Mount Sinai Institute for Systems Biomedicine

2022

Severe Obesity and Heart Failure

Aguilar-Gallardo, J. S., Romeo, F. J., Bhatia, K., Correa, A., Mechanick, J. I. & Contreras, J. P., 15 Aug 2022, In: American Journal of Cardiology. 177, p. 53-60 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Sex differences in appetitive and reactive aggression

Aubry, A. V., Joseph Burnett, C., Goodwin, N. L., Li, L., Navarrete, J., Zhang, Y., Tsai, V., Durand-de Cuttoli, R., Golden, S. A. & Russo, S. J., Sep 2022, In: Neuropsychopharmacology. 47, 10, p. 1746-1754 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Sex-Specific Differences in Clinical Outcomes After Percutaneous Coronary Intervention: Insights from the TAILOR-PCI Trial

Madan, M., Abbott, J. D., Lennon, R., So, D. Y. F., Macdougall, A. M., McLaughlin, M. A., Murthy, V., Saw, J., Rihal, C., Farkouh, M. E., Pereira, N. L. & Goodman, S. G., 21 Jun 2022, In: Journal of the American Heart Association. 11, 12, e024709.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

Moraes, B. C., Ribeiro-Filho, H. V., Roldão, A. P., Toniolo, E. F., Carretero, G. P. B., Sgro, G. G., Batista, F. A. H., Berardi, D. E., Oliveira, V. R. S., Tomasin, R., Vieceli, F. M., Pramio, D. T., Cardoso, A. B., Figueira, A. C. M., Farah, S. C., Devi, L. A., Dale, C. S., de Oliveira, P. S. L. & Schechtman, D., 26 Apr 2022, In: Science Signaling. 15, 731, abm6046.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Structural signatures: A web server for exploring a database of and generating protein structural features from human cell lines and tissues

Zatorski, N., Stein, D., Rahman, R., Iyengar, R. & Schlessinger, A., 2022, In: Database : the journal of biological databases and curation. 2022, baac053.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure and function differences in the prelimbic cortex to basolateral amygdala circuit mediate trait vulnerability in a novel model of acute social defeat stress in male mice

Grossman, Y. S., Fillinger, C., Manganaro, A., Voren, G., Waldman, R., Zou, T., Janssen, W. G., Kenny, P. J. & Dumitriu, D., Feb 2022, In: Neuropsychopharmacology. 47, 3, p. 788-799 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αvβ3

Sen, S., Spasic, A., Sinha, A., Wang, J., Bush, M., Li, J., Nešić, D., Zhou, Y., Angiulli, G., Morgan, P., Salas-Estrada, L., Takagi, J., Walz, T., Coller, B. S. & Filizola, M., 28 Nov 2022, In: Journal of Chemical Information and Modeling. 62, 22, p. 5607-5621 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting drug-resistant mutations in ALK

He, L. & Dar, A. C., Jun 2022, In: Nature Cancer. 3, 6, p. 659-661 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The Combined Effects of Television Viewing and Physical Activity on Cardiometabolic Risk Factors: The Kardiovize Study

Maranhao Neto, G. A., Pavlovska, I., Polcrova, A., Mechanick, J. I., Infante-Garcia, M. M., Medina-Inojosa, J., Nieto-Martinez, R., Lopez-Jimenez, F. & Gonzalez-Rivas, J. P., 1 Feb 2022, In: Journal of Clinical Medicine. 11, 3, 545.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry

Bayes, A., Short, B., Zarate, C. A., Park, L., Murrough, J. W., McLoughlin, D. M., Riva-Posse, P., Schoevers, R., Veraart, J., Parikh, S., Glue, P., Fam, J., McShane, R., Galvez, V., Martin, D., Tor, P. C., Brunoni, A. & Loo, C. K., 1 Jul 2022, In: Journal of Affective Disorders. 308, p. 44-46 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression

Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Xia, S., Zinsmaier, A. K., Tan, C., Li, W., Browne, C. J., Walker, D. M., Salery, M., Torres-Berrío, A., Futamura, R., Duffy, J. E., Labonte, B., Girgenti, M. J., Tamminga, C. A., Dupree, J. L., Dong, Y., Murrough, J. W. & Shen, L. & 1 others, Nestler, E. J., Dec 2022, In: Science advances. 8, 48, eabn9494.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants

Costi, S., Han, M. H. & Murrough, J. W., Mar 2022, In: CNS Drugs. 36, 3, p. 207-216 10 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation

Muñoz, J. J. A. M., Dariolli, R., da Silva, C. M., Neri, E. A., Valadão, I. C., Turaça, L. T., Lima, V. M., de Carvalho, M. L. P., Velho, M. R., Sobie, E. A. & Krieger, J. E., Dec 2022, In: Stem Cell Research and Therapy. 13, 1, 437.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Uncovering the role of neuropeptide receptor GPR83 in nociception

Hanlon, J. P., Young, R. E., Devi, L. A. & Fakira, A. K., 1 May 2022, In: FASEB Journal. 36

Research output: Contribution to journal › Article › peer-review

Open Access

Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses

Morris, L. S., Mehta, M., Ahn, C., Corniquel, M., Verma, G., Delman, B., Hof, P. R., Jacob, Y., Balchandani, P. & Murrough, J. W., 1 Dec 2022, In: NeuroImage. 264, 119704.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression

Cathomas, F., Bevilacqua, L., Ramakrishnan, A., Kronman, H., Costi, S., Schneider, M., Chan, K. L., Li, L., Nestler, E. J., Shen, L., Charney, D. S., Russo, S. J. & Murrough, J. W., Dec 2022, In: Translational Psychiatry. 12, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes

Hansen, J., Siddiq, M. M., Yadaw, A. S., Tolentino, R. E., Rabinovich, V., Jayaraman, G., Jain, M. R., Liu, T., Li, H., Xiong, Y., Goldfarb, J. & Iyengar, R., Oct 2022, In: Journal of Biological Chemistry. 298, 10, 102325.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2021

a3p Nicotinic acetylcholine receptors in the habenula-interpeduncular nucleus circuit regulate nicotine intake

Elayouby, K. S., Ishikawa, M., Dukes, A. J., Smith, A. C. W., Lu, Q., Fowler, C. D. & Kenny, P. J., 24 Feb 2021, In: Journal of Neuroscience. 41, 8, p. 1779-1787 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

AKI in hospitalized patients with COVID-19

on behalf of the Mount Sinai COVID Informatics Center (MSCIC), Jan 2021, In: Journal of the American Society of Nephrology : JASN. 32, 1, p. 151-160 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

515 Scopus citations

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

Schaniel, C., Dhanan, P., Hu, B., Xiong, Y., Raghunandan, T., Gonzalez, D. M., Dariolli, R., D'Souza, S. L., Yadaw, A. S., Hansen, J., Jayaraman, G., Mathew, B., Machado, M., Berger, S. I., Tripodi, J., Najfeld, V., Garg, J., Miller, M., Surlyn, C. S. & Michelis, K. C. & 16 others, Tangirala, N. C., Weerahandi, H., Thomas, D. C., Beaumont, K. G., Sebra, R., Mahajan, M., Schadt, E., Vidovic, D., Schürer, S. C., Goldfarb, J., Azeloglu, E. U., Birtwistle, M. R., Sobie, E. A., Kovacic, J. C., Dubois, N. C. & Iyengar, R., 14 Dec 2021, In: Stem Cell Reports. 16, 12, p. 3036-3049 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

AMPK mediates regulation of glomerular volume and podocyte survival

Banu, K., Lin, Q., Basgen, J. M., Planoutene, M., Wei, C., Reghuvaran, A. C., Tian, X., Shi, H., Garzon, F., Garzia, A., Chun, N., Cumpelik, A., Santeusanio, A. D., Zhang, W., Das, B., Salem, F., Li, L., Ishibe, S., Cantley, L. G. & Kaufman, L. & 5 others, Lemley, K. V., Ni, Z., He, J. C., Murphy, B. & Menon, M. C., 8 Oct 2021, In: JCI insight. 6, 19, e150004.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: Guidelines from the kidney precision medicine project

Kidney Precision Medicine Project, 2021, In: Physiological Genomics. 53, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects

Chakraborty, S., DiBerto, J. F., Faouzi, A., Bernhard, S. M., Gutridge, A. M., Ramsey, S., Zhou, Y., Provasi, D., Nuthikattu, N., Jilakara, R., Nelson, M. N. F., Asher, W. B., Eans, S. O., Wilson, L. L., Chintala, S. M., Filizola, M., van Rijn, R. M., Margolis, E. B., Roth, B. L. & McLaughlin, J. P. & 4 others, Che, T., Sames, D., Javitch, J. A. & Majumdar, S., 23 Sep 2021, In: Journal of Medicinal Chemistry. 64, 18, p. 13873-13892 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Pryce, K. D., Kang, H. J., Sakloth, F., Liu, Y., Khan, S., Toth, K., Kapoor, A., Nicolais, A., Che, T., Qin, L., Bertherat, F., Kaniskan, H. Ü., Jin, J., Cameron, M. D., Roth, B. L., Zachariou, V. & Filizola, M., 1 Sep 2021, In: Neuropharmacology. 195, 108673.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

A randomized controlled trial of repeated ketamine administration for chronic posttraumatic stress disorder

Feder, A., Costi, S., Rutter, S. B., Collins, A. B., Govindarajulu, U., Jha, M. K., Horn, S. R., Kautz, M., Corniquel, M., Collins, K. A., Bevilacqua, L., Glasgow, A. M., Brallier, J., Pietrzak, R. H., Murrough, J. W. & Charney, D. S., 1 Feb 2021, In: American Journal of Psychiatry. 178, 2, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Arterial Stiffness and Cardiometabolic-Based Chronic Disease: The Kardiovize Study

Pavlovska, I., Mechanick, J. I., Maranhao Neto, G. A., Infante-Garcia, M. M., Nieto-Martinez, R., Kunzova, S., Polcrova, A., Vysoky, R., Medina-Inojosa, J. R., Lopez-Jimenez, F., Stokin, G. B. & González-Rivas, J. P., Jun 2021, In: Endocrine Practice. 27, 6, p. 571-578 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Kidney Precision Medicine Project (KPMP), Sep 2021, In: Kidney International. 100, 3, p. 672-683 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Cardiometabolic risk factors in Venezuela. The EVESCAM study: a national cross-sectional survey in adults

Nieto-Martínez, R., González-Rivas, J. P., Ugel, E., Duran, M., Dávila, E., Constantino, R., García, A., Mechanick, J. I. & Marulanda, M. I., Feb 2021, In: Primary Care Diabetes. 15, 1, p. 106-114 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Case presentation and panel discussion: Cardiometabolic risk mitigation

Mundi, M. S., Mechanick, J. I., Patel, J. J., Al-Kazaz, M., Garvey, W. T. & Still, C. D., Nov 2021, In: Journal of Parenteral and Enteral Nutrition. 45, p. 93-99 7 p.

Research output: Contribution to journal › Article › peer-review

Case presentation and panel discussion: Nutrition issues in cancer

Mundi, M. S., Mechanick, J. I., Patel, J. J., Laviano, A., Martindale, R. G. & Zimmers, T. A., Nov 2021, In: Journal of Parenteral and Enteral Nutrition. 45, p. 41-46 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Case presentation and panel discussion: Critical illness

Mundi, M. S., Patel, J. J., Mechanick, J. I., Arabi, Y. M., Alverdy, J., Puthucheary, Z. & McClave, S. A., Nov 2021, In: Journal of Parenteral and Enteral Nutrition. 45, p. 79-84 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chemical, Manufacturing, and Standardization Controls of Grape Polyphenol Dietary Supplements in Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage, and Profiles

Lyu, W., Rodriguez, D., Ferruzzi, M. G., Pasinetti, G. M., Murrough, J. W., Simon, J. E. & Wu, Q., 16 Dec 2021, In: Frontiers in Nutrition. 8, 780226.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation

Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz-Kausch, A. M., Dietz, D. M. & Lobo, M. K., Dec 2021, In: Molecular Brain. 14, 1, 101.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

Kunselman, J. M., Gupta, A., Gomes, I., Devi, L. A. & Puthenveedu, M. A., Apr 2021, In: eLife. 10, e60270.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Crowdsourced identification of multi-target kinase inhibitors for RET- And TAU- based disease- And Multi-Targeting Drug DREAM Challenge

Xiong, Z., Jeon, M., Allaway, R. J., Kang, J., Park, D., Lee, J., Jeon, H., Ko, M., Jiang, H., Zheng, M., Tan, A. C., Guo, X., Dang, K. K., Tropsha, A., Hecht, C., Das, T. K., Carlson, H. A., Abagyan, R., Guinney, J. & Schlessinger, A. & 1 others, Cagan, R., Sep 2021, In: PLoS Computational Biology. 17, 9, e1009302.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Crowdsourced mapping of unexplored target space of kinase inhibitors

Team KinaseHunter, Team AmsterdamUMC-KU-team, Team DruginaseLearning, Team KERMIT-LAB - Ghent University, Team QED, Team METU_EMBLEBI_CROssBAR, Team DMIS_DK, Team AI Winter is Coming, Team hulab, Team ML-Med, Team Prospectors, Challenge organizers, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, User oselot, Team N121, Team Let_Data_Talk, User thinng, Team KKT & Team Boun, Dec 2021, In: Nature Communications. 12, 1, 3307.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity

Cao, A., Li, J., Asadi, M., Basgen, J. M., Zhu, B., Yi, Z., Jiang, S., Doke, T., El Shamy, O., Patel, N., Cravedi, P., Azeloglu, E. U., Campbell, K. N., Menon, M., Coca, S., Zhang, W., Wang, H., Zen, K., Liu, Z. & Murphy, B. & 4 others, He, J. C., D’Agati, V. D., Susztak, K. & Kaufman, L., May 2021, In: Journal of Clinical Investigation. 131, 10, e141279.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Deficiency in nebulin repeats of sarcomeric nebulette is detrimental for cardiomyocyte tolerance to exercise and biomechanical stress

Vejandla, R. M., Orgil, B. O., Alberson, N. R., Li, N., Munkhsaikhan, U., Khuchua, Z., Martherus, R., Azeloglu, E. U., Xu, F., Lu, L., Towbin, J. A. & Purevjav, E., 2021, In: American Journal of Physiology - Heart and Circulatory Physiology. 320, 5, p. H2130-H2146

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Derivation and validation of a machine learning risk score using biomarker and electronic patient data to predict progression of diabetic kidney disease

Chan, L., Nadkarni, G. N., Fleming, F., McCullough, J. R., Connolly, P., Mosoyan, G., El Salem, F., Kattan, M. W., Vassalotti, J. A., Murphy, B., Donovan, M. J., Coca, S. G. & Damrauer, S. M., Jul 2021, In: Diabetologia. 64, 7, p. 1504-1515 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Thibado, J. K., Tano, J. Y., Lee, J., Salas-Estrada, L., Provasi, D., Strauss, A., Ribeiro, J. M. L., Xiang, G., Broichhagen, J., Filizola, M., Lohse, M. J. & Levitz, J., 2021, In: eLife. 10, e67027.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Dissolution Study on Grape Polyphenol Hard Gelatin Capsule Dietary Supplements

Lyu, W., Omar, T., Patel, H., Rodriguez, D., Ferruzzi, M. G., Pasinetti, G. M., Murrough, J. W., Muzzio, F. J., Simon, J. E. & Wu, Q., 25 Nov 2021, In: Frontiers in Nutrition. 8, 780260.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Dual targeting of salt inducible kinases and csf1r uncouples bone formation and bone resorption

Tang, C. C., Andrade, C. D. C., O’meara, M. J., Yoon, S. H., Sato, T., Brooks, D. J., Bouxsein, M. L., Martins, J. D. S., Wang, J., Gray, N. S., Misof, B., Roschger, P., Boulin, S., Klaushofer, K., Velduis-Vlug, A., Vegting, Y., Rosen, C. J., O’connell, D., Sundberg, T. B. & Xavier, R. J. & 6 others, Ung, P., Schlessinger, A., Kronenberg, H. M., Berdeaux, R., Foretz, M. & Wein, M. N., Jun 2021, In: eLife. 10, e67772.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Evaluation of a clinical-grade, cryopreserved, ex vivo-expanded stem cell product from cryopreserved primary umbilical cord blood demonstrates multilineage hematopoietic engraftment in mouse xenografts

Schaniel, C., Papa, L., Meseck, M. L., Kintali, M., Djedaini, M., Zangui, M., Iancu-Rubin, C. & Hoffman, R., Sep 2021, In: Cytotherapy. 23, 9, p. 841-851 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Exploiting allosteric properties of raf and mek inhibitors to target therapy-resistant tumors driven by oncogenic braf signaling

Adamopoulos, C., Ahmed, T. A., Tucker, M. R., Ung, P. M. U., Xiao, M., Karoulia, Z., Amabile, A., Wu, X., Aaronson, S. A., Ang, C., Rebecca, V. W., Brown, B. D., Schlessinger, A., Herlyn, M., Wang, Q., Shaw, D. E. & Poulikakos, P. I., Jul 2021, In: Cancer Discovery. 11, 7, p. 1716-1735 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Factors associated with longitudinal psychological and physiological stress in health care workers during the covid-19 pandemic: Observational study using apple watch data

Hirten, R. P., Danieletto, M., Tomalin, L., Choi, K. H., Zweig, M., Golden, E., Kaur, S., Helmus, D., Biello, A., Pyzik, R., Calcagno, C., Freeman, R., Sands, B. E., Charney, D., Bottinger, E. P., Murrough, J. W., Keefer, L., Suarez-Farinas, M., Nadkarni, G. N. & Fayad, Z. A., Sep 2021, In: Journal of Medical Internet Research. 23, 9, e31295.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Gene splicing SETs the scene for cocaine addiction

Bali, P. & Kenny, P. J., 15 Sep 2021, In: Neuron. 109, 18, p. 2802-2804 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Habenula Connectivity and Intravenous Ketamine in Treatment-Resistant Depression

Rivas-Grajales, A. M., Salas, R., Robinson, M. E., Qi, K., Murrough, J. W. & Mathew, S. J., 1 May 2021, In: International Journal of Neuropsychopharmacology. 24, 5, p. 383-391 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

High-throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics

Lemos Duarte, M., Trimbake, N. A., Gupta, A., Tumanut, C., Fan, X., Woods, C., Ram, A., Gomes, I., Bobeck, E. N., Schechtman, D. & Devi, L. A., Dec 2021, In: Communications Biology. 4, 1, 238.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies

Lizarraga, S. B., Ma, L., Maguire, A. M., van Dyck, L. I., Wu, Q., Ouyang, Q., Kavanaugh, B. C., Nagda, D., Livi, L. L., Pescosolido, M. F., Schmidt, M., Alabi, S., Cowen, M. H., Brito-Vargas, P., Hoffman-Kim, D., Gamsiz Uzun, E. D., Schlessinger, A., Jones, R. N. & Morrow, E. M., 10 Feb 2021, In: Science Translational Medicine. 13, 580, eaaw0682.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants

Sevim Bayrak, C., Stein, D., Jain, A., Chaudhary, K., Nadkarni, G. N., Van Vleck, T. T., Puel, A., Boisson-Dupuis, S., Okada, S., Stenson, P. D., Cooper, D. N., Schlessinger, A. & Itan, Y., 2 Dec 2021, In: American Journal of Human Genetics. 108, 12, p. 2301-2318 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Mount Sinai Institute for Systems Biomedicine

Research output

Search results