Mount Sinai Drug Discovery Institute

Icahn School of Medicine at Mount Sinai

12 Active
15 Finished

Preclinical Validation of Novel Gut-Restricted LRRK2 Inhibitors as Therapeutic Leads for IBD
Peter, I. & DeVita, R.
National Institute of Diabetes and Digestive and Kidney Diseases
30/09/22 → 30/06/23
Project: Research
A novel treatment option for disorders of propionate metabolism
Houten, S., DeVita, R., Houten, S. M. & Devita, R. R. J.
National Institute of Child Health and Human Development
22/09/21 → 31/08/23
Project: Research
Training Program in Substance Use Disorders
Kenny, P. & Kenny, P. J.
National Institute on Drug Abuse
1/07/21 → 30/06/23
Project: Research
Substrate reduction as a novel therapeutic strategy for Glutaric Aciduria Type 1
Houten, S., DeVita, R., Houten, S. M. & Devita, R. R. J.
National Institute of Child Health and Human Development
1/05/21 → 30/04/23
Project: Research
Development of novel therapeutics for opioid dependence
Kenny, P., Kamenecka, T. M., Kenny, P. J. & Kamenecka, T. T. M.
National Institute on Drug Abuse
1/09/20 → 31/08/23
Project: Research
Modulate Cullin-RING E3 ubiquitin ligases by small molecule agents
Pan, Z., DeVita, R., Pan, Z. & Devita, R. R. J.
National Cancer Institute
1/07/20 → 30/06/23
Project: Research
Transcriptional Mechanisms of Drug Addiction
Nestler, E., Schaefer, A. A., Hurd, Y. L., Kenny, P. J., Shen, L. L., Nestler, E. J., Kenny, P., Schaefer, A., Shen, L., Zachariou, V. V., Hurd, Y. & Zachariou, V.
National Institute on Drug Abuse
15/02/19 → 30/11/23
Project: Research
Role for Circular RNAs in Compulsive Cocaine Intake
Kenny, P. J. & Kenny, P.
National Institute on Drug Abuse
1/02/19 → 30/11/23
Project: Research
Habenular immune signaling and addiction
Kenny, P. & Kenny, P. J.
National Institute on Drug Abuse
30/09/18 → 30/06/23
Project: Research
Mechanisms of nicotine reinforcement
Kenny, P. & Kenny, P. J.
National Institute on Drug Abuse
1/07/18 → 31/05/23
Project: Research
DYRK Inhibitors for Human Beta Cell Expansion
Stewart, A., DeVita, R., García-Ocaña, A., García-Ocaña, A., Devita, R. R. J. & Stewart, A. F.
National Institute of Diabetes and Digestive and Kidney Diseases
1/03/16 → 31/05/23
Project: Research
DISTINGUISHED INVESTIGATOR 2015
Kenny, P.
Brain and Behavior Research Foundation
1/01/15 → …
Project: Research

2205 Citations
26 h-index
53 Article
14 Short survey
13 Review article
11 Comment/debate
More
- 2 Chapter
- 1 Editorial

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1
Leandro, J., Khamrui, S., Suebsuwong, C., Chen, P. J., Secor, C., Dodatko, T., Yu, C., Sanchez, R., Devita, R. J., Houten, S. M. & Lazarus, M. B., 21 Sep 2022, In: Open Biology. 12, 9, 220179.
Research output: Contribution to journal › Article › peer-review

Open Access
Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information
Cummings, K. A., Bayshtok, S., Dong, T. N., Kenny, P. J. & Clem, R. L., 21 Sep 2022, In: Neuron. 110, 18, p. 3036-3052.e5
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Hedgehog-interacting protein acts in the habenula to regulate nicotine intake
Caligiuri, S. P. B., Howe, W. M., Wills, L., Smith, A. C. W., Lei, Y., Bali, P., Heyer, M. P., Moen, J. K., Ables, J. L., Elayouby, K. S., Williams, M., Fillinger, C., Oketokoun, Z., Lehmann, V. E., DiFeliceantonio, A. G., Johnson, P. M., Beaumont, K., Sebra, R. P., Ibanez-Tallon, I. & Kenny, P. J., 15 Nov 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 46, e2209870119.
Research output: Contribution to journal › Article › peer-review

Open Access
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K. & Kenny, P. J., 2022, In: Pharmacological Reviews. 74, 1, p. 271-310 40 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Scopus citations
Structure and function differences in the prelimbic cortex to basolateral amygdala circuit mediate trait vulnerability in a novel model of acute social defeat stress in male mice
Grossman, Y. S., Fillinger, C., Manganaro, A., Voren, G., Waldman, R., Zou, T., Janssen, W. G., Kenny, P. J. & Dumitriu, D., Feb 2022, In: Neuropsychopharmacology. 47, 3, p. 788-799 12 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Utility of ‘substance use disorder’ as a heuristic for understanding overeating and obesity
O'Connor, R. M. & Kenny, P. J., 30 Aug 2022, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 118, 110580.
Research output: Contribution to journal › Review article › peer-review
3 Scopus citations
a3p Nicotinic acetylcholine receptors in the habenula-interpeduncular nucleus circuit regulate nicotine intake
Elayouby, K. S., Ishikawa, M., Dukes, A. J., Smith, A. C. W., Lu, Q., Fowler, C. D. & Kenny, P. J., 24 Feb 2021, In: Journal of Neuroscience. 41, 8, p. 1779-1787 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
12 Scopus citations
Addiction-related neuroadaptations following chronic nicotine exposure
Wills, L. & Kenny, P. J., Jun 2021, In: Journal of Neurochemistry. 157, 5, p. 1652-1673 22 p.
Research output: Contribution to journal › Review article › peer-review
10 Scopus citations
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function
Lin, W. J., Zhao, Y., Li, Z., Zheng, S., Zou, J. L., Warren, N. A., Bali, P., Wu, J., Xing, M., Jiang, C., Tang, Y., Salton, S. R. & Ye, X., Jun 2021, In: Translational Psychiatry. 11, 1, 383.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Scopus citations
Diseases, Disorders, and Comorbidities of Interoception
Bonaz, B., Lane, R. D., Oshinsky, M. L., Kenny, P. J., Sinha, R., Mayer, E. A. & Critchley, H. D., Jan 2021, In: Trends in Neurosciences. 44, 1, p. 39-51 13 p.
Research output: Contribution to journal › Review article › peer-review
43 Scopus citations
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes
Kumar, K., Suebsuwong, C., Wang, P., Garcia-Ocana, A., Stewart, A. F. & Devita, R. J., 25 Mar 2021, In: Journal of Medicinal Chemistry. 64, 6, p. 2901-2922 22 p.
Research output: Contribution to journal › Review article › peer-review
13 Scopus citations
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23
He, Z., Chen, L., Catalan-Dibene, J., Bongers, G., Faith, J. J., Suebsuwong, C., DeVita, R. J., Shen, Z., Fox, J. G., Lafaille, J. J., Furtado, G. C. & Lira, S. A., 6 Jul 2021, In: Cell Metabolism. 33, 7, p. 1358-1371.e5
Research output: Contribution to journal › Article › peer-review

Open Access
26 Scopus citations

US Patent Issued to ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI on Jan. 10 for "Kinase inhibitor compounds and compositions and methods of use" (New York Inventors)
Robert DeVita, Avner Schlessinger & Andrew Stewart
23/01/23
1 item of Media coverage
Press/Media
Australia Patent: Application for 'Kinase inhibitor compounds and compositions and methods of use' Lapses
Chalada Suebsuwong, Robert DeVita & Peng Wang
12/01/23
1 item of Media coverage
Press/Media
Kinase Inhibitor Compounds and Compositions and Methods of Use
Robert DeVita, Avner Schlessinger & Andrew Stewart
10/01/23
1 item of Media coverage
Press/Media
Data on Chronic Obstructive Pulmonary Disease Detailed by a Researcher at Icahn School of Medicine at Mount Sinai (Hedgehog-interacting protein acts in the habenula to regulate nicotine intake)
Mary Heyer, ALEXANDER SMITH , Alexandra DiFeliceantonio, Purva Bali, Paul Kenny, Robert Sebra & Jessica Ables
29/11/22
1 item of Media coverage
Press/Media
Mount Sinai Launches Neural Epigenomics Research Center
Eric Nestler, Paul Kenny & Ian Maze
23/05/22 → 24/05/22
5 items of Media coverage
Press/Media
Mount Sinai launches Neural Epigenomics Research Center
Eric Nestler, Paul Kenny & Ian Maze
23/05/22
2 items of Media coverage
Press/Media
Sprint Bioscience: Sprint Bioscience appoints Scientific Advisory Board (MFN)
Robert DeVita
11/05/22
1 item of Media coverage
Press/Media
JDRF Recognizes Mount Sinai’s Contribution to Diabetes Research and Patient Care
joan han, Joan Han, Andrea Dunaif, Robert DeVita, Carol Levy, Andrew Stewart & Peng Wang
30/04/22
1 item of Media coverage
Press/Media
JDRF Recognizes Mount Sinai's Contribution to Diabetes Research and Patient Care at the 49th Annual New York City Chapter Promise Ball
joan han, Joan Han, Andrea Dunaif, Robert DeVita, Carol Levy, Andrew Stewart & Peng Wang
29/04/22
2 items of Media coverage
Press/Media
JDRF Recognizes Mount Sinai’s Contribution to Diabetes Research and Patient Care at the 49th Annual New York City Chapter Promise Ball
joan han, Joan Han, Andrea Dunaif, Robert DeVita, Carol Levy, Andrew Stewart & Peng Wang
29/04/22
1 item of Media coverage
Press/Media
Sorrento Therapeutics Announces Covishield (Sti-9167), a Broad-Spectrum Neutralizing Antibody, Potently Neutralizes Omicron and Omicron (+R346k) Variants of Sars-Cov-2
James Duty, & Domenico Tortorella
21/01/22 → 24/01/22
18 items of Media coverage
Press/Media
Sorrento Therapeutics Announces Covishield (Sti-9167), A Broad-Spectrum Neutralizing Antibody, Potently Neutralizes Omicron And Omicron (+R346k) Variants Of Sars-Cov-2
James Duty, & Domenico Tortorella
21/01/22
1 item of Media coverage
Press/Media

Mount Sinai Drug Discovery Institute

Fingerprint

Network

Profiles

Projects

Research output

Press / Media