Mindich Child Health and Development Institute

Projects

Projects per year 1984 2004 2005 2007 2009 2010 2017 2018 2021 2026

• 71 Active
• 247 Finished

Projects per year

Search results

• Finished

  Mechanistic modeling of epigenetic modifier mutations in human pluripotent stem cell-derived immune cells

  Byun, M.

  National Institute of Allergy and Infectious Diseases

  1/02/22 → 31/01/23

  Project: Research

  • Pluripotent Stem Cells 100%
  • Epigenomics 74%
  • Mutation 63%
  • Hematologic Diseases 49%
  • Hematologic Neoplasms 43%

• A Cytochrome P450 Therapeutic Space for Tauopathies

  Dar, A. & Cagan, R.

  National Institute on Aging

  30/09/21 → 31/08/22

  Project: Research

  • Anastrozole 100%
  • cytochrome P-450 92%
  • Tauopathies 80%
  • therapeutics 76%
  • neurodegenerative diseases 62%

• Transient Gene Therapy as Broad Spectrum Antiviral

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  1/09/21 → 31/08/22

  Project: Research

  • Influenza A virus 100%
  • SARS Virus 95%
  • Antiviral Agents 66%
  • Genetic Therapy 48%
  • Cricetinae 39%

• Childhood Asthma in Urban Settings

  Busse, P., Bunyavanich, S. & Wisnivesky, J. P.

  National Institute of Allergy and Infectious Diseases

  15/04/21 → 31/03/22

  Project: Research

  • Asthma 100%
  • National Institute of Allergy and Infectious Diseases (U.S.) 33%
  • Research Personnel 29%
  • Systems Biology 25%
  • N,N-dimethylarginine 14%

• A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

  Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.

  National Cancer Institute

  1/03/21 → 28/02/23

  Project: Research

  • regorafenib 100%
  • Phosphotransferases 62%
  • Colorectal Neoplasms 60%
  • Polypharmacology 20%
  • Aurora Kinase A 17%

• Deciphering the molecular control of intratumoral dendritic cells

  Merad, M., Brown, B., Brown, B. B. D. & Merad, M.

  National Cancer Institute

  1/02/21 → 31/01/23

  Project: Research

  • Dendritic Cells 100%
  • Immunity 36%
  • Neoplasms 21%
  • Antigens 19%
  • Genes 16%

• Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity

  Merad, M., Brown, B., Brown, B. B. D. & Merad, M.

  National Cancer Institute

  1/02/21 → 31/01/23

  Project: Research

  • Immunity 100%
  • Macrophages 96%
  • Immunotherapy 72%
  • Lung Neoplasms 62%
  • Neoplasms 44%

• Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• Coordinate regulation of erythroid and macrophage lineages in development by EKLF/KLF1

  Bieker, J. & Bieker, J. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/04/20 → 31/01/23

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Macrophages 37%
  • Islands 16%
  • Zinc Fingers 9%
  • Erythrocytes 9%

• Positive and Negative Valence Systems Underlying Suicide in Youth

  Gabbay, V.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  10/04/20 → 9/04/22

  Project: Research

  • Suicide 100%
  • Reward 82%
  • Habenula 59%
  • Anhedonia 56%
  • Completed Suicide 30%

• Biobehavioral Predictors of Illness Progression in Adolescent Depression

  Gabbay, V. V. & Gabbay, V.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/04/20 → 31/01/23

  Project: Research

  • Anhedonia 100%
  • Reward 75%
  • Depression 54%
  • Kynurenine 36%
  • gamma-Aminobutyric Acid 34%

• Einstein-Mount Sinai Diabetes Research Center

  García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/20 → 31/03/22

  Project: Research

  • diabetes 100%
  • rodents 41%
  • Adenoviridae 37%
  • islets of Langerhans 29%
  • Lentivirus 23%

• Nuclear import of beta-Catenin in Wnt-signaling

  Mlodzik, M.

  National Institute of Child Health and Human Development

  3/02/20 → 31/01/22

  Project: Research

  • Catenins 100%
  • Kinesin 92%
  • Cell Nucleus Active Transport 65%
  • beta Catenin 55%
  • Drosophila 20%

• Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome

  Kolevzon, A.

  National Institute of Neurological Disorders and Stroke

  20/09/19 → 31/07/22

  Project: Research

  • Telomeric 22q13 Monosomy Syndrome 100%
  • Intellectual Disability 46%
  • Natural History 45%
  • Autism Spectrum Disorder 45%
  • Genotype 30%

• Cellular and molecular characterization of LIG1 mutations causing a spectrum of primary immune deficiencies

  O’Brien, P. J. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  19/06/19 → 31/05/21

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • DNA Replication 73%
  • Alleles 53%
  • Ligases 53%
  • Mutation 44%

• Dermal Papilla Regulation and Function for Stem Cell Activation in the Hair Cycle

  Rendl, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/04/19 → 31/03/20

  Project: Research

  • Stem Cells 100%
  • Skin 94%
  • Stem Cell Niche 33%
  • Hair 32%
  • Hair Follicle 30%

• Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: ALSPAC-MRI-II

  Kempton, M. J. M. J., Reichenberg, A., Jones, D. D., Zammit, S. S., Boyd, A. A., David, A. A., De Stavola, B. B., Lewis, G. G. & Bullmore, E. E.

  Medical Research Council

  1/03/19 → 28/02/23

  Project: Research

  • Longitudinal Studies 100%
  • Parents 90%
  • Brain 82%
  • Magnetic Resonance Imaging 79%
  • Mental Disorders 74%

• An RNA-based approach to intranasal delivery of neuropeptides to the brain

  Zangi, L. & Harony-Nicolas, H.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/03/19 → 31/12/21

  Project: Research

  • Neuropeptides 100%
  • RNA 55%
  • Brain 42%
  • Mood Disorders 27%
  • Intranasal Administration 24%

• RACH-Mix, New tools for risk assessment of chemical mixtures

  Bornehag, C. C., Sturve, J. J., Rüegg, J. J., Rudén, C. C., Rudén, C. C. & Gennings, C.

  Svenska Forskningsrådet Formas

  1/12/18 → 30/11/22

  Project: Research

  • Risk assessment 100%
  • Epidemiology 21%
  • Health 11%

• Generation of cultured RBCs with rare phenotypes for transfusion from sources usually discarded during regular blood donations

  Bieker, J. & Migliaccio, A. R. F.

  National Heart, Lung, and Blood Institute

  20/09/18 → 31/05/19

  Project: Research

  • Blood Donors 100%
  • Phenotype 67%
  • Costs and Cost Analysis 50%
  • Transfusion Medicine 37%
  • Gene Editing 32%

• Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health

  Sanders, A. & Sanders, A. A. P.

  National Institute of Environmental Health Sciences

  15/09/18 → 30/11/22

  Project: Research

  • Metals 100%
  • MicroRNAs 97%
  • Biomarkers 75%
  • Kidney 62%
  • Health 56%

• A Transgenic System for Targeted Ablation of Reproductive and Maternal-Effectgenes

  Marlow, F.

  National Institute of Child Health and Human Development

  6/08/18 → 31/07/20

  Project: Research

  • germ cells 100%
  • maternal effect 95%
  • genetically modified organisms 82%
  • Danio rerio 60%
  • genes 50%

• Intrinsic and extrinsic control of erythropoietic maturation

  Bieker, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/07/18 → 30/06/19

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Macrophages 23%
  • Islands 11%
  • Congenital Dyserythropoietic Anemia 9%
  • Cell Cycle 8%

• Nrf2 and the adaptive expansion of beta cell mass

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/18 → 30/04/19

  Project: Research

  • Response Elements 100%
  • Carbohydrates 80%
  • Carrier Proteins 78%
  • Glucose 65%
  • Cell Proliferation 53%

• Develop functional screening and genetic diagnosis for inborn errors in the NF-kappaB pathways

  Guennoun, A. A., Marr, N. N., Fuleihan, R. R., Lo, B. B., Cunningham-Rundles, C., Casanova, J. J. & Zhang, Q. Q.

  Qatar National Research Fund

  15/06/18 → 14/04/22

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Genetic Testing 44%
  • NF-kappa B 42%
  • Qatar 29%
  • Mutation 22%

• Cell motility regulation by PCP signaling

  Mlodzik, M.

  National Institute of Child Health and Human Development

  8/06/18 → 31/05/20

  Project: Research

  • Cell Polarity 100%
  • Cell Movement 57%
  • Signal Transduction 50%
  • Drosophila 24%
  • Eye 12%

• Role of THC as an inhibitor of Shh-dependent midlineand neuronal patterning

  Krauss, R.

  National Institute on Drug Abuse

  1/06/18 → 31/05/21

  Project: Research

  • Holoprosencephaly 100%
  • Dronabinol 78%
  • Hedgehogs 30%
  • Mutation 16%
  • Neural Tube 14%

• FASEB SRC on Skeletal Muscle Satellite Cells and Regeneration

  Krauss, R.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/06/18 → 31/05/19

  Project: Research

  • skeletal muscle 100%
  • Biological Sciences 79%
  • career development 54%
  • cells 50%
  • myocytes 45%

• Methods for Data Integration and Risk Assessment for Environmental Mixtures

  Gennings, C., Coull, B. B. A., Coull, B. A. & Gennings, C.

  National Institute of Environmental Health Sciences

  15/05/18 → 30/04/22

  Project: Research

  • risk assessment 100%
  • exposure 51%
  • biomarker 44%
  • method 32%
  • project 18%

• Epigenetic Control of Human Beta Cell Proliferation

  Stewart, A., Argmann, C., Scott, D. & Walsh, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 31/03/19

  Project: Research

  • Epigenomics 100%
  • Insulinoma 96%
  • Cell Proliferation 78%
  • Chromosomes, Human, Pair 11 49%
  • Pancreatic adenoma 23%

• Biostatistics and Bioinformatics Facility Core

  Gennings, C.

  National Institute of Environmental Health Sciences

  1/04/18 → 31/03/22

  Project: Research

  • Biostatistics 100%
  • Bioinformatics 69%
  • Health 32%
  • Statistical methods 14%
  • Biomarkers 11%

• Defining the spatio-temporal mechanisms of ventricular cell specification and differentiation

  DuBois, N.

  National Heart, Lung, and Blood Institute

  15/02/18 → 31/01/22

  Project: Research

  • Pluripotent Stem Cells 100%
  • Cell Differentiation 97%
  • Cardiac Myocytes 47%
  • Heart Diseases 27%
  • Heart 22%

• Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health

  Sanders, A.

  National Institute of Environmental Health Sciences

  15/09/17 → 31/08/18

  Project: Research

  • Metals 100%
  • Kidney 75%
  • MicroRNAs 69%
  • Biomarkers 53%
  • Health 38%

• ZIKA VIRUS RESISTANCE; HOST DETERMINANTS

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  5/08/17 → 31/07/19

  Project: Research

  • Zika Virus 100%
  • Zika Virus Infection 67%
  • Interferons 33%
  • Preliminary Data 26%
  • Central America 16%

• DEXTRAN SULFATE, BETA CELL PRESERVATION, AND IMMUNE REGULATION IN TYPE 1 DIABETES

  García-Ocaña, A.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 59%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Military medical research and development

  García-Ocaña, A.

  U.S. Army

  1/08/17 → 31/07/20

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 73%
  • Biomedical Research 41%
  • Immune Tolerance 9%
  • Immune System 6%

• Interplay between Negative Regulators of Type I Interferon and HIV control

  Bogunovic, D. & Simon, V.

  National Institute of Allergy and Infectious Diseases

  10/06/17 → 31/05/19

  Project: Research

  • Interferon Type I 100%
  • Interferons 98%
  • HIV 77%
  • Antiviral Agents 26%
  • Germ-Line Mutation 17%

• The Origin and Memory of Human IgE Responses

  Curotto de Lafaille, M.

  National Institute of Allergy and Infectious Diseases

  15/05/17 → 30/04/19

  Project: Research

  • Immunoglobulin E 100%
  • Memory 56%
  • Immunoglobulin G 16%
  • Germinal Center 12%
  • Allergens 10%

• Administrative Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Personnel 100%
  • Direction compound 17%

• Patient Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Ethics Committees 100%
  • Ambulatory Care 94%
  • Confidentiality 57%
  • Research Personnel 49%
  • Patient Selection 41%

• Blocks to B Cell Memory

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • B-Lymphocytes 100%
  • Common Variable Immunodeficiency 80%
  • Plasma Cells 28%
  • Autoimmunity 28%
  • Transmembrane Activator and CAML Interactor Protein 27%

• ChREBP Isoforms in Pancreatic Beta Cells

  Scott, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  18/04/17 → 31/03/21

  Project: Research

  • Insulin-Secreting Cells 100%
  • Protein Isoforms 75%
  • Glucose 70%
  • Response Elements 21%
  • Cell Proliferation 20%

• Dextran Sulfate, Beta Cell Preservation and Immune Regulation in Type 1 Diabetes

  García-Ocaña, A. & Homann, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/17 → 31/03/21

  Project: Research

  • Dextran Sulfate 100%
  • Type 1 Diabetes Mellitus 65%
  • Inbred NOD Mouse 27%
  • Peripheral Tolerance 12%
  • Immune Tolerance 10%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  American Diabetes Association

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• Targeting the ChREBP-Nrf2 axis to expand functional beta cell mass

  Scott, D.

  1/01/17 → 31/12/19

  Project: Research

  • Glucose 100%
  • Islets of Langerhans Transplantation 81%
  • Cell Proliferation 62%
  • Transcription Factors 47%
  • Antioxidants 47%

• PAGES: Physical Activity Genomics, Epigenomics/transcriptomics Site

  Sealfon, S., Walsh, M. M. J., Sealfon, S. C. & Walsh, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/12/16 → 30/11/22

  Project: Research

  • Transducers 100%
  • Genomics 98%
  • Epigenomics 85%
  • Chromatin Immunoprecipitation Sequencing 46%
  • Whole Genome Sequencing 31%

• Improving Medication Adherence in children who had a Liver Transplant: iMALT

  Shemesh, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  14/09/16 → 31/08/18

  Project: Research

  • Psychology Rejection 100%
  • Medication Adherence 96%
  • Liver Transplantation 86%
  • Organized Financing 68%
  • Transplants 54%

• Atrial-ventricular specification during mammalian heart development

  DuBois, N.

  National Heart, Lung, and Blood Institute

  1/09/16 → 28/02/18

  Project: Research

  • Heart 100%
  • Pluripotent Stem Cells 77%
  • Heart Diseases 71%
  • Population 51%
  • Pericardium 49%

• Enhanced transplant efficiency and function of human beta cells with ChREBP-alpha

  Scott, D.

  Juvenile Diabetes Research Foundation United States of America

  1/05/16 → 30/04/17

  Project: Research

  • Insulin 100%
  • Glucose 92%
  • Islets of Langerhans 73%
  • Transplants 68%
  • Protein Isoforms 59%

• Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood Obesity

  Just, A.

  National Institute of Environmental Health Sciences

  1/04/16 → 31/03/20

  Project: Research

  • Methylation 100%
  • Pediatric Obesity 97%
  • DNA Methylation 87%
  • Epigenomics 38%
  • phthalic acid 29%