Nash Family Department of Neuroscience

Projects

Projects per year 1984 2009 2010 2011 2014 2015 2016 2017 2018 2019 2020 2021 2027

• 187 Active
• 476 Finished

Projects per year

Search results

• Finished

  Transcriptional Control of Neuroinflammation in Alzheimer's Disease

  Zhou, M., Cai, D. & Cai, D.

  National Institute on Aging

  15/06/21 → 28/02/23

  Project: Research

  • Th17 Cells 100%
  • Microglia 69%
  • Alzheimer Disease 56%
  • Interleukin-18 47%
  • Immunologic Factors 44%

• The Role of Myeloid Cells in Parkinson's Disease

  Raj, T.

  National Institute of Neurological Disorders and Stroke

  1/04/21 → 31/03/22

  Project: Research

  • Microglia 100%
  • Transcriptome 90%
  • Myeloid Cells 88%
  • Monocytes 81%
  • Parkinson Disease 61%

• A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia

  Elahi, F.

  U.S. Department of Veterans Affairs

  1/01/21 → 21/12/21

  Project: Research

  • Neurodegenerative Diseases 100%
  • Vascular Dementia 93%
  • Precision Medicine 93%
  • Veterans 59%
  • Data Science 53%

• Identifying genetic and transcriptomic drivers of Parkinson's disease progression

  Raj, T.

  National Institute of Neurological Disorders and Stroke

  30/09/20 → 31/08/21

  Project: Research

  • Biomarkers 100%
  • Genes 38%
  • Immune system 24%
  • Gene expression 21%
  • Genomics 20%

• Determining neuroprotective autophagy functions using different types of human neurons

  Yue, Z. & Yang, N.

  National Institute on Aging

  15/09/20 → 31/08/22

  Project: Research

  • Autophagy 100%
  • Synucleins 54%
  • Neurons 53%
  • Dementia 36%
  • Lewy Body Disease 27%

• Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M. & Gandy, S.

  National Institute on Aging

  15/09/20 → 31/08/21

  Project: Research

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 66%
  • Alzheimer Disease 57%
  • Amyloidosis 32%
  • Insulin 30%

• Mitochondrial Protection to Prevent Neurobehavioral Changes after Postnatal Anesthesia

  Baxter, M. & Alvarado, M. C.

  National Institute of Child Health and Human Development

  1/06/20 → 30/04/21

  Project: Research

  • anesthesia 100%
  • anesthetics 83%
  • cognitive development 61%
  • general anesthetics 60%
  • sevoflurane 56%

• Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease

  McAlpine, C.

  National Heart, Lung, and Blood Institute

  1/05/20 → 30/04/21

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Sleep 71%
  • Cardiovascular Diseases 43%
  • Hematopoiesis 35%
  • Sleep Deprivation 30%

• Cellular and molecular mechanisms of brain dysfunction in NF1

  Yang, N. N. & Yang, N.

  National Institute of Neurological Disorders and Stroke

  15/04/20 → 31/01/21

  Project: Research

  • Neurofibromatosis 1 100%
  • National Institute of Neurological Disorders and Stroke (U.S.) 90%
  • Brain 80%
  • Neurofibromin 1 62%
  • Nervous System 50%

• Administrative Core

  Sano, M.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • dementia 100%
  • director 27%
  • Schools of medicine 25%
  • leadership 21%
  • leader 21%

• Genetics and Genomics Core

  Goate, A.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • Genome-Wide Association Study 100%
  • Genomics 96%
  • Exome 76%
  • Apolipoproteins E 67%
  • Biomarkers 41%

• Research Education Component

  Robakis, N.

  National Institute on Aging

  1/04/20 → 28/02/22

  Project: Research

  • education 100%
  • Career development 91%
  • trainee 81%
  • dementia 53%
  • grant 44%

• The impact of Alzheimer's disease susceptibility alleles on microglia transcriptome

  Raj, T. & De Witte, L. D.

  National Institute on Aging

  1/03/20 → 28/02/22

  Project: Research

  • Microglia 100%
  • Alzheimer Disease 82%
  • Disease Susceptibility 81%
  • Transcriptome 73%
  • Alleles 53%

• Transcriptional control of microglia diversification and inflammation

  Schaefer, A. & Tarakhovsky, A.

  National Institute of Neurological Disorders and Stroke

  1/03/20 → 28/02/21

  Project: Research

  • Microglia 100%
  • Polycomb Repressive Complex 2 49%
  • Inflammation 39%
  • Brain 15%
  • Neurons 8%

• Circuit mechanisms of self-organized cognitive strategies

  Rich, E. E. L. & Rich, E.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  5/02/20 → 31/01/23

  Project: Research

  • Short-Term Memory 100%
  • Cognition 65%
  • Memory 58%
  • Prefrontal Cortex 44%
  • Corpus Striatum 40%

• Neural Mechanisms of Self-Generated Mnemonic Strategies.

  Rich, E.

  Whitehall Foundation

  1/01/20 → 31/12/22

  Project: Research

• Regulation of PTSD Via Neuropeptidergic Signaling in the Brain-Vagus-Body Axis.

  Rajbhandari, A.

  Whitehall Foundation

  1/01/20 → 31/12/20

  Project: Research

• Construction of an integrated immune - vascular brain - chip as a platform for the study, drug screening, and treatments of Alzheimer's disease

  Tsai, L. H., Blanchard, J. & Kellis, M.

  National Institute of Neurological Disorders and Stroke

  20/09/19 → 31/05/21

  Project: Research

  • Preclinical Drug Evaluations 100%
  • Alzheimer Disease 94%
  • Blood Vessels 51%
  • Brain 48%
  • Cerebral Amyloid Angiopathy 38%

• Multi-region 'Network of Networks' Recurrent Neural Network Models of Adaptive and Maladaptive Learning

  Rajan, K.

  National Institute of Biomedical Imaging and Bioengineering

  16/09/19 → 15/09/22

  Project: Research

  • Recurrent neural networks 100%
  • Brain 48%
  • Networks (circuits) 26%
  • Communication 11%
  • Pipelines 9%

• Neuroimmune modulation of neuronal function during cocaine conditioning

  Shuman, T. & Kiraly, D.

  National Institute on Drug Abuse

  15/09/19 → 31/08/21

  Project: Research

  • Granulocyte Colony-Stimulating Factor 100%
  • Cocaine 93%
  • Microglia 67%
  • Nucleus Accumbens 43%
  • Granulocyte Colony-Stimulating Factor Receptors 41%

• The Role of Alternative Splicing in Neurodegeneration

  Raj, T.

  National Institute on Aging

  15/09/19 → 31/08/21

  Project: Research

  • Alzheimer Disease 100%
  • Alternative Splicing 85%
  • RNA-Binding Proteins 49%
  • Brain 35%
  • Antisense Oligonucleotides 33%

• Characterization of protective roles of ApoE2 against aging and Alzheimer's disease

  Cai, D., LaDu, M. J. & Zhang, B.

  National Institute on Aging

  15/09/19 → 31/08/21

  Project: Research

  • Apolipoprotein E2 100%
  • Alzheimer Disease 93%
  • Brain 49%
  • Datasets 40%
  • Gene Frequency 37%

• Molecular Neurobiology of Human Drug Abuse

  Hurd, Y.

  National Institute on Drug Abuse

  1/09/19 → 31/08/20

  Project: Research

  • Heroin 100%
  • Opioid Analgesics 90%
  • Opioid-Related Disorders 71%
  • Neurobiology 68%
  • Substance-Related Disorders 51%

• NCS-FO: State Representations in Multi-purpose and Multi-region Neural Network Models of Cognition

  Rajan, K., Rich, E. & Rudebeck, P.

  National Science Foundation

  1/09/19 → 31/08/22

  Project: Research

  • Brain 100%
  • Neural networks 46%
  • Switches 39%
  • Recurrent neural networks 34%
  • Artificial intelligence 28%

• Development of new photo-releasable neuropeptide nano-vesicles for studying modulation in the brain

  Qin, Z. & Slesinger, P.

  National Institute of Neurological Disorders and Stroke

  1/09/19 → 31/08/22

  Project: Research

  • Neuropeptides 100%
  • Brain 32%
  • Photons 20%
  • Neuropeptide Receptors 9%
  • Technology 8%

• Interneuron and Network Synchrony in Alzheimer's Disease

  Shuman, T.

  National Institute of Neurological Disorders and Stroke

  15/08/19 → 31/07/21

  Project: Research

  • Interneurons 100%
  • Alzheimer Disease 74%
  • Memory 37%
  • Dentate Gyrus 15%
  • Cognitive Dysfunction 11%

• Determination of the GIRK channel proteome

  Slesinger, P.

  National Institute on Drug Abuse

  1/08/19 → 31/07/21

  Project: Research

  • Proteome 100%
  • Proteins 43%
  • Reward 25%
  • Inwardly Rectifying Potassium Channels 18%
  • Biotin 14%

• IDENTIFYING BIO-SIGNATURES OF SUICIDAL SUBTYPES IN VETERANS

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/07/19 → 30/06/21

  Project: Research

  • Veterans 100%
  • Psychological Power 30%
  • Self Report 28%
  • Longitudinal Studies 26%
  • Mental Disorders 26%

• IDENTIFYING BIO-SIGNATURES OF SUICIDAL SUBTYPES IN VETERANS

  Haghighi, F.

  U.S. Department of Veterans Affairs

  1/07/19 → 30/06/22

  Project: Research

• Modulation of Microglial Function by SPI1 (PU.1) in AD

  Pimenova, A.

  BrightFocus Foundation

  1/07/19 → 30/06/21

  Project: Research

  • Alzheimer Disease 100%
  • Intrinsic Factor 53%
  • Encephalitis 45%
  • Brain 42%
  • Neurodegenerative Diseases 37%

• A Female Specific Role of RGSz1 in Modulation of Chronic Pain

  Zachariou, V.

  National Institute of Neurological Disorders and Stroke

  1/07/19 → 30/06/20

  Project: Research

  • Periaqueductal Gray 100%
  • Chronic Pain 79%
  • Hyperalgesia 51%
  • Signal Transduction 49%
  • G-Protein-Coupled Receptors 31%

• Characterizing the inflammatory phenotype of human and mouse models of depression

  Chan, K. & Russo, S.

  Institute of Neurosciences, Mental Health and Addiction

  1/06/19 → 31/05/22

  Project: Research

  • Major Depressive Disorder 100%
  • Inflammation 56%
  • Depression 54%
  • Phenotype 33%
  • Brain 26%

• Impact of human disease-causing mutation on striatal synaptic and behavioral plasticity

  Huntley, G. & Benson, D.

  National Institute of Neurological Disorders and Stroke

  15/05/19 → 31/03/20

  Project: Research

  • Leucine 100%
  • Corpus Striatum 99%
  • Neuronal Plasticity 97%
  • Phosphotransferases 91%
  • Mutation 57%

• PTSD Prevention Using Oral Hydrocortisone in the Immediate Aftermath of Trauma

  Yehuda, R.

  U.S. Army

  1/05/19 → 1/05/19

  Project: Research

  • Hydrocortisone 100%
  • Post-Traumatic Stress Disorders 85%
  • Wounds and Injuries 50%
  • Survivors 23%
  • Mental Health 21%

• Generation and characterization of MGE-derived GABAergic neurons from human pluripotent stem cells

  Yang, N.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/04/19 → 31/01/21

  Project: Research

  • Median Eminence 100%
  • GABAergic Neurons 93%
  • Pluripotent Stem Cells 91%
  • Interneurons 68%
  • Parvalbumins 35%

• Studying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRI

  Fayad, Z. & Fayad, Z. A.

  National Heart, Lung, and Blood Institute

  15/01/19 → 31/12/22

  Project: Research

  • Fluorine 100%
  • Atherosclerosis 61%
  • Macrophages 50%
  • Magnetic Resonance Imaging 47%
  • Positron-Emission Tomography 42%

• Neural Mechanisms of Self- Generated Mnemonic Strategies

  Rich, E.

  Whitehall Foundation

  1/01/19 → 31/12/21

  Project: Research

• LARGE-SCALE TRANSCRIPTOME AND EPIGENOME ASSOCIATION ANALYSIS ACROSS MULTIPLE TRAITS

  Roussos, P.

  U.S. Department of Veterans Affairs

  1/10/18 → 31/03/21

  Project: Research

• LARGE-SCALE TRANSCRIPTOME AND EPIGENOME ASSOCIATION ANALYSIS ACROSS MULTIPLE TRAITS

  Roussos, P.

  U.S. Department of Veterans Affairs

  1/10/18 → 30/09/20

  Project: Research

  • Epigenome 100%
  • Veterans 74%
  • Transcriptome 51%
  • Genome 49%
  • Multifactorial Inheritance 22%

• Machine Learning of Genetic, Clinical and Environmental Data for Early Morbidity Detection in the UK Biobank.

  O'Reilly, P. & Sharapova, N. N.

  Medical Research Council

  1/10/18 → 30/06/22

  Project: Research

  • Machine learning 100%
  • Genetics 91%
  • Biomarkers 85%
  • Students 75%
  • Statistical Models 61%

• Development of novel therapeutics for opioid dependence

  Kenny, P. & Kamenecka, T. M.

  National Institute on Drug Abuse

  30/09/18 → 31/08/20

  Project: Research

  • Opioid-Related Disorders 100%
  • Opioid Analgesics 95%
  • Habenula 64%
  • Oxycodone 62%
  • Structure-Activity Relationship 36%

• Mechanistic and causal basis of fMRI functional connectivity in non-human primates

  Rudebeck, P. & Russ, B. E.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  18/09/18 → 17/09/22

  Project: Research

  • Magnetic Resonance Imaging 100%
  • Primates 78%
  • Oxygen 38%
  • Prefrontal Cortex 32%
  • Brain 26%

• Neural mechanisms for VGF regulation of energy balance

  Salton, S., Bartolomucci, A. & Buettner, C.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/09/18 → 30/06/22

  Project: Research

  • Hypothalamus 100%
  • Lipolysis 78%
  • VGF peptide 77%
  • Energy Metabolism 60%
  • TLQP-21 peptide 59%

• CRCNS Research Proposal: Collaborative Research: Modeling and Manipulating Dynamic Network Activity in the Brain

  Keilholz, S. S. & Mayberg, H.

  National Science Foundation

  15/09/18 → 31/08/21

  Project: Research

  • Connectome 100%
  • Deep Brain Stimulation 75%
  • Research Design 58%
  • Brain 53%
  • Neurosciences 34%

• Neuro-Immune Biotypes of Depression: Towards Pathophysiology-Based Diagnosis and Personalized Treatment

  Murrough, J.

  Dana Foundation

  6/09/18 → 5/09/21

  Project: Research

  • Major Depressive Disorder 100%
  • Blood-Brain Barrier 57%
  • Depression 41%
  • Tegmentum Mesencephali 30%
  • Anhedonia 29%

• Mechanism of activation and modulation in human GABA(B) receptor

  Fan, Q. R., Quick, M. & Slesinger, P.

  National Institute of General Medical Sciences

  1/09/18 → 31/07/22

  Project: Research

  • GABA-B Receptors 100%
  • GTP-Binding Proteins 75%
  • gamma-Aminobutyric Acid 56%
  • Structural Models 54%
  • Potassium Channels 33%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/08/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C. & Swirski, F.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/12/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• TRAF6 Nanoimmunotherapy to resolve plaque inflammation

  Fayad, Z. & Mulder, W.

  National Heart, Lung, and Blood Institute

  15/08/18 → 30/06/20

  Project: Research

  • TNF Receptor-Associated Factor 6 100%
  • HDL Lipoproteins 82%
  • Primates 41%
  • Inflammation 39%
  • Apolipoproteins E 35%

• Role of genomic imprinting in the etiology of Alcohol Dependence

  Kapoor, M.

  National Institute on Alcohol Abuse and Alcoholism

  1/08/18 → 31/07/21

  Project: Research

  • Genomic Imprinting 100%
  • Alcoholism 65%
  • Epigenomics 56%
  • Genes 39%
  • Genome-Wide Association Study 22%