Mount Sinai Global Health and Emerging Pathogens Institute

Research output

Research output per year 1992 2010 2013 2020 2021 2022 2023

• 76920 Citations
• 136 h-index
• 739 Article
• 58 Review article
• 42 Comment/debate
• 20 Letter
• 28 More
  • 11 Chapter
  • 11 Short survey
  • 6 Editorial

Research output per year

Research output per year

Search results

• 2023

  An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination

  Carreño, J. M., Raskin, A., Singh, G., Tcheou, J., Kawabata, H., Gleason, C., Srivastava, K., Vigdorovich, V., Dambrauskas, N., Gupta, S. L., González Domínguez, I., Martinez, J. L., Slamanig, S., Sather, D. N., Raghunandan, R., Wirachwong, P., Muangnoicharoen, S., Pitisuttithum, P., Wrammert, J., Suthar, M. S., & 5 othersSun, W., Palese, P., García-Sastre, A., Simon, V. & Krammer, F., 15 Feb 2023, In: Science Translational Medicine. 15, 683, p. eabo2847

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neutralizing Antibodies 100%
  • Vaccination 79%
  • Vaccines 74%
  • Messenger RNA 57%
  • SARS Virus 49%

• Antigenic Landscape Analysis of Individuals Vaccinated with a Universal Influenza Virus Vaccine Candidate Reveals Induction of Cross-Subtype Immunity

  Meade, P., Strohmeier, S., Bermúdez-González, M. C., García-Sastre, A., Palese, P., Simon, V. & Krammer, F., Jan 2023, In: Journal of Virology. 97, 1

  Research output: Contribution to journal › Article › peer-review

  • influenza vaccines 100%
  • Influenza Vaccines 76%
  • hemagglutinins 76%
  • Hemagglutinins 66%
  • immunity 59%

• Bat pluripotent stem cells reveal unusual entanglement between host and viruses

  Déjosez, M., Marin, A., Hughes, G. M., Morales, A. E., Godoy-Parejo, C., Gray, J. L., Qin, Y., Singh, A. A., Xu, H., Juste, J., Ibáñez, C., White, K. M., Rosales, R., Francoeur, N. J., Sebra, R. P., Alcock, D., Volkert, T. L., Puechmaille, S. J., Pastusiak, A., Frost, S. D. W., & 5 othersHiller, M., Young, R. A., Teeling, E. C., García-Sastre, A. & Zwaka, T. P., 2 Mar 2023, In: Cell. 186, 5, p. 957-974.e28

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chiroptera 100%
  • Pluripotent Stem Cells 90%
  • Viruses 51%
  • Induced Pluripotent Stem Cells 23%
  • Echolocation 11%
  1 Scopus citations

• Evaluation and validation of an RT-PCR assay for specific detection of monkeypox virus (MPXV)

  Paniz-Mondolfi, A., Guerra, S., Muñoz, M., Luna, N., Hernandez, M. M., Patino, L. H., Reidy, J., Banu, R., Shrestha, P., Liggayu, B., Umeaku, A., Chen, F., Cao, L., Patel, A., Hanna, A., Li, S., Look, A., Pagani, N., Albrecht, R., Pearl, R., & 24 othersGarcia-Sastre, A., Bogunovic, D., Palacios, G., Bonnier, L., Cera, F., Lopez, H., Calderon, Y., Eiting, E., Mullen, K., Shin, S. J., Lugo, L. A., Urbina, A. E., Starks, C., Koo, T., Uychiat, P., Look, A., van Bakel, H., Gonzalez-Reiche, A., Betancourt, A. F., Reich, D., Cordon-Cardo, C., Simon, V., Sordillo, E. M. & Ramírez, J. D., Jan 2023, In: Journal of Medical Virology. 95, 1, e28247.

  Research output: Contribution to journal › Article › peer-review

  • Monkeypox virus 100%
  • Polymerase Chain Reaction 34%
  • Orthopoxvirus 12%
  • Sensitivity and Specificity 12%
  • Virus Inactivation 12%
  3 Scopus citations

• Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs

  Aslam, S., Rajendran, M., Kriti, D., Kurland, A., Johnson, J., van Bakel, H., Krammer, F., García-Sastre, A. & Ayllon, J., Dec 2023, In: npj Vaccines. 8, 1, 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza B virus 100%
  • Eggs 80%
  • Chickens 71%
  • Vaccines 55%
  • Reassortant Viruses 42%

• Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

  Wei, J., Patil, A., Collings, C. K., Alfajaro, M. M., Liang, Y., Cai, W. L., Strine, M. S., Filler, R. B., DeWeirdt, P. C., Hanna, R. E., Menasche, B. L., Ökten, A., Peña-Hernández, M. A., Klein, J., McNamara, A., Rosales, R., McGovern, B. L., Luis Rodriguez, M., García-Sastre, A., White, K. M., & 8 othersQin, Y., Doench, J. G., Yan, Q., Iwasaki, A., Zwaka, T. P., Qi, J., Kadoch, C. & Wilen, C. B., 2023, (Accepted/In press) In: Nature Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus Infections 100%
  • Severe Acute Respiratory Syndrome 90%
  • angiotensin converting enzyme 2 83%
  • Sucrose 68%
  • Coronavirus 52%

• SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation

  Cai, H., Chen, Y., Feng, Y., Asadi, M., Kaufman, L., Lee, K., Kehrer, T., Miorin, L., Garcia-Sastre, A., Gusella, G. L., Gu, L., Ni, Z., Mou, S., He, J. C. & Zhou, W., 1 Mar 2023, In: Molecular Therapy. 31, 3, p. 774-787 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Tripartite Motif Proteins 100%
  • SARS Virus 92%
  • STAT3 Transcription Factor 75%
  • Viral Proteins 66%
  • Transcriptional Activation 56%
  1 Scopus citations
• 2022

  2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

  Kuhn, J. H., Adkins, S., Alkhovsky, S. V., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Bandte, M., Beer, M., Bejerman, N., Bergeron, É., Biedenkopf, N., Bigarré, L., Blair, C. D., Blasdell, K. R., Bradfute, S. B., Briese, T., Brown, P. A., Bruggmann, R., & 161 othersBuchholz, U. J., Buchmeier, M. J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C. H., Candresse, T., Carson, J., Casas, I., Chandran, K., Charrel, R. N., Chiaki, Y., Crane, A., Crane, M., Dacheux, L., Bó, E. D., de la Torre, J. C., de Lamballerie, X., de Souza, W. M., de Swart, R. L., Dheilly, N. M., Di Paola, N., Di Serio, F., Dietzgen, R. G., Digiaro, M., Drexler, J. F., Duprex, W. P., Dürrwald, R., Easton, A. J., Elbeaino, T., Ergünay, K., Feng, G., Feuvrier, C., Firth, A. E., Fooks, A. R., Formenty, P. B. H., Freitas-Astúa, J., Gago-Zachert, S., García, M. L., García-Sastre, A., Garrison, A. R., Godwin, S. E., Gonzalez, J. P. J., de Bellocq, J. G., Griffiths, A., Groschup, M. H., Günther, S., Hammond, J., Hepojoki, J., Hierweger, M. M., Hongō, S., Horie, M., Horikawa, H., Hughes, H. R., Hume, A. J., Hyndman, T. H., Jiāng, D., Jonson, G. B., Junglen, S., Kadono, F., Karlin, D. G., Klempa, B., Klingström, J., Koch, M. C., Kondō, H., Koonin, E. V., Krásová, J., Krupovic, M., Kubota, K., Kuzmin, I. V., Laenen, L., Lambert, A. J., Lǐ, J., Li, J. M., Lieffrig, F., Lukashevich, I. S., Luo, D., Maes, P., Marklewitz, M., Marshall, S. H., Marzano, S. Y. L., McCauley, J. W., Mirazimi, A., Mohr, P. G., Moody, N. J. G., Morita, Y., Morrison, R. N., Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J. A., Neriya, Y., Netesov, S. V., Neumann, G., Nowotny, N., Ochoa-Corona, F. M., Palacios, G., Pallandre, L., Pallás, V., Papa, A., Paraskevopoulou, S., Parrish, C. R., Pauvolid-Corrêa, A., Pawęska, J. T., Pérez, D. R., Pfaff, F., Plemper, R. K., Postler, T. S., Pozet, F., Radoshitzky, S. R., Ramos-González, P. L., Rehanek, M., Resende, R. O., Reyes, C. A., Romanowski, V., Rubbenstroth, D., Rubino, L., Rumbou, A., Runstadler, J. A., Rupp, M., Sabanadzovic, S., Sasaya, T., Schmidt-Posthaus, H., Schwemmle, M., Seuberlich, T., Sharpe, S. R., Shi, M., Sironi, M., Smither, S., Song, J. W., Spann, K. M., Spengler, J. R., Stenglein, M. D., Takada, A., Tesh, R. B., Těšíková, J., Thornburg, N. J., Tischler, N. D., Tomitaka, Y., Tomonaga, K., Tordo, N., Tsunekawa, K., Turina, M., Tzanetakis, I. E., Vaira, A. M., van den Hoogen, B., Vanmechelen, B., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P. J., Whitfield, A. E., Williams, J. V., Wolf, Y. I., Yamasaki, J., Yanagisawa, H., Ye, G., Zhang, Y. Z. & Økland, A. L., Dec 2022, In: Archives of Virology. 167, 12, p. 2857-2906 50 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mononegavirales 100%
  • Aprepitant 27%
  • Viruses 24%
  • Names 17%
  1 Scopus citations

• ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2

  Iwanaga, N., Cooper, L., Rong, L., Maness, N. J., Beddingfield, B., Qin, Z., Crabtree, J., Tripp, R. A., Yang, H., Blair, R., Jangra, S., García-Sastre, A., Schotsaert, M., Chandra, S., Robinson, J. E., Srivastava, A., Rabito, F., Qin, X. & Kolls, J. K., 21 Jan 2022, In: iScience. 25, 1, 103670.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Immunoglobulin G 51%
  • Catalytic Domain 40%
  • Lung 36%
  • In Vitro Techniques 29%
  6 Scopus citations

• Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

  PSP-PARIS Study Group, 24 Feb 2022, In: Nature. 602, 7898, p. 682-688 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Vaccines 58%
  • South Africa 54%
  • Botswana 38%
  199 Scopus citations

• A multinational Delphi consensus to end the COVID-19 public health threat

  The COVID-19 Consensus Statement Panel, 10 Nov 2022, In: Nature. 611, 7935, p. 332-345 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Consensus 100%
  • Public Health 74%
  • Pandemics 55%
  • Organizations 43%
  • Vaccination 42%
  14 Scopus citations

• An intranasal recombinant NDV-BRSV F_opt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of RSV infection

  Sacco, R. E., Mena, I., Palmer, M. V., Durbin, R. K., García-Sastre, A. & Durbin, J. E., Dec 2022, In: Scientific Reports. 12, 1, 22552.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Virus Vaccines 100%
  • Newcastle disease virus 87%
  • Colostrum 86%
  • Human respiratory syncytial virus 78%
  • Cattle 51%

• Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

  Stadlbauer, D., McMahon, M., Turner, H. L., Zhu, X., Wan, H., Carreño, J. M., O’Dell, G., Strohmeier, S., Khalil, Z., Luksza, M., van Bakel, H., Simon, V., Ellebedy, A. H., Wilson, I. A., Ward, A. B. & Krammer, F., Dec 2022, In: Nature Communications. 13, 1, 7864.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • influenza 100%
  • H3N2 Subtype Influenza A Virus 91%
  • viruses 77%
  • antibodies 77%
  • Neuraminidase 74%

• A Robust, Highly Multiplexed Mass Spectrometry Assay to Identify SARS-CoV-2 Variants

  Mount Sinai PSP Study Group, Sep 2022, In: Microbiology spectrum. 10, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe acute respiratory syndrome coronavirus 100%
  • severe acute respiratory syndrome 88%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 72%
  • Whole Genome Sequencing 67%
  1 Scopus citations

• A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility

  VA Million Veteran Program COVID-19 Science Initiative & Mount Sinai COVID-19 Biobank, Dec 2022, In: npj Genomic Medicine. 7, 1, 52.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Disease Susceptibility 88%
  • Genomics 80%
  • Genes 31%
  • Virus Activation 13%

• Autoantibodies against type I IFNs in patients with critical influenza pneumonia

  Zhang, Q., Pizzorno, A., Miorin, L., Bastard, P., Gervais, A., Le Voyer, T., Bizien, L., Manry, J., Rosain, J., Philippot, Q., Goavec, K., Padey, B., Cupic, A., Laurent, E., Saker, K., Vanker, M., Särekannu, K., García-Salum, T., Ferres, M., Corre, N. L., & 49 othersSánchez-Céspedes, J., Balsera-Manzanero, M., Carratala, J., Retamar-Gentil, P., Abelenda-Alonso, G., Valiente, A., Tiberghien, P., Zins, M., Debette, S., Meyts, I., Haerynck, F., Castagnoli, R., Notarangelo, L. D., Gonzalez-Granado, L. I., Dominguez-Pinilla, N., Andreakos, E., Triantafyllia, V., Rodríguez-Gallego, C., Solé-Violán, J., Ruiz-Hernandez, J. J., de Castro, F. R., Ferreres, J., Briones, M., Wauters, J., Vanderbeke, L., Feys, S., Kuo, C. Y., Lei, W. T., Ku, C. L., Tal, G., Etzioni, A., Hanna, S., Fournet, T., Casalegno, J. S., Queromes, G., Argaud, L., Javouhey, E., Rosa-Calatrava, M., Cordero, E., Aydillo, T., Medina, R. A., Kisand, K., Puel, A., Jouanguy, E., Abel, L., Cobat, A., Trouillet-Assant, S., García-Sastre, A. & Casanova, J. L., 7 Nov 2022, In: Journal of Experimental Medicine. 219, 11, e20220514.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferon Type I 100%
  • Autoantibodies 77%
  • Human Influenza 77%
  • Pneumonia 67%
  • Interferons 38%
  5 Scopus citations

• Broadly neutralizing antibodies target a haemagglutinin anchor epitope

  Guthmiller, J. J., Han, J., Utset, H. A., Li, L., Lan, L. Y. L., Henry, C., Stamper, C. T., McMahon, M., O’Dell, G., Fernández-Quintero, M. L., Freyn, A. W., Amanat, F., Stovicek, O., Gentles, L., Richey, S. T., de la Peña, A. T., Rosado, V., Dugan, H. L., Zheng, N. Y., Tepora, M. E., & 13 othersBitar, D. J., Changrob, S., Strohmeier, S., Huang, M., García-Sastre, A., Liedl, K. R., Bloom, J. D., Nachbagauer, R., Palese, P., Krammer, F., Coughlan, L., Ward, A. B. & Wilson, P. C., 10 Feb 2022, In: Nature. 602, 7896, p. 314-320 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Broadly Neutralizing Antibodies 100%
  • Hemagglutinins 79%
  • Influenza Vaccines 67%
  • Epitopes 60%
  • Pandemics 25%
  22 Scopus citations

• Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

  PVI study group, Dec 2022, In: Nature Communications. 13, 1, 3921.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • infectious diseases 85%
  • serums 81%
  • mutations 78%
  • mice 70%
  5 Scopus citations

• Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4

  Campisi, L., Chizari, S., Ho, J. S. Y., Gromova, A., Arnold, F., Mosca, L., Mei, X., Fstkchyan, Y., Torre, D., Beharry, C., Garcia-Forn, M., Jiménez-Alcázar, M., Korobeynikov, V. A., Prazich, J., Fayad, Z. A., Seldin, M. M., De Rubeis, S., Bennett, C. L., Ostrow, L. W., Lunetta, C., & 6 othersSquatrito, M., Byun, M., Shneider, N. A., Jiang, N., La Spada, A. R. & Marazzi, I., 30 Jun 2022, In: Nature. 606, 7916, p. 945-952 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • T-Lymphocytes 57%
  • CD8 Antigens 23%
  • Mutation 14%
  • Motor Neuron Disease 10%
  4 Scopus citations

• Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans

  Forst, C. V., Martin-Sancho, L., Tripathi, S., Wang, G., Dos Anjos Borges, L. G., Wang, M., Geber, A., Lashua, L., Ding, T., Zhou, X., Carter, C. E., Metreveli, G., Rodriguez-Frandsen, A., Urbanowski, M. D., White, K. M., Stein, D. A., Moulton, H., Chanda, S. K., Pache, L., Shaw, M. L., & 4 othersRoss, T. M., Ghedin, E., García-Sastre, A. & Zhang, B., Oct 2022, In: Science advances. 8, 40, eabm5859.

  Research output: Contribution to journal › Article › peer-review

  • Ferrets 100%
  • Influenza A virus 85%
  • Orthomyxoviridae 78%
  • Virus Diseases 57%
  • Interferons 47%

• Development of an HIV reporter virus that identifies latently infected CD4⁺ T cells

  Kim, E. H., Manganaro, L., Schotsaert, M., Brown, B. D., Mulder, L. C. F. & Simon, V., 20 Jun 2022, In: Cell Reports Methods. 2, 6, 100238.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-cells 100%
  • Ports and harbors 79%
  • Viruses 79%
  • Proviruses 66%
  • Antiretroviral 48%

• Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants

  Duty, J. A., Kraus, T., Zhou, H., Zhang, Y., Shaabani, N., Yildiz, S., Du, N., Singh, A., Miorin, L., Li, D., Stegman, K., Ophir, S., Cao, X., Atanasoff, K., Lim, R., Mena, I., Bouvier, N. M., Kowdle, S., Carreño, J. M., Rivero-Nava, L., & 29 othersRaskin, A., Moreno, E., Johnson, S., Rathnasinghe, R., Pai, C. I., Kehrer, T., Cabral, E. P., Jangra, S., Healy, L., Singh, G., Warang, P., Simon, V., Sordillo, E. M., van Bakel, H., Liu, Y., Sun, W., Kerwin, L., Teijaro, J., Schotsaert, M., Krammer, F., Bresson, D., García-Sastre, A., Fu, Y., Lee, B., Powers, C., Moran, T., Ji, H., Tortorella, D. & Allen, R., 14 Oct 2022, In: Med. 3, 10, p. 705-721.e11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Broadly Neutralizing Antibodies 100%
  • Severe Acute Respiratory Syndrome 91%
  • Intranasal Administration 90%
  • Coronavirus 89%
  • Sexually Transmitted Diseases 52%
  4 Scopus citations

• Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

  Adrover, J. M., Carrau, L., Daßler-Plenker, J., Bram, Y., Chandar, V., Houghton, S., Redmond, D., Merrill, J. R., Shevik, M., tenOever, B. R., Lyons, S. K., Schwartz, R. E. & Egeblad, M., 8 Mar 2022, In: JCI insight. 7, 5, e157342.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Extracellular Traps 95%
  • Disulfiram 95%
  • Acute Lung Injury 77%
  • Rodentia 56%
  27 Scopus citations

• DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression

  Price, J. D., Lindtner, S., Ypsilanti, A., Binyameen, F., Johnson, J. R., Newton, B. W., Krogan, N. J. & Rubenstein, J. L. R., Jun 2022, In: Development (Cambridge). 149, 11, dev199508.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mi-2 Nucleosome Remodeling and Deacetylase Complex 100%
  • Transcription Factors 44%
  • Oligodendrocyte Precursor Cells 26%
  • Chromatin Immunoprecipitation Sequencing 25%
  • Genes 23%
  1 Scopus citations

• Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path

  Bram, Y., Duan, X., Nilsson-Payant, B. E., Chandar, V., Wu, H., Shore, D., Fajardo, A., Sinha, S., Hassan, N., Weinstein, H., Tenoever, B. R., Chen, S. & Schwartz, R. E., 21 Dec 2022, In: ACS Bio and Med Chem Au. 2, 6, p. 627-641 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS coronavirus 3C-like protease 100%
  • Computer Systems 58%
  • Protease Inhibitor 57%
  • SARS Virus 36%
  • Life Cycle Stages 26%

• eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production

  Seoane, R., Llamas-González, Y. Y., Vidal, S., El Motiam, A., Bouzaher, Y. H., Fonseca, D., Farrás, R., García-Sastre, A., González-Santamaría, J. & Rivas, C., 27 Jul 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 960138.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Virus Replication 100%
  • Interferons 91%
  • Virus Diseases 73%
  • Viruses 66%
  • Punta Toro phlebovirus 65%

• Evolution of enhanced innate immune evasion by SARS-CoV-2

  Thorne, L. G., Bouhaddou, M., Reuschl, A. K., Zuliani-Alvarez, L., Polacco, B., Pelin, A., Batra, J., Whelan, M. V. X., Hosmillo, M., Fossati, A., Ragazzini, R., Jungreis, I., Ummadi, M., Rojc, A., Turner, J., Bischof, M. L., Obernier, K., Braberg, H., Soucheray, M., Richards, A., & 23 othersChen, K. H., Harjai, B., Memon, D., Hiatt, J., Rosales, R., McGovern, B. L., Jahun, A., Fabius, J. M., White, K., Goodfellow, I. G., Takeuchi, Y., Bonfanti, P., Shokat, K., Jura, N., Verba, K., Noursadeghi, M., Beltrao, P., Kellis, M., Swaney, D. L., García-Sastre, A., Jolly, C., Towers, G. J. & Krogan, N. J., 17 Feb 2022, In: Nature. 602, 7897, p. 487-495 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Immune Evasion 85%
  • Innate Immunity 41%
  • Mutation 37%
  • RNA 31%
  76 Scopus citations

• Evolution of influenza A virus in intensive and free-range swine farms in Spain

  Encinas, P., Del Real, G., Dutta, J., Khan, Z., Van Bakel, H., Del Burgo, M. Á. M., García-Sastre, A. & Nelson, M. I., 1 Jan 2022, In: Virus Evolution. 7, 2, veab099.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Farms 100%
  • Influenza A virus 96%
  • Spain 85%
  • Swine 69%
  • Zoonoses 6%

• Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

  Svensson-Arvelund, J., Cuadrado-Castano, S., Pantsulaia, G., Kim, K., Aleynick, M., Hammerich, L., Upadhyay, R., Yellin, M., Marsh, H., Oreper, D., Jhunjhunwala, S., Moussion, C., Merad, M., Brown, B. D., García-Sastre, A. & Brody, J. D., Dec 2022, In: Nature Communications. 13, 1, 7149.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncolytic 100%
  • Oncolytic Virotherapy 87%
  • immunity 66%
  • tumors 54%
  • Dendritic Cells 51%

• Functional Effects of Cardiomyocyte Injury in COVID-19

  Siddiq, M. M., Chan, A. T., Miorin, L., Yadaw, A. S., Beaumont, K. G., Kehrer, T., Cupic, A., White, K. M., Tolentino, R. E., Hu, B., Stern, A. D., Tavassoly, I., Hansen, J., Sebra, R., Martinez, P., Prabha, S., Dubois, N., Schaniel, C., Iyengar-Kapuganti, R., Kukar, N., & 13 othersGiustino, G., Sud, K., Nirenberg, S., Kovatch, P., Albrecht, R. A., Goldfarb, J., Croft, L., McLaughlin, M. A., Argulian, E., Lerakis, S., Narula, J., García-Sastre, A. & Iyengar, R., Jan 2022, In: Journal of Virology. 96, 2, e01063-21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cardiomyocytes 100%
  • Cardiac Myocytes 76%
  • Interleukins 67%
  • heart diseases 65%
  • interleukins 60%
  7 Scopus citations

• Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

  Johnson, J. R., Crosby, D. C., Hultquist, J. F., Kurland, A. P., Adhikary, P., Li, D., Marlett, J., Swann, J., Hüttenhain, R., Verschueren, E., Johnson, T. L., Newton, B. W., Shales, M., Simon, V. A., Beltrao, P., Frankel, A. D., Marson, A., Cox, J. S., Fregoso, O. I., Young, J. A. T., & 1 othersKrogan, N. J., 12 Apr 2022, In: Cell Reports. 39, 2, 110690.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Post Translational Protein Processing 100%
  • HIV-1 84%
  • Viruses 64%
  • Human immunodeficiency virus 1 vpr protein 59%
  • HIV Infections 57%
  2 Scopus citations

• Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15

  Butta, G. M., Bozzi, G., Gallo, G., Copaloni, G., Cordiglieri, C., Crosti, M., Mancino, M., Prati, D., Simon, V., Gori, A., Bandera, A., De Francesco, R. & Manganaro, L., May 2022, In: Journal of Virology. 96, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • interleukin-15 100%
  • Interleukin-15 70%
  • T-Lymphocyte Subsets 59%
  • T-lymphocytes 50%
  • HIV 21%

• Heterologous ChAdOx1/BNT162b2 vaccination induces stronger immune response than homologous ChAdOx1 vaccination: The pragmatic, multi-center, three-arm, partially randomized HEVACC trial

  HEVACC Study Group, Jun 2022, In: eBioMedicine. 80, 104073.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaccination 100%
  • Vaccines 93%
  • SARS Virus 61%
  • Safety 53%
  • Appointments and Schedules 50%
  10 Scopus citations

• Human Anti-neuraminidase Antibodies Reduce Airborne Transmission of Clinical Influenza Virus Isolates in the Guinea Pig Model

  Tan, J., O'Dell, G., Hernandez, M. M., Sordillo, E. M., Kahn, Z., Kriti, D., van Bakel, H., Ellebedy, A. H., Wilson, P. C., Simon, V., Krammer, F. & McMahon, M., Jan 2022, In: Journal of Virology. 96, 2, e01421-21.

  Research output: Contribution to journal › Article › peer-review

  • airborne transmission 100%
  • Orthomyxoviridae 72%
  • sialidase 70%
  • Neuraminidase 69%
  • Guinea Pigs 53%
  4 Scopus citations

• Human SUMOylation Pathway Is Critical for Influenza B Virus

  Dang, R., Rodgers, V. G. J., García-Sastre, A. & Liao, J., Feb 2022, In: Viruses. 14, 2, 314.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza B virus 100%
  • Sumoylation 99%
  • Critical Pathways 85%
  • Life Cycle Stages 33%
  • Viruses 21%

• Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients

  Klingler, J., Lambert, G. S., Bandres, J. C., Emami-Gorizi, R., Nádas, A., Oguntuyo, K. Y., Amanat, F., Bermúdez-González, M. C., Gleason, C., Kleiner, G., Simon, V., Lee, B., Zolla-Pazner, S., Upadhyay, C. & Hioe, C. E., 22 Dec 2022, In: iScience. 25, 12, 105608.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-27 100%
  • Antibodies 93%
  • Cytokines 62%
  • SARS Virus 49%
  • Demography 43%

• Immunodominance hierarchy after seasonal influenza vaccination

  Sánchez-de Prada, L., Sanz-Muñoz, I., de Lejarazu, R. O., Eiros, J. M., García-Sastre, A. & Aydillo, T., 2022, In: Emerging Microbes and Infections. 11, 1, p. 2670-2679 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • influenza vaccination 100%
  • influenza vaccines 86%
  • Influenza Vaccines 66%
  • Human Influenza 53%
  • hemagglutinins 52%

• Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

  Cool, K., Gaudreault, N. N., Morozov, I., Trujillo, J. D., Meekins, D. A., McDowell, C., Carossino, M., Bold, D., Mitzel, D., Kwon, T., Balaraman, V., Madden, D. W., Artiaga, B. L., Pogranichniy, R. M., Roman-Sosa, G., Henningson, J., Wilson, W. C., Balasuriya, U. B. R., García-Sastre, A. & Richt, J. A., 2022, In: Emerging Microbes and Infections. 11, 1, p. 95-112 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Deer 94%
  • Nasal 89%
  • Odocoileus virginianus 83%
  • Infectious Disease Transmission 80%
  28 Scopus citations

• Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy

  Argueta, L. B., Lacko, L. A., Bram, Y., Tada, T., Carrau, L., Rendeiro, A. F., Zhang, T., Uhl, S., Lubor, B. C., Chandar, V., Gil, C., Zhang, W., Dodson, B. J., Bastiaans, J., Prabhu, M., Houghton, S., Redmond, D., Salvatore, C. M., Yang, Y. J., Elemento, O., & 6 othersBaergen, R. N., tenOever, B. R., Landau, N. R., Chen, S., Schwartz, R. E. & Stuhlmann, H., 20 May 2022, In: iScience. 25, 5, 104223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Placenta 63%
  • Trophoblasts 49%
  • RNA 47%
  • Mothers 43%
  13 Scopus citations

• Interaction between chicken TRIM25 and MDA5 and their role in mediated antiviral activity against IBDV infection

  Diaz-Beneitez, E., Cubas-Gaona, L. L., Candelas-Rivera, O., Benito-Zafra, A., Sánchez-Aparicio, M. T., Miorin, L., Rodríguez, J. F., García-Sastre, A. & Rodríguez, D., 28 Nov 2022, In: Frontiers in Microbiology. 13, 1068328.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infectious bursal disease virus 100%
  • Chickens 61%
  • Antiviral Agents 54%
  • Virus Diseases 46%
  • Ubiquitin-Protein Ligases 31%

• ISG15 deficiency restricts HIV-1 infection

  Jurczyszak, D., Manganaro, L., Buta, S., Gruber, C., Martin-Fernandez, M., Taft, J., Patel, R., Cipolla, M., Alshammary, H., Mulder, L. C. F., Sachidanandam, R., Bogunovic, D. & Simon, V., Mar 2022, In: PLoS Pathogens. 18, 3, e1010405.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human immunodeficiency virus 1 100%
  • interferons 92%
  • Interferons 74%
  • HIV Infections 72%
  • HIV-1 70%
  3 Scopus citations

• Limited extent and consequences of pancreatic SARS-CoV-2 infection

  van der Heide, V., Jangra, S., Cohen, P., Rathnasinghe, R., Aslam, S., Aydillo, T., Geanon, D., Handler, D., Kelley, G., Lee, B., Rahman, A., Dawson, T., Qi, J., D'Souza, D., Kim-Schulze, S., Panzer, J. K., Caicedo, A., Kusmartseva, I., Posgai, A. L., Atkinson, M. A., & 5 othersAlbrecht, R. A., García-Sastre, A., Rosenberg, B. R., Schotsaert, M. & Homann, D., 15 Mar 2022, In: Cell Reports. 38, 11, 110508.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus Infections 100%
  • Severe Acute Respiratory Syndrome 90%
  • Coronavirus 87%
  • Risk Assessment 84%
  • Infections 19%
  13 Scopus citations

• Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination

  Pang, A. P. S., Higgins-Chen, A. T., Comite, F., Raica, I., Arboleda, C., Went, H., Mendez, T., Schotsaert, M., Dwaraka, V., Smith, R., Levine, M. E., Ndhlovu, L. C. & Corley, M. J., 3 Jun 2022, In: Frontiers in Genetics. 13, 819749.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Epigenomics 88%
  • Longitudinal Studies 84%
  • Vaccination 81%
  • Messenger RNA 57%
  3 Scopus citations

• Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies

  Figueiredo, J. C., Hirsch, F. R., Kushi, L. H., Nembhard, W. N., Crawford, J. M., Mantis, N., Finster, L., Merin, N. M., Merchant, A., Reckamp, K. L., Melmed, G. Y., Braun, J., Mcgovern, D., Parekh, S., Corley, D. A., Zohoori, N., Amick, B. C., Du, R., Gregersen, P. K., Diamond, B., & 77 othersTaioli, E., Sariol, C., Espino, A., Weiskopf, D., Gifoni, A., Brien, J., Hanege, W., Lipsitch, M., Zidar, D. A., Scheck Mcalearney, A., Wajnberg, A., Labaer, J., Yvonne Lewis, E., Binder, R. A., Moormann, A. M., Forconi, C., Forrester, S., Batista, J., Schieffelin, J., Kim, D., Biancon, G., Vanoudenhove, J., Halene, S., Fan, R., Barouch, D. H., Alter, G., Pinninti, S., Boppana, S. B., Pati, S. K., Latting, M., Karaba, A. H., Roback, J., Sekaly, R., Neish, A., Brincks, A. M., Granger, D. A., Karger, A. B., Thyagarajan, B., Thomas, S. N., Klein, S. L., Cox, A. L., Lucas, T., Furr-Holden, D., Key, K., Jones, N., Wrammerr, J., Suthar, M., Yu Wong, S., Bowman, N. M., Simon, V., Richardson, L. D., Mcbride, R., Krammer, F., Rana, M., Kennedy, J., Boehme, K., Forrest, C., Granger, S. W., Heaney, C. D., Knight Lapinski, M., Wallet, S., Baric, R. S., Schifanella, L., Lopez, M., Fernandez, S., Kenah, E., Panchal, A. R., Britt, W. J., Sanz, I., Dhodapkar, M., Ahmed, R., Bartelt, L. A., Markmann, A. J., Lin, J. T., Hagan, R. S., Wolfgang, M. C. & Skarbinski, J., 1 Jun 2022, In: Open Forum Infectious Diseases. 9, 6, ofac171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Organizations 66%
  • Epidemiologic Studies 66%
  • Direction compound 57%
  • Cohort Studies 54%
  2 Scopus citations

• Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models

  Choudhary, S., Kanevsky, I., Yildiz, S., Sellers, R. S., Swanson, K. A., Franks, T., Rathnasinghe, R., Munoz-Moreno, R., Jangra, S., Gonzalez, O., Meade, P., Coskran, T., Qian, J., Lanz, T. A., Johnson, J. G., Tierney, C. A., Smith, J. D., Tompkins, K., Illenberger, A., Corts, P., & 13 othersCiolino, T., Dormitzer, P. R., Dick, E. J., Shivanna, V., Hall-Ursone, S., Cole, J., Kaushal, D., Fontenot, J. A., Martinez-Romero, C., McMahon, M., Krammer, F., Schotsaert, M. & García-Sastre, A., Apr 2022, In: Toxicologic Pathology. 50, 3, p. 280-293 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytopathic 100%
  • Severe Acute Respiratory Syndrome 82%
  • Coronavirus 80%
  • Mesocricetus 77%
  • Macaca mulatta 67%
  7 Scopus citations

• mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

  Carreño, J. M., Singh, G., Tcheou, J., Srivastava, K., Gleason, C., Muramatsu, H., Desai, P., Aberg, J. A., Miller, R. L., study group, PARIS., Pardi, N., Simon, V. & Krammer, F., 6 Oct 2022, In: Vaccine. 40, 42, p. 6114-6124 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Polyethylene Glycols 100%
  • polyethylene glycol 86%
  • messenger RNA 86%
  • vaccines 77%
  • Vaccines 67%
  4 Scopus citations

• Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model

  Tan, J., Chromikova, V., O'Dell, G., Sordillo, E. M., Simon, V., van Bakel, H., Krammer, F. & McMahon, M., Sep 2022, In: mSphere. 7, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza B virus 100%
  • Guinea Pigs 64%
  • Monoclonal Antibodies 53%
  • Viruses 49%
  • Intranasal Administration 46%

• Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine

  Nogales, A., Steel, J., Liu, W. C., Lowen, A. C., Rodriguez, L., Chiem, K., Cox, A., García-Sastre, A., Albrecht, R. A., Dewhurst, S. & Martínez-Sobrido, L., Jun 2022, In: Microbiology spectrum. 10, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • influenza 100%
  • vaccine 99%
  • Influenza Vaccines 91%
  • Influenza A virus 88%
  • mutation 79%
  1 Scopus citations

• Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

  Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Mena, I., Laporte, M., Pearl, R. L., Fossati, A., Rathnasinghe, R., Alshammary, H., van de Guchte, A., Farrugia, K., Qin, Y., Bouhaddou, M., Kehrer, T., Zuliani-Alvarez, L., Meekins, D. A., Balaraman, V., McDowell, C., Richt, J. A., Bajic, G., & 9 othersSordillo, E. M., Dejosez, M., Zwaka, T. P., Krogan, N. J., Simon, V., Albrecht, R. A., van Bakel, H., García-Sastre, A. & Aydillo, T., 9 Mar 2022, In: Cell Host and Microbe. 30, 3, p. 373-387.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • virus transmission 80%
  • hamsters 63%
  • mutation 46%
  • Cricetinae 45%
  45 Scopus citations

• Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

  Zazhytska, M., Kodra, A., Hoagland, D. A., Frere, J., Fullard, J. F., Shayya, H., McArthur, N. G., Moeller, R., Uhl, S., Omer, A. D., Gottesman, M. E., Firestein, S., Gong, Q., Canoll, P. D., Goldman, J. E., Roussos, P., tenOever, B. R., Jonathan, B. O. & Lomvardas, S., 17 Mar 2022, In: Cell. 185, 6, p. 1052-1064.e12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Effect 100%
  • SARS Virus 87%
  • Olfaction Disorders 84%
  • Dissipation 64%
  • Odorant Receptors 41%
  60 Scopus citations