, M., Ziegemeier, E., Bartzel, J., McDade, E., Libre-Guerra, J. J., Supnet-Bell, C., Xiong, C., Xu, X., Lu, R. & Wang, G. & 106 others, Li, Y., Nie, Y., Gremminger, E., Perrin, R. J., Franklin, E., Ibanez, L., Jerome, G., Stauber, J., Baker, B., Minton, M., Cruchaga, C., Goate, A. M., Renton, A. E., Picarello, D. M., Fulton-Howard, B., Benzinger, T. L. S., Gordon, B. A., Banks, J., Hornbeck, R., Chen, A., Chen, C., Flores, S., Goyal, M., Hobbs, D., Joseph-Mathurin, N., Jackson, K., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Sabaredzovic, E., Scott, J., Simmons, A., Rizzo, J., Vlassenko, A., Wang, Y., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holzman, D. M., Barthélemy, N. R., Xu, J., Berman, S. B., Ikonomovic, S., Day, G. S., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Ikeuchi, T., Kasuga, K., Ishiguro, T., Ishii, K., Senda, M., Niimi, Y., Huey, E. D., Salloway, S., Devenney, E., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Jucker, M., Laske, C., Timofejavaite, R., Kuder-Buletta, E., Graber-Sultan, S., la Fougère, C., Reischl, G., Obermueller, U., Levin, J., Rödenbeck, Y., Vöglein, J., Lee, J. H., Roh, J. H., Vitali, P., Allegri, R. F., Mendez, P. C., Surace, E., Vazquez, S., Aguillon, D., Leon, Y. M., Ramirez, L., Serna, L., Baena, A., Bocanegra, Y., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J., Fagan, A. M., Mori, H., Masters, C., Nobles, J. M., Sanchez-Valle, R. & Lopera, F., Apr 2026, In: Journal of Prevention of Alzheimer's Disease. 13, 4, 100513.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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