Mount Sinai Center for Transformative Disease Modeling

Icahn School of Medicine at Mount Sinai

33074 Citations
94 h-index
280 Article
39 Comment/debate
23 Review article
8 Chapter
More

Expression-driven genetic dependency reveals targets for precision oncology
Elmas, A., Layden, H. M., Ellis, J. D., Bartlett, L. N., Zhao, X., Kawabata-Iwakawa, R., Wang, Z., Obinata, H., Hiebert, S. W. & Huang, K. L., 2026, In: GigaScience. 15, giag011.
Research output: Contribution to journal › Article › peer-review

Open Access
Functional implications of polygenic risk for schizophrenia in human neurons
Michael Deans, P. J., Retallick-Townsley, K. G., Li, A., Seah, C., Johnson, J., Garcia Gonzalez, J., Cao, E., Schrode, N., Yu, A., Cartwright, S., Voloudakis, G., Zhang, W., Wang, M., Fullard, J. F., Girdhar, K., Stahl, E., Akbarian, S., Zhang, B., Roussos, P. & O’Reilly, P. & 2 others, Huckins, L. M. & Brennand, K. J., Dec 2026, In: Nature Communications. 17, 1, 1355.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Leveraging machine learning and network biology approaches to predict brain gene expression from blood transcriptomes
Sevim Bayrak, C., Zeng, Q., Ilkov, M., Russo, S. J., Wang, M. & Zhang, B., 2026, (Accepted/In press) In: GigaScience.
Research output: Contribution to journal › Article › peer-review

Open Access
LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice
Arzola, E., Yu, G., Xiong, L., Lee, D., Wu, A., Paruchuri, S., Skinner, J., Wang, M., Zhang, B., Mei, L. & Xiong, W. C., Feb 2026, In: GLIA. 74, 2, e70114.
Research output: Contribution to journal › Article › peer-review

Open Access
Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences
Wang, N., Yu, G., Wang, Z., Alnobani, A., Jeevaratnam, S., Zhang, X., McReynolds, M., Chang, Y., Qi, F., Tauer, W., Rosenberg, C., Wren, M., Ikezu, T. C., Martens, Y. A., Wang, M., Zhang, B., Carter, G. W., Sasner, M., Holtzman, D. M. & Peng, J. & 4 others, Wu, L. J., Kanekiyo, T., Liu, C. C. & Bu, G., Dec 2026, In: Molecular Neurodegeneration. 21, 1, 26.
Research output: Contribution to journal › Article › peer-review

Open Access
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
Shrestha, H. K., Sun, H., Yarbro, J. M., Lee, D. G., Liu, D., Wang, E., McReynolds, M., Zhang, N., Xie, B., Yang, S., Yu, K., Poudel, S., Li, Y., Yuan, Z. F., Kong, D., Wang, M., Wang, Z., Niu, M., Wang, H. & Zaman, M. & 27 others, Wang, J., Vanderwall, D. R., Sun, Y., Wu, Z., Chen, P. C., Bai, B., High, A. A., Faura, J., Liu, C., Bennett, D. A., Johnson, E. C. B., Seyfried, N. T., Levey, A. I., Haroutunian, V., Serrano, G. E., Beach, T. G., DeTure, M., Kanekiyo, T., Petersen, R. C., Bu, G., McLean, P. J., Dickson, D. W., Rademakers, R., Yu, G., Wang, X., Zhang, B. & Peng, J., 14 May 2026, In: Cell. 189, 10, p. 3124-3143.e15
Research output: Contribution to journal › Article › peer-review

Open Access
Predicting Patient Self-reported Race From Skin Histological Images with Deep Learning
Chen, S., Verma, R., Clare, K., Jegminat, J., Alleva, E., Huang, K. L., Veremis, B., Fuchs, T. & Campanella, G., 2026, Fairness of AI in Medical Imaging - 3rd International Workshop, FAIMI 2025, Held in Conjunction with MICCAI 2025, Proceedings. Puyol-Antón, E., Feragen, A., Cheplygina, V., Glocker, B., Lee, H., Ferrante, E., King, A., Ganz-Benjaminsen, M. & Petersen, E. (eds.). Springer Science and Business Media Deutschland GmbH, p. 104-114 11 p. (Lecture Notes in Computer Science; vol. 15976 LNCS).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Quantifying rate-limiting genetic variation in breast and ovarian tumourigenesis
Houlahan, K. E., Bihie, M., Greatti, Y., Contreras, J. G., Fulop, D. J., Lopez, G., Williams, M., Huang, H. H., Van Loo, P., Boutros, P. C. & Huang, K. L., Mar 2026, In: eBioMedicine. 125, 106181.
Research output: Contribution to journal › Article › peer-review

Open Access
Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease
Members of the Alzheimers Disease Neuroimaging Initiative, 2026, (Accepted/In press) In: GeroScience.
Research output: Contribution to journal › Article › peer-review

Open Access
Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease
Yu, G., Thorpe, A., Zeng, Q., Wang, E., Goate, A., Cai, D., Wang, M. & Zhang, B., May 2026, In: Alzheimer's and Dementia. 22, 5, e71463.
Research output: Contribution to journal › Article › peer-review

Open Access
A clinical benchmark of public self-supervised pathology foundation models
Campanella, G., Chen, S., Singh, M., Verma, R., Muehlstedt, S., Zeng, J., Stock, A., Croken, M., Veremis, B., Elmas, A., Shujski, I., Neittaanmäki, N., Huang, K. L., Kwan, R., Houldsworth, J., Schoenfeld, A. J. & Vanderbilt, C., Dec 2025, In: Nature Communications. 16, 1, 3640.
Research output: Contribution to journal › Article › peer-review

Open Access
47 Scopus citations
Actionable targets in breast cancer: a multi-omics approach to uncover tumor-specific vulnerabilities
Elmas, A., 15 Mar 2025, In: Gumushane Universitesi Fen Bilimleri Dergisi. 15, 1, p. 260-273 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access

Effects of different storage conditions on volatile components of wheat
Wang, M.
3/06/26
1 item of Media coverage
Press/Media
Researchers at Icahn School of Medicine at Mount Sinai Target Prostate Cancer (A Unified Agent-Enabled Platform for Drug Repurposing across Molecular, Phenotypic, and Clinical Scales)
Huang, K. & Chakraborty, G.
2/06/26
1 item of Media coverage
Press/Media
Cornell University Describes Findings in Science (PAM1 regulates meiosis by coupling RNA processing to the chromosome axis)
Wang, M.
27/05/26
1 item of Media coverage
Press/Media
Researchers at Icahn School of Medicine at Mount Sinai Report Findings in Alzheimer Disease (Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease)
Wang, M. & Goate, A.
22/05/26
1 item of Media coverage
Press/Media
New Findings from Henan University Update Understanding of Human-Computer Interaction [Deconstructing Ambivalence Toward Ai: Development and Validation of a Five-dimension Scale (Aaais)]
Wang, M.
18/05/26
1 item of Media coverage
Press/Media
Researchers at Icahn School of Medicine at Mount Sinai Describe Findings in Influenza A Virus (Re-engineering segment 8 facilitates generation of a versatile live-attenuated influenza A virus vector platform for secretory protein delivery)
Wang, Q. & Garcia-Sastre, A.
6/05/26
1 item of Media coverage
Press/Media
New Findings from Icahn School of Medicine at Mount Sinai in the Area of Schizophrenia Reported (Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia)
Akbarian, S., Wang, M., Roussos, P., Girdhar, K. & Hoffman, G.
20/04/26
1 item of Media coverage
Press/Media
Research from Shandong University Has Provided New Study Findings on Fisheries Research [Physiological and molecular effects of 17a-methyltestosterone and letrozole on sexual differentiation of black rockfish (Sebastes schlegelii)]
Wang, Q.
6/04/26
1 item of Media coverage
Press/Media
Yangtze University Researchers Illuminate Research in Fisheries Research (Effects of dietary methyl farnesoate on growth and ovarian development of Macrobrachium rosenbergii and underlying mechanisms)
Wang, Q.
6/04/26
1 item of Media coverage
Press/Media
Mount Sinai wins $1 million AI prize for Alzheimer's research platform that cuts analysis time from months to minutes
Huang, K.
30/03/26
1 item of Media coverage
Press/Media
Mount Sinai Scientists Recognized With Global AI Prize for Novel Alzheimer’s Disease Research Platform
Huang, K. & Goate, A.
27/03/26 → 29/03/26
7 items of Media coverage
Press/Media
AI for AD: Developers Throw Their Hats into the Ring
Wang, M. & Huang, K.
28/03/26
1 item of Media coverage
Press/Media

Mount Sinai Center for Transformative Disease Modeling

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Lap Ho

Kuanlin Huang

Aiqun Li

Won-min Song

Minghui Wang

Bin Zhang

Xianxiao Zhou

Expression-driven genetic dependency reveals targets for precision oncology

Functional implications of polygenic risk for schizophrenia in human neurons

Leveraging machine learning and network biology approaches to predict brain gene expression from blood transcriptomes

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences

Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures

Predicting Patient Self-reported Race From Skin Histological Images with Deep Learning

Quantifying rate-limiting genetic variation in breast and ovarian tumourigenesis

Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease

Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease

A clinical benchmark of public self-supervised pathology foundation models

Actionable targets in breast cancer: a multi-omics approach to uncover tumor-specific vulnerabilities

Effects of different storage conditions on volatile components of wheat

Researchers at Icahn School of Medicine at Mount Sinai Target Prostate Cancer (A Unified Agent-Enabled Platform for Drug Repurposing across Molecular, Phenotypic, and Clinical Scales)

Cornell University Describes Findings in Science (PAM1 regulates meiosis by coupling RNA processing to the chromosome axis)

Researchers at Icahn School of Medicine at Mount Sinai Report Findings in Alzheimer Disease (Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease)

New Findings from Henan University Update Understanding of Human-Computer Interaction [Deconstructing Ambivalence Toward Ai: Development and Validation of a Five-dimension Scale (Aaais)]

Researchers at Icahn School of Medicine at Mount Sinai Describe Findings in Influenza A Virus (Re-engineering segment 8 facilitates generation of a versatile live-attenuated influenza A virus vector platform for secretory protein delivery)

New Findings from Icahn School of Medicine at Mount Sinai in the Area of Schizophrenia Reported (Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia)

Research from Shandong University Has Provided New Study Findings on Fisheries Research [Physiological and molecular effects of 17a-methyltestosterone and letrozole on sexual differentiation of black rockfish (Sebastes schlegelii)]

Yangtze University Researchers Illuminate Research in Fisheries Research (Effects of dietary methyl farnesoate on growth and ovarian development of Macrobrachium rosenbergii and underlying mechanisms)

Mount Sinai wins $1 million AI prize for Alzheimer's research platform that cuts analysis time from months to minutes

Mount Sinai Scientists Recognized With Global AI Prize for Novel Alzheimer’s Disease Research Platform

AI for AD: Developers Throw Their Hats into the Ring

Mount Sinai Center for Transformative Disease Modeling

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media