Mount Sinai Institute for Systems Biomedicine

Icahn School of Medicine at Mount Sinai

1 Not started
37 Active
78 Finished

Preclinical Validation of Novel Gut-Restricted LRRK2 Inhibitors as Therapeutic Leads for IBD
Peter, I. & DeVita, R.
National Institute of Diabetes and Digestive and Kidney Diseases
30/09/22 → 30/06/23
Project: Research
Graduate Research Fellowship Program (GRFP)
Filizola, M.
National Science Foundation
15/08/22 → 31/07/27
Project: Research
Multi-modal data integration to identify kinase substrates
Pandey, G. & Schlessinger, A.
National Cancer Institute
5/07/22 → 30/06/23
Project: Research
Biomechanical drivers of cystogenesis
Gusella, L., Azeloglu, E., Azeloglu, E. E. U. & Gusella, L.
National Institute of Diabetes and Digestive and Kidney Diseases
24/09/21 → 31/07/23
Project: Research
A novel treatment option for disorders of propionate metabolism
Houten, S., DeVita, R., Houten, S. M. & Devita, R. R. J.
National Institute of Child Health and Human Development
22/09/21 → 31/08/23
Project: Research
Training Program in Substance Use Disorders
Kenny, P. & Kenny, P. J.
National Institute on Drug Abuse
1/07/21 → 30/06/23
Project: Research
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
Dar, A., Guccione, E., Lujambio, A., Guccione, E. E., Guccione, E. & Lujambio, A.
National Cancer Institute
1/07/21 → 30/06/23
Project: Research
Neural Circuit Mechanisms of Stress-Impaired Social Reward
Russo, S. & Russo, S. J.
NATIONAL INSTITUTE OF MENTAL HEALTH
1/06/21 → 31/03/23
Project: Research
Substrate reduction as a novel therapeutic strategy for Glutaric Aciduria Type 1
Houten, S., DeVita, R., Houten, S. M. & Devita, R. R. J.
National Institute of Child Health and Human Development
1/05/21 → 30/04/23
Project: Research
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.
National Cancer Institute
1/03/21 → 28/02/23
Project: Research
IND-Enabling Studies for WNTinib, a Novel Selective Therapeutic for CTNNB1 Mutant Hepatoblastomas
Guccione, E., Llovet, J. J. & Dar, A.
Alex's Lemonade Stand Foundation for Childhood Cancer
1/01/21 → …
Project: Research
Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathies
Mallipattu, S., He, J. C., Cijiang He, J., He, J. J. C. & Mallipattu, S. K.
National Institute of Diabetes and Digestive and Kidney Diseases
14/09/20 → 31/05/23
Project: Research

103473 Citations
155 h-index
1252 Article
294 Review article
86 Comment/debate
78 Chapter
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A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults
Costi, S., Evers, A., Jha, M. K., Klein, M., Overbey, J. R., Goosens, K. A., Burgess, J. C., Alvarez, K., Feder, A., Charney, D. S. & Murrough, J. W., Jan 2023, In: Neurobiology of Stress. 22, 100505.
Research output: Contribution to journal › Article › peer-review

Open Access
Noradrenergic modulation of stress resilience
Zhai, X., Zhou, D., Han, Y., Han, M. H. & Zhang, H., Jan 2023, In: Pharmacological Research. 187, 106598.
Research output: Contribution to journal › Review article › peer-review

Open Access
Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters
Ndaru, E., Zielewicz, L., Shi, Y., Hutchinson, K., Garibsingh, R. A. A., Schlessinger, A. & Grewer, C., Nov 2022, In: Journal of Physical Organic Chemistry. 35, 11, e4347.
Research output: Contribution to journal › Article › peer-review
Altered hippocampus and amygdala subregion connectome hierarchy in major depressive disorder
Jacob, Y., Morris, L. S., Verma, G., Rutter, S. B., Balchandani, P. & Murrough, J. W., Dec 2022, In: Translational Psychiatry. 12, 1, 209.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)
Cusi, K., Isaacs, S., Barb, D., Basu, R., Caprio, S., Garvey, W. T., Kashyap, S., Mechanick, J. I., Mouzaki, M., Nadolsky, K., Rinella, M. E., Vos, M. B. & Younossi, Z., May 2022, In: Endocrine Practice. 28, 5, p. 528-562 35 p.
Research output: Contribution to journal › Article › peer-review

Open Access
41 Scopus citations
An Antagonist of KSR1-Driven Adaptive Resistance to Clinical RAS-MAPK Inhibitors
Chow, A., Yerabolu, J. R., Reyes, K., Scopton, A. & Dar, A. C., 1 May 2022, In: FASEB Journal. 36
Research output: Contribution to journal › Article › peer-review

Open Access
Antidepressant effect of prolonged twice-weekly intranasal esketamine treatments after nonresponse to electroconvulsive therapy in a patient with treatment-resistant depression
Evers, A., Klein, M., Aloysi, A., Murrough, J. & Jha, M. K., 1 Feb 2022, In: Annals of Clinical Psychiatry. 34, 1, p. 61-64 4 p.
Research output: Contribution to journal › Letter › peer-review
A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project
Kidney Precision Medicine Project, Jul 2022, In: American Journal of Kidney Diseases. 80, 1, p. 132-138 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine
Bloomfield-Clagett, B., Ballard, E. D., Greenstein, D. K., Wilkinson, S. T., Grunebaum, M. F., Murrough, J. W., Mathew, S. J., Phillips, J. L., Fava, M., Sanacora, G. & Zarate, C. A., 25 Oct 2022, In: International Journal of Neuropsychopharmacology. 25, 10, p. 827-838 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
A prospective cohort study of the psychological consequences of the COVID-19 pandemic on frontline healthcare workers in New York City
Peccoralo, L. A., Pietrzak, R. H., Feingold, J. H., Syed, S., Chan, C. C., Murrough, J. W., Kaplan, C., Verity, J., Feder, A., Charney, D. S., Southwick, S. M. & Ripp, J. A., Aug 2022, In: International Archives of Occupational and Environmental Health. 95, 6, p. 1279-1291 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Scopus citations
A prospective study of transdiagnostic psychiatric symptoms associated with burnout and functional difficulties in COVID-19 frontline healthcare workers
Kachadourian, L., Murrough, J., Kaplan, C., Kaplan, S., Feingold, J., Feder, A., Charney, D., Southwick, S., Peccoralo, L., DePierro, J., Ripp, J. & Pietrzak, R., Aug 2022, In: Journal of Psychiatric Research. 152, p. 219-224 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
A reference tissue atlas for the human kidney
Kidney Precision Medicine Project, Jun 2022, In: Science advances. 8, 23, eabn4965.
Research output: Contribution to journal › Article › peer-review
6 Scopus citations

Heightened Activity of Specific Brain Cells Following Traumatic Social Experience Blocks Social Reward and Promotes Sustained Social Avoidance
Scott Russo & Long Li
30/11/22 → 1/02/23
7 items of Media coverage
Press/Media
US Patent Issued to ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI on Jan. 10 for "Kinase inhibitor compounds and compositions and methods of use" (New York Inventors)
Robert DeVita, Avner Schlessinger & Andrew Stewart
23/01/23
1 item of Media coverage
Press/Media
New Data from Icahn School of Medicine at Mount Sinai Illuminate Findings in Science (Distinct Forms of Regret Linked To Resilience Versus Susceptibility To Stress Are Regulated By Region-specific Creb Function In Mice)
Brian Sweis, Flurin Cathomas, Eric Nestler, Scott Russo & Long Li
17/01/23
1 item of Media coverage
Press/Media
Australia Patent: Application for 'Kinase inhibitor compounds and compositions and methods of use' Lapses
Chalada Suebsuwong, Robert DeVita & Peng Wang
12/01/23
1 item of Media coverage
Press/Media
Kinase Inhibitor Compounds and Compositions and Methods of Use
Robert DeVita, Avner Schlessinger & Andrew Stewart
10/01/23
1 item of Media coverage
Press/Media
Data from Icahn School of Medicine at Mount Sinai Update Knowledge in Salivary Proteins and Peptides (A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults)
Sara Costi, Jessica Overbey, James Murrough, Dennis Charney & Adriana Feder
9/01/23
1 item of Media coverage
Press/Media
Reports from Icahn School of Medicine at Mount Sinai Advance Knowledge in Health and Medicine (Implementation of an Online Reporting System to Identify Unprofessional Behaviors and Mistreatment Directed at Trainees at an Academic Medical Center)
Marta Filizola, David Muller & Basil Hanss
20/12/22
1 item of Media coverage
Press/Media
Research in the Area of Science Reported from Icahn School of Medicine at Mount Sinai (The long noncoding RNA FEDORA is a cell type- and sex-specific regulator of depression)
Orna Issler, Eric Nestler, James Murrough & Li Shen
20/12/22
1 item of Media coverage
Press/Media
Researchers from University of Chicago Describe Findings in Heart Failure (The Prognostic Role of Advanced Hemodynamic Variables In Patients With Left Ventricular Assist Devices)
Sean Pinney
14/12/22
1 item of Media coverage
Press/Media
Researchers at Icahn School of Medicine at Mount Sinai Zero in on Anxiety Disorders (Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses)
Gaurav Verma, Yael Jacob, James Murrough, Patrick Hof, Priti Balchandani & Bradley Delman
14/12/22
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Researchers Release New Study Findings on Tumor Necrosis Factors (Inflammation and emotion regulation: Findings from the MIDUS II study)
Luz H. Ospina, Scott Russo & David Kimhy
9/12/22
1 item of Media coverage
Press/Media
Ketamine Flips a “Switch” in Mice’s Brain Circuitry: Study
James Murrough
9/12/22
1 item of Media coverage
Press/Media