Ronald M. Loeb Center for Alzheimer’s Disease

Projects

Projects per year 1984 2011 2014 2016 2017 2018 2019 2020 2021 2027

• 99 Active
• 218 Finished

Projects per year

Search results

• Finished

  Transcriptional Control of Neuroinflammation in Alzheimer's Disease

  Zhou, M., Cai, D. & Cai, D.

  National Institute on Aging

  15/06/21 → 28/02/23

  Project: Research

  • Th17 Cells 100%
  • Microglia 69%
  • Alzheimer Disease 56%
  • Interleukin-18 47%
  • Immunologic Factors 44%

• The Role of Myeloid Cells in Parkinson's Disease

  Raj, T.

  National Institute of Neurological Disorders and Stroke

  1/04/21 → 31/03/22

  Project: Research

  • Microglia 100%
  • Transcriptome 90%
  • Myeloid Cells 88%
  • Monocytes 81%
  • Parkinson Disease 61%

• A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia

  Elahi, F.

  U.S. Department of Veterans Affairs

  1/01/21 → 21/12/21

  Project: Research

  • Neurodegenerative Diseases 100%
  • Vascular Dementia 93%
  • Precision Medicine 93%
  • Veterans 59%
  • Data Science 53%

• Identifying genetic and transcriptomic drivers of Parkinson's disease progression

  Raj, T.

  National Institute of Neurological Disorders and Stroke

  30/09/20 → 31/08/21

  Project: Research

  • Biomarkers 100%
  • Genes 38%
  • Immune system 24%
  • Gene expression 21%
  • Genomics 20%

• Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M. & Gandy, S.

  National Institute on Aging

  15/09/20 → 31/08/21

  Project: Research

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 66%
  • Alzheimer Disease 57%
  • Amyloidosis 32%
  • Insulin 30%

• Determining neuroprotective autophagy functions using different types of human neurons

  Yue, Z. & Yang, N.

  National Institute on Aging

  15/09/20 → 31/08/22

  Project: Research

  • Autophagy 100%
  • Synucleins 54%
  • Neurons 53%
  • Dementia 36%
  • Lewy Body Disease 27%

• Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease

  McAlpine, C.

  National Heart, Lung, and Blood Institute

  1/05/20 → 30/04/21

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Sleep 71%
  • Cardiovascular Diseases 43%
  • Hematopoiesis 35%
  • Sleep Deprivation 30%

• Cellular and molecular mechanisms of brain dysfunction in NF1

  Yang, N. N. & Yang, N.

  National Institute of Neurological Disorders and Stroke

  15/04/20 → 31/01/21

  Project: Research

  • Neurofibromatosis 1 100%
  • National Institute of Neurological Disorders and Stroke (U.S.) 90%
  • Brain 80%
  • Neurofibromin 1 62%
  • Nervous System 50%

• Genetics and Genomics Core

  Goate, A.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • Genome-Wide Association Study 100%
  • Genomics 96%
  • Exome 76%
  • Apolipoproteins E 67%
  • Biomarkers 41%

• Research Education Component

  Robakis, N.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • education 100%
  • Career development 91%
  • trainee 81%
  • dementia 53%
  • grant 44%

• Administrative Core

  Sano, M.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • dementia 100%
  • director 27%
  • Schools of medicine 25%
  • leadership 21%
  • leader 21%

• The impact of Alzheimer's disease susceptibility alleles on microglia transcriptome

  Raj, T. & De Witte, L. D.

  National Institute on Aging

  1/03/20 → 28/02/22

  Project: Research

  • Microglia 100%
  • Alzheimer Disease 82%
  • Disease Susceptibility 81%
  • Transcriptome 73%
  • Alleles 53%

• Construction of an integrated immune - vascular brain - chip as a platform for the study, drug screening, and treatments of Alzheimer's disease

  Tsai, L. H., Blanchard, J. & Kellis, M.

  National Institute of Neurological Disorders and Stroke

  20/09/19 → 31/05/21

  Project: Research

  • Preclinical Drug Evaluations 100%
  • Alzheimer Disease 94%
  • Blood Vessels 51%
  • Brain 48%
  • Cerebral Amyloid Angiopathy 38%

• Neuroimmune modulation of neuronal function during cocaine conditioning

  Shuman, T. & Kiraly, D.

  National Institute on Drug Abuse

  15/09/19 → 31/08/21

  Project: Research

  • Granulocyte Colony-Stimulating Factor 100%
  • Cocaine 93%
  • Microglia 67%
  • Nucleus Accumbens 43%
  • Granulocyte Colony-Stimulating Factor Receptors 41%

• Characterization of protective roles of ApoE2 against aging and Alzheimer's disease

  Cai, D., LaDu, M. J. & Zhang, B.

  National Institute on Aging

  15/09/19 → 31/08/21

  Project: Research

  • Apolipoprotein E2 100%
  • Alzheimer Disease 93%
  • Brain 49%
  • Datasets 40%
  • Gene Frequency 37%

• The Role of Alternative Splicing in Neurodegeneration

  Raj, T.

  National Institute on Aging

  15/09/19 → 31/08/21

  Project: Research

  • Alzheimer Disease 100%
  • Alternative Splicing 85%
  • RNA-Binding Proteins 49%
  • Brain 35%
  • Antisense Oligonucleotides 33%

• Interneuron and Network Synchrony in Alzheimer's Disease

  Shuman, T.

  National Institute of Neurological Disorders and Stroke

  15/08/19 → 31/07/21

  Project: Research

  • Interneurons 100%
  • Alzheimer Disease 74%
  • Memory 37%
  • Dentate Gyrus 15%
  • Cognitive Dysfunction 11%

• IDENTIFYING BIO-SIGNATURES OF SUICIDAL SUBTYPES IN VETERANS

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/07/19 → 30/06/22

  Project: Research

• IDENTIFYING BIO-SIGNATURES OF SUICIDAL SUBTYPES IN VETERANS

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/07/19 → 30/06/21

  Project: Research

  • Veterans 100%
  • Psychological Power 30%
  • Self Report 28%
  • Longitudinal Studies 26%
  • Mental Disorders 26%

• Generation and characterization of MGE-derived GABAergic neurons from human pluripotent stem cells

  Yang, N.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/04/19 → 31/01/21

  Project: Research

  • Median Eminence 100%
  • GABAergic Neurons 93%
  • Pluripotent Stem Cells 91%
  • Interneurons 68%
  • Parvalbumins 35%

• Machine Learning of Genetic, Clinical and Environmental Data for Early Morbidity Detection in the UK Biobank.

  O'Reilly, P. & Sharapova, N. N.

  Medical Research Council

  1/10/18 → 30/06/22

  Project: Research

  • Machine learning 100%
  • Genetics 91%
  • Biomarkers 85%
  • Students 75%
  • Statistical Models 61%

• LARGE-SCALE TRANSCRIPTOME AND EPIGENOME ASSOCIATION ANALYSIS ACROSS MULTIPLE TRAITS

  Roussos, P.

  U.S. Department of Veterans Affairs

  1/10/18 → 30/09/20

  Project: Research

  • Epigenome 100%
  • Veterans 74%
  • Transcriptome 51%
  • Genome 49%
  • Multifactorial Inheritance 22%

• LARGE-SCALE TRANSCRIPTOME AND EPIGENOME ASSOCIATION ANALYSIS ACROSS MULTIPLE TRAITS

  Roussos, P.

  U.S. Department of Veterans Affairs

  1/10/18 → 31/03/21

  Project: Research

• Development of novel therapeutics for opioid dependence

  Kenny, P. & Kamenecka, T. M.

  National Institute on Drug Abuse

  30/09/18 → 31/08/20

  Project: Research

  • Opioid-Related Disorders 100%
  • Opioid Analgesics 95%
  • Habenula 64%
  • Oxycodone 62%
  • Structure-Activity Relationship 36%

• Neural mechanisms for VGF regulation of energy balance

  Salton, S., Bartolomucci, A. & Buettner, C.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/09/18 → 30/06/22

  Project: Research

  • Hypothalamus 100%
  • Lipolysis 78%
  • VGF peptide 77%
  • Energy Metabolism 60%
  • TLQP-21 peptide 59%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C. & Swirski, F.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/12/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/08/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• Brain Circuit Mechanisms in Sleep Stage Specific Processing of Memory

  Varga, A.

  National Institute on Aging

  15/07/18 → 31/03/21

  Project: Research

  • REM Sleep 100%
  • Slow-Wave Sleep 93%
  • Sleep Stages 80%
  • Obstructive Sleep Apnea 79%
  • Sleep 70%

• Parallel Multimodal High-throughput screening to identify activators of the orexin receptors

  Kamenecka, T. M., Kenny, P., Scampavia, L. D., Kamenecka, T. T. M., Scampavia, L. L. D. & Kenny, P. P. J.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  5/07/18 → 30/09/22

  Project: Research

  • Orexin Receptors 100%
  • Orexins 84%
  • Orexin Receptor Antagonists 26%
  • suvorexant 14%
  • Pharmaceutical Chemistry 11%

• Plasma Protein-mediated Effects of ApoE4 Expression on Brain in AD

  Castellano, J.

  BrightFocus Foundation

  1/07/18 → 30/06/21

  Project: Research

  • Apolipoprotein E4 100%
  • Alzheimer Disease 91%
  • Blood Proteins 78%
  • Brain 57%
  • Neurons 42%

• Meeting: Developing a Global Inventory of Brain Initiatives

  Hale, M. M. E. & Hof, P.

  National Science Foundation

  1/05/18 → 30/04/19

  Project: Research

  • brain 100%
  • scientific community 14%
  • neurosciences 14%
  • brain research 10%
  • international communication 9%

• Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey

  Luebke, J. J. I., Hof, P. R., Luebke, J. I. & Hof, P.

  National Institute on Aging

  1/04/18 → 31/01/23

  Project: Research

  • Macaca mulatta 100%
  • Cognitive Dysfunction 78%
  • Neuroglia 60%
  • Brain 58%
  • Neurons 58%

• Glutamatergic Dysfunction in Cognitive Aging: Riluzole in Mild Cognitive Impairment - Expansion to an additional clinical site

  Pereira, A.

  ALZHEIMER'S DRUG DISCOVERY FOUNDATION

  1/03/18 → 1/09/20

  Project: Research

• NEUROINFLAMMATORY AND EPIGENETIC MECHANISMS OF BLOOD-BRAIN BARRIER COMPROMISE IN SUICIDE

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/01/18 → 30/09/22

  Project: Research

• SHEEP REQUEST FOR AN AGILENT 9470 TRIPLE QUADRUPOLE LC/MS DETECTION SYSTEM WITH JET STREAM TECHNOLOGY

  Cai, D.

  U.S. Department of Veterans Affairs

  1/01/18 → 30/09/18

  Project: Research

  • Lipids 100%
  • Lipidomics 83%
  • Sheep 82%
  • Technology 79%
  • Dermatoglyphics 71%

• NEUROINFLAMMATORY AND EPIGENETIC MECHANISMS OF BLOOD-BRAIN BARRIER COMPROMISE IN SUICIDE

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/01/18 → 31/12/21

  Project: Research

  • Suicide 100%
  • Blood-Brain Barrier 67%
  • Epigenomics 50%
  • Microglia 32%
  • Veterans 25%

• NEUROINFLAMMATORY AND EPIGENETIC MECHANISMS OF BLOOD-BRAIN BARRIER COMPROMISE IN SUICIDE

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/01/18 → 31/12/21

  Project: Research

  • Suicide 100%
  • Blood-Brain Barrier 67%
  • Epigenomics 50%
  • Microglia 32%
  • Veterans 25%

• ShEEP Request for an Agilent 9470 Triple Quadrupole LC/MS Detection System with Jet Stream Technology

  Cai, D.

  U.S. Department of Veterans Affairs

  1/01/18 → 30/09/18

  Project: Research

  • Lipidomics 100%
  • Lipids 72%
  • Metabolomics 60%
  • Technology 53%
  • Dermatoglyphics 42%

• NOVEL SMALL MOLECULES TARGETING BRAIN PHOSPHOLIPID DYSREGULATION IN AD

  Cai, D.

  U.S. Department of Veterans Affairs

  1/12/17 → 30/11/21

  Project: Research

  • synaptojanin 100%
  • Alzheimer Disease 81%
  • Phospholipids 49%
  • Apolipoprotein E4 46%
  • Nimodipine 29%

• NOVEL SMALL MOLECULES TARGETING BRAIN PHOSPHOLIPID DYSREGULATION IN AD

  Cai, D.

  U.S. Department of Veterans Affairs

  1/12/17 → 30/11/21

  Project: Research

  • synaptojanin 100%
  • Alzheimer Disease 81%
  • Phospholipids 49%
  • Apolipoprotein E4 46%
  • Nimodipine 29%

• NOVEL SMALL MOLECULES TARGETING BRAIN PHOSPHOLIPID DYSREGULATION IN AD

  Cai, D.

  U.S. Department of Veterans Affairs

  1/12/17 → 30/11/21

  Project: Research

• Regulation of hippocampal plasticity and learning and memory by a bloodborne rejuvenation factor

  Castellano, J.

  National Institute on Aging

  30/09/17 → 30/04/20

  Project: Research

  • Rejuvenation 100%
  • Learning 57%
  • Memory 57%
  • Transcription Factor AP-1 36%
  • Cognitive Dysfunction 35%

• Integrated understanding of complex viral network biology in Alzheimer's Disease

  Dudley, J., Ehrlich, M. & Gandy, S.

  National Institute on Aging

  15/09/17 → 28/02/19

  Project: Research

  • Alzheimer Disease 100%
  • Neuropathology 24%
  • CYS2-HIS2 Zinc Fingers 23%
  • Molecular Pathology 16%
  • Viruses 14%

• Role of slow waves and sleep apnea in memory and risk for Alzheimer disease

  Varga, A.

  National Institute on Aging

  15/08/17 → 31/05/18

  Project: Research

  • Slow-Wave Sleep 100%
  • Obstructive Sleep Apnea 87%
  • Sleep Apnea Syndromes 79%
  • Continuous Positive Airway Pressure 78%
  • Alzheimer Disease 61%

• MicroRNAs in schizophrenia

  Kenny, P.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  21/07/17 → 30/04/22

  Project: Research

  • Parvalbumins 100%
  • Interneurons 77%
  • MicroRNAs 64%
  • Schizophrenia 54%
  • Mouse Mirn206 microRNA 23%

• MICRORNA REGULATION OF PHOSPHOLIPID HOMEOSTASIS IN ALZHEIMER'S DISEASE PATHOGENESIS

  Cai, D.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Apolipoprotein E4 100%
  • MicroRNAs 44%
  • Phospholipids 42%
  • Homeostasis 33%
  • Alzheimer Disease 29%

• MICRORNA REGULATION OF PHOSPHOLIPID HOMEOSTASIS IN ALZHEIMER'S DISEASE PATHOGENESIS

  Cai, D.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

• MICRORNA REGULATION OF PHOSPHOLIPID HOMEOSTASIS IN ALZHEIMER'S DISEASE PATHOGENESIS

  Cai, D.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Apolipoprotein E4 100%
  • MicroRNAs 44%
  • Phospholipids 42%
  • Homeostasis 33%
  • Alzheimer Disease 29%

• MICRORNA REGULATION OF PHOSPHOLIPID HOMEOSTASIS IN ALZHEIMER'S DISEASE PATHOGENESIS

  Cai, D.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Apolipoprotein E4 100%
  • MicroRNAs 44%
  • Phospholipids 42%
  • Homeostasis 33%
  • Alzheimer Disease 29%

• Understanding the Role of Apolipoprotein E in Microglia

  Young, J. J., Jayadev, S. S., Marcora, E., Schaefer, A. & Goate, A.

  BrightFocus Foundation

  1/07/17 → 30/06/21

  Project: Research

  • Apolipoproteins E 100%
  • Microglia 95%
  • Alzheimer Disease 76%
  • Brain 28%
  • Human Genetics 23%