Pathology, Molecular and Cell-Based Medicine

Projects

Projects per year 1985 2006 2008 2009 2012 2015 2016 2017 2018 2019 2026

• 29 Active
• 50 Finished

Projects per year

Search results

• Active

  Mechanisms of age-related tauopathy

  Crary, J.

  National Institute of Neurological Disorders and Stroke

  19/09/22 → 31/08/25

  Project: Research

  • Tauopathies 100%
  • Alzheimer Disease 14%
  • Alzheimer's disease without Neurofibrillary tangles 8%
  • Alleles 5%
  • Chromosomes, Human, Pair 4 5%

• Novel artificial intelligence-based approaches to understand the pathological and genetic drivers of primary tauopathies

  Farrell, K.

  National Institute on Aging

  15/09/22 → 31/05/23

  Project: Research

  • Amyloid 100%
  • Pathology 66%
  • Machine learning 64%
  • Artificial intelligence 64%
  • Neuroglia 50%

• Profiling and Elucidating Molecular Mechanism of Neurodegeneration in Parki

  Yue, Z. Z., Yang, N. N., Crary, J., Wu, Z. Z., Blanchard, J. J. & Zhang, B. B.

  Parkinson's Foundation

  30/06/22 → 30/06/26

  Project: Research

  • Dopaminergic Neurons 100%
  • Parkinson Disease 70%
  • Brain 23%
  • Gene Expression 14%
  • Genetic Models 13%

• Determine the Microphthalmia Transcription Factor (MITF)-regulated cell rewiring mechanisms in lethal prostate cancer

  Domingo-Domenech, J. & Domingo-domenech, J. M.

  National Cancer Institute

  1/07/21 → 30/06/23

  Project: Research

  • Microphthalmia-Associated Transcription Factor 100%
  • Prostatic Neoplasms 54%
  • Prostate 13%
  • Neoplasms 13%
  • Castration 8%

• A Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor Immunity

  Greenbaum, B., Ting, D. D. T., Greenbaum, B. & Ting, D. T.

  National Cancer Institute

  15/09/20 → 31/08/23

  Project: Research

  • Physics 100%
  • Immunity 61%
  • RNA 55%
  • Neoplasms 30%
  • Immunotherapy 22%

• The effects of age on tumor dormancy

  Weeraratna, A. A., Celebi, J., Aguirre-ghiso, J. A. J. A. & Smith, K. K.

  Melanoma Research Alliance

  1/01/20 → …

  Project: Research

  • neoplasms 100%
  • dormancy 85%
  • metastasis 69%
  • melanoma 62%

• Role of Nuclear Pore-Regulated Mechanisms in Prostate Cancer Aggressiveness

  Rodriguez-Bravo, V.

  National Cancer Institute

  1/12/19 → 30/11/23

  Project: Research

  • Prostate Cancer, Hereditary, 7 100%
  • Nuclear Pore 85%
  • Nuclear Pore Complex Proteins 55%
  • Prostatic Neoplasms 46%
  • Cell Nucleus Active Transport 20%

• Reverse transcriptase inhibitor effects on the mobilome of colon cancer

  Ting, D. D. T., Greenbaum, B., Greenbaum, B. & Ting, D. T.

  National Cancer Institute

  1/07/19 → 30/06/23

  Project: Research

  • Reverse Transcriptase Inhibitors 100%
  • Lamivudine 77%
  • Colonic Neoplasms 66%
  • RNA 63%
  • Colorectal Neoplasms 60%

• Crosstalk between EGFR and TEAD Activity Directs Migration in Human Glioblastoma

  Tsankova, N. N. M. & Tsankova, N.

  National Institute of Neurological Disorders and Stroke

  15/01/19 → 31/12/23

  Project: Research

  • Glioblastoma 100%
  • Verteporfin 28%
  • Glioma 28%
  • Neoplasms 25%
  • Epigenomics 25%

• The Contribution of Age-Related Taupahtoies to Alzheimer's Disease-Supplement

  Mckee, A. A. C., Crary, J., Dickson, D. D. W., Dickson, D. W., Crary, J. J. F. & McKee, A. C.

  National Institute on Aging

  30/09/18 → 31/05/23

  Project: Research

  • Tauopathies 100%
  • Alzheimer Disease 46%
  • Chronic Traumatic Encephalopathy 31%
  • Neuropathology 13%
  • Cognitive Dysfunction 12%

• Age-related Tauopathy in HIV-associated Neurocognitive Disorders

  Morgello, S. & Crary, J.

  National Institute on Aging

  30/09/18 → 31/03/23

  Project: Research

  • Tauopathies 100%
  • Neurocognitive Disorders 73%
  • HIV 67%
  • Chronic Traumatic Encephalopathy 22%
  • Pathology 14%

• Melanoma Epigenetics and the Functional Role of MacroH2A in Melanoma Progression

  Goldberg, M.

  Dermatology Foundation

  1/01/18 → …

  Project: Research

• Identification of Novel Targetable NPC-Mitotic Regulated Mechanisms in Lethal Prostate Cancer

  Rodriguez-Bravo, V.

  Prostate Cancer Foundation

  1/01/18 → …

  Project: Research

  • Nuclear Pore Complex Proteins 100%
  • Nuclear Pore 92%
  • Prostatic Neoplasms 75%
  • tetrachloroisophthalonitrile 37%
  • Cell Division 32%

• 2018 FRIENDS OF THE AACR FOUNDATION EARLY CAREER INVESTIGATOR AWARD

  Rodriguez-Bravo, V.

  American Association for Cancer Research

  1/01/18 → …

  Project: Research

  • Prostatic Neoplasms 100%
  • Nuclear Pore Complex Proteins 93%
  • Genome 64%
  • Research Personnel 54%
  • tetrachloroisophthalonitrile 52%

• gC1qR/HABP1/p32: A novel therapeutic target for mesothelioma

  Peerschke, E.

  Mesothelioma Applied Research Foundation

  1/01/17 → …

  Project: Research

  • Mesothelioma 100%
  • Antibodies 40%
  • Neoplasms 33%
  • Therapeutics 16%
  • Animal Models 15%

• Ensaio funcional personalizado para terapêutica antineoplásica dirigida

  De Figueiredo Fior Sousa Soares, R. L. A. C. R. L. A. C., Da Silva Pinto Gomes, A. P. A. P., Figueiredo, N. F. L. N. F. L., Costa, B. B., Da Rocha Cardoso, M. M., Ribeiro, J. T. M. L. J. T. M. L., De Carvalho, C. A. T. C. A. T., Castillo-Martin, M., Grau, O. P. I. O. P. I., Ferreira, M. G. M. G. & Mendes, R. R.

  Fundação para a Ciência e a Tecnologia

  1/01/17 → …

  Project: Research

• TOWARDS PREDICTIVE MODELS OF IMMUNOTHERAPY RESPONSE

  Wolchok, J. D. J. D. & Greenbaum, B.

  American Association for Cancer Research

  1/05/16 → …

  Project: Research

  • Immunotherapy 100%
  • Neoplasms 16%
  • Mutation 14%

• Neuropathological characterization of primary age-related tauopathy

  Crary, J.

  Alzheimer's Association

  1/01/15 → …

  Project: Research

  • Tauopathies 100%
  • tau Proteins 73%
  • Alzheimer Disease 45%
  • Brain 43%
  • Neurons 36%

• Liberating the Immunologic Response to Pancreatic Cancer

  Greenbaum, B. & Solovyov, A.

  V Foundation for Cancer Research

  1/01/15 → …

  Project: Research

  • Pancreatic Neoplasms 100%
  • Cause of Death 46%
  • Neoplasms 24%
  • Cellular Immunity 18%
  • Adenocarcinoma 15%

• Novel Targeted Therapies for Inflammatory Breast Cancer

  Silva, J.

  Congressionally Directed Medical Research Programs

  1/01/15 → …

  Project: Research

  • Histone Deacetylase 6 100%
  • Inflammatory Breast Neoplasms 54%
  • ricolinostat 12%
  • Breast Neoplasms 11%
  • Therapeutics 10%

• Therapeutic modulation of repeat RNAs

  Greenbaum, B. & Solovyov, A.

  V Foundation for Cancer Research

  1/01/15 → …

  Project: Research

  • RNA 100%
  • Tumor Microenvironment 74%
  • Direction compound 52%
  • Neoplasms 46%
  • Untranslated RNA 40%

• Molecular & Genetic Investigation of Tau in Chronic Traumatic Encephalopathy

  Crary, J.

  Congressionally Directed Medical Research Programs

  1/01/13 → …

  Project: Research

• MicroRNA Regulation of MAPT in Alzheimer’s disease, Limbic Type

  Crary, J.

  Alzheimer's Association

  1/01/11 → …

  Project: Research

  • Neurofibrillary Tangles 100%
  • Dementia 69%
  • Alzheimer Disease 64%
  • MicroRNAs 52%
  • Amyloid Plaques 45%

• Genetic Approaches for Next Generation of Breast Cancer Tailored Therapies

  Silva, J.

  American Association for Cancer Research

  1/01/09 → …

  Project: Research

• A Novel Approach to the Selection and Application of Aptamers

  Hamula, C.

  Natural Sciences and Engineering Research Council of Canada

  1/01/08 → …

  Project: Research

• A Novel Approach to the Selection and Application of Aptamers

  Hamula, C.

  Natural Sciences and Engineering Research Council of Canada

  1/01/07 → …

  Project: Research

• A Novel Approach to the Selection and Application of Aptamers

  Hamula, C.

  Natural Sciences and Engineering Research Council of Canada

  1/01/06 → …

  Project: Research

• Monitoring Effects of Human Exposure to Arsenic in Canada

  Hamula, C.

  Natural Sciences and Engineering Research Council of Canada

  1/01/05 → …

  Project: Research

• Cancer Center Support Grant

  Ellison, R. R., Ginsberg, H. S., Weinstein, I. B. I. B., Weinstein, B. I., Rustgi, A. A. K., Abate-Shen, C., Stall, A. A., Califano, A. A., Antman, K., Fojo, A. A. T., Efstratiadis, A. A., Lassman, A. A. B., Floratos, A. A., Benson, M. C., Bestor, N. T. H., Stockwell, B. B. R., Califano, A., Chung, W. K., Cohen, C., Constantine, C., Constantini, F. D., Cordon-Cardo, C., Constantine, C. C., Costantini, F. D., Couronne, O., Creusot, R. J., Crew, K. D., Dalla-Favera, R., Hershman, D. D., Emerson, S. G., Ferrando, A. A., Fojo, A. T., Maxfield, F. F., Gautier, J., Gelmann, E. P., Grann, V. R., Freyer, G. G. A., Heitjan, D. F., Hershman, D., Hibshoosh, H., Hu, J., Hibshoosh, H. H., Gautier, J. J., Hu, J. J., Que, J. J., Wilhelmsen, K. K., Klein, U., Antman, K. K., Crew, K. K. D., Olive, K. K. P., Lassman, A. B., Lieberman, H. B., Lyons, J., Pon, L. L. A., Terry, M. B. M. B., Mears, G. J., Shen, M. M. M., Miller, R. C., Benson, M. M. C., Neugut, A. I., O'connor, O., Olive, K. P., Parsons, R., Meier, P. P., Pon, L. A., Rustgi, A. K., Santella, R. R. M., Dalla-favera, R. R., Santella, R. M., Seshan, V. E., Shapiro, L. S., Shen, M. M., Silverstein, S. J., Siu, G., Soni, R. K., Zha, S. S., Bestor, T. T. H., Terry, M. B., Campbell, S. W., Wolgemuth, D. J., Chung, W. W. K., Zha, S., Efstratiadis, A., Freyer, G. A., Maxfield, F., Meier, P., Santella, R., Stall, A. & Wilhelmsen, K.

  1/01/85 → 30/06/23

  Project: Research

  • neoplasms 100%
  • funding 19%
  • research programs 19%
  • species recruitment 15%
  • patient care 13%
• Finished

  Melanoma Epigenetics and the Functional Role of MacroH2A in Melanoma Progression

  Goldberg, M.

  Dermatology Foundation

  1/01/20 → 31/12/22

  Project: Research

• Chromatin Plasticity, Transcriptional Activity and Kinetics in Developing and Adult Human Astrocyte and Oligodendroglial Lineages

  Tsankova, N.

  National Institute on Drug Abuse

  15/08/19 → 31/07/22

  Project: Research

  • Neuroglia 100%
  • Astrocytes 97%
  • Chromatin 79%
  • Kinetics 54%
  • Chromatin Immunoprecipitation Sequencing 41%

• Post-doctoral fellowship in the mechanisms of age-related tauopathy

  Farrell, K.

  National Institute on Aging

  1/12/17 → 30/11/20

  Project: Research

  • Tauopathies 100%
  • Alzheimer Disease 26%
  • Neurofibrillary Tangles 17%
  • peptide A 14%
  • Amyloid beta-Peptides 10%

• Defining the Chromatin Landscape and Transcriptional Drivers Of Proliferation and Migration In Human Glioblastoma.

  Tsankova, N.

  National Institute of Neurological Disorders and Stroke

  30/09/17 → 31/08/19

  Project: Research

  • Glioblastoma 100%
  • Chromatin 74%
  • Glioma 49%
  • Cell Movement 36%
  • Stem Cells 26%

• Profiling Glial and Neuronal Changes in Chromatin Accessibility and Transcriptional Dynamics in Drug-Resistant Human Epilepsy

  Tsankova, N.

  National Institute of Neurological Disorders and Stroke

  15/04/17 → 31/03/19

  Project: Research

  • Neuroglia 100%
  • Drug Resistant Epilepsy 96%
  • Chromatin 74%
  • Astrocytes 71%
  • Epilepsy 65%

• Core C - The Molecular Systems Pathology Core

  Cordon-Cardo, C.

  National Cancer Institute

  1/04/17 → 31/03/22

  Project: Research

  • neoplasms 100%
  • hepatoma 71%
  • carcinogenesis 70%
  • biomarkers 59%
  • animal models 57%

• Novel Targeted Therapies for Inflammatory Breast Cancer

  Silva, J.

  U.S. Army

  30/09/16 → 30/09/16

  Project: Research

  • Histone Deacetylase 6 100%
  • Inflammatory Breast Neoplasms 54%
  • ricolinostat 12%
  • Breast Neoplasms 11%
  • Therapeutics 10%

• NOVEL TARGETED THERAPIES FOR INFLAMMATORY BREAST CANCER

  Silva, J.

  Congressionally Directed Medical Research Programs

  30/09/16 → 29/09/19

  Project: Research

  • Histone Deacetylase 6 100%
  • Inflammatory Breast Neoplasms 78%
  • Histone Deacetylase Inhibitors 17%
  • ricolinostat 11%
  • Therapeutics 7%

• Role of GATA2 signaling network in Lethal Prostate Cancer

  Domingo-Domenech, J.

  National Cancer Institute

  26/08/16 → 31/07/21

  Project: Research

  • Prostatic Neoplasms 100%
  • Prostate Cancer, Hereditary, 7 59%
  • Nuclear Pore 33%
  • Nuclear Pore Complex Proteins 18%
  • Circulating Neoplastic Cells 15%

• Genome Stability Regulation by the Nuclear Pore-Chromosome Axis and Defects in Tumor Cells

  Rodriguez-Bravo, V.

  National Cancer Institute

  11/08/16 → 31/12/19

  Project: Research

  • Nuclear Pore 100%
  • Genomic Instability 81%
  • Chromosomes 59%
  • Veronica 48%
  • Neoplasms 29%

• Investigating the molecular mechanism that mediates the addiction of inflammatory breast cancer cells to HDAC6 function

  Silva, J.

  National Cancer Institute

  29/07/16 → 30/06/21

  Project: Research

  • Histone Deacetylase 6 100%
  • Inflammatory Breast Neoplasms 82%
  • Histone Deacetylase Inhibitors 10%
  • ricolinostat 8%
  • Autophagy 8%

• Regulation of tau expression in Alzheimer disease and aging

  Crary, J.

  National Institute on Aging

  15/07/16 → 31/03/21

  Project: Research

  • Tauopathies 100%
  • Alzheimer Disease 52%
  • Alleles 14%
  • Clinical Studies 9%
  • RNA Isoforms 9%

• Mechanisms of age-related tauopathy

  Crary, J.

  National Institute of Neurological Disorders and Stroke

  15/09/15 → 30/06/20

  Project: Research

  • Tauopathies 100%
  • Alzheimer Disease 31%
  • Neurofibrillary Tangles 22%
  • Dementia 11%
  • Molecular Biology 11%

• Project 3 - Post-transcriptional regulation of tau in aging and AD

  Crary, J. & Santa-maria Perez, I.

  National Institute on Aging

  15/06/15 → 31/05/20

  Project: Research

  • Alzheimer Disease 100%
  • MicroRNAs 95%
  • Glycogen Synthase Kinase 3 30%
  • Entorhinal Cortex 28%
  • Neurofibrillary Tangles 27%

• MOLECULAR & GENETIC INVESTIGATION OF TAU IN CHRONIC TRAUMATIC ENCEPHALOPATHY

  Crary, J.

  Congressionally Directed Medical Research Programs

  30/09/14 → 31/10/18

  Project: Research

  • Chronic Traumatic Encephalopathy 100%
  • Molecular Biology 49%

• NOTCH inhibition in melanoma

  Celebi, J.

  National Cancer Institute

  1/07/14 → 30/06/17

  Project: Research

  • Melanoma 100%
  • F-Box Proteins 35%
  • Ubiquitin-Protein Ligase Complexes 22%
  • Cullin Proteins 17%
  • Genetic Profile 15%

• Co-regulation and function of Pur-gamma and WRN in the CNS

  Daniel, D.

  National Institute of Neurological Disorders and Stroke

  15/09/13 → 31/08/16

  Project: Research

  • Proteins 100%
  • Werner Syndrome 80%
  • Genes 76%
  • DNA Repair 75%
  • Genomic Instability 59%

• Molecular Systems Pathology Core

  Cordon-Cardo, C.

  National Cancer Institute

  1/09/12 → 31/08/16

  Project: Research

  • prostatic neoplasms 100%
  • neoplasms 37%
  • DNA damage 35%
  • tissues 21%
  • assays 19%

• Pathology Core

  Harpaz, N.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/12 → 31/08/16

  Project: Research

  • Pathology 100%
  • Research Personnel 55%
  • Databases 47%
  • Cell Separation 46%
  • Budgets 45%

• Molecular Studies of the p53 Pathway in Human Cancer

  Cordon-Cardo, C.

  National Cancer Institute

  1/08/12 → 31/07/16

  Project: Research

  • Urinary Bladder Neoplasms 100%
  • Protein Isoforms 70%
  • Urothelium 40%
  • Neoplastic Stem Cells 36%
  • Neoplasms 27%

• Dissecting the Melanoma Genome

  Celebi, J.

  National Cancer Institute

  29/02/12 → 31/01/15

  Project: Research

  • Melanoma 100%
  • Genome 62%
  • Molecular Biology 31%
  • Tumor Suppressor Genes 25%
  • Oncogenes 24%