Alan E. Renton

Research output

Research output per year 2003 2012 2014 2015 2019 2020 2021 2022 2023 2023

• 66 Article
• 3 Review article
• 2 Comment/debate
• 2 Editorial
• 2 More
  • 1 Letter
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2015

  TBK1 is associated with ALS and ALS-FTD in Sardinian patients

  Borghero, G., Pugliatti, M., Marrosu, F., Marrosu, M. G., Murru, M. R., Floris, G., Cannas, A., Occhineri, P., Cau, T. B., Loi, D., Ticca, A., Traccis, S., Manera, U., Canosa, A., Moglia, C., Calvo, A., Barberis, M., Brunetti, M., Gibbs, J. R., Renton, A. E., & 85 othersErrichiello, E., Zoledziewska, M., Mulas, A., Qian, Y., Din, J., Pliner, H. A., Traynor, B. J., Chiò, A., Logullo, F. O., Simone, I., Logroscino, G., Salvi, F., Bartolomei, I., Capasso, M., Caponnetto, C., Mandich, P., Mancardi, G., Origone, P., Conforti, F. L., Vita, G., Messina, S., Russo, M., Mora, G., Marinou, K., Sideri, R., Lunetta, C., Penco, S., Mosca, L., Pinter, G. L., Corbo, M., Riva, N., Carrera, P., Volanti, P., Tremolizzo, L., Ferrarese, C., Fini, N., Fasano, A., Monsurrò, M. R., Tedeschi, G., Trojsi, F., Piccirillo, G., Cristillo, V., Mazzini, L., D'Alfonso, S., Bersano, A., Corrado, L., Bagarotti, A., La Bella, V., Spataro, R., Colletti, T., Sabatelli, M., Zollino, M., Conte, A., Luigetti, M., Lattante, S., Marangi, G., Santarelli, M., Petrucci, A., Giannini, F., Battistini, S., Ricci, C., Benigni, M., Restagno, G., Casale, F., Marrali, G., Fuda, G., Ossola, I., Cammarosano, S., Ilardi, A., Bertuzzo, D., Tanel, R., Pisano, F., Costantino, E., Pani, C., Puddu, R., Caredda, C., Piras, V., Tranquilli, S., Cuccu, S., Corongiu, D., Melis, M., Milia, A., Pirisi, A., Parish, L. D. & Ortu, E., 18 Oct 2015, In: Neurobiology of Aging. 43, p. 180.e1-180.e5

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Phosphotransferases 72%
  • Mutation 43%
  • Exons 38%
  • Frontotemporal Dementia 38%
  35 Scopus citations
• 2014

  Genetic architecture of ALS in Sardinia

  ITALSGEN & SARDINALS Consortia, 1 Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2882.e7-2882.e12

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Italy 88%
  • Mutation 52%
  • Amyotrophic lateral sclerosis 1 31%
  • Scandinavian and Nordic Countries 15%
  58 Scopus citations

• Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion

  Pletnikova, O., Sloane, K. L., Renton, A. E., Traynor, B. J., Crain, B. J., Reid, T., Zu, T., Ranum, L. P. W., Troncoso, J. C., Rabins, P. V. & Onyike, C. U., Oct 2014, In: Neurobiology of Aging. 35, 10, p. 2419.e17-2419.e21

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 9 100%
  • Sclerosis 81%
  • Dementia 63%
  • Frontotemporal Dementia 47%
  • Frontotemporal Dementia With Motor Neuron Disease 29%
  20 Scopus citations

• Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

  ITALSGEN, 2014, In: Nature Neuroscience. 17, 5, p. 664-666 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Amyotrophic Lateral Sclerosis 80%
  • Frontotemporal Dementia With Motor Neuron Disease 57%
  • Nerve Degeneration 47%
  • Exome 44%
  336 Scopus citations

• Novel TARDBP sequence variant and C9ORF72 repeat expansion in a family with frontotemporal dementia

  Kaivorinne, A. L., Moilanen, V., Kervinen, M., Renton, A. E., Traynor, B. J., Majamaa, K. & Remes, A. M., 2014, In: Alzheimer Disease and Associated Disorders. 28, 2, p. 190-193 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Dementia 100%
  • Frontotemporal Lobar Degeneration 93%
  • dementia 80%
  • heredity 48%
  • cause 47%
  16 Scopus citations

• State of play in amyotrophic lateral sclerosis genetics

  Renton, A. E., Chiò, A. & Traynor, B. J., Jan 2014, In: Nature Neuroscience. 17, 1, p. 17-23 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Amyotrophic lateral sclerosis 1 62%
  • Nerve Degeneration 29%
  • Motor Neuron Disease 29%
  • Genome-Wide Association Study 24%
  1105 Scopus citations
• 2013

  CRESTing the ALS mountain

  Renton, A. E. & Traynor, B. J., Jul 2013, In: Nature Neuroscience. 16, 7, p. 774-775 2 p.

  Research output: Contribution to journal › Short survey › peer-review

• Frontotemporal dementia with a C9ORF72 expansion in a Swedish family: Clinical and neuropathological characteristics

  Waldö, M. L., Gustafson, L., Nilsson, K., Traynor, B. J., Renton, A. E., Englund, E. & Passant, U., 15 Dec 2013, In: American Journal of Neurodegenerative Diseases. 2, 4, p. 276-286 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Dementia 100%
  • Psychomotor Agitation 33%
  • Medically Unexplained Symptoms 32%
  • Staining and Labeling 17%
  • Phenotype 16%
  18 Scopus citations

• GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia

  Rytty, R., Nikkinen, J., Paavola, L., Abou Elseoud, A., Moilanen, V., Visuri, A., Tervonen, O., Renton, A. E., Traynor, B. J., Kiviniemi, V. & Remes, A. M., 26 Aug 2013, In: Frontiers in Human Neuroscience. AUG, 461.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia 100%
  • Regression Analysis 52%
  • Magnetic Resonance Imaging 26%
  • Apathy 25%
  • Executive Function 20%
  59 Scopus citations
• 2012

  ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations

  Chiò, A., Restagno, G., Brunetti, M., Ossola, I., Calvo, A., Canosa, A., Moglia, C., Floris, G., Tacconi, P., Marrosu, F., Marrosu, M. G., Murru, M. R., Majounie, E., Renton, A. E., Abramzon, Y., Pugliatti, M., Sotgiu, M. A., Traynor, B. J., Borghero, G., Cammarosano, S., & 12 othersIlardi, A., Montuschi, A., Bersano, E., Cannas, A., Costantino, E., Piras, V., Pani, C., Ticca, A., Parish, L. D., Cossu, P., Solinas, G. & Ulgheri, L., Jul 2012, In: Journal of Neurology, Neurosurgery and Psychiatry. 83, 7, p. 730-733 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia 100%
  • Phenotype 71%
  • Mutation 66%
  • Genes 48%
  • 25-aminolanosterol 37%
  50 Scopus citations

• C9ORF72 hexanucleotide repeat expansions in the Italian sporadic ALS population

  Sabatelli, M., Conforti, F. L., Zollino, M., Mora, G., Monsurrò, M. R., Volanti, P., Marinou, K., Salvi, F., Corbo, M., Giannini, F., Battistini, S., Penco, S., Lunetta, C., Quattrone, A., Gambardella, A., Logroscino, G., Simone, I., Bartolomei, I., Pisano, F., Tedeschi, G., & 53 othersConte, A., Spataro, R., La Bella, V., Caponnetto, C., Mancardi, G., Mandich, P., Sola, P., Mandrioli, J., Renton, A. E., Majounie, E., Abramzon, Y., Marrosu, F., Marrosu, M. G., Murru, M. R., Sotgiu, M. A., Pugliatti, M., Rodolico, C., Moglia, C., Calvo, A., Ossola, I., Brunetti, M., Traynor, B. J., Borghero, G., Restagno, G., Chiò, A., Cammarosano, S., Fuda, G., Antonio Canosa, C., Gallo, S., Papetti, L., Pharm.D., Pinter, G. L., Luigetti, M., Lattante, S., Marangi, G., Colletti, T., Ricci, C., Origone, P., Floris, G., Cannas, A., Piras, V., Costantino, E., Pani, C., Parish, L. D., Cossu, P., Solinas, G., Ulgheri, L., Ticca, A., Izzo, F., Laiola, A., Trojsi, F., Portaro, S. & Sproviero, W., Aug 2012, In: Neurobiology of Aging. 33, 8, p. e15-e20

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic lateral sclerosis 1 100%
  • Italy 71%
  • Frontotemporal Dementia 70%
  • Amyotrophic Lateral Sclerosis 40%
  • Population 29%
  70 Scopus citations

• Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72

  Chiò, A., Borghero, G., Restagno, G., Mora, G., Drepper, C., Traynor, B. J., Sendtner, M., Brunetti, M., Ossola, I., Calvo, A., Pugliatti, M., Sotgiu, M. A., Murru, M. R., Marrosu, M. G., Marrosu, F., Marinou, K., Mandrioli, J., Sola, P., Caponnetto, C., Mancardi, G., & 48 othersMandich, P., La Bella, V., Spataro, R., Conte, A., Monsurrò, M. R., Tedeschi, G., Pisano, F., Bartolomei, I., Salvi, F., Lauria Pinter, G., Simone, I., Logroscino, G., Gambardella, A., Quattrone, A., Lunetta, C., Volanti, P., Zollino, M., Penco, S., Battistini, S., Renton, A. E., Majounie, E., Abramzon, Y., Conforti, F. L., Giannini, F., Corbo, M., Sabatelli, M., Moglia, C., Cammarosano, S., Fuda, G., Canosa, A., Gallo, S., Papetti, L., Luigetti, M., Lattante, S., Marangi, G., Colletti, T., Ricci, C., Origone, P., Floris, G., Cannas, A., Piras, V., Parish, L. D., Solinas, G., Ulgheri, L., Ticca, A., Izzo, F., Laiola, A. & Trojsi, F., Mar 2012, In: Brain. 135, 3, p. 784-793 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic lateral sclerosis 1 100%
  • Mutation 41%
  • Frontotemporal Dementia 35%
  • Pedigree 30%
  • Frontotemporal Dementia With Motor Neuron Disease 28%
  170 Scopus citations

• Extensive genetics of ALS: A population-based study in Italy

  Chio, A., Calvo, A., Mazzini, L., Cantello, R., Mora, G., Moglia, C., Corrado, L., D'Alfonso, S., Majounie, E., Renton, A., Pisano, F., Ossola, I., Brunetti, M., Traynor, B. J. & Restagno, G., 6 Nov 2012, In: Neurology. 79, 19, p. 1983-1989 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Italy 88%
  • Mutation 52%
  • Frontotemporal Dementia With Motor Neuron Disease 47%
  • Frontotemporal Dementia 38%
  130 Scopus citations

• Familial Lund frontotemporal dementia caused by C9ORF72 hexanucleotide expansion

  Englund, E., Gustafson, L., Passant, U., Majounie, E., Renton, A. E., Traynor, B. J., Rohrer, J. D., Mok, K. & Hardy, J., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1850.e13-1850.e16

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Dementia 100%
  • Chromosomes, Human, Pair 9 53%
  • Pedigree 43%
  13 Scopus citations

• Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study

  The ITALSGEN Consortium, The Chromosome 9-ALS/FTD Consortium & The French research network on FTLD/FTLD-ALS, 1 Apr 2012, In: The Lancet Neurology. 11, 4, p. 323-330 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Amyotrophic lateral sclerosis 1 82%
  • Frontotemporal Dementia 64%
  • Cross-Sectional Studies 60%
  • Haplotypes 29%
  891 Scopus citations

• Large C9orf72 repeat expansions are not a common cause of Parkinson's disease

  Majounie, E., Abramzon, Y., Renton, A. E., Keller, M. F., Traynor, B. J. & Singleton, A. B., Oct 2012, In: Neurobiology of Aging. 33, 10, p. e1-e2

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Neurodegenerative Diseases 56%
  • Parkinson Disease 54%
  36 Scopus citations

• Repeat expansion in C9ORF72 in Alzheimer's disease

  Majounie, E., Abramzon, Y., Renton, A. E., Perry, R., Bassett, S. S., Pletnikova, O., Troncoso, J. C., Hardy, J., Singleton, A. B. & Traynor, B. J., 19 Jan 2012, In: New England Journal of Medicine. 366, 3, p. 283-284 2 p.

  Research output: Contribution to journal › Letter › peer-review
  144 Scopus citations

• The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients

  Collins, M., Riascos, D., Kovalik, T., An, J., Krupa, K., Krupa, K., Hood, B. L., Conrads, T. P., Renton, A. E., Traynor, B. J. & Bowser, R., Nov 2012, In: Acta Neuropathologica. 124, 5, p. 717-732 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Lobar Degeneration 100%
  • RNA-Binding Motifs 99%
  • Inclusion Bodies 82%
  • DNA-Binding Proteins 79%
  • Amyotrophic Lateral Sclerosis 76%
  59 Scopus citations
• 2011

  A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

  Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A. M., Kaganovich, A., Scholz, S. W., Duckworth, J., Ding, J., Harmer, D. W., Hernandez, D. G., & 56 othersJohnson, J. O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R. J., Orrell, R. W., Neal, J., Murray, A., Pearson, J., Jansen, I. E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J. B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M. A., Peuralinna, T., Jansson, L., Isoviita, V. M., Kaivorinne, A. L., Hölttä-Vuori, M., Ikonen, E., Sulkava, R., Benatar, M., Wuu, J., Chiò, A., Restagno, G., Borghero, G., Sabatelli, M., Heckerman, D., Rogaeva, E., Zinman, L., Rothstein, J. D., Sendtner, M., Drepper, C., Eichler, E. E., Alkan, C., Abdullaev, Z., Pack, S. D., Dutra, A., Pak, E., Hardy, J., Singleton, A., Williams, N. M., Heutink, P., Pickering-Brown, S., Morris, H. R., Tienari, P. J. & Traynor, B. J., 20 Oct 2011, In: Neuron. 72, 2, p. 257-268 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Haplotypes 60%
  • Neurodegenerative Diseases 56%
  • Chromosomes 51%
  • Dominant Genes 45%
  3260 Scopus citations

• LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: A morphological and quantitative study

  Sharma, S., Bandopadhyay, R., Lashley, T., Renton, A. E. M., Kingsbury, A. E., Kumaran, R., Kallis, C., Vilariño-Güell, C., O'Sullivan, S. S., Lees, A. J., Revesz, T., Wood, N. W. & Holton, J. L., Dec 2011, In: Neuropathology and Applied Neurobiology. 37, 7, p. 777-790 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucine 100%
  • Parkinson Disease 81%
  • Phosphotransferases 75%
  • Messenger RNA 27%
  • Brain 10%
  40 Scopus citations

• PINK1 cleavage at position A103 by the mitochondrial protease PARL

  Deas, E., Plun-Favreau, H., Gandhi, S., Desmond, H., Kjaer, S., Loh, S. H. Y., Renton, A. E. M., Harvey, R. J., Whitworth, A. J., Martins, L. M., Abramov, A. Y. & Wood, N. W., Mar 2011, In: Human Molecular Genetics. 20, 5, p. 867-879 13 p., ddq526.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • A 103 100%
  • Presenilins 75%
  • Peptide Hydrolases 43%
  • Phosphotransferases 40%
  • Proteins 19%
  330 Scopus citations
• 2009

  Differential DJ-1 gene expression in Parkinson's disease

  Kumaran, R., Vandrovcova, J., Luk, C., Sharma, S., Renton, A., Wood, N. W., Hardy, J. A., Lees, A. J. & Bandopadhyay, R., Nov 2009, In: Neurobiology of Disease. 36, 2, p. 393-400 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Parkinson Disease 100%
  • Gene Expression 71%
  • Frontal Lobe 56%
  • Putamen 44%
  • Protein Deglycase DJ-1 33%
  41 Scopus citations

• Genetic variants of the α-synuclein gene SNCA are associated with multiple system atrophy

  Al-Chalabi, A., Dürr, A., Wood, N. W., Parkinson, M. H., Camuzat, A., Hulot, J. S., Morrison, K. E., Renton, A., Sussmuth, S. D., Landwehrmeyer, B. G., Ludolph, A., Agid, Y., Brice, A., Leigh, P. N. & Bensimon, G., 22 Sep 2009, In: PLoS ONE. 4, 9, e7114.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Multiple System Atrophy 87%
  • Single Nucleotide Polymorphism 34%
  • Genes 26%
  • Haplotypes 15%
  130 Scopus citations

• Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

  Moisoi, N., Klupsch, K., Fedele, V., East, P., Sharma, S., Renton, A., Plun-Favreau, H., Edwards, R. E., Teismann, P., Esposti, M. D., Morrison, A. D., Wood, N. W., Downward, J. & Martins, L. M., 2009, In: Cell Death and Differentiation. 16, 3, p. 449-464 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondria 100%
  • Brain 89%
  • Transcription Factor CHOP 88%
  • Protein Unfolding 82%
  • Serine Proteases 68%
  145 Scopus citations
• 2003

  Hypoxia induces p53 through a pathway distinct from most DNA-damaging and stress-inducing agents

  Renton, A., Llanos, S. & Lu, X., 2003, In: Carcinogenesis. 24, 7, p. 1177-1182 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Caffeine 100%
  • Hypoxia 75%
  • DNA 53%
  • leucylleucine 32%
  • leptomycin B 29%
  18 Scopus citations