Mount Sinai Institute for Systems Biomedicine

Projects

Projects per year 1986 2009 2013 2014 2015 2017 2018 2020 2021 2027

• 1 Not started
• 35 Active
• 76 Finished

Projects per year

Search results

• Finished

  A Cytochrome P450 Therapeutic Space for Tauopathies

  Dar, A. & Cagan, R.

  National Institute on Aging

  30/09/21 → 31/08/22

  Project: Research

  • Anastrozole 100%
  • cytochrome P-450 92%
  • Tauopathies 80%
  • therapeutics 76%
  • neurodegenerative diseases 62%

• A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

  Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.

  National Cancer Institute

  1/03/21 → 28/02/23

  Project: Research

  • regorafenib 100%
  • Phosphotransferases 62%
  • Colorectal Neoplasms 60%
  • Polypharmacology 20%
  • Aurora Kinase A 17%

• Intercellular Signaling and Biomechanics of Podocytes and Endothelial Cells in FSGS

  Azeloglu, E.

  U.S. Army

  1/09/20 → 1/09/20

  Project: Research

  • kidney diseases 100%
  • renal failure 73%
  • biomechanics 67%
  • therapeutics 61%
  • cell communication 60%

• Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• MERRIT: Multidisciplinary Engineering and Renal Research for Innovation of Technology

  Azeloglu, E., Azeloglu, E. U., Lima, E. E. G. & Lima, E. G.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/20 → 31/01/23

  Project: Research

  • engineering 100%
  • innovation 95%
  • research project 39%
  • trainee 12%
  • joint venture 7%

• Characterizing the inflammatory phenotype of human and mouse models of depression

  Chan, K. & Russo, S.

  Institute of Neurosciences, Mental Health and Addiction

  1/06/19 → 31/05/22

  Project: Research

  • Major Depressive Disorder 100%
  • Inflammation 56%
  • Depression 54%
  • Phenotype 33%
  • Brain 26%

• Development of novel therapeutics for opioid dependence

  Kenny, P. & Kamenecka, T. M.

  National Institute on Drug Abuse

  30/09/18 → 31/08/20

  Project: Research

  • Opioid-Related Disorders 100%
  • Opioid Analgesics 95%
  • Habenula 64%
  • Oxycodone 62%
  • Structure-Activity Relationship 36%

• Neuro-Immune Biotypes of Depression: Towards Pathophysiology-Based Diagnosis and Personalized Treatment

  Murrough, J.

  Dana Foundation

  6/09/18 → 5/09/21

  Project: Research

  • Major Depressive Disorder 100%
  • Blood-Brain Barrier 57%
  • Depression 41%
  • Tegmentum Mesencephali 30%
  • Anhedonia 29%

• Parallel Multimodal High-throughput screening to identify activators of the orexin receptors

  Kamenecka, T. M., Kenny, P., Scampavia, L. D., Kamenecka, T. T. M., Scampavia, L. L. D. & Kenny, P. P. J.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  5/07/18 → 30/09/22

  Project: Research

  • Orexin Receptors 100%
  • Orexins 84%
  • Orexin Receptor Antagonists 26%
  • suvorexant 14%
  • Pharmaceutical Chemistry 11%

• Targeting Oncogenic Ras-MAPK Signaling Complexes via the Scaffold KSR

  Dar, A. & Dar, A.

  National Cancer Institute

  15/03/18 → 28/02/23

  Project: Research

  • Mitogen-Activated Protein Kinases 100%
  • Phosphotransferases 76%
  • Neoplasms 24%
  • Protein Kinase Inhibitors 18%
  • Therapeutic Index 13%

• Altered Mechanotransduction as a Therapeutic Target for Thoracic Aortic Aneurysm

  Rifkin, D. B., Humphrey, J. D., Iyengar, S. R. V., Ramirez, F. & Schwartz, M. A.

  National Heart, Lung, and Blood Institute

  1/03/18 → 28/02/22

  Project: Research

  • Thoracic Aortic Aneurysm 100%
  • Committee Membership 27%
  • Organized Financing 22%
  • Compliance 17%
  • Computational Biology 14%

• Role of lateral habenula orexin receptor signaling in aggressive social behavior

  Russo, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  15/09/17 → 30/06/22

  Project: Research

  • Habenula 100%
  • Orexin Receptors 98%
  • Social Behavior 87%
  • Interpersonal Relations 33%
  • Orexins 27%

• Characterization of Altered Mechanosensing in Mouse Models of ECM-induced TAA

  Ramirez, F.

  National Heart, Lung, and Blood Institute

  1/09/17 → 28/02/22

  Project: Research

  • Thoracic Aortic Aneurysm 100%
  • Marfan Syndrome 68%
  • Extracellular Matrix 55%
  • Angiotensin II 34%
  • Fibrillin-1 26%

• Novel Treatment Options for Glutaric Aciduria

  Houten, S. & DeVita, R.

  National Institute of Child Health and Human Development

  1/09/17 → 31/08/19

  Project: Research

  • Glutaryl-CoA Dehydrogenase 100%
  • Pharmaceutical Chemistry 74%
  • 3-hydroxyglutaric acid 68%
  • glutaric acid 61%
  • Lysine 52%

• MicroRNAs in schizophrenia

  Kenny, P.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  21/07/17 → 30/04/22

  Project: Research

  • Parvalbumins 100%
  • Interneurons 77%
  • MicroRNAs 64%
  • Schizophrenia 54%
  • Mouse Mirn206 microRNA 23%

• LINKING THE EFFECTS OF 9/11 TO KIDNEY DISEASE

  McLaughlin, M. A.

  National Institute for Occupational Safety and Health

  1/07/17 → 30/06/20

  Project: Research

  • Kidney Diseases 100%
  • Obstructive Sleep Apnea 35%
  • Health 17%
  • Phenotype 10%
  • Kidney 9%

• LINKING THE EFFECTS OF 9/11 TO KIDNEY DISEASE

  McLaughlin, M. A.

  National Institute for Occupational Safety and Health

  1/07/17 → 30/06/20

  Project: Research

  • Kidney Diseases 100%
  • Obstructive Sleep Apnea 35%
  • Health 17%
  • Phenotype 10%
  • Kidney 9%

• LINKING THE EFFECTS OF 9/11 TO KIDNEY DISEASE

  McLaughlin, M. A.

  National Institute for Occupational Safety and Health

  1/07/17 → 30/06/20

  Project: Research

  • Kidney Diseases 100%
  • Obstructive Sleep Apnea 35%
  • Health 17%
  • Phenotype 10%
  • Kidney 9%

• Nicotinic receptors and alcohol reinforcement

  Kenny, P.

  National Institute on Alcohol Abuse and Alcoholism

  15/07/16 → 31/03/21

  Project: Research

  • Nicotinyl Alcohol 100%
  • Interpeduncular Nucleus 95%
  • Habenula 84%
  • Nicotinic Receptors 63%
  • Psychology Reinforcement 55%

• Quantitative analysis of local calcium release across cell types

  Sobie, E.

  National Science Foundation

  15/07/16 → 30/06/21

  Project: Research

  • calcium 100%
  • quantitative analysis 79%
  • cells 42%
  • college students 35%
  • oocytes 34%

• Development of new therapeutic strategy targeting interaction between RTP4-mu-delta heteromers

  Fujita, W. W., Devi, L., Ueda, H. H. & Yokote, M. M.

  Japan Society for the Promotion of Science

  1/04/16 → 31/03/18

  Project: Research

• DEVELOPING NOVEL PEPT1-TARGETED MODULATORS FOR INFLAMMATORY BOWEL DISEASE (IBD) THERAPY

  Schlessinger, A.

  Congressionally Directed Medical Research Programs

  15/09/15 → 14/03/17

  Project: Research

  • Drug Target 100%
  • Drug 92%
  • Prescription Drug 73%
  • Biologic Agent 61%
  • Molecule 60%

• Developing Novel PepT1-Targeted Modulators for Inflammatory Bowel Disease (IBD) Therapy

  Schlessinger, A.

  U.S. Army

  15/09/15 → 15/09/15

  Project: Research

  • Drug 100%
  • Chemical Entity 96%
  • Drug Target 86%
  • Prescription Drug 63%
  • Biologic Agent 53%

• Pasinetti: Project 1; Preservation of Psychological Resilience under Chronic Stress (Russo)

  Russo, S.

  National Center for Complementary and Integrative Health

  1/09/15 → 30/06/20

  Project: Research

  • Psychological Resilience 100%
  • Anxiety 45%
  • Psychological Tests 41%
  • Depression 41%
  • Anxiety Disorders 30%

• Pasinetti: Overall; Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience (Pasinetti)

  Pasinetti, G., Dixon, R. A., Faith, J., Ho, L., Russo, S. & Wang, J.

  National Center for Complementary and Integrative Health

  1/09/15 → 30/06/21

  Project: Research

  • polyphenols 100%
  • dietary supplements 51%
  • microbiome 37%
  • bioavailability 37%
  • career development 34%

• An intronic locus determines SHROOM3-expression and potentiates renal allograft fibrosis

  Murphy, B.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/08/15 → 31/07/20

  Project: Research

  • Allografts 100%
  • Fibrosis 86%
  • Chronic Renal Insufficiency 62%
  • Kidney 60%
  • Single Nucleotide Polymorphism 38%

• Intracellular and Intercellular variability in cardiac calcium release

  Sobie, E.

  American Heart Association

  1/07/15 → 30/06/18

  Project: Research

  • Sarcoplasmic Reticulum 100%
  • Calcium 47%
  • Muscle Cells 23%
  • Heart 16%
  • Organized Financing 14%

• Neural circuit of frustration aggression

  Takahashi, A. A. & Russo, S.

  Japan Society for the Promotion of Science

  1/04/15 → 31/03/19

  Project: Research

• Endothelial Dysfunction as the Trigger of Aortic Aneurysm in the Marfan Syndrome

  Ramirez, F.

  Marfan Foundation

  1/01/15 → 31/12/16

  Project: Research

• Administrative Core

  Birtwistle, M., Iyengar, S. R. V. & Sobie, E.

  National Human Genome Research Institute

  10/09/14 → 30/06/20

  Project: Research

  • Glues 100%
  • Process engineering 97%
  • Quality assurance 85%
  • Supply chains 79%
  • Quality control 76%

• Data Generation Core

  Birtwistle, M., Sobie, E. & Sobie, E. A.

  National Human Genome Research Institute

  10/09/14 → 30/06/20

  Project: Research

  • Drug Combinations 100%
  • Pharmaceutical Preparations 46%
  • Drug-Related Side Effects and Adverse Reactions 29%
  • Explosions 19%
  • Cell Line 19%

• Data Analysis and Signature Generation Core

  Birtwistle, M., Sobie, E. & Sobie, E. A.

  National Human Genome Research Institute

  10/09/14 → 30/06/20

  Project: Research

  • Messenger RNA 100%
  • Proteins 86%
  • Toxicity 83%
  • Assays 55%
  • Genes 45%

• Community Operations

  Birtwistle, M., Sobie, E. & Sobie, E. A.

  National Human Genome Research Institute

  10/09/14 → 30/06/20

  Project: Research

  • Websites 100%
  • Industry 68%
  • Drug Discovery 52%
  • Data visualization 44%
  • Cloud computing 34%

• Can Ventricular Assist Devices Reverse the Frailty Phenotype

  Maurer, M. S., Horn, E., Pinney, S. & Reyentovich, A.

  National Institute on Aging

  1/09/14 → 30/04/17

  Project: Research

  • Frailty 100%
  • Heart-Assist Devices 85%
  • Phenotype 45%
  • Heart Failure 33%
  • Frail Elderly 19%

• RENAL AND CARDIOVASCULAR IMPAIRMENT IN WTC RESPONDERS: IMPLICATIONS FOR DIAGNOSIS

  McLaughlin, M. A.

  National Institute for Occupational Safety and Health

  1/07/14 → 30/06/17

  Project: Research

  • Particulate Matter 100%
  • Emergency Responders 58%
  • Chronic Renal Insufficiency 56%
  • Kidney 49%
  • Health 40%

• RENAL AND CARDIOVASCULAR IMPAIRMENT IN WTC RESPONDERS: IMPLICATIONS FOR DIAGNOSIS

  McLaughlin, M. A.

  National Institute for Occupational Safety and Health

  1/07/14 → 30/06/16

  Project: Research

  • Particulate Matter 100%
  • Emergency Responders 58%
  • Chronic Renal Insufficiency 56%
  • Kidney 49%
  • Health 40%

• Graduate Research Fellowship Program (GRFP)

  Filizola, M. & Morrisson, J. J.

  National Science Foundation

  1/05/14 → 30/04/19

  Project: Research

  • graduate 100%
  • engineering 22%
  • education 11%

• Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase

  Dar, A.

  National Cancer Institute

  30/09/13 → 30/06/18

  Project: Research

  • KSR-1 protein kinase 100%
  • Phosphotransferases 32%
  • Neoplasms 14%
  • Point Mutation 7%
  • Protein Kinases 6%

• Project 4 (Sobie)

  Sobie, E.

  National Institute of General Medical Sciences

  1/09/13 → 31/08/18

  Project: Research

• Structural microenvironment of bone marrow stem cells

  Ramirez, F.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/08/13 → 31/07/15

  Project: Research

  • Fibrillin-1 100%
  • Bone Marrow Cells 43%
  • Bone Marrow 38%
  • Stem Cells 37%
  • Marfan Syndrome 34%

• Ketamine Plus Lithium as a Novel Pharmacotherapeutic Strategy in Treatment-Resistant Depression

  Murrough, J.

  Doris Duke Charitable Foundation

  1/07/13 → 30/06/16

  Project: Research

• Orexin receptor antagonists for drug addiction and panic disorder

  Kenny, P. & Kenny, P. J.

  National Institute of Neurological Disorders and Stroke

  1/06/13 → 31/05/19

  Project: Research

  • Orexin Receptor Antagonists 100%
  • Orexins 67%
  • Panic Disorder 61%
  • Orexin Receptors 51%
  • Nicotine 51%

• Novel approach for developing antibody reagents to probe changes in the synapse p

  Fan, X. & Devi, L.

  National Institute on Drug Abuse

  1/05/13 → 30/04/14

  Project: Research

  • Synapses 100%
  • Antibodies 57%
  • Proteome 45%
  • Proteins 40%
  • Yeasts 35%

• In Vivo Screening Strategies

  Kenny, P.

  National Institute on Drug Abuse

  1/05/13 → 30/04/15

  Project: Research

  • Nicotine 100%
  • Self Stimulation 51%
  • Self Administration 21%
  • Knockout Mice 16%
  • Craving 10%

• Sex Differences in Stress-Induced Genome-Wide Transcriptional Profiles

  Russo, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/01/13 → 31/12/14

  Project: Research

  • Sex Characteristics 100%
  • Depression 78%
  • Genome 58%
  • Anxiety 57%
  • RNA Sequence Analysis 44%

• Development of Orexin-1 Receptor Antagonists for Drug Addiction

  Kamenecka, T. M., Cameron, M. D., Kamenecka, T. M., Kenny, P. & Mcdonald, P. H.

  National Institute on Drug Abuse

  15/05/12 → 30/04/13

  Project: Research

  • Orexin Receptor Antagonists 100%
  • Structure-Activity Relationship 50%
  • Substance-Related Disorders 46%
  • Orexin Receptors 38%
  • Pharmaceutical Chemistry 23%

• Scripps Florida Product Development Partnership for smoking cessation therapeutic

  Griffin, P. R. & Kenny, P.

  National Institute on Drug Abuse

  30/09/11 → 31/08/13

  Project: Research

  • Smoking Cessation 100%
  • Tobacco 62%
  • N-nitrosoiminodiacetic acid 57%
  • Smokers 56%
  • Smoking 47%

• Development of a5* nAChR positive allosteric modulators for tobacco dependence

  Kenny, P., Lindstrom, J. M. & Kenny, P. J.

  National Institute on Drug Abuse

  1/01/11 → 30/11/16

  Project: Research

  • Nicotinic Receptors 100%
  • Tobacco Use Disorder 98%
  • Pharmaceutical Chemistry 49%
  • Structure-Activity Relationship 42%
  • Smoking Cessation 41%

• Role of thalamic versus cortical inputs to nucleus accumbens in stress-related disorders

  Russo, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  15/11/10 → 30/11/20

  Project: Research

  • Nucleus Accumbens 100%
  • Thalamus 26%
  • Dendritic Spines 25%
  • Anxiety Disorders 23%
  • Mood Disorders 23%

• Effects of Glycoxidative Stress on Human Aging

  He, J. C. & Vlassara, H.

  National Institute of Diabetes and Digestive and Kidney Diseases

  25/09/10 → 30/06/16

  Project: Research

  • Advanced Glycation End Products 100%
  • Metabolic Syndrome 36%
  • Oxidative Stress 30%
  • Inflammation 21%
  • Oxidants 8%