Mount Sinai Diabetes, Obesity, and Metabolism Institute

Projects

Projects per year 1986 2004 2017 2024

• 16 Active
• 69 Finished

Projects per year

Search results

• Finished

  Studying Autonomic Peripheral Innervation in Chronic Pancreatitis

  Jimenez Gonzalez, M.

  U.S. Army

  15/07/20 → 15/07/20

  Project: Research

  • Chronic Pancreatitis 100%
  • Pancreas 80%
  • Pain 30%
  • Inflammation 24%
  • Nausea 18%

• Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• Einstein-Mount Sinai Diabetes Research Center

  García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/20 → 31/03/22

  Project: Research

  • diabetes 100%
  • rodents 41%
  • Adenoviridae 37%
  • islets of Langerhans 29%
  • Lentivirus 23%

• Human Pancreas Analysis Program-T2D

  Powers, A. C., Atkinson, M. A., Bottino, R., Brissova, M., Gloyn, A., Homann, D., Kim, S. K., Macdonald, P. & Moore, J. H.

  National Institute of Diabetes and Digestive and Kidney Diseases

  22/09/19 → 30/06/21

  Project: Research

  • noninsulin-dependent diabetes mellitus 100%
  • pancreas 59%
  • diabetes 11%
  • insulin resistance 6%
  • islets of Langerhans 6%

• Interleukin-10 Signaling in Adipose Tissue Thermogenesis and Energy expenditure

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/08/19 → 31/07/21

  Project: Research

  • Thermogenesis 100%
  • Interleukin-10 87%
  • Interleukin-10 Receptors 75%
  • Adipose Tissue 74%
  • Energy Metabolism 71%

• Nrf2 and the adaptive expansion of beta cell mass

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/18 → 30/04/19

  Project: Research

  • Response Elements 100%
  • Carbohydrates 80%
  • Carrier Proteins 78%
  • Glucose 65%
  • Cell Proliferation 53%

• Interleukin-10 Signaling in Adipose Tissue Thermogenesis and Energy expenditure

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 30/04/19

  Project: Research

  • Thermogenesis 100%
  • Interleukin-10 93%
  • Interleukin-10 Receptors 80%
  • Adipose Tissue 77%
  • Energy Metabolism 70%

• Epigenetic Control of Human Beta Cell Proliferation

  Stewart, A., Argmann, C., Scott, D. & Walsh, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 31/03/19

  Project: Research

  • Epigenomics 100%
  • Insulinoma 96%
  • Cell Proliferation 78%
  • Chromosomes, Human, Pair 11 49%
  • Pancreatic adenoma 23%

• Mapping Essential Elements and Toxic Metals in the Human Pancreas in Health and Disease

  Homann, D. & Arora, M.

  National Institute of Environmental Health Sciences

  15/12/17 → 30/11/19

  Project: Research

  • Type 1 Diabetes Mellitus 100%
  • Metals 90%
  • Pancreas 83%
  • Laser Therapy 72%
  • Poisons 60%

• Integrated Functional Histopathology of the Diabetic Human Pancreas

  Von Herrath, M. M. G., Homann, D., Homann, D. & Von Herrath, M. G.

  National Institute of Allergy and Infectious Diseases

  7/12/17 → 30/11/22

  Project: Research

  • Pancreas 100%
  • Type 1 Diabetes Mellitus 72%
  • Endocrine Cells 48%
  • Tissue Donors 27%
  • Insulin-Secreting Cells 25%

• Combined harmalog-tgf beta inhibitors for human beta cell expansion

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/17 → 31/08/19

  Project: Research

  • Pharmaceutical Preparations 100%
  • Harmine 80%
  • Drive 49%
  • Pancreas 41%
  • Regeneration 40%

• DEXTRAN SULFATE, BETA CELL PRESERVATION, AND IMMUNE REGULATION IN TYPE 1 DIABETES

  Homann, D.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 59%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Military medical research and development

  Homann, D.

  U.S. Army

  1/08/17 → 31/07/19

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 73%
  • Biomedical Research 41%
  • Immune Tolerance 9%
  • Immune System 6%

• Military medical research and development

  García-Ocaña, A.

  U.S. Army

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 73%
  • Biomedical Research 41%
  • Immune Tolerance 9%
  • Immune System 6%

• DEXTRAN SULFATE, BETA CELL PRESERVATION, AND IMMUNE REGULATION IN TYPE 1 DIABETES

  García-Ocaña, A.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 59%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• ChREBP Isoforms in Pancreatic Beta Cells

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  18/04/17 → 31/03/21

  Project: Research

  • Insulin-Secreting Cells 100%
  • Protein Isoforms 75%
  • Glucose 70%
  • Response Elements 21%
  • Cell Proliferation 20%

• Dextran Sulfate, Beta Cell Preservation and Immune Regulation in Type 1 Diabetes

  García-Ocaña, A. & Homann, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/17 → 31/03/21

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 65%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  American Diabetes Association

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• Decay accelerating factor dependent inhibition of T cell immunity

  Heeger, P. & Homann, D.

  National Institute of Allergy and Infectious Diseases

  1/06/16 → 31/05/19

  Project: Research

  • CD55 Antigens 100%
  • Immunity 60%
  • T-Lymphocytes 56%
  • Psychological Inhibition 51%
  • Complement Activation 40%

• Enhanced transplant efficiency and function of human beta cells with ChREBP-alpha

  Scott, D.

  Juvenile Diabetes Research Foundation United States of America

  1/05/16 → 30/04/17

  Project: Research

  • Insulin 100%
  • Glucose 92%
  • Islets of Langerhans 73%
  • Transplants 68%
  • Protein Isoforms 59%

• Optimizing harmalog dosing and combinatorial therapy for human beta cell replication, enhanced survival and differentiation

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/06/15 → 31/05/17

  Project: Research

  • Survival 100%
  • Type 1 Diabetes Mellitus 68%
  • Cell Survival 58%
  • Genetic Therapy 35%
  • Rodentia 31%

• Reprogramming Fatty Acid Handling to Improve Adipocyte Function in Human Obesity

  Fried, S.

  1/01/15 → 31/12/17

  Project: Research

  • Adipocytes 100%
  • Fats 94%
  • White Adipocytes 62%
  • Fatty Acids 35%
  • Type 2 Diabetes Mellitus 31%

• Reprogramming Fatty Acid Handling to Improve Adipocyte Function in Human Obesity

  Fried, S.

  American Diabetes Association

  1/01/15 → 31/12/17

  Project: Research

  • Adipocytes 100%
  • Fats 86%
  • Fatty Acids 65%
  • White Adipocytes 56%
  • Obesity 46%

• Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity

  Fried, S., Pilch, P. F. & Fried, S. K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  25/09/14 → 31/08/18

  Project: Research

  • adipocytes 100%
  • adiponectin 85%
  • obesity 82%
  • adipokines 34%
  • insulin resistance 18%

• Mechanisms of TLE3 Action in Adipose Subtype-selective Gene Expression

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  5/09/14 → 4/09/15

  Project: Research

  • White Adipose Tissue 100%
  • Brown Adipose Tissue 87%
  • PPAR gamma 79%
  • Gene Expression 44%
  • Adipocytes 29%

• Mapping the histopathological landscape of type 1 diabetes: a pilot study

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/05/14 → 30/04/15

  Project: Research

  • Type 1 Diabetes Mellitus 100%
  • Pancreas 47%
  • Technology 36%

• Dextran Sulfate and Beta Cell Regeneration and Protection for Type 1 Diabetes

  García-Ocaña, A.

  American Diabetes Association

  1/01/14 → 31/12/16

  Project: Research

  • dextran sulfate 100%
  • insulin-dependent diabetes mellitus 78%
  • islets of Langerhans 27%
  • cells 14%
  • cell proliferation 13%

• Dextran Sulfate and Beta Cell Regeneration and Protection for Type 1 Diabetes

  García-Ocaña, A.

  1/01/14 → 31/12/16

  Project: Research

  • dextran sulfate 100%
  • insulin-dependent diabetes mellitus 52%
  • islets of Langerhans 25%
  • cell proliferation 12%
  • mice 12%

• Mapping the histopathological landscape of type 1 diabetes: A pilot study

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/11/13 → 31/10/14

  Project: Research

• Administrative

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/13 → 31/03/18

  Project: Research

  • nutrition science 100%
  • nutrition 61%
  • director 59%
  • expertise 25%
  • energy 23%

• Adipocyte Biology and Nutrient Metabolism

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/13 → 31/03/18

  Project: Research

  • adipocytes 100%
  • Biological Sciences 58%
  • nutrients 50%
  • metabolism 48%
  • adipose tissue 27%

• Regulation of Pathogen-specific T Cell Immunity by Adenosine Generation

  Homann, D. & Homann, D.

  National Institute of Allergy and Infectious Diseases

  1/02/12 → 31/01/16

  Project: Research

  • Adenosine 100%
  • Immunity 80%
  • T-Lymphocytes 65%
  • Acute Lung Injury 48%
  • Viruses 48%

• Exploiting normal cMyc biology for human beta cell expansion

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/11 → 28/02/14

  Project: Research

  • Rodentia 100%
  • Preclinical Drug Evaluations 71%
  • Cell Line 71%
  • Cell Proliferation 59%
  • Transgenic Mice 53%

• Epigenomic Regulation of Gene Expression in Diet Induced Obesity

  Peters, D. G. & Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/08/11 → 31/05/14

  Project: Research

  • Epigenomics 100%
  • Gene Expression Regulation 97%
  • Obesity 89%
  • DNA Methylation 64%
  • Diet 62%

• Defining and removing the blockades to human beta cell replication

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/08/11 → 31/07/14

  Project: Research

  • Nutrients 100%
  • Cell Cycle 92%
  • Cyclin D2 86%
  • Regeneration 73%
  • Intercellular Signaling Peptides and Proteins 71%

• Address the interaction of signaling proteins in survival, regeneration and secretory function of islet cells in the context of type 1 and type 2 diabetes.

  Stewart, A.

  Pfizer

  8/11/10 → 10/11/10

  Project: Research

• The Role of Myc in ChREBP-dependent, Glucose-stimulated Gene Expression

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  30/09/10 → 31/08/11

  Project: Research

  • Response Elements 100%
  • Carbohydrates 80%
  • Carrier Proteins 78%
  • Glucose 70%
  • Gene Expression 40%

• Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication

  Stewart, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/09/10 → 30/06/15

  Project: Research

  • Cell Cycle Checkpoints 100%
  • Cell Biology 72%
  • Cell- and Tissue-Based Therapy 52%
  • Therapeutics 51%
  • Cell Cycle 43%

• Chemokine expression by islet and islet-infiltrating cells in human T1D

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/03/10 → 28/02/11

  Project: Research

  • Chemokines 100%
  • Type 1 Diabetes Mellitus 91%
  • Islets of Langerhans 66%
  • Pancreas 23%
  • Animals 18%

• Glucocorticoids & Adipocyte Function in Human Obesity

  Fried, S. & Fried, S. K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/06/09 → 31/03/20

  Project: Research

  • glucocorticoids 100%
  • adipose tissue 93%
  • adipocytes 92%
  • obesity 89%
  • Adipocytes 74%

• Relief of Cell Cycle Inhibition for Human Beta Cell Proliferation

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/08 → 31/08/11

  Project: Research

  • Cell Cycle 100%
  • Cell Proliferation 69%
  • Cell Cycle Proteins 51%
  • Insulin Secretion 13%
  • Cell Division 13%

• Protein Kinase C (PKC) Zeta and the Pancreatic Beta Cell

  García-Ocaña, A. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/08/08 → 31/05/14

  Project: Research

  • protein kinase C zeta 100%
  • Protein Kinase C 70%
  • Insulin-Secreting Cells 69%
  • Cell Proliferation 27%
  • PKC-3 protein 21%

• Activation of Human Beta Cell Replication

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/03/08 → 28/02/11

  Project: Research

  • Cell Cycle 100%
  • Proteome 88%
  • Rodentia 70%
  • Islets of Langerhans Transplantation 54%
  • Insulin-Secreting Cells 45%

• Admin Core

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/07 → 31/08/08

  Project: Research

• Adipose Biology Core

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/07 → 31/08/08

  Project: Research

• Chemokine Signatures in Pathogenesis and Prevention of Type 1 Diabetes

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/04/07 → 31/03/12

  Project: Research

  • Chemokines 100%
  • Type 1 Diabetes Mellitus 51%
  • T-Lymphocytes 15%
  • Pancreas 14%
  • Carbohydrate Metabolism 9%

• Modeling Bone Formation and 1,25 Vitamin D in Humoral Hypercalcemia of Malignancy

  Stewart, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/07/06 → 30/06/10

  Project: Research

  • Humoral Hypercalcemia Of Malignancy 100%
  • Parathyroid Hormone-Related Protein 96%
  • Osteogenesis 57%
  • Vitamin D 55%
  • Hyperparathyroidism 14%

• Newfoundland Bone Conference / Workshop

  Kovacs, C. S. C. & Stewart, A.

  Canadian Institutes of Health Research

  1/03/06 → 28/02/07

  Project: Research

• Newfoundland Bone Conference / Workshop

  Kovacs, C. S. C. S. & Stewart, A.

  Institute of Nutrition, Metabolism and Diabetes

  1/03/06 → 28/02/07

  Project: Research