Pharmacological Sciences

Icahn School of Medicine at Mount Sinai

Small Molecule AI Drug Discovery Center
Pharmacological Sciences
Organizational unit: Center

279756 Citations
227 h-index
2356 Article
367 Review article
130 Chapter
129 Comment/debate
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A critical residue mediates proper assembly and gating of GIRK2 channels
Nguyen, H., Mount, J., Hutchinson, K., Zhao, Y., Zhao, Y., Glaaser, I. W., Yuan, P., Schlessinger, A. & Slesinger, P. A., 5 Jan 2026, In: Journal of General Physiology. 158, 1
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR
Yi, Y., Li, Y., Wang, R., Yu, X., Liu, Q., Yum, C., Zhang, Y., Qiao, Y., Szczepanski, A., Wu, S., Li, Q., Fazli, L., Shen, J., Wang, X., Li, X., Mu, P., Schaeffer, E. M., Hundley, H. A., Niu, H. & Chinnaiyan, A. M. & 7 others, Wang, L., Shi, J., Jin, J., Dong, X., Zhao, W., Chen, K. & Cao, Q., Dec 2026, In: Nature Communications. 17, 1, 4421.
Research output: Contribution to journal › Article › peer-review

Open Access
A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
Gelles, J. D., Chen, Y., Luna-Vargas, M. P. A., Viacava Follis, A., Al Noman, M. A., Kabir, M., Bayiokos, S. G., Mohammed, J. N., Sebastian, T. M., Pham, N. D., Shi, Y., Jin, J., Kriwacki, R. W. & Chipuk, J. E., Dec 2026, In: Nature Communications. 17, 1, 3180.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
Xia, Z., Yang, X., Samovich, S. N., Tyurina, Y. Y., Tyurin, V. A., Kon, N., Zhang, J., Jiang, X., Stockwell, B. R., Jin, J., Bayir, H., Kagan, V. E. & Gu, W., 2 Apr 2026, In: Cell. 189, 7, p. 1957-1974.e17
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
A highly promising new avenue for targeting K-RAS: The small-molecule degrader XMU-MP-9
Jin, J., Feb 2026, In: Acta Pharmaceutica Sinica B. 16, 2, p. 1166-1167 2 p.
Research output: Contribution to journal › Editorial

Open Access
Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation
Herrington, N. B., Khamrui, S., Zhao, Y., Lansiquot, C., Wu, R., Pandey, G., Lazarus, M. B. & Schlessinger, A., 17 Jun 2026, In: Journal of the American Chemical Society. 148, 23, p. 24274-24286 13 p.
Research output: Contribution to journal › Article › peer-review
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis
Yashaswini, C. N., Cogliati, B., Qin, T., To, T., Williamson, T., Papp, T. E., Li, K., Rasul, R., Chen, L., Lightstone, A., Aghajanian, H., Parhiz, H., Wang, S., Rurik, J. G., Epstein, J. A. & Friedman, S. L., 21 Jan 2026, In: Science Translational Medicine. 18, 833, eadx0368.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML
Param, N. J., Arceci, E., Fiorentino, F., Pignata, L., Torre, D., Gutiérrez-Trejo, N., Fong, J. Y., Goy, P. A., Han, B. Y., Lambona, C., Bello, E. D., Castiello, C., Barone, M., Schwarz, M., Arrowsmith, C., Ito, K., Scherle, P., Wee, D. K. B., Ndoye, S. & Tabaglio, T. & 9 others, Jeyasekharan, A. D., Lakshmanan, M., Cirilli, R., Habisch, H., Madl, T., Mattevi, A., Valente, S., Mai, A. & Guccione, E., 27 Mar 2026, In: Science advances. 12, 13, eaea4059.
Research output: Contribution to journal › Article › peer-review

Open Access
A tool based on objective data to identify patients at elevated risk of hospital-onset Staphylococcus aureus bacteremia: a nested case–control study
Silvera, R., Jeon, M., Ma’Ayan, A., Aberg, J., Camins, B. & Factor, S. H., 7 Apr 2026, In: Antimicrobial Stewardship and Healthcare Epidemiology. 6, 1, e94.
Research output: Contribution to journal › Article › peer-review

Open Access
Biased Signaling in Psychedelic Action
Wacker, D. & McCorvy, J. D., 2026, In: Annual Review of Pharmacology and Toxicology. 66, 1, p. 241-260 20 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
3 Scopus citations
BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects across Class A GPCRs
Provasi, D., Konovalov, K., Riina, N., Cullen, O. & Filizola, M., 26 Jan 2026, In: Journal of Chemical Information and Modeling. 66, 2, p. 855-866 12 p.
Research output: Contribution to journal › Article › peer-review
BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma
Wei, E., Ji, D., Jia, Y., Sun, Z., Gao, C., Zeng, C., Wang, C., Yu, M., Shang, G., Xie, L., Zhang, W., Li, Y., Liang, Y., Ji, B., Yue, Y., Liu, Y., Zhou, M. M. & Zeng, L., 2026, (Accepted/In press) In: Cell Death and Differentiation.
Research output: Contribution to journal › Article › peer-review
8 Scopus citations

Findings from University of Michigan Broaden Understanding of Acute Myeloid Leukemia (Integrated Proteogenomic and Metabolomic Profiling of Acute Myeloid Leukemias To Identify Molecular Subtypes and Associated Therapy Targets)
Ma’ayan, A.
9/07/26
1 item of Media coverage
Press/Media
UC San Diego Health launches Institute for Applied Health Intelligence to integrate AI into clinical practice
Friedman, S.
8/07/26
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Reports Findings in Alzheimer Disease (SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease)
Chen, T.-Y., Kyprianou, N., Gordon, R., Lee, D., Hoffman, G. & Chen, Y.-B.
8/07/26
1 item of Media coverage
Press/Media
Researchers from Columbia University Report Recent Findings in Chemicals and Chemistry (Biomonitoring of nutritional and toxic elements in raw and cooked rice in the Health Effects of Arsenic Longitudinal Study, Bangladesh)
Sanchez, R.
8/07/26
1 item of Media coverage
Press/Media
Researchers from Institute of Chemical Technology Detail New Studies and Findings in the Area of Cancer Gene Therapy (Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview)
Rojekar, S.
1/07/26
1 item of Media coverage
Press/Media
New Drug Research Findings from Icahn School of Medicine at Mount Sinai Reported (Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolism)
Houten, S., Lazarus, M. & Osman, R.
1/07/26
1 item of Media coverage
Press/Media
Who Is Keiko Fujimori? Peru's New President Wins Election On 4th Attempt
Sanchez, R.
30/06/26
1 item of Media coverage
Press/Media
Keiko Fujimori Wins Peru's Presidency on Razor-Thin Margin
Sanchez, R.
30/06/26
1 item of Media coverage
Press/Media
Milei congratulated Keiko Fujimori on her election victory: "The region wants to return to the path of freedom"
Sanchez, R.
30/06/26
1 item of Media coverage
Press/Media
What did Keiko Fujimori study? Here is the academic and political background of Peru's next president
Sanchez, R.
30/06/26
1 item of Media coverage
Press/Media
Small Molecule Modulators of KSR-bound MEK
Khan, Z. & Dar, A.
30/06/26
1 item of Media coverage
Press/Media
U.S. Patents Awarded to Inventors in New York (June 30)
Thompson, M., Shah, B., Goodman, K., Khan, Z. & Dar, A.
30/06/26
1 item of Media coverage
Press/Media

Pharmacological Sciences

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