Ronald M. Loeb Center for Alzheimer’s Disease

96 Active
214 Finished

Profiling and Elucidating Molecular Mechanism of Neurodegeneration in Parki
Yue, Z. Z., Yang, N. N., Crary, J., Wu, Z. Z., Blanchard, J. J. & Zhang, B. B.
Parkinson's Foundation
30/06/22 → 30/06/26
Project: Research
Entorhinal-hippocampal interactions during progressive memory impairments in mouse models of Alzheimer's disease pathology
Shuman, T.
National Institute on Aging
1/06/22 → 31/05/25
Project: Research
Dissect regulation of glial nets surrounding amyloid plaques in Alzheimer's disease
Friedel, R., Wang, M. & Zou, H.
National Institute on Aging
5/05/22 → 30/04/25
Project: Research
Identifying DNA Methylation Alterations of Chronic Effects Of Blast and Disturbed Sleep
Haghighi, F.
U.S. Department of Veterans Affairs
1/04/22 → 31/03/23
Project: Research
2022 Neurobiology of Brain Disorders GRC and GRS
Goate, A.
National Institute on Aging
1/04/22 → 31/03/23
Project: Research
Neuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's disease
Goate, A., Schaefer, A. & Schaefer, A. A.
National Institute on Aging
1/02/22 → 30/11/23
Project: Research
Amyloid ß and EAAT2 mediated network hyperexcitability and tau propagation
Pereira, A.
Alzheimer's Association
1/01/22 → …
Project: Research
SYSTEMS INTEGRATION AND THERAPEUTICS TRANSLATION IN ALZHEIMER'S DISEASE
Goate, A. & Marcora, E.
Cure Alzheimer's Fund
1/01/22 → …
Project: Research
Immune response to tau pathology and impact of sleep augmentation
Varga, A.
Alzheimer's Association
1/01/22 → …
Project: Research
SYSTEMS INTEGRATION AND THERAPEUTICS TRANSLATION IN ALZHEIMER'S DISEASE
Goate, A. & Marcora, E.
Cure Alzheimer's Fund
1/01/22 → …
Project: Research
MICROGLIAL-SPECIFIC INPP5D KNOCKDOWN MODULATES BEHAVIOR, AMYLOIDOSIS AND TAUOPATHY IN ALZHEIMER'S MOUSE MODELS
Gandy, S. & Ehrlich, M.
Cure Alzheimer's Fund
1/01/22 → …
Project: Research
Dissect the interplay between sex and APOE at the single cell level to uncover novel pathways, targets and therapeutics for Alzheimer's disease
Zhang, B. B. & Cai, D.
National Institute on Aging
30/09/21 → 31/08/24
Project: Research

199902 Citations
205 h-index
2147 Article
250 Review article
118 Comment/debate
72 Chapter
More

A single closed head injury in male adult mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes
Havlicek, D. F., Furhang, R., Nikulina, E., Smith-Salzberg, B., Lawless, S., Severin, S. A., Mallaboeva, S., Nayab, F., Seifert, A. C., Crary, J. F. & Bergold, P. J., Jan 2023, In: Experimental Neurology. 359, 114241.
Research output: Contribution to journal › Article › peer-review
DDX3X Syndrome: Summary of Findings and Recommendations for Evaluation and Care
Levy, T., Siper, P. M., Lerman, B., Halpern, D., Zweifach, J., Belani, P., Thurm, A., Kleefstra, T., Berry-Kravis, E., Buxbaum, J. D. & Grice, D. E., Jan 2023, In: Pediatric Neurology. 138, p. 87-94 8 p.
Research output: Contribution to journal › Review article › peer-review
Ensemble-specific deficit in neuronal intrinsic excitability in aged mice
Chen, L., Francisco, T. R., Baggetta, A. M., Zaki, Y., Ramirez, S., Clem, R. L., Shuman, T. & Cai, D. J., Mar 2023, In: Neurobiology of Aging. 123, p. 92-97 6 p.
Research output: Contribution to journal › Article › peer-review
Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome
the Developmental Synaptopathies Consortium, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100145.
Research output: Contribution to journal › Article › peer-review

Open Access
Smaller rostral cingulate volume and psychosocial correlates in veterans at risk for suicide
Goldstein, K. E., Feinberg, A., Vaccaro, D. H., Ahmed, T., Chu, K. W., Goodman, M., Govindarajulu, U., Challman, K. N., Haghighi, F., Yehuda, R., Szeszko, P. R., Osterberg, T., Tang, C. Y., Haznedar, M. M. & Hazlett, E. A., Feb 2023, In: Psychiatry Research. 320, 115032.
Research output: Contribution to journal › Article › peer-review
Somatic comorbidities of mental disorders in pregnancy
Khachadourian, V., Kodesh, A., Levine, S. Z., Lin, E., Buxbaum, J. D., Bergink, V., Sandin, S., Reichenberg, A. & Janecka, M., 2023, (Accepted/In press) In: European Psychiatry.
Research output: Contribution to journal › Article › peer-review

Open Access
World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation
Huang, C., Kritikos, M., Sosa, M. S., Hagan, T., Domkan, A., Meliker, J., Pellecchia, A. C., Santiago-Michels, S., Carr, M. A., Kotov, R., Horton, M., Gandy, S., Sano, M., Bromet, E. J., Lucchini, R. G., Clouston, S. A. P. & Luft, B. J., Jan 2023, In: Molecular Neurobiology. 60, 1, p. 160-170 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes
International Parkinson’s Disease Genomics Consortium (IPDGC), Dec 2022, In: Molecular Neurodegeneration. 17, 1, 48.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy
Pesce, L., Scardigli, M., Gavryusev, V., Laurino, A., Mazzamuto, G., Brady, N., Sancataldo, G., Silvestri, L., Destrieux, C., Hof, P. R., Costantini, I. & Pavone, F. S., Dec 2022, In: Communications Biology. 5, 1, 447.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning
Hafez, A. K., Zimmerman, A. J., Papageorgiou, G., Chandrasekaran, J., Amoah, S. K., Lin, R., Lozano, E., Pierotti, C., Dell'Orco, M., Hartley, B. J., Alural, B., Lalonde, J., Esposito, J. M., Berretta, S., Squassina, A., Chillotti, C., Voloudakis, G., Shao, Z., Fullard, J. F., Brennand, K. J., & 7 othersTurecki, G., Roussos, P., Perlis, R. H., Haggarty, S. J., Perrone-Bizzozero, N., Brigman, J. L. & Mellios, N., 18 Jan 2022, In: Cell Reports. 38, 3, 110282.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
A complete temporal transcription factor series in the fly visual system
Konstantinides, N., Holguera, I., Rossi, A. M., Escobar, A., Dudragne, L., Chen, Y. C., Tran, T. N., Martínez Jaimes, A. M., Özel, M. N., Simon, F., Shao, Z., Tsankova, N. M., Fullard, J. F., Walldorf, U., Roussos, P. & Desplan, C., 14 Apr 2022, In: Nature. 604, 7905, p. 316-322 7 p.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations
Acute OSA Impacts Diurnal Alzheimer's Biomarkers through Nocturnal Hypoxemia and State Transitions
Kam, K., Jun, J., Parekh, A., Bubu, O. M., Mullins, A. E., Gu, C., Pham, L., Wisniewski, T. M., Rapoport, D. M., Ayappa, I., Osorio, R. S. & Varga, A. W., 15 Oct 2022, In: American Journal of Respiratory and Critical Care Medicine. 206, 8, p. 1039-1042 4 p.
Research output: Contribution to journal › Letter › peer-review

Study Data from Research and Development Service Provide New Insights into Post-Traumatic Stress Disorders (Progressive Transcriptional Changes In the Amygdala Implicate Neuroinflammation In the Effects of Repetitive Low-level Blast Exposure In ...)
Patrick Hof & Gregory Elder
1/02/23
1 item of Media coverage
Press/Media
Study Results from Washington University Update Understanding of Alzheimer Disease (Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease)
Yan Li & Alison Goate
31/01/23
1 item of Media coverage
Press/Media
Katie Taylor vs. Amanda Serrano fight reignites debate around 2-minute rounds in women's boxing
Patrick Hof
31/01/23
3 items of Media coverage
Press/Media
New Alzheimer's drug appears to slow progression of disease
Mary Sano
30/01/23
1 item of Media coverage
Press/Media
Initial Symptoms Could Predict How Fast Alzheimer's Progresses
Mary Sano & David Reich
25/01/23 → 27/01/23
104 items of Media coverage
Press/Media
Alarm Bells Ring for Great Hammerheads After Scientists Sequence the Genomes of Endangered Sharks
Minghui Wang
23/01/23
2 items of Media coverage
Press/Media
University of Zagreb School of Medicine Researchers Add New Study Findings to Research in Alzheimer Disease (Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease)
Patrick Hof
23/01/23
1 item of Media coverage
Press/Media
New Amyotrophic Lateral Sclerosis Study Findings Have Been Reported from Icahn School of Medicine at Mount Sinai (Integrative Transcriptomic Analysis of the Amyotrophic Lateral Sclerosis Spinal Cord Implicates Glial Activation and Suggests New ...)
Jack Humphrey, Sanan Venkatesh & Towfique Raj
23/01/23
1 item of Media coverage
Press/Media
Alzheimer's risk gene undermines insulation of brain's 'wiring'.
Joel Blanchard
18/01/23
1 item of Media coverage
Press/Media
New Findings Reported from Icahn School of Medicine at Mount Sinai Describe Advances in Alzheimer Disease [Dual-specificity Protein Phosphatase 4 (Dusp4) Overexpression Improves Learning Behavior Selectively In Female 5xfad Mice, and Reduces ...]
Noam Beckmann, Mickael Audrain, Qian Wang, Eric Schadt, Minghui Wang, Michelle Ehrlich, Samuel Gandy & Rajeev Joshi
16/01/23
1 item of Media coverage
Press/Media
University of Zagreb School of Medicine Researchers Discuss Findings in Alzheimer Disease (Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer's Disease)
Patrick Hof
10/01/23
1 item of Media coverage
Press/Media
Bold trial targets Alzheimer's risks
Howard Fillit & Samuel Gandy
8/01/23
1 item of Media coverage
Press/Media