Pamela Sklar Division of Psychiatric Genomics

2023

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci

Sherva, R., Zhang, R., Sahelijo, N., Jun, G., Anglin, T., Chanfreau, C., Cho, K., Fonda, J. R., Gaziano, J. M., Harrington, K. M., Ho, Y. L., Kremen, W. S., Litkowski, E., Lynch, J., Neale, Z., Roussos, P., Marra, D., Mez, J., Miller, M. W., Salat, D. H., & 8 othersTsuang, D., Wolf, E., Zeng, Q., Panizzon, M. S., Merritt, V. C., Farrer, L. A., Hauger, R. L. & Logue, M. W., Mar 2023, In: Molecular Psychiatry. 28, 3, p. 1293-1302 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Cannabis Use and CKD: Epidemiological Associations and Mendelian Randomization

Dellepiane, S., Paranjpe, I., Rajagopal, M., Kamat, S., O'Hagan, R., Gulamali, F., Rein, J. L., Charney, A. W., Do, R., Coca, S., Glicksberg, B. S. & Nadkarni, G. N., Feb 2023, In: Kidney Medicine. 5, 2, 100582.

Research output: Contribution to journal › Article › peer-review

Open Access

Comorbidity and healthcare utilization in patients with treatment resistant depression: A large-scale retrospective cohort analysis using electronic health records

Adekkanattu, P., Olfson, M., Susser, L. C., Patra, B., Vekaria, V., Coombes, B. J., Lepow, L., Fennessy, B., Charney, A., Ryu, E., Miller, K. D., Pan, L., Yangchen, T., Talati, A., Wickramaratne, P., Weissman, M., Mann, J., Biernacka, J. M. & Pathak, J., 1 Mar 2023, In: Journal of Affective Disorders. 324, p. 102-113 12 p.

Research output: Contribution to journal › Article › peer-review

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

ADHD Working Group of the Psychiatric Genomics Consortium & iPSYCH-Broad Consortium, Feb 2023, In: Nature Genetics. 55, 2, p. 198-208 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Genome-wide methylomic regulation of multiscale gene networks in Alzheimer's disease

Wang, E., Wang, M., Guo, L., Fullard, J. F., Micallef, C., Bendl, J., Song, W. M., Ming, C., Huang, Y., Li, Y., Yu, K., Peng, J., Bennett, D. A., De Jager, P. L., Roussos, P., Haroutunian, V. & Zhang, B., 2023, (Accepted/In press) In: Alzheimer's and Dementia.

Research output: Contribution to journal › Article › peer-review

Open Access

Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome

the Developmental Synaptopathies Consortium, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100145.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

The Mount Sinai COVID-19 Biobank Team, Jan 2023, In: Nature Medicine. 29, 1, p. 236-246 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

International Parkinson’s Disease Genomics Consortium (IPDGC), Dec 2022, In: Molecular Neurodegeneration. 17, 1, 48.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning

Hafez, A. K., Zimmerman, A. J., Papageorgiou, G., Chandrasekaran, J., Amoah, S. K., Lin, R., Lozano, E., Pierotti, C., Dell'Orco, M., Hartley, B. J., Alural, B., Lalonde, J., Esposito, J. M., Berretta, S., Squassina, A., Chillotti, C., Voloudakis, G., Shao, Z., Fullard, J. F., Brennand, K. J., & 7 othersTurecki, G., Roussos, P., Perlis, R. H., Haggarty, S. J., Perrone-Bizzozero, N., Brigman, J. L. & Mellios, N., 18 Jan 2022, In: Cell Reports. 38, 3, 110282.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

A complete temporal transcription factor series in the fly visual system

Konstantinides, N., Holguera, I., Rossi, A. M., Escobar, A., Dudragne, L., Chen, Y. C., Tran, T. N., Martínez Jaimes, A. M., Özel, M. N., Simon, F., Shao, Z., Tsankova, N. M., Fullard, J. F., Walldorf, U., Roussos, P. & Desplan, C., 14 Apr 2022, In: Nature. 604, 7905, p. 316-322 7 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Altered gene expression and PTSD symptom dimensions in World Trade Center responders

Marchese, S., Cancelmo, L., Diab, O., Cahn, L., Aaronson, C., Daskalakis, N. P., Schaffer, J., Horn, S. R., Johnson, J. S., Schechter, C., Desarnaud, F., Bierer, L. M., Makotkine, I., Flory, J. D., Crane, M., Moline, J. M., Udasin, I. G., Harrison, D. J., Roussos, P., Charney, D. S., & 6 othersKoenen, K. C., Southwick, S. M., Yehuda, R., Pietrzak, R. H., Huckins, L. M. & Feder, A., Apr 2022, In: Molecular Psychiatry. 27, 4, p. 2225-2246 22 p.

Research output: Contribution to journal › Article › peer-review

A shift in lung macrophage composition is associated with COVID-19 severity and recovery

Chen, S. T., Park, M. D., Del Valle, D. M., Buckup, M., Tabachnikova, A., Thompson, R. C., Simons, N. W., Mouskas, K., Lee, B., Geanon, D., D'Souza, D., Dawson, T., Marvin, R., Nie, K., Zhao, Z., LeBerichel, J., Chang, C., Jamal, H., Akturk, G., Chaddha, U., & 16 othersMathews, K., Acquah, S., Brown, S. A., Reiss, M., Harkin, T., Feldmann, M., Powell, C. A., Hook, J. L., Kim-Schulze, S., Rahman, A. H., Brown, B. D., Beckmann, N. D., Gnjatic, S., Kenigsberg, E., Charney, A. W. & Merad, M., 14 Sep 2022, In: Science Translational Medicine. 14, 662, abn5168.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility

VA Million Veteran Program COVID-19 Science Initiative & Mount Sinai COVID-19 Biobank, Dec 2022, In: npj Genomic Medicine. 7, 1, 52.

Research output: Contribution to journal › Article › peer-review

Open Access

Autoencoders for sample size estimation for fully connected neural network classifiers

Gulamali, F. F., Sawant, A. S., Kovatch, P., Glicksberg, B., Charney, A., Nadkarni, G. N. & Oermann, E., Dec 2022, In: npj Digital Medicine. 5, 1, 180.

Research output: Contribution to journal › Article › peer-review

Open Access

Automated Determination of Left Ventricular Function Using Electrocardiogram Data in Patients on Maintenance Hemodialysis

Vaid, A., Jiang, J. J., Sawant, A., Singh, K., Kovatch, P., Charney, A. W., Charytan, D. M., Divers, J., Glicksberg, B. S., Chan, L. & Nadkarni, G. N., Jul 2022, In: Clinical Journal of the American Society of Nephrology. 17, 7, p. 1017-1025 9 p.

Research output: Contribution to journal › Article › peer-review

Brain microRNAs are associated with variation in cognitive trajectory in advanced age

Wingo, A. P., Wang, M., Liu, J., Breen, M. S., Yang, H. S., Tang, B., Schneider, J. A., Seyfried, N. T., Lah, J. J., Levey, A. I., Bennett, D. A., Jin, P., De Jager, P. L. & Wingo, T. S., Dec 2022, In: Translational Psychiatry. 12, 1, 47.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

PsychENCODE Consortium, Apr 2022, In: Nature Neuroscience. 25, 4, p. 474-483 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia

Farrelly, L. A., Zheng, S., Schrode, N., Topol, A., Bhanu, N. V., Bastle, R. M., Ramakrishnan, A., Chan, J. C., Cetin, B., Flaherty, E., Shen, L., Gleason, K., Tamminga, C. A., Garcia, B. A., Li, H., Brennand, K. J. & Maze, I., Dec 2022, In: Nature Communications. 13, 1, 2195.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Common variants contribute to intrinsic human brain functional networks

Zhao, B., Li, T., Smith, S. M., Xiong, D., Wang, X., Yang, Y., Luo, T., Zhu, Z., Shan, Y., Matoba, N., Sun, Q., Yang, Y., Hauberg, M. E., Bendl, J., Fullard, J. F., Roussos, P., Lin, W., Li, Y., Stein, J. L. & Zhu, H., Apr 2022, In: Nature Genetics. 54, 4, p. 508-517 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Comparison of confound adjustment methods in the construction of gene co-expression networks

Cote, A. C., Young, H. E. & Huckins, L. M., Dec 2022, In: Genome Biology. 23, 1, 44.

Research output: Contribution to journal › Article › peer-review

Open Access

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, MVP Suicide Exemplar Workgroup & VA Million Veteran Program, 1 Feb 2022, In: Biological Psychiatry. 91, 3, p. 313-327 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19

Tantillo, G. B., Jetté, N., Gururangan, K., Agarwal, P., Marcuse, L., Singh, A., Goldstein, J., Kwon, C. S., Dhamoon, M. S., Navis, A., Nadkarni, G. N., Charney, A. W., Young, J. J., Blank, L. J., Fields, M. & Yoo, J. Y., May 2022, In: Clinical Neurophysiology. 137, p. 102-112 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Engagement of vascular early response genes typifies mild cognitive impairment

Katsel, P., Fam, P., Tan, W., Khan, S., Gama-Sosa, M., De Gasperi, R., Roussos, P., Robinson, A., Cooper, I., Schnaider-Beeri, M. & Haroutunian, V., Jul 2022, In: Alzheimer's and Dementia. 18, 7, p. 1357-1369 13 p.

Research output: Contribution to journal › Article › peer-review

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

Butler-Laporte, G., Povysil, G., Kosmicki, J. A., Cirulli, E. T., Drivas, T., Furini, S., Saad, C., Schmidt, A., Olszewski, P., Korotko, U., Quinodoz, M., Çelik, E., Kundu, K., Walter, K., Jung, J., Stockwell, A. D., Sloofman, L. G., Jordan, D. M., Thompson, R. C., Del Valle, D., & 139 othersSimons, N., Cheng, E., Sebra, R., Schadt, E. E., Kim-Schulze, S., Gnjatic, S., Merad, M., Buxbaum, J. D., Beckmann, N. D., Charney, A. W., Przychodzen, B., Chang, T., Pottinger, T. D., Shang, N., Brand, F., Fava, F., Mari, F., Chwialkowska, K., Niemira, M., Pula, S., Kenneth Baillie, J., Stuckey, A., Salas, A., Bello, X., Pardo-Seco, J., Gómez-Carballa, A., Rivero-Calle, I., Martinón-Torres, F., Ganna, A., Karczewski, K. J., Veerapen, K., Bourgey, M., Bourque, G., Eveleigh, R. J. M., Forgetta, V., Morrison, D., Langlais, D., Lathrop, M., Mooser, V., Nakanishi, T., Frithiof, R., Hultström, M., Lipcsey, M., Marincevic-Zuniga, Y., Nordlund, J., Schiabor Barrett, K. M., Lee, W., Bolze, A., White, S., Riffle, S., Tanudjaja, F., Sandoval, E., Neveux, I., Dabe, S., Casadei, N., Motameny, S., Alaamery, M., Massadeh, S., Aljawini, N., Almutairi, M. S., Arabi, Y. M., Alqahtani, S. A., Al Harthi, F. S., Almutairi, A., Alqubaishi, F., Alotaibi, S., Binowayn, A., Alsolm, E. A., Bardisy, H. E., Fawzy, M., Cai, F., Soranzo, N., Butterworth, A., Center, R. G., Geschwind, D. H., Arteaga, S., Stephens, A., Butte, M. J., Boutros, P. C., Yamaguchi, T. N., Tao, S., Eng, S., Sanders, T., Tung, P. J., Broudy, M. E., Pan, Y., Gonzalez, A., Chavan, N., Johnson, R., Pasaniuc, B., Yaspan, B., Smieszek, S., Rivolta, C., Bibert, S., Bochud, P. Y., Dabrowski, M., Zawadzki, P., Sypniewski, M., Kaja, E., Chariyavilaskul, P., Nilaratanakul, V., Hirankarn, N., Shotelersuk, V., Pongpanich, M., Phokaew, C., Chetruengchai, W., Tokunaga, K., Sugiyama, M., Kawai, Y., Hasegawa, T., Naito, T., Namkoong, H., Edahiro, R., Kimura, A., Ogawa, S., Kanai, T., Fukunaga, K., Okada, Y., Imoto, S., Miyano, S., Mangul, S., Abedalthagafi, M. S., Zeberg, H., Grzymski, J. J., Washington, N. L., Ossowski, S., Ludwig, K. U., Schulte, E. C., Riess, O., Moniuszko, M., Kwasniewski, M., Mbarek, H., Ismail, S. I., Verma, A., Goldstein, D. B., Kiryluk, K., Renieri, A., Ferreira, M. A. R. & Brent Richards, J., 3 Nov 2022, In: PLoS Genetics. 18, 11, e1010367.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: a phenome-wide and polygenic risk study

Eating Disorders Working Group of the Psychiatric Genomics Consortium, Aug 2022, In: The Lancet Digital Health. 4, 8, p. e604-e614

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Genetics of the human microglia regulome refines Alzheimer’s disease risk loci

Kosoy, R., Fullard, J. F., Zeng, B., Bendl, J., Dong, P., Rahman, S., Kleopoulos, S. P., Shao, Z., Girdhar, K., Humphrey, J., de Paiva Lopes, K., Charney, A. W., Kopell, B. H., Raj, T., Bennett, D., Kellner, C. P., Haroutunian, V., Hoffman, G. E. & Roussos, P., Aug 2022, In: Nature Genetics. 54, 8, p. 1145-1154 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

Mattheisen, M., Grove, J., Als, T. D., Martin, J., Voloudakis, G., Meier, S., Demontis, D., Bendl, J., Walters, R., Carey, C. E., Rosengren, A., Strom, N. I., Hauberg, M. E., Zeng, B., Hoffman, G., Zhang, W., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Agerbo, E., Cormand, B., & 14 othersNordentoft, M., Werge, T., Mors, O., Hougaard, D. M., Buxbaum, J. D., Faraone, S. V., Franke, B., Dalsgaard, S., Mortensen, P. B., Robinson, E. B., Roussos, P., Neale, B. M., Daly, M. J. & Børglum, A. D., Oct 2022, In: Nature Genetics. 54, 10, p. 1470-1478 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Liu, D., Zinski, A., Mishra, A., Noh, H., Park, G. H., Qin, Y., Olorife, O., Park, J. M., Abani, C. P., Park, J. S., Fung, J., Sawaqed, F., Coyle, J. T., Stahl, E., Bendl, J., Fullard, J. F., Roussos, P., Zhang, X., Stanton, P. K., Yin, C., & 5 othersHuang, W., Kim, H. Y., Won, H., Cho, J. H. & Chung, S., Oct 2022, In: Molecular Psychiatry. 27, 10, p. 4218-4233 16 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder

Wingo, T. S., Gerasimov, E. S., Liu, Y., Duong, D. M., Vattathil, S. M., Lori, A., Gockley, J., Breen, M. S., Maihofer, A. X., Nievergelt, C. M., Koenen, K. C., Levey, D. F., Gelernter, J., Stein, M. B., Ressler, K. J., Bennett, D. A., Levey, A. I., Seyfried, N. T. & Wingo, A. P., Jul 2022, In: Molecular Psychiatry. 27, 7, p. 3075-3084 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Mapping anorexia nervosa genes to clinical phenotypes

Johnson, J. S., Cote, A. C., Dobbyn, A., Sloofman, L. G., Xu, J., Cotter, L., Charney, A. W., Birgegård, A., Jordan, J., Kennedy, M., Landén, M., Maguire, S. L., Martin, N. G., Mortensen, P. B., Thornton, L. M., Bulik, C. M. & Huckins, L. M., 2022, (Accepted/In press) In: Psychological Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Indonesia Schizophrenia Consortium, PsychENCODE, Psychosis Endophenotypes International Consortium, The SynGO Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 21 Apr 2022, In: Nature. 604, 7906, p. 502-508 7 p.

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Maternal health around pregnancy and autism risk: A diagnosis-wide, population-based study

Kodesh, A., Levine, S. Z., Khachadourian, V., Rahman, R., Schlessinger, A., O'Reilly, P. F., Grove, J., Schendel, D., Buxbaum, J. D., Croen, L., Reichenberg, A., Sandin, S. & Janecka, M., 26 Dec 2022, In: Psychological Medicine. 52, 16, p. 4076-4084 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression

NYSCF Global Stem Cell Array® Team, Nov 2022, In: Nature Neuroscience. 25, 11, p. 1434-1445 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits

Zeng, B., Bendl, J., Kosoy, R., Fullard, J. F., Hoffman, G. E. & Roussos, P., Feb 2022, In: Nature Genetics. 54, 2, p. 161-169 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

Zazhytska, M., Kodra, A., Hoagland, D. A., Frere, J., Fullard, J. F., Shayya, H., McArthur, N. G., Moeller, R., Uhl, S., Omer, A. D., Gottesman, M. E., Firestein, S., Gong, Q., Canoll, P. D., Goldman, J. E., Roussos, P., tenOever, B. R., Jonathan, B. O. & Lomvardas, S., 17 Mar 2022, In: Cell. 185, 6, p. 1052-1064.e12

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression among Adults in the US Veterans Affairs Health Care System

Bigdeli, T. B., Voloudakis, G., Barr, P. B., Gorman, B. R., Genovese, G., Peterson, R. E., Burstein, D. E., Velicu, V. I., Li, Y., Gupta, R., Mattheisen, M., Tomasi, S., Rajeevan, N., Sayward, F., Radhakrishnan, K., Natarajan, S., Malhotra, A. K., Shi, Y., Zhao, H., Kosten, T. R., & 13 othersConcato, J., O'Leary, T. J., Przygodzki, R., Gleason, T., Pyarajan, S., Brophy, M., Huang, G. D., Muralidhar, S., Gaziano, J. M., Aslan, M., Fanous, A. H., Harvey, P. D. & Roussos, P., 2 Nov 2022, In: JAMA Psychiatry. 79, 11, p. 1092-1101 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Population-level variation in enhancer expression identifies disease mechanisms in the human brain

the CommonMind Consortium, Oct 2022, In: Nature Genetics. 54, 10, p. 1493-1503 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

Privé, F., Aschard, H., Carmi, S., Folkersen, L., Hoggart, C., O'Reilly, P. F. & Vilhjálmsson, B. J., 6 Jan 2022, In: American Journal of Human Genetics. 109, 1, p. 12-23 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits

Highland, H. M., Wojcik, G. L., Graff, M., Nishimura, K. K., Hodonsky, C. J., Baldassari, A. R., Cote, A. C., Cheng, I., Gignoux, C. R., Tao, R., Li, Y., Boerwinkle, E., Fornage, M., Haessler, J., Hindorff, L. A., Hu, Y., Justice, A. E., Lin, B. M., Lin, D., Stram, D. O., & 16 othersHaiman, C. A., Kooperberg, C., Le Marchand, L., Matise, T. C., Kenny, E. E., Carlson, C. S., Stahl, E. A., Avery, C. L., North, K. E., Ambite, J. L., Buyske, S., Loos, R. J., Peters, U., Young, K. L., Bien, S. A. & Huckins, L. M., 7 Apr 2022, In: American Journal of Human Genetics. 109, 4, p. 669-679 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Prenatal Δ⁹-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation

Ellis, R. J., Bara, A., Vargas, C. A., Frick, A. L., Loh, E., Landry, J., Uzamere, T. O., Callens, J. E., Martin, Q., Rajarajan, P., Brennand, K., Ramakrishnan, A., Shen, L., Szutorisz, H. & Hurd, Y. L., 15 Jul 2022, In: Biological Psychiatry. 92, 2, p. 127-138 12 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome

Talvio, K., Minkeviciene, R., Townsley, K. G., Achuta, V. S., Huckins, L. M., Corcoran, P., Brennand, K. J. & Castrén, M. L., 21 Nov 2022, In: Frontiers in Cell and Developmental Biology. 10, 1034679.

Research output: Contribution to journal › Article › peer-review

Open Access

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

Fulton, S. L., Wenderski, W., Lepack, A. E., Eagle, A. L., Fanutza, T., Bastle, R. M., Ramakrishnan, A., Hays, E. C., Neal, A., Bendl, J., Farrelly, L. A., Al-Kachak, A., Lyu, Y., Cetin, B., Chan, J. C., Tran, T. N., Neve, R. L., Roper, R. J., Brennand, K. J., Roussos, P., & 7 othersSchimenti, J. C., Friedman, A. K., Shen, L., Blitzer, R. D., Robison, A. J., Crabtree, G. R. & Maze, I., Dec 2022, In: Nature Communications. 13, 1, 6384.

Research output: Contribution to journal › Article › peer-review

Open Access

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

iPSYCH, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, 1 Jan 2022, In: Biological Psychiatry. 91, 1, p. 102-117 16 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Sex Differences in Molecular Rhythms in the Human Cortex

Logan, R. W., Xue, X., Ketchesin, K. D., Hoffman, G., Roussos, P., Tseng, G., McClung, C. A. & Seney, M. L., 1 Jan 2022, In: Biological Psychiatry. 91, 1, p. 152-162 11 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia

Hoffman, G. E., Ma, Y., Montgomery, K. S., Bendl, J., Jaiswal, M. K., Kozlenkov, A., Peters, M. A., Dracheva, S., Fullard, J. F., Chess, A., Devlin, B., Sieberts, S. K. & Roussos, P., 1 Jan 2022, In: Biological Psychiatry. 91, 1, p. 92-101 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development

Cuddleston, W. H., Fan, X., Sloofman, L., Liang, L., Mossotto, E., Moore, K., Zipkowitz, S., Wang, M., Zhang, B., Wang, J., Sestan, N., Devlin, B., Roeder, K., Sanders, S. J., Buxbaum, J. D. & Breen, M. S., 1 Nov 2022, In: Cell Reports. 41, 5, 111585.

Research output: Contribution to journal › Article › peer-review

Open Access

The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease

Bendl, J., Hauberg, M. E., Girdhar, K., Im, E., Vicari, J. M., Rahman, S., Fernando, M. B., Townsley, K. G., Dong, P., Misir, R., Kleopoulos, S. P., Reach, S. M., Apontes, P., Zeng, B., Zhang, W., Voloudakis, G., Brennand, K. J., Nixon, R. A., Haroutunian, V., Hoffman, G. E., & 2 othersFullard, J. F. & Roussos, P., Oct 2022, In: Nature Neuroscience. 25, 10, p. 1366-1378 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits

Rowland, B., Venkatesh, S., Tardaguila, M., Wen, J., Rosen, J. D., Tapia, A. L., Sun, Q., Graff, M., Vuckovic, D., Lettre, G., Sankaran, V. G., Voloudakis, G., Roussos, P., Huffman, J. E., Reiner, A. P., Soranzo, N., Raffield, L. M. & Li, Y., 15 Jul 2022, In: Human Molecular Genetics. 31, 14, p. 2333-2347 15 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Using Deep-Learning Algorithms to Simultaneously Identify Right and Left Ventricular Dysfunction From the Electrocardiogram

Vaid, A., Johnson, K. W., Badgeley, M. A., Somani, S. S., Bicak, M., Landi, I., Russak, A., Zhao, S., Levin, M. A., Freeman, R. S., Charney, A. W., Kukar, A., Kim, B., Danilov, T., Lerakis, S., Argulian, E., Narula, J., Nadkarni, G. N. & Glicksberg, B. S., Mar 2022, In: JACC: Cardiovascular Imaging. 15, 3, p. 395-410 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Wendt, F. R., Pathak, G. A., Deak, J. D., De Angelis, F., Koller, D., Cabrera-Mendoza, B., Lebovitch, D. S., Levey, D. F., Stein, M. B., Kranzler, H. R., Koenen, K. C., Gelernter, J., Huckins, L. M. & Polimanti, R., Apr 2022, In: Molecular Psychiatry. 27, 4, p. 2206-2215 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Pamela Sklar Division of Psychiatric Genomics

Research output

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