Pamela Sklar Division of Psychiatric Genomics

Research output

Research output per year 2008 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 41778 Citations
• 82 h-index
• 333 Article
• 43 Comment/debate
• 38 Review article
• 14 Chapter
• 16 More
  • 9 Letter
  • 4 Editorial
  • 3 Short survey

Research output per year

Research output per year

Search results

• 2023

  Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders

  Seah, C., Huckins, L. M. & Brennand, K. J., 1 Apr 2023, In: Biological Psychiatry. 93, 7, p. 642-650 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Mental Disorders 100%
  • Induced Pluripotent Stem Cells 92%
  • Stem Cells 90%
  • Genome-Wide Association Study 85%
  • Organoids 53%
  1 Scopus citations
• 2022

  Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits

  Lencz, T., Sabatello, M., Docherty, A., Peterson, R. E., Soda, T., Austin, J., Bierut, L., Crepaz-Keay, D., Curtis, D., Degenhardt, F., Huckins, L., Lazaro-Munoz, G., Mattheisen, M., Meiser, B., Peay, H., Rietschel, M., Walss-Bass, C. & Davis, L. K., Oct 2022, In: The Lancet Psychiatry. 9, 10, p. 838-844 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Embryonic Structures 100%
  • Psychiatry 90%
  • Fertilization in Vitro 21%
  • Ethics 20%
  • Mental Disorders 16%
  1 Scopus citations

• Social connectedness as a determinant of mental health: A scoping review

  Wickramaratne, P. J., Yangchen, T., Lepow, L., Patra, B. G., Glicksburg, B., Talati, A., Adekkanattu, P., Ryu, E., Biernacka, J. M., Charney, A., Mann, J. J., Pathak, J., Olfson, M. & Weissman, M. M., Oct 2022, In: PLoS ONE. 17, 10 October, e0275004.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Mental Health 100%
  • Depression 83%
  • Social Support 70%
  • Loneliness 46%
  • Depressive Disorder 37%

• The Neuroepigenome: Implications of Chemical and Physical Modifications of Genomic DNA in Schizophrenia

  Girdhar, K., Rahman, S., Dong, P., Fullard, J. F. & Roussos, P., 15 Sep 2022, In: Biological Psychiatry. 92, 6, p. 443-449 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Schizophrenia 100%
  • Epigenome 76%
  • DNA 68%
  • Population Biological Variation 37%
  • Gene Expression 36%
  1 Scopus citations

• What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding

  Huckins, L. M., Signer, R., Johnson, J., Wu, Y. K., Mitchell, K. S. & Bulik, C. M., Oct 2022, In: Molecular Psychiatry. 27, 10, p. 3929-3938 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Feeding and Eating Disorders 100%
  • Anorexia Nervosa 43%
  • Sexual Behavior 18%
  • Social Class 17%
  • Mental Disorders 15%
• 2021

  Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia

  Michael Deans, P. J. & Brennand, K. J., Aug 2021, In: Current Opinion in Neurobiology. 69, p. 193-201 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cell Engineering 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 86%
  • Schizophrenia 61%
  • Induced Pluripotent Stem Cells 56%
  • Stem Cells 55%
  9 Scopus citations

• Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective

  De Los Angeles, A., Fernando, M. B., Hall, N. A. L., Brennand, K. J., Harrison, P. J., Maher, B. J., Weinberger, D. R. & Tunbridge, E. M., 15 Sep 2021, In: Biological Psychiatry. 90, 6, p. 362-372 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Psychiatry 65%
  • Study Guides 21%
  • Research Personnel 20%
  • Phenotype 17%
  10 Scopus citations

• Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome

  Powell, S. K., O'Shea, C., Brennand, K. J. & Akbarian, S., 1 Jan 2021, In: Biological Psychiatry. 89, 1, p. 65-75 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Epigenome 100%
  • Epigenomics 70%
  • Mental Disorders 43%
  • Psychiatry 39%
  • Brain 39%
  6 Scopus citations
• 2020

  Implicit bias of encoded variables: Frameworks for addressing structured bias in EHR–GWAS data

  Dueñas, H. R., Seah, C., Johnson, J. S. & Huckins, L. M., 15 Sep 2020, In: Human Molecular Genetics. 29, R1, p. R33-R41

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Electronic Health Records 100%
  • Phenotype 29%
  • Genome-Wide Association Study 25%
  • Medical Records 20%
  8 Scopus citations

• Integrating CRISPR engineering and hiPSC-derived 2D disease modeling systems

  Rehbach, K., Fernando, M. B. & Brennand, K. J., 5 Feb 2020, In: Journal of Neuroscience. 40, 6, p. 1176-1185 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Induced Pluripotent Stem Cells 98%
  • Drug Discovery 22%
  • Neuroglia 19%
  • Neurodegenerative Diseases 18%
  9 Scopus citations

• Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics

  Matos, M. R., Ho, S. M., Schrode, N. & Brennand, K. J., Sep 2020, In: Molecular and Cellular Neurosciences. 107, 103532.

  Research output: Contribution to journal › Review article › peer-review

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Induced Pluripotent Stem Cells 98%
  • Genomics 88%
  • Mental Disorders 70%
  • Psychiatry 64%
  6 Scopus citations

• Massively parallel techniques for cataloguing the regulome of the human brain

  Townsley, K. G., Brennand, K. J. & Huckins, L. M., Dec 2020, In: Nature Neuroscience. 23, 12, p. 1509-1521 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cataloging 100%
  • Induced Pluripotent Stem Cells 36%
  • Brain 31%
  • Nucleic Acid Regulatory Sequences 18%
  • Clustered Regularly Interspaced Short Palindromic Repeats 18%
  18 Scopus citations

• On the diagnostic and neurobiological origins of bipolar disorder

  Charney, A. W., Mullins, N., Park, Y. J. & Xu, J., 1 Dec 2020, In: Translational Psychiatry. 10, 1, 118.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Psychiatry 76%
  • Bipolar and Related Disorders 59%
  • Neurosciences 36%
  • Pharmacology 22%
  5 Scopus citations
• 2019

  Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

  Halpern, M., Brennand, K. J. & Gregory, J., Dec 2019, In: Neurobiology of Disease. 132, 104562.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Astrocytes 85%
  • Disease Progression 55%
  • Induced Pluripotent Stem Cells 52%
  • Neurodegenerative Diseases 40%
  14 Scopus citations

• International Society of Psychiatric Genetics Ethics Committee: Issues facing us

  on behalf of the ISPG Ethics Committee, 1 Dec 2019, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 8, p. 543-554 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ethics Committees 100%
  • Psychiatry 61%
  • Ethicists 11%
  • Lawyers 10%
  • Community Psychiatry 10%
  11 Scopus citations

• New considerations for hiPSC-based models of neuropsychiatric disorders

  Hoffman, G. E., Schrode, N., Flaherty, E. & Brennand, K. J., 1 Jan 2019, In: Molecular Psychiatry. 24, 1, p. 49-66 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Induced Pluripotent Stem Cells 100%
  • Inborn Genetic Diseases 23%
  • Patient-Specific Modeling 21%
  • Clustered Regularly Interspaced Short Palindromic Repeats 14%
  • Cell Size 12%
  53 Scopus citations

• Spatial genome exploration in the context of cognitive and neurological disease

  Rajarajan, P., Borrman, T., Liao, W., Espeso-Gil, S., Chandrasekaran, S., Jiang, Y., Weng, Z., Brennand, K. J. & Akbarian, S., Dec 2019, In: Current Opinion in Neurobiology. 59, p. 112-119 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genome 100%
  • Chromosome Mapping 45%
  • Brain 36%
  • Chromatin 32%
  • Neurodegenerative Diseases 31%
  11 Scopus citations
• 2018

  Modeling neuropsychiatric and neurodegenerative diseases with induced pluripotent stem cells

  LaMarca, E. A., Powell, S. K., Akbarian, S. & Brennand, K. J., 2018, In: Frontiers in Pediatrics. 6, 82.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Neurodegenerative Diseases 76%
  • Parkinson Disease 18%
  • Schizophrenia 18%
  • Aptitude 15%
  14 Scopus citations

• Recent Genetics and Epigenetics Approaches to PTSD

  Daskalakis, N. P., Rijal, C. M., King, C., Huckins, L. M. & Ressler, K. J., 1 May 2018, In: Current Psychiatry Reports. 20, 5, 30.

  Research output: Contribution to journal › Review article › peer-review

  • Post-Traumatic Stress Disorders 100%
  • Epigenomics 88%
  • Wounds and Injuries 24%
  • Epigenome 21%
  • Avoidance Learning 20%
  65 Scopus citations
• 2017

  Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease

  Powell, S. K., Gregory, J., Akbarian, S. & Brennand, K. J., Jul 2017, In: Molecular and Cellular Neurosciences. 82, p. 157-166 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Enzyme Repression 80%
  • Enzyme Activation 55%
  • Epigenome 54%
  • Gene Targeting 50%
  18 Scopus citations

• Microvascular anomaly conditions in psychiatric disease. Schizophrenia – angiogenesis connection

  Katsel, P., Roussos, P., Pletnikov, M. & Haroutunian, V., 1 Jun 2017, In: Neuroscience and Biobehavioral Reviews. 77, p. 327-339 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Schizophrenia 100%
  • Mental Disorders 99%
  • Neuronal Plasticity 39%
  • Neurobiology 23%
  • Regional Blood Flow 23%
  42 Scopus citations

• Personalized medicine in a dish: The growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells

  Brennand, K. J., 1 Nov 2017, In: Stem Cell Investigation. 4, 11, 91.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  6 Scopus citations

• The importance of non-neuronal cell types in hiPSC-based disease modeling and drug screening

  Gonzalez, D. M., Gregory, J. & Brennand, K. J., 19 Dec 2017, In: Frontiers in Cell and Developmental Biology. 5, DEC, 117.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Preclinical Drug Evaluations 100%
  • Induced Pluripotent Stem Cells 95%
  • Oligodendroglia 30%
  • Population Health 30%
  • Microglia 28%
  17 Scopus citations

• Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms

  Flaherty, E. K. & Brennand, K. J., 15 Jan 2017, In: Brain Research. 1655, p. 283-293 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Induced Pluripotent Stem Cells 100%
  • Schizophrenia 72%
  • Gene Editing 27%
  • Penetrance 25%
  • Clustered Regularly Interspaced Short Palindromic Repeats 25%
  13 Scopus citations
• 2016

  Gene expression elucidates functional impact of polygenic risk for schizophrenia

  Fromer, M., Roussos, P., Sieberts, S. K., Johnson, J. S., Kavanagh, D. H., Perumal, T. M., Ruderfer, D. M., Oh, E. C., Topol, A., Shah, H. R., Klei, L. L., Kramer, R., Pinto, D., Gümüş, Z. H., Cicek, A. E., Dang, K. K., Browne, A., Lu, C., Xie, L., Readhead, B., & 38 othersStahl, E. A., Xiao, J., Parvizi, M., Hamamsy, T., Fullard, J. F., Wang, Y. C., Mahajan, M. C., Derry, J. M. J., Dudley, J. T., Hemby, S. E., Logsdon, B. A., Talbot, K., Raj, T., Bennett, D. A., De Jager, P. L., Zhu, J., Zhang, B., Sullivan, P. F., Chess, A., Purcell, S. M., Shinobu, L. A., Mangravite, L. M., Toyoshiba, H., Gur, R. E., Hahn, C. G., Lewis, D. A., Haroutunian, V., Peters, M. A., Lipska, B. K., Buxbaum, J. D., Schadt, E. E., Hirai, K., Roeder, K., Brennand, K. J., Katsanis, N., Domenici, E., Devlin, B. & Sklar, P., 26 Oct 2016, In: Nature Neuroscience. 19, 11, p. 1442-1453 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Schizophrenia 100%
  • Gene Expression 73%
  • Furin 34%
  • Genetic Loci 30%
  • Zebrafish 24%
  588 Scopus citations

• Spatial genome organization and cognition

  Rajarajan, P., Gil, S. E., Brennand, K. J. & Akbarian, S., 1 Nov 2016, In: Nature Reviews Neuroscience. 17, 11, p. 681-691 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cognition 100%
  • Genome 85%
  • Neurodegenerative Diseases 36%
  • Psychiatry 31%
  • Learning 30%
  55 Scopus citations

• Systematic review of blood transcriptome profiling in neuropsychiatric disorders: guidelines for biomarker discovery

  Breen, M. S., Stein, D. J. & Baldwin, D. S., 1 Sep 2016, In: Human Psychopharmacology. p. 373-381 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gene Expression Profiling 100%
  • Systematic Reviews 71%
  • Machine Learning 65%
  • Gene Regulatory Networks 63%
  • Biomarkers 63%
  11 Scopus citations

• Understanding the genetic liability to schizophrenia through the neuroepigenome

  Fullard, J. F., Halene, T. B., Giambartolomei, C., Haroutunian, V., Akbarian, S. & Roussos, P., 1 Nov 2016, In: Schizophrenia Research. 177, 1-3, p. 115-124 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Schizophrenia 100%
  • Genomics 62%
  • Quantitative Trait Loci 38%
  • Epigenome 38%
  • Brain Diseases 29%
  18 Scopus citations
• 2015

  Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells

  Lee, I. S., Carvalho, C. M. B., Douvaras, P., Ho, S. M., Hartley, B. J., Zuccherato, L. W., Ladran, I. G., Siegel, A. J., McCarthy, S., Malhotra, D., Sebat, J., Rapoport, J., Fossati, V., Lupski, J. R., Levy, D. L. & Brennand, K. J., 24 Jun 2015, In: npj Schizophrenia. 1, 15019.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Contactins 100%
  • Induced Pluripotent Stem Cells 69%
  • Phenotype 36%
  • Exons 32%
  • Proteins 22%
  46 Scopus citations

• Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease

  Kocerha, J., Dwivedi, Y. & Brennand, K. J., 26 Jun 2015, In: Molecular Psychiatry. 20, 6, p. 677-684 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Untranslated RNA 100%
  • MicroRNAs 74%
  • Mental Disorders 71%
  • Epigenomics 51%
  • Human Genome Project 41%
  59 Scopus citations

• The PsychENCODE project

  Akbarian, S., Liu, C., Knowles, J. A., Vaccarino, F. M., Farnham, P. J., Crawford, G. E., Jaffe, A. E., Pinto, D., Dracheva, S., Geschwind, D. H., Mill, J., Nairn, A. C., Abyzov, A., Pochareddy, S., Prabhakar, S., Weissman, S., Sullivan, P. F., State, M. W., Weng, Z., Peters, M. A., & 64 othersWhite, K. P., Gerstein, M. B., Amiri, A., Armoskus, C., Ashley-Koch, A. E., Bae, T., Beckel-Mitchener, A., Berman, B. P., Coetzee, G. A., Coppola, G., Francoeur, N., Fromer, M., Gao, R., Grennan, K., Herstein, J., Kavanagh, D. H., Ivanov, N. A., Jiang, Y., Kitchen, R. R., Kozlenkov, A., Kundakovic, M., Li, M., Li, Z., Liu, S., Mangravite, L. M., Mattei, E., Markenscoff-Papadimitriou, E., Navarro, F. C. P., North, N., Omberg, L., Panchision, D., Parikshak, N., Poschmann, J., Price, A. J., Purcaro, M., Reddy, T. E., Roussos, P., Schreiner, S., Scuderi, S., Sebra, R., Shibata, M., Shieh, A. W., Skarica, M., Sun, W., Swarup, V., Thomas, A., Tsuji, J., Van Bakel, H., Wang, D., Wang, Y., Wang, K., Werling, D. M., Willsey, A. J., Witt, H., Won, H., Wong, C. C. Y., Wray, G. A., Wu, E. Y., Xu, X., Yao, L., Senthil, G., Lehner, T., Sklar, P. & Sestan, N., 25 Nov 2015, In: Nature Neuroscience. 18, 12, p. 1707-1712 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Mental Disorders 100%
  • Genes 74%
  • Nucleic Acid Regulatory Sequences 70%
  • Autism Spectrum Disorder 63%
  • Brain 60%
  236 Scopus citations
• 2014

  Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

  Schadt, E. E., Buchanan, S., Brennand, K. J. & Merchant, K. M., 2014, In: Frontiers in Pharmacology. 5, DEC, 252.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Central Nervous System Diseases 100%
  • Drug Discovery 93%
  • Induced Pluripotent Stem Cells 29%
  • Technology 17%
  • Systems Biology 15%
  31 Scopus citations

• Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells

  Brennand, K. J., Landek-Salgado, M. A. & Sawa, A., 15 Jun 2014, In: Biological Psychiatry. 75, 12, p. 936-944 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Induced Pluripotent Stem Cells 100%
  • Schizophrenia 72%
  • Aptitude 40%
  • Neuroimaging 26%
  • Animal Models 21%
  47 Scopus citations

• Myelination, oligodendrocytes, and serious mental illness

  Haroutunian, V., Katsel, P., Roussos, P., Davis, K. L., Altshuler, L. L. & Bartzokis, G., Nov 2014, In: GLIA. 62, 11, p. 1856-1877 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oligodendroglia 100%
  • Brain 44%
  • Myelin Sheath 35%
  • Gray Matter 34%
  • Neurons 20%
  168 Scopus citations

• Schizophrenia: Susceptibility genes and oligodendroglial and myelin related abnormalities

  Roussos, P. & Haroutunian, V., 21 Jan 2014, In: Frontiers in Cellular Neuroscience. 8, JAN, 5.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Myelin Sheath 100%
  • Schizophrenia 78%
  • Neuroglia 51%
  • Oligodendroglia 42%
  • Genes 39%
  69 Scopus citations
• 2013

  Neural stem and progenitor cells in health and disease

  Ladran, I., Tran, N., Topol, A. & Brennand, K. J., Nov 2013, In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 5, 6, p. 701-715 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neural Stem Cells 100%
  • Stem Cells 65%
  • Health 43%
  • Oligodendroglia 32%
  • Cell- and Tissue-Based Therapy 28%
  22 Scopus citations

• Paranoid personality disorder.

  Triebwasser, J., Chemerinski, E., Roussos, P. & Siever, L. J., Dec 2013, In: Journal of Personality Disorders. 27, 6, p. 795-805 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Paranoid Personality Disorder 100%
  • personality disorder 69%
  • Paranoid Disorders 27%
  • Diagnostic and Statistical Manual of Mental Disorders 18%
  • Research Personnel 13%
  25 Scopus citations
• 2008

  Treating pediatric patients with antipsychotic drugs: Balancing benefits and safety

  Ivanov, I. & Charney, A., Jun 2008, In: Mount Sinai Journal of Medicine. 75, 3, p. 276-286 11 p.

  Research output: Contribution to journal › Review article › peer-review
  10 Scopus citations