Mount Sinai Diabetes, Obesity, and Metabolism Institute

Projects

Projects per year 1986 2004 2017 2024

• 16 Active
• 69 Finished

Projects per year

Search results

• Active

  Identification of CaMKII as a novel substrate of dopaminylation following heroin self administration

  Stewart, A.

  National Institute on Drug Abuse

  19/01/22 → 18/01/24

  Project: Research

  • Substance-Related Disorders 100%
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 96%
  • Self Administration 90%
  • Heroin 86%
  • Dopamine 63%

• Experimental and natural SARS-CoV-2 infection of the human pancreas

  Homann, D., Homann, D., Schotsaert, M. M. & Schotsaert, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  17/09/21 → 31/08/23

  Project: Research

  • SARS Virus 100%
  • Pancreas 49%
  • Infections 31%
  • In Vitro Techniques 9%
  • Viral Structures 9%

• Alleviation of Glucotoxicity in Pancreatic Beta Cells

  Scott, D. & Scott, D. K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  20/07/21 → 30/06/23

  Project: Research

  • islets of Langerhans 100%
  • noninsulin-dependent diabetes mellitus 97%
  • Insulin-Secreting Cells 75%
  • cells 44%
  • glucose 38%

• DREAM Complex Maintenance of Human Beta Cell Quiescence

  Stewart, A. A. F., Wang, P. P., Stewart, A. & Wang, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/21 → 31/05/23

  Project: Research

  • Cell Proliferation 100%
  • Psychological Inhibition 82%
  • Insulinoma 63%
  • Transforming Growth Factor beta 46%
  • Chromatin 44%

• Epigenetic regulation in therapeutic human pancreatic beta cell proliferation

  Karakose, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/21 → 31/12/23

  Project: Research

  • Insulin-Secreting Cells 100%
  • Epigenomics 81%
  • Cell Proliferation 53%
  • Pharmaceutical Preparations 29%
  • Chronic Disease 21%

• Myc Physiology in the Pancreatic Beta Cell

  Scott, D., García-Ocaña, A., García-Ocaña, A. & Scott, D. K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  28/07/20 → 30/04/23

  Project: Research

  • Insulin-Secreting Cells 100%
  • Nutrients 24%
  • Insulin Resistance 11%
  • Up-Regulation 10%
  • Demethylation 8%

• TOX4 integrates hormone signaling on hepatic glucose and lipid metabolism

  Wang, L. & Wang, L. L.

  4/09/19 → 31/08/23

  Project: Research

  • Glucose 100%
  • Insulin 45%
  • Hepatocytes 44%
  • Lipid Metabolism 38%
  • Liver 34%

• Mechanisms regulating functional heterogeneity of subcutaneous adipose tissues in women

  Fried, S. S. K. & Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/07/19 → 30/04/23

  Project: Research

  • adipose tissue 100%
  • body fat distribution 83%
  • metabolic diseases 74%
  • adipocytes 54%
  • apples 41%

• Studying Autonomic Peripheral Innervation in Chronic Pancreatitis

  Jimenez Gonzalez, M.

  Congressionally Directed Medical Research Programs

  1/01/19 → …

  Project: Research

  • Chronic Pancreatitis 100%
  • Pancreas 80%
  • Pain 30%
  • Inflammation 24%
  • Nausea 18%

• Novel Selective Type II kinase Inhibitors to treat Diabetes

  DeVita, R., Stewart, A., Devita, R. J. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 28/02/23

  Project: Research

  • Phosphotransferases 100%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 92%
  • Cell Proliferation 41%
  • Pharmaceutical Chemistry 34%
  • Computational Chemistry 27%

• Does TBI Increase Susceptibility to Diabetes and Can This Be Prevented by Glucocorticoid Blockade?

  Homann, D.

  Congressionally Directed Medical Research Programs

  1/01/17 → …

  Project: Research

  • Brain Concussion 100%
  • Metabolic Diseases 49%
  • Glucocorticoids 43%
  • Afghanistan 20%
  • National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division 20%

• DYRK Inhibitors for Human Beta Cell Expansion

  Stewart, A., Garcia-ocana, A. A., Devita, R. J., García-Ocaña, A., DeVita, R. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/03/16 → 31/05/23

  Project: Research

  • Harmine 100%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 60%
  • Libraries 41%
  • Cell Proliferation 33%
  • Small Molecule Libraries 32%

• Dextran Sulfate, Beta Cell Preservation, and Immune Regulation in Type 1 Diabetes

  García-Ocaña, A.

  Congressionally Directed Medical Research Programs

  1/01/16 → …

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 84%
  • Immune Tolerance 21%
  • Immune System 14%
  • Inbred NOD Mouse 11%

• Dextran Sulfate, Beta Cell Preservation, and Immune Regulation in Type 1 Diabetes

  Homann, D.

  Congressionally Directed Medical Research Programs

  1/01/16 → …

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 84%
  • Immune Tolerance 21%
  • Immune System 14%
  • Inbred NOD Mouse 11%

• Einstein-Mount Sinai Diabetes Research Center

  Pessin, J. J. E., Chua, S. C., Crandall, J. P., DiLorenzo, T. P., García-Ocaña, A., Hawkins, M. A., Kurland, I. J., Pessin, J. E., Schwartz, G. J. & Stein, D. T.

  1/04/15 → 31/03/23

  Project: Research

  • diabetes 100%
  • translational medical research 26%
  • biomedical research 20%
  • infrastructure 18%
  • species recruitment 15%

• T32 Research Training in Diabetes and Endocrinology

  O'doherty, R. R. M., Robinson, A. A. G., Stewart, A., Derubertis, F. F. R., Goodpaster, B. H., O'doherty, R. M. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/86 → 30/06/23

  Project: Research

  • endocrinology 100%
  • diabetes 82%
  • chronic illness 62%
  • mentoring 58%
  • trainee 33%
• Finished

  Studying Autonomic Peripheral Innervation in Chronic Pancreatitis

  Jimenez Gonzalez, M.

  U.S. Army

  15/07/20 → 15/07/20

  Project: Research

  • Chronic Pancreatitis 100%
  • Pancreas 80%
  • Pain 30%
  • Inflammation 24%
  • Nausea 18%

• Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• Einstein-Mount Sinai Diabetes Research Center

  García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/20 → 31/03/22

  Project: Research

  • diabetes 100%
  • rodents 41%
  • Adenoviridae 37%
  • islets of Langerhans 29%
  • Lentivirus 23%

• Human Pancreas Analysis Program-T2D

  Powers, A. C., Atkinson, M. A., Bottino, R., Brissova, M., Gloyn, A., Homann, D., Kim, S. K., Macdonald, P. & Moore, J. H.

  National Institute of Diabetes and Digestive and Kidney Diseases

  22/09/19 → 30/06/21

  Project: Research

  • noninsulin-dependent diabetes mellitus 100%
  • pancreas 59%
  • diabetes 11%
  • insulin resistance 6%
  • islets of Langerhans 6%

• Interleukin-10 Signaling in Adipose Tissue Thermogenesis and Energy expenditure

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/08/19 → 31/07/21

  Project: Research

  • Thermogenesis 100%
  • Interleukin-10 87%
  • Interleukin-10 Receptors 75%
  • Adipose Tissue 74%
  • Energy Metabolism 71%

• Nrf2 and the adaptive expansion of beta cell mass

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/18 → 30/04/19

  Project: Research

  • Response Elements 100%
  • Carbohydrates 80%
  • Carrier Proteins 78%
  • Glucose 65%
  • Cell Proliferation 53%

• Interleukin-10 Signaling in Adipose Tissue Thermogenesis and Energy expenditure

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 30/04/19

  Project: Research

  • Thermogenesis 100%
  • Interleukin-10 93%
  • Interleukin-10 Receptors 80%
  • Adipose Tissue 77%
  • Energy Metabolism 70%

• Epigenetic Control of Human Beta Cell Proliferation

  Stewart, A., Argmann, C., Scott, D. & Walsh, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 31/03/19

  Project: Research

  • Epigenomics 100%
  • Insulinoma 96%
  • Cell Proliferation 78%
  • Chromosomes, Human, Pair 11 49%
  • Pancreatic adenoma 23%

• Mapping Essential Elements and Toxic Metals in the Human Pancreas in Health and Disease

  Homann, D. & Arora, M.

  National Institute of Environmental Health Sciences

  15/12/17 → 30/11/19

  Project: Research

  • Type 1 Diabetes Mellitus 100%
  • Metals 90%
  • Pancreas 83%
  • Laser Therapy 72%
  • Poisons 60%

• Integrated Functional Histopathology of the Diabetic Human Pancreas

  Von Herrath, M. M. G., Homann, D., Homann, D. & Von Herrath, M. G.

  National Institute of Allergy and Infectious Diseases

  7/12/17 → 30/11/22

  Project: Research

  • Pancreas 100%
  • Type 1 Diabetes Mellitus 72%
  • Endocrine Cells 48%
  • Tissue Donors 27%
  • Insulin-Secreting Cells 25%

• Combined harmalog-tgf beta inhibitors for human beta cell expansion

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/17 → 31/08/19

  Project: Research

  • Pharmaceutical Preparations 100%
  • Harmine 80%
  • Drive 49%
  • Pancreas 41%
  • Regeneration 40%

• DEXTRAN SULFATE, BETA CELL PRESERVATION, AND IMMUNE REGULATION IN TYPE 1 DIABETES

  Homann, D.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 59%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Military medical research and development

  Homann, D.

  U.S. Army

  1/08/17 → 31/07/19

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 73%
  • Biomedical Research 41%
  • Immune Tolerance 9%
  • Immune System 6%

• Military medical research and development

  García-Ocaña, A.

  U.S. Army

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 73%
  • Biomedical Research 41%
  • Immune Tolerance 9%
  • Immune System 6%

• DEXTRAN SULFATE, BETA CELL PRESERVATION, AND IMMUNE REGULATION IN TYPE 1 DIABETES

  García-Ocaña, A.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 59%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• ChREBP Isoforms in Pancreatic Beta Cells

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  18/04/17 → 31/03/21

  Project: Research

  • Insulin-Secreting Cells 100%
  • Protein Isoforms 75%
  • Glucose 70%
  • Response Elements 21%
  • Cell Proliferation 20%

• Dextran Sulfate, Beta Cell Preservation and Immune Regulation in Type 1 Diabetes

  García-Ocaña, A. & Homann, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/17 → 31/03/21

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 65%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  American Diabetes Association

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• Decay accelerating factor dependent inhibition of T cell immunity

  Heeger, P. & Homann, D.

  National Institute of Allergy and Infectious Diseases

  1/06/16 → 31/05/19

  Project: Research

  • CD55 Antigens 100%
  • Immunity 60%
  • T-Lymphocytes 56%
  • Psychological Inhibition 51%
  • Complement Activation 40%

• Enhanced transplant efficiency and function of human beta cells with ChREBP-alpha

  Scott, D.

  Juvenile Diabetes Research Foundation United States of America

  1/05/16 → 30/04/17

  Project: Research

  • Insulin 100%
  • Glucose 92%
  • Islets of Langerhans 73%
  • Transplants 68%
  • Protein Isoforms 59%

• Optimizing harmalog dosing and combinatorial therapy for human beta cell replication, enhanced survival and differentiation

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/06/15 → 31/05/17

  Project: Research

  • Survival 100%
  • Type 1 Diabetes Mellitus 68%
  • Cell Survival 58%
  • Genetic Therapy 35%
  • Rodentia 31%

• Reprogramming Fatty Acid Handling to Improve Adipocyte Function in Human Obesity

  Fried, S.

  1/01/15 → 31/12/17

  Project: Research

  • Adipocytes 100%
  • Fats 94%
  • White Adipocytes 62%
  • Fatty Acids 35%
  • Type 2 Diabetes Mellitus 31%

• Reprogramming Fatty Acid Handling to Improve Adipocyte Function in Human Obesity

  Fried, S.

  American Diabetes Association

  1/01/15 → 31/12/17

  Project: Research

  • Adipocytes 100%
  • Fats 86%
  • Fatty Acids 65%
  • White Adipocytes 56%
  • Obesity 46%

• Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity

  Fried, S., Pilch, P. F. & Fried, S. K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  25/09/14 → 31/08/18

  Project: Research

  • adipocytes 100%
  • adiponectin 85%
  • obesity 82%
  • adipokines 34%
  • insulin resistance 18%

• Mechanisms of TLE3 Action in Adipose Subtype-selective Gene Expression

  Rajbhandari, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  5/09/14 → 4/09/15

  Project: Research

  • White Adipose Tissue 100%
  • Brown Adipose Tissue 87%
  • PPAR gamma 79%
  • Gene Expression 44%
  • Adipocytes 29%

• Mapping the histopathological landscape of type 1 diabetes: a pilot study

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/05/14 → 30/04/15

  Project: Research

  • Type 1 Diabetes Mellitus 100%
  • Pancreas 47%
  • Technology 36%

• Dextran Sulfate and Beta Cell Regeneration and Protection for Type 1 Diabetes

  García-Ocaña, A.

  American Diabetes Association

  1/01/14 → 31/12/16

  Project: Research

  • dextran sulfate 100%
  • insulin-dependent diabetes mellitus 78%
  • islets of Langerhans 27%
  • cells 14%
  • cell proliferation 13%

• Dextran Sulfate and Beta Cell Regeneration and Protection for Type 1 Diabetes

  García-Ocaña, A.

  1/01/14 → 31/12/16

  Project: Research

  • dextran sulfate 100%
  • insulin-dependent diabetes mellitus 52%
  • islets of Langerhans 25%
  • cell proliferation 12%
  • mice 12%

• Mapping the histopathological landscape of type 1 diabetes: A pilot study

  Homann, D.

  Juvenile Diabetes Research Foundation United States of America

  1/11/13 → 31/10/14

  Project: Research

• Administrative

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/13 → 31/03/18

  Project: Research

  • nutrition science 100%
  • nutrition 61%
  • director 59%
  • expertise 25%
  • energy 23%

• Adipocyte Biology and Nutrient Metabolism

  Fried, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/13 → 31/03/18

  Project: Research

  • adipocytes 100%
  • Biological Sciences 58%
  • nutrients 50%
  • metabolism 48%
  • adipose tissue 27%

• Regulation of Pathogen-specific T Cell Immunity by Adenosine Generation

  Homann, D. & Homann, D.

  National Institute of Allergy and Infectious Diseases

  1/02/12 → 31/01/16

  Project: Research

  • Adenosine 100%
  • Immunity 80%
  • T-Lymphocytes 65%
  • Acute Lung Injury 48%
  • Viruses 48%

• Exploiting normal cMyc biology for human beta cell expansion

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/11 → 28/02/14

  Project: Research

  • Rodentia 100%
  • Preclinical Drug Evaluations 71%
  • Cell Line 71%
  • Cell Proliferation 59%
  • Transgenic Mice 53%