Mount Sinai Diabetes, Obesity, and Metabolism Institute

Research output

Research output per year 1981 2003 2004 2005 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 16689 Citations
• 59 h-index
• 225 Article
• 29 Review article
• 20 Comment/debate
• 11 Conference article
• 22 More
  • 10 Editorial
  • 7 Chapter
  • 4 Conference contribution
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2023

  Generation of functional thymic organoids from human pluripotent stem cells

  Ramos, S. A., Armitage, L. H., Morton, J. J., Alzofon, N., Handler, D., Kelly, G., Homann, D., Jimeno, A. & Russ, H. A., 11 Apr 2023, In: Stem Cell Reports. 18, 4, p. 829-840 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Pluripotent Stem Cells 89%
  • Marker 66%
  • Thymus Gland 44%
  • Protein 31%

• l-Arginine supplementation regulates energy-substrate metabolism in skeletal muscle and adipose tissue of diet-induced obese rats

  Jobgen, W. S., Lee, M. J., Fried, S. K. & Wu, G., Feb 2023, In: Experimental Biology and Medicine. 248, 3, p. 209-216 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Retroperitoneal 100%
  • Arginine 71%
  • Energy Metabolism 70%
  • Adipose Tissue 65%
  • Skeletal Muscle 61%
  3 Scopus citations

• Mammary duct luminal epithelium controls adipocyte thermogenic programme

  Patel, S., Sparman, N. Z. R., Arneson, D., Alvarsson, A., Santos, L. C., Duesman, S. J., Centonze, A., Hathaway, E., Ahn, I. S., Diamante, G., Cely, I., Cho, C. H., Talari, N. K., Rajbhandari, A. K., Goedeke, L., Wang, P., Butte, A. J., Blanpain, C., Chella Krishnan, K., Lusis, A. J., & 3 othersStanley, S. A., Yang, X. & Rajbhandari, P., 3 Aug 2023, In: Nature. 620, 7972, p. 192-199 8 p.

  Research output: Contribution to journal › Article › peer-review

  • adipocytes 100%
  • breasts 84%
  • epithelium 74%
  • white adipose tissue 59%
  • proteins 31%
  1 Scopus citations

• Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

  Kang, R. B., Li, Y., Rosselot, C., Zhang, T., Siddiq, M., Rajbhandari, P., Stewart, A. F., Scott, D. K., Garcia-Ocana, A. & Lu, G., Dec 2023, In: Genome Medicine. 15, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequence Analysis 100%
  • Islets of Langerhans 89%
  • Transcriptome 82%
  • Genes 35%
  • RNA Precursors 30%
  4 Scopus citations
• 2022

  A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets

  Patel, R., Parmar, N., Rathwa, N., Palit, S. P., Li, Y., Garcia-Ocaña, A. & Begum, R., Aug 2022, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1869, 8, 119263.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sitagliptin Phosphate 100%
  • Melatonin 75%
  • Cell Transdifferentiation 40%
  • Regeneration 22%
  • Apoptosis 16%
  6 Scopus citations

• Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells

  Wang, P., Karakose, E., Argmann, C., Wang, H., Balev, M., Brody, R. I., Rivas, H. G., Liu, X., Wood, O., Liu, H., Choleva, L., Hasson, D., Bernstein, E., Paulo, J. A., Scott, D. K., Lambertini, L., DeCaprio, J. A. & Stewart, A. F., 1 Aug 2022, In: Journal of Clinical Investigation. 132, 15, e157086.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulinoma 100%
  • Phosphotransferases 61%
  • Type 1 Diabetes Mellitus 35%
  • Regeneration 33%
  • Type 2 Diabetes Mellitus 29%
  7 Scopus citations

• Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

  The Immunology of Diabetes Society T-Cell Cytometry Group, Mar 2022, In: European Journal of Immunology. 52, 3, p. 372-388 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunophenotyping 100%
  • Type 1 Diabetes Mellitus 94%
  • Biomarkers 68%
  • Guidelines 67%
  • T-Lymphocytes 65%
  6 Scopus citations

• Limited extent and consequences of pancreatic SARS-CoV-2 infection

  van der Heide, V., Jangra, S., Cohen, P., Rathnasinghe, R., Aslam, S., Aydillo, T., Geanon, D., Handler, D., Kelley, G., Lee, B., Rahman, A., Dawson, T., Qi, J., D'Souza, D., Kim-Schulze, S., Panzer, J. K., Caicedo, A., Kusmartseva, I., Posgai, A. L., Atkinson, M. A., & 5 othersAlbrecht, R. A., García-Sastre, A., Rosenberg, B. R., Schotsaert, M. & Homann, D., 15 Mar 2022, In: Cell Reports. 38, 11, 110508.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus Infections 100%
  • Severe Acute Respiratory Syndrome 90%
  • Coronavirus 87%
  • Risk Assessment 84%
  • Infections 19%
  25 Scopus citations

• Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure

  Katz, L. S., Brill, G., Zhang, P., Kumar, A., Baumel-Alterzon, S., Honig, L. B., Gómez-Banoy, N., Karakose, E., Tanase, M., Doridot, L., Alvarsson, A., Davenport, B., Wang, P., Lambertini, L., Stanley, S. A., Homann, D., Stewart, A. F., Lo, J. C., Herman, M. A., Garcia-Ocaña, A., & 1 othersScott, D. K., Dec 2022, In: Nature Communications. 13, 1, 4423.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • carbohydrates 100%
  • positive feedback 93%
  • Response Elements 78%
  • Carbohydrates 63%
  • Carrier Proteins 61%
  5 Scopus citations

• Mapping and specific viral targeting of peripheral pancreatic innervation

  Jimenez Gonzalez, M., Li, R., Pomeranz, L. E., Alvarsson, A., Marongiu, R., Hampton, R. F., Vasavada, R. C., Schwartz, G. J. & Stanley, S. A., 1 May 2022, In: FASEB Journal. 36

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreas 100%
  • Glucose 85%
  • Insulin Derivative 71%
  • Intrapancreatic 50%
  • Pancreas Hormone 44%

• Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism

  Jimenez-Gonzalez, M., Li, R., Pomeranz, L. E., Alvarsson, A., Marongiu, R., Hampton, R. F., Kaplitt, M. G., Vasavada, R. C., Schwartz, G. J. & Stanley, S. A., Nov 2022, In: Nature Biomedical Engineering. 6, 11, p. 1298-1316 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Intrapancreatic 100%
  • Virus Activation 60%
  • Metabolism 58%
  • Glucose 51%
  • Neurons 42%
  3 Scopus citations

• Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity

  Rajan, S., Hofer, P., Christiano, A., Stevenson, M., Ragolia, L., Villa-Cuesta, E., Fried, S. K., Lau, R., Braithwaite, C., Zechner, R., Schwartz, G. J. & Hussain, M. M., Dec 2022, In: Metabolism: Clinical and Experimental. 137, 155331.

  Research output: Contribution to journal › Article › peer-review

  • microsomal triglyceride transfer protein 100%
  • Lipolysis 74%
  • Adipocytes 60%
  • Lipase 56%
  • Lipids 41%
  2 Scopus citations

• Nrf2 Regulates b-Cell Mass by Suppressing b-Cell Death and Promoting b-Cell Proliferation

  Baumel-Alterzon, S., Katz, L. S., Brill, G., Jean-Pierre, C., Li, Y., Tse, I., Biswal, S., Garcia-Ocaña, A. & Scott, D. K., May 2022, In: Diabetes. 71, 5, p. 989-1011 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Death 100%
  • Cell Proliferation 86%
  • High Fat Diet 37%
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate 33%
  • Glucose 23%
  7 Scopus citations

• Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit

  Zhu, Q., Yang, S., Wei, C., Lu, G., Lee, K., He, J. C., Liu, R. & Zhong, Y., Jul 2022, In: Journal of Cellular and Molecular Medicine. 26, 14, p. 3816-3827 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • puerarin 100%
  • Guanidine 85%
  • Protein Subunits 75%
  • Carrier Proteins 56%
  • Podocytes 54%
  4 Scopus citations

• Sexually dimorphic role of the locus coeruleus PAC1 receptors in regulating acute stress-associated energy metabolism

  Duesman, S. J., Shetty, S., Patel, S., Ogale, N., Mohamed, F., Sparman, N., Rajbhandari, P. & Rajbhandari, A. K., 5 Oct 2022, In: Frontiers in Behavioral Neuroscience. 16, 995573.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I 100%
  • Locus Coeruleus 74%
  • Energy Metabolism 56%
  • Pituitary Adenylate Cyclase-Activating Polypeptide Receptors 24%
  • Brown Adipose Tissue 18%
  1 Scopus citations

• T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation

  Katz, L. S., Argmann, C., Lambertini, L. & Scott, D. K., Dec 2022, In: Molecular Metabolism. 66, 101646.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphoenolpyruvate 100%
  • Cell Proliferation 50%
  • Glucose 47%
  • Thyroid Hormone Receptors 42%
  • Response Elements 23%
  1 Scopus citations

• The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair

  Portal, C., Wang, Z., Scott, D. K., Wolosin, J. M. & Iomini, C., Feb 2022, In: Investigative Ophthalmology and Visual Science. 63, 2, 3.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Corneal Epithelium 100%
  • myc Genes 98%
  • Homeostasis 58%
  • Keratin-14 19%
  • Wounds and Injuries 19%
  2 Scopus citations
• 2021

  Dynamic regulation of B cell complement signaling is integral to germinal center responses

  Cumpelik, A., Heja, D., Hu, Y., Varano, G., Ordikhani, F., Roberto, M. P., He, Z., Homann, D., Lira, S. A., Dominguez-Sola, D. & Heeger, P. S., Jun 2021, In: Nature Immunology. 22, 6, p. 757-768 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Germinal Center 100%
  • Signal Transduction 65%
  • B-Lymphocytes 65%
  • Anaphylatoxin C5a Receptor 37%
  • Complement Membrane Attack Complex 32%
  30 Scopus citations

• GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells

  Saikia, M., Holter, M. M., Donahue, L. R., Lee, I. S., Zheng, Q. C., Wise, J. L., Todero, J. E., Phuong, D. J., Garibay, D., Coch, R., Sloop, K. W., Garcia-Ocana, A., Danko, C. G. & Cummings, B. P., 8 Feb 2021, In: JCI insight. 6, 3, e141851.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon-Like Peptide-1 Receptor 100%
  • Proprotein Convertase 1 70%
  • Glucagon-Like Peptide 1 49%
  • Liraglutide 39%
  • Small Cytoplasmic RNA 25%
  15 Scopus citations

• Intrauterine Growth Restriction Is Associated with Unique Features of the Reproductive Microbiome

  Hu, J., Benny, P., Wang, M., Ma, Y., Lambertini, L., Peter, I., Xu, Y. & Lee, M. J., Mar 2021, In: Reproductive Sciences. 28, 3, p. 828-837 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fetal Growth Retardation 100%
  • Microbiota 90%
  • Neisseriaceae 38%
  • Placenta 28%
  • Desulfovibrio 17%
  12 Scopus citations

• In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

  Charbord, J., Ren, L., Sharma, R. B., Johansson, A., Ågren, R., Chu, L., Tworus, D., Schulz, N., Charbord, P., Stewart, A. F., Wang, P., Alonso, L. C. & Andersson, O., May 2021, In: Nature Metabolism. 3, 5, p. 682-700 19 p.

  Research output: Contribution to journal › Article › peer-review

  • HG-9-91-01 100%
  • Unfolded Protein Response 54%
  • Salts 38%
  • Phosphotransferases 33%
  • Cell Proliferation 28%
  14 Scopus citations

• NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice

  Guo, F., Seldin, M., Péterfy, M., Charugundla, S., Zhou, Z., Lee, S. D., Mouton, A., Rajbhandari, P., Zhang, W., Pellegrini, M., Tontonoz, P., Lusis, A. J. & Shih, D. M., Dec 2021, In: Scientific Reports. 11, 1, 16409.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dependovirus 100%
  • Obesity 65%
  • Diet 64%
  • Brown Adipocytes 38%
  • Lipolysis 31%
  3 Scopus citations

• Optical clearing and 3D analysis optimized for mouse and human pancreata

  Alvarsson, A., Jimenez-Gonzalez, M., Li, R., Rosselot, C., Tzavaras, N., Wu, Z. & Stanley, S. A., 5 Aug 2021, In: Bio-protocol. 11, 15, e4103.

  Research output: Contribution to journal › Article › peer-review

  • pancreas 100%
  • Transparency 99%
  • Light Scattering 90%
  • innervation 87%
  • Marker 86%
  3 Scopus citations

• Pharmacological blockade of the EP3 prostaglandin E₂ receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage

  Bosma, K. J., Andrei, S. R., Katz, L. S., Smith, A. A., Dunn, J. C., Ricciardi, V. F., Ramirez, M. A., Baumel-Alterzon, S., Pace, W. A., Carroll, D. T., Overway, E. M., Wolf, E. M., Kimple, M. E., Sheng, Q., Scott, D. K., Breyer, R. M. & Gannon, M., Dec 2021, In: Molecular Metabolism. 54, 101347.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostaglandin Receptors 100%
  • Dinoprostone 67%
  • Type 2 Diabetes Mellitus 52%
  • Pharmacology 46%
  • Cell Proliferation 45%
  12 Scopus citations

• T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death

  Chun, N., Ang, R. L., Chan, M., Fairchild, R. L., Baldwin, W. M., Horwitz, J. K., Gelles, J. D., Chipuk, J. E., Kelliher, M. A., Pavlov, V. I., Li, Y., Homann, D., Heeger, P. S. & Ting, A. T., 22 Dec 2021, In: JCI insight. 6, 24, e148643.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Death 100%
  • Tumor Necrosis Factor-alpha 93%
  • T-Lymphocytes 65%
  • Allografts 46%
  • Death Domain Receptor Signaling Adaptor Proteins 42%
  3 Scopus citations

• USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors

  Uzilov, A. V., Taik, P., Cheesman, K. C., Javanmard, P., Ying, K., Roehnelt, A., Wang, H., Fink, M. Y., Lau, C. Y., Moe, A. S., Villar, J., Bederson, J. B., Stewart, A. F., Donovan, M. J., Mahajan, M., Sebra, R., Post, K. D., Chen, R. & Geer, E. B., 1 Mar 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 3, p. 826-842 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ACTH-Secreting Pituitary Adenoma 100%
  • Mutation 52%
  • Corticotrophs 43%
  • Neoplasms 20%
  • Cortisol 16%
  27 Scopus citations

• Vitamin D Inhibits Adipokine Production and Inflammatory Signaling Through the Vitamin D Receptor in Human Adipocytes

  Nimitphong, H., Guo, W., Holick, M. F., Fried, S. K. & Lee, M. J., Mar 2021, In: Obesity. 29, 3, p. 562-568 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcitriol Receptors 100%
  • Adipokines 95%
  • Adipocytes 79%
  • Vitamin D 77%
  • Adipose Tissue 34%
  7 Scopus citations
• 2020

  A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes

  Alvarsson, A., Jimenez-Gonzalez, M., Li, R., Rosselot, C., Tzavaras, N., Wu, Z., Stewart, A. F., Garcia-Ocaña, A. & Stanley, S. A., 7 Oct 2020, In: Science advances. 6, 41, eaaz9124.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atlases 100%
  • Islets of Langerhans 46%
  • Pancreas 39%
  • Inbred NOD Mouse 28%
  • Metabolic Diseases 24%
  28 Scopus citations

• Aberrant methylation underlies insulin gene expression in human insulinoma

  Karakose, E., Wang, H., Inabnet, W., Thakker, R. V., Libutti, S., Fernandez-Ranvier, G., Suh, H., Stevenson, M., Kinoshita, Y., Donovan, M., Antipin, Y., Li, Y., Liu, X., Jin, F., Wang, P., Uzilov, A., Argmann, C., Schadt, E. E., Stewart, A. F., Scott, D. K., & 1 othersLambertini, L., 1 Dec 2020, In: Nature Communications. 11, 1, 5210.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methylation 100%
  • insulin 90%
  • gene expression 85%
  • Insulinoma 79%
  • Insulin Derivative 64%
  5 Scopus citations

• An ampk-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

  Wang, H., Wan, X., Pilch, P. F., Ellisen, L. W., Fried, S. K. & Liu, L., Dec 2020, In: eLife. 9, p. 1-23 23 p., e63665.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adipocytes 100%
  • Metabolic 85%
  • Nutrient 37%
  • Energy 32%
  • Protein 28%
  3 Scopus citations

• Chemokine signatures of pathogen-Specific T cells I: Effector T cells

  Eberlein, J., Davenport, B., Nguyen, T. T., Victorino, F., Jhun, K., van der Heide, V., Kuleshov, M., Ma’ayan, A., Kedl, R. & Homann, D., 15 Oct 2020, In: Journal of Immunology. 205, 8, p. 2169-2187 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemokines 100%
  • T-Lymphocytes 65%
  • Chemotaxis 14%
  • Allergy and Immunology 14%
  • Antigen-Antibody Complex 13%
  16 Scopus citations

• Chemokine signatures of pathogen-Specific T cells II: Memory T cells in acute and chronic infection

  Davenport, B., Eberlein, J., Nguyen, T. T., Victorino, F., van der Heide, V., Kuleshov, M., Ma’ayan, A., Kedl, R. & Homann, D., 15 Oct 2020, In: Journal of Immunology. 205, 8, p. 2188-2206 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokines 100%
  • T-Lymphocytes 65%
  • Infections 50%
  • Chemokine CCL1 24%
  • Allergy and Immunology 14%
  4 Scopus citations

• Copper associates with differential methylation in placentae from two US birth cohorts

  Kennedy, E., Everson, T. M., Punshon, T., Jackson, B. P., Hao, K., Lambertini, L., Chen, J., Karagas, M. R. & Marsit, C. J., 3 Mar 2020, In: Epigenetics. 15, 3, p. 215-230 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Copper 100%
  • Placenta 93%
  • Methylation 90%
  • Parturition 69%
  • Placentation 31%
  10 Scopus citations

• Dextran sulfate protects pancreatic β-cells, reduces autoimmunity, and ameliorates type 1 diabetes

  Lu, G., Rausell-Palamos, F., Zhang, J., Zheng, Z., Zhang, T., Valle, S., Rosselot, C., Berrouet, C., Conde, P., Spindler, M. P., Graham, J. G., Homann, D. & Garcia-Ocaña, A., Aug 2020, In: Diabetes. 69, 8, p. 1692-1707 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dextran Sulfate 100%
  • Autoimmunity 79%
  • Type 1 Diabetes Mellitus 73%
  • Inbred NOD Mouse 37%
  • Self Tolerance 13%
  8 Scopus citations

• Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19

  Kusmartseva, I., Wu, W., Syed, F., Van Der Heide, V., Jorgensen, M., Joseph, P., Tang, X., Candelario-Jalil, E., Yang, C., Nick, H., Harbert, J. L., Posgai, A. L., Paulsen, J. D., Lloyd, R., Cechin, S., Pugliese, A., Campbell-Thompson, M., Vander Heide, R. S., Evans-Molina, C., Homann, D., & 1 othersAtkinson, M. A., 1 Dec 2020, In: Cell Metabolism. 32, 6, p. 1041-1051.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • angiotensin converting enzyme 2 92%
  • Coronavirus Infections 66%
  • Pancreas 66%
  115 Scopus citations

• GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

  Ackeifi, C., Wang, P., Karakose, E., Manning Fox, J. E., González, B. J., Liu, H., Wilson, J., Swartz, E., Berrouet, C., Li, Y., Kumar, K., MacDonald, P. E., Sanchez, R., Thorens, B., DeVita, R., Homann, D., Egli, D., Scott, D. K., Garcia-Ocaña, A. & Stewart, A. F., 12 Feb 2020, In: Science Translational Medicine. 12, 530, eaaw9996.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon-Like Peptide-1 Receptor 100%
  • Protein-Tyrosine Kinases 70%
  • Regeneration 64%
  • Insulin Secretion 17%
  • Cell Proliferation 17%
  61 Scopus citations

• Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

  Fu, A., Alvarez-Perez, J. C., Avizonis, D., Kin, T., Ficarro, S. B., Choi, D. W., Karakose, E., Badur, M. G., Evans, L., Rosselot, C., Bridon, G., Bird, G. H., Seo, H. S., Dhe-Paganon, S., Kamphorst, J. J., Stewart, A. F., James Shapiro, A. M., Marto, J. A., Walensky, L. D., Jones, R. G., & 2 othersGarcia-Ocana, A. & Danial, N. N., 1 May 2020, In: Nature Metabolism. 2, 5, p. 432-446 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Urea 100%
  • Arginine 97%
  • Cell Cycle 83%
  • Pyruvate Carboxylase 81%
  • Glucose 66%
  20 Scopus citations

• HB-EGF signaling is required for glucose-induced pancreatic β-cell proliferation in rats

  Maachi, H., Fergusson, G., Ethier, M., Brill, G. N., Katz, L. S., Honig, L. B., Metukuri, M. R., Scott, D. K., Ghislain, J. & Poitout, V., 1 Mar 2020, In: Diabetes. 69, 3, p. 369-380 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Heparin-binding EGF-like Growth Factor 100%
  • Cell Proliferation 43%
  • Glucose 41%
  • ErbB Receptors 31%
  • rat Hbegf protein 18%
  11 Scopus citations

• In-depth characterization of the placental imprintome reveals novel differentially methylated regions across birth weight categories

  Deyssenroth, M. A., Marsit, C. J., Chen, J. & Lambertini, L., 1 Feb 2020, In: Epigenetics. 15, 1-2, p. 47-60 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Birth Weight 100%
  • Gestational Age 90%
  • Methylation 76%
  • Fetal Development 64%
  • DNA Methylation 62%
  8 Scopus citations

• Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis

  Liu, Q., Yu, J., Wang, L., Tang, Y., Zhou, Q., Ji, S., Wang, Y., Santos, L., Haeusler, R. A., Que, J., Rajbhandari, P., Lei, X., Valenti, L., Pajvani, U. B., Qin, J. & Qiang, L., Aug 2020, In: Journal of Hepatology. 73, 2, p. 361-370 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fatty Liver 100%
  • Liver 48%
  • Liver Diseases 35%
  • Transcription Factors 31%
  • Inflammation 30%
  21 Scopus citations

• Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells

  Walker, J. T., Haliyur, R., Nelson, H. A., Ishahak, M., Poffenberger, G., Aramandla, R., Reihsmann, C., Luchsinger, J. R., Saunders, D. C., Wang, P., Garcia-Ocaña, A., Bottino, R., Agarwal, A., Powers, A. C. & Brissova, M., May 2020, In: JCI insight. 5, 10, e137017.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microfluidics 100%
  • Glucagon 87%
  • Islets of Langerhans 83%
  • Insulin Secretion 62%
  • Hormones 58%
  29 Scopus citations

• Lactogens reduce endoplasmic reticulum stress– induced rodent and human β-cell death and diabetes incidence in akita mice

  Li, R., Kondegowda, N. G., Filipowska, J., Hampton, R. F., Leblanc, S., Garcia-Ocana, A. & Vasavada, R. C., Jul 2020, In: Diabetes. 69, 7, p. 1463-1475 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Reticulum 100%
  • Endoplasmic Reticulum Stress 86%
  • Rodentia 64%
  • Cell Death 59%
  • Incidence 37%
  6 Scopus citations

• Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection

  Norton, T. D., Tada, T., Leibowitz, R., van der Heide, V., Homann, D. & Landau, N. R., 5 Aug 2020, In: Molecular Therapy. 28, 8, p. 1795-1805 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dendritic Cells 100%
  • Vaccines 83%
  • Virus Diseases 82%
  • Epitope 75%
  • Molecular Cluster 72%
  3 Scopus citations

• Mitochondrial and glycolysis-regulatory gene expression profiles are associated with intrauterine growth restriction

  Jones, R., Peña, J., Mystal, E., Marsit, C., Lee, M. J., Stone, J. & Lambertini, L., 17 Apr 2020, In: Journal of Maternal-Fetal and Neonatal Medicine. 33, 8, p. 1336-1345 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fetal Growth Retardation 100%
  • Glycolysis 95%
  • Regulator Genes 94%
  • Transcriptome 83%
  • Oxidative Stress 30%
  14 Scopus citations

• Moderate prenatal stress may buffer the impact of Superstorm Sandy on placental genes: Stress in Pregnancy (SIP) Study

  Zhang, W., Ham, J., Li, Q., Deyssenroth, M. A., Lambertini, L., Huang, Y., Tsuchiya, K. J., Chen, J. & Nomura, Y., 1 Jan 2020, In: PLoS ONE. 15, 1, e0226605.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Buffers 100%
  • Placenta 67%
  • Pregnancy 65%
  • Gene Expression 64%
  • Epigenomics 63%
  5 Scopus citations

• Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors

  Ackeifi, C., Swartz, E., Kumar, K., Liu, H., Chalada, S., Karakose, E., Scott, D. K., Garcia-Ocaña, A., Sanchez, R., DeVita, R. J., Stewart, A. F. & Wang, P., 16 Jan 2020, In: JCI insight. 5, 1, e132594.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Harmine 100%
  • Dyrk kinase 53%
  • Cell Proliferation 39%
  • Drug Design 34%
  • RNA Sequence Analysis 33%
  26 Scopus citations

• Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

  Kima, S. M., Kima, S. M., Taneja, C., Taneja, C., Perez-Pena, H., Ryu, V., Ryu, V., Gumerova, A., Gumerova, A., Li, W., Ahmad, N., Ahmad, N., Zhu, L. L., Zhu, L. L., Liu, P., Liu, P., Mathew, M., Mathew, M., Korkmaz, F., Korkmaz, F., & 34 othersGera, S., Gera, S., Sant, D., Sant, D., Hadelia, E., Hadelia, E., Ievleva, K., Ievleva, K., Ievleva, K., Kuo, T. C., Kuo, T. C., Miyashita, H., Miyashita, H., Liu, L., Liu, L., Tourkova, I., Tourkova, I., Stanley, S., Lizneva, D., Lizneva, D., Iqbal, J., Iqbal, J., Sun, L., Sun, L., Tamler, R., Blair, H. C., Blair, H. C., New, M. I., New, M. I., Haider, S., Yuen, T., Yuen, T., Zaidi, M. & Zaidi, M., 23 Jun 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14386-14394 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vardenafil Dihydrochloride 100%
  • Type 5 Cyclic Nucleotide Phosphodiesterases 94%
  • Tadalafil 93%
  • Erectile Dysfunction 69%
  • Bone and Bones 38%
  14 Scopus citations

• Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification

  Lorberbaum, D. S., Kishore, S., Rosselot, C., Sarbaugh, D., Brooks, E. P., Aragon, E., Xuan, S., Simon, O., Ghosh, D., Mendelsohn, C., Gadue, P. & Sussel, L., 22 Jun 2020, In: Development (Cambridge). 147, 12, dev189977.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tretinoin 100%
  • Endocrine Cells 29%
  • Cell Differentiation 19%
  • Endoderm 15%
  • Human Embryonic Stem Cells 14%
  19 Scopus citations

• Structure–activity relationships and biological evaluation of 7-substituted harmine analogs for human β-cell proliferation

  Kumar, K., Wang, P., Swartz, E. A., Khamrui, S., Secor, C., Lazarus, M. B., Sanchez, R., Stewart, A. F. & DeVita, R. J., Apr 2020, In: Molecules. 25, 8, 1983.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Harmine 100%
  • analogs 48%
  • Cell Proliferation 39%
  • evaluation 37%
  • inhibitors 27%
  10 Scopus citations

• Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor

  Kumar, K., Wang, P., Wilson, J., Zlatanic, V., Berrouet, C., Khamrui, S., Secor, C., Swartz, E. A., Lazarus, M., Sanchez, R., Stewart, A. F., Garcia-Ocana, A. & Devita, R. J., 26 Mar 2020, In: Journal of Medicinal Chemistry. 63, 6, p. 2986-3003 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Dyrk kinase 100%
  • Harmine 94%
  • Tyrosine 51%
  • Central Nervous System 41%
  • Cell Proliferation 21%
  32 Scopus citations